scholarly journals POSTNATAL IMPLICATIONS FOR PRENATAL DIAGNOSED TETRALOGY OF FALLOT

2016 ◽  
Vol 65 (3) ◽  
pp. 264-267
Author(s):  
Georgiana Nicolae ◽  
◽  
Cristina Filip ◽  
Adriana Diaconu ◽  
Alin Nicolescu ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Developed Countries ◽  
Postnatal Period ◽  
Diagnostic Methods ◽  
Term Survival ◽  
Heart Malformation ◽  
Cardiovascular Surgical Procedures

Over the last few years, prenatal diagnosis of congenital heart diseases experienced an important development. Overall survival of patients with congenital heart disease was improved in the last decade due to the advanced diagnostic methods and progression of cardiovascular surgical procedures in this field. Due to the significant increase of the long-term survival rate, currently, in most developed countries, there are departments dedicated to monitoring the adults with congenital heart malformation due to the particularities and special needs of this type of patients, compared with the regular cardiac pathology of adults. This article proposes a review of existing data at this moment related to the prenatal and postnatal diagnosis and their impact on the evolution regarding the most common cyanotic congenital malformation – Tetralogy of Fallot. In the following pages, we is emphasize the importance of knowing the precise fetal pathology for early determination of medical behavior in the postnatal period for the best care of these children.

The case for preoperative coronary angiography in patients with tetralogy of Fallot and other complex congenital heart diseases

1982 ◽  
Vol 103 (3) ◽  
pp. 451-456 ◽  
Author(s):  
Bruce M. McManus ◽  
Bruce F. Waller ◽  
Michael Jones ◽  
Stephen E. Epstein ◽  
William C. Roberts
Keyword(s):  
Coronary Angiography ◽  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Congenital Heart Diseases

scholarly journals TETRALOGI FALLOT DAN ATRESIA PULMONAL

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Alice I. Supit ◽  
Erling D. Kaunang
Keyword(s):  
Patent Ductus Arteriosus ◽  
Right Ventricle ◽  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Ductus Arteriosus ◽  
Ventricle Hypertrophy ◽  
The Right ◽  
Right Ventricle Hypertrophy ◽  
Patent Ductus

Abstract: Congenital heart disease is a structural defect due to the malformation of the heart, aorta, and or great blood vessels. It is the most frequent congenital malformation in newborn babies. Tetralogy of Fallot is one of the congenital heart diseases (CHD) with central cyanosis, and covers 5-10% of all CHD. We reported a boy of one year old with Tetralogy of Fallot and pulmonal atresia (ToF-PA), associated with bronchopneumonia. The diagnosis was based on anamnesis, physical examination, and other supporting examinations. The chest X-ray showed a normal sized heart (CTR 57%) with coer-en-sabot shape, and right and left parahilar infiltration, which resulted in bronchopneumonia and ToF. The electrocardiography showed a right deviation of axis and a hypertrophy of the right ventricle; the echocardiography showed a right ventricle hypertrophy, an over-riding aorta, a large malalignment of the ventricular septal defect, no visualization of pulmonar artery, and no visualization of patent ductus arteriosus (PDA). Conclusion: Based on all the tests performed, the diagnosis of this patient was Tetralogy of Fallot and pulmonal atresia (ToF-PA), associated with bronchopneumonia. The prognosis related to bronchopneumonia in this case was good due to the use of antibiotics. Keywords: tetralogy of Fallot, pulmona atresia, bronchopneumonia.  Abstrak: Penyakit jantung bawaan (PJB) ialah kelainan struktural akibat malformasi jantung, aorta dan atau pembuluh darah besar, dan merupakan kelainan kongenital tersering pada bayi baru lahir. Tetralogi Fallot merupakan salah satu PJB dengan sianosis sentral, dan mencakup 5-10% dari seluruh PJB. Kami melaporkan kasus seorang anak laki-laki berusia satu tahun dengan Tetralogi Fallot dan atresia pulmonal (ToF-PA) disertai bronkopneumonia. Diagnosis ditegakkan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Hasil ekspertisi foto toraks AP memperlihatkan ukuran jantung normal (CTR 57%) berbentuk coer-en-sabot, dan pada paru-paru terlihat infiltrat parahilar kanan dan kiri serta corakan vaskular paru berkurang yang menunjukkan suspek bronkopneumonia dan ToF. Elektrokardiografi memperlihatkan deviasi aksis ke kanan dan hipertrofi ventrikel kanan, dan pada ekokardiografi tampak right ventricle hypertrophy, overriding aorta, VSD malalignment besar, tidak tampak visualisasi arteri pulmonal, dan tidak tampak patent ductus arteriosus (PDA) dengan hasil Tetralogi Fallot dan atresia pulmonal. Simpulan: Berdasarkan hasil pemeriksaan yang dilakukan, diagnosis pasien ini ialah Tetralogi Fallot dan atresia pulmonal (ToF-PA) disertai bronkopneumonia. Prognosis bronkopenumonia pada kasus ini baik yang dapat diatasi dengan antibiotika.Kata kunci: tetralogi Fallot, atresia pulmonal, bronkopneumonia.  

scholarly journals Tetralogy of Fallot with Double Aortic Arch in an 8-Month-Old Girl: A Rare Association

2020 ◽  
Vol 23 (4) ◽  
pp. E507-E509
Author(s):  
Huang Feng ◽  
Xiaohui Bian ◽  
Yuru Lan ◽  
Yunfei Ling ◽  
Yong jun Qian
Keyword(s):  
Aortic Arch ◽  
Tetralogy Of Fallot ◽  
Rare Case ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Relative Size ◽  
Double Aortic Arch ◽  
Congenital Heart Diseases ◽  
Rare Congenital Anomaly ◽  
Rare Association

Double aortic arch (DAA) is an extremely rare congenital anomaly that can be divided into right dominant, left dominant, and balanced DAA according to the relative size of the two arches. The incidence of balanced DAA is only 5% among double arch anomalies. DAA is symptomatic only when it produces symptoms secondary to compression of the trachea or esophagus. DAA is rarely associated with other congenital heart diseases. In this report, we present a rare case of asymptomatic DAA combined with Tetralogy of Fallot (TOF) in an 8-month-old girl.

scholarly journals Antibiotic Therapy for Infective Endocarditis in Childhood

2006 ◽  
Vol 11 (2) ◽  
pp. 64-91
Author(s):  
Leonardo Calza ◽  
Roberto Manfredi ◽  
Francesco Chiodo
Keyword(s):  
Infective Endocarditis ◽  
Antibiotic Therapy ◽  
Congenital Heart ◽  
Western Europe ◽  
Antimicrobial Agents ◽  
Heart Diseases ◽  
Survival Rates ◽  
Developed Countries ◽  
Resistant Bacteria ◽  
Vancomycin Resistant

Infective endocarditis is relatively uncommon in childhood, but its epidemiology has changed in the past three to four decades and its incidence has been increasing in recent years. With the improved survival rates of children with congenital heart diseases and the overall decreased frequency of rheumatic valvular heart disease in developed countries, congenital cardiac abnormalities now represent the predominant underlying condition for infective endocarditis in children over the age of two years in Western Europe and Northern America. Moreover, the complex management of neonatal and pediatric intensive care unit patients has increased the risk of catheter-related endocarditis. More specifically, the surgical correction of congenital heart alterations is associated with the risk of postoperative infections. Endocarditis in children may be difficult to diagnosis and manage. Emerging resistant bacteria, such as methicillin- or vancomycin-resistant staphylococci and vancomycin-resistant enterococci, are becoming a new challenge for conventional antibiotic therapy. Newer antimicrobial compounds recently introduced in clinical practice, such as streptogramins and oxazolidinones, may be effective alternatives in children with endocarditis sustained by Gram-positive cocci resistant to glycopeptides. Home intravenous therapy has become an acceptable approach for stable patients who are at low risk for embolic complications. However, further clinical studies are needed in order to assess efficacy and safety of these antimicrobial agents in children. This review should help outline the most appropriate antimicrobial treatments for infective endocarditis in children.

Comparison of Different Approaches for Pediatric Congenital Heart Diseases

2003 ◽  
Vol 11 (3) ◽  
pp. 226-228 ◽  
Author(s):  
Qingyu Wu ◽  
Guohua Luo ◽  
Shoujun Li ◽  
Xiangdong Shen ◽  
Feng Lu
Keyword(s):  
Ventricular Septal Defect ◽  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Pediatric Patients ◽  
Septal Defect ◽  
Heart Diseases ◽  
Hemoglobin Concentration ◽  
Clinical Results ◽  
Pulmonary Complications ◽  
Surgical Approaches

To compare the clinical results of different surgical approaches for congenital heart disease in pediatric patients, 1,669 cases of atrial septal defect, ventricular septal defect, or tetralogy of Fallot, which were corrected from January 1999 to December 2001, were classified according to approach (sternotomy, ministernotomy, or minithoracotomy). In cases of ventricular septal defect, the incidence of pulmonary complications was significantly higher in the minithoracotomy group than in the full sternotomy or ministernotomy groups. In patients with tetralogy of Fallot, hemoglobin concentration was higher, oxygen saturation was lower, and more patients required a transanular patch in the sternotomy group than in the other groups, but the clinical results were similar. Patients with complex defects or severe pulmonary hypertension should undergo a full sternotomy.

scholarly journals Surgical Treatment of Infective Endocarditis in Pulmonary Position—15 Years Single Centre Experience

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 608 ◽  
Author(s):  
Liekiene ◽  
Bezuska ◽  
Semeniene ◽  
Cypiene ◽  
Lebetkevicius ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Congenital Heart ◽  
Pulmonary Valve ◽  
Late Results ◽  
Term Survival ◽  
Single Centre Experience ◽  
Heart Malformation ◽  
Long Term Follow Up

Background and Objectives: Infective endocarditis in the pulmonary position is a rare disease. Isolated pulmonary valve endocarditis is extremely rare. The aim of our study was to assess patients who were treated surgically for pulmonary endocarditis at our institution from January 2003 to December 2017. Materials and Methods: We analyze eight cases of infectious endocarditis in pulmonary position out of 293 patients who were operated for infective endocarditis (2.7%, 8/293). Only two of these eight patients were not related to congenital heart malformation. They were followed for early and late mortality, long-term survival, postoperative morbidity and reoperations. Results: Among six patients suffering from congenital heart disease, four patients underwent corrections of pulmonary valve malformation previously, and their infected grafts were replaced by two allografts and two xenografts. The two other patients had replaced their infected pulmonary valves with allografts. Two non-congenital patients with pulmonary valve endocarditis underwent valve replacement with biological prosthesis. All patients survived the early postoperative course. The mean follow-up time was 9.1 (interquartile range (IQR), 5.3–12.6) years. The long-term follow-up included seven patients. One patient (12.5%, 1/8) died more than 4 years after the surgery due to sepsis. Pulmonary endocarditis was the rarest endocarditis treated surgically (p < 0.001). Conclusion: Surgery for infective endocarditis in the pulmonary position (IEPP) is an effective method of treatment with excellent early outcome and good late results despite a very uncommon pathology and few operations being performed. Surgery performed earlier may make the procedure less radical.

scholarly journals Differential Expression and Interaction network construction of Noncoding RNA and mRNA in Heart Tissue associated with Tetralogy of Fallot

2020 ◽  
Author(s):  
Hongdan Wang ◽  
Cunying Cui ◽  
Yanan Li ◽  
Yuanyuan Liu ◽  
Taibing Fan ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Messenger Rna ◽  
Noncoding Rna ◽  
Congenital Heart ◽  
Chromosomal Abnormalities ◽  
Heart Diseases ◽  
Right Ventricular Outflow Tract ◽  
Interaction Network ◽  
Tissue Samples ◽  
Non Coding Rna

ABSTRACTTetralogy of Fallot (TOF) is still the most common and complicated cyanotic congenital heart defect of all congenital heart diseases with a 10% incidence. Surgery repair is often necessary in infancy. The etiology of TOF is complex and genetic and epigenetic mechanisms such as chromosomal abnormalities, gene mutations, nucleic acid modifications, non-coding RNA, and circular RNA(circRNA) play an important role in its occurrence. RNA not only plays an auxiliary role of genetic information carrier, but also plays a more important role in various regulatory functions. There are few studies on the action mechanism of non-coding RNA. Aim to gain more in-depth knowledge of TOF, we collected tissue samples of the right ventricular outflow tract of 5 TOF children with no other intracardiac and extracardiac malformations and 5 normal fetuses. We systematically analyzed the specific long non-coding RNA (lncRNA), microRNA(miRNA), circRNA and messenger RNA(mRNA) profiles of TOF. To our knowledge, there are no reports of genome-wide study of transcriptome in TOF and we first obtained meaningful differentially expressed lncRNAs, miRNAs, circle RNA and mRNAs.

scholarly journals Burden of congenital heart diseases in a tertiary cardiac care institute of high altitude area

2019 ◽  
Vol 7 (5) ◽  
pp. 1441
Author(s):  
Zubair Mushtaq Tramboo ◽  
Aamir Rashid Patigaroo ◽  
Nazir Ahmad
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Indian Subcontinent ◽  
Ductus Arteriosus ◽  
Tertiary Care ◽  
Developed Countries ◽  
Care Hospital ◽  
Mortality And Morbidity

Background: Congenital heart disease is one of the major causes of mortality and morbidity in the paediatric population of both the developing and developed countries. Variability in incidence and prevalence of CHD from various countries of Indian subcontinent and rest of the world could be because of genetic, cultural, and environmental factors.  The objective of the study was to find the prevalence and pattern of CHD in a tertiary care hospital in Kashmir (Jammu and Kashmir).Methods: All children admitted at territary care hospital with age 0-15 years were screened for congenital heart disease. The study was conducted for period of one year to ascertain the prevalence and spectrum of CHDs.Results: A total of 232 patients out of 23000, were found having CHDs measuring a prevalence of 10.5/1000. About 170 (73%) were the acyanotics, and 62 (27%) were cyanotic heart patients. Among the acyanotic heart diseases ventricular septal defect was the most frequent lesion seen in 54 (23%), followed by patent ductus arteriosus in 50 (22%) children. Among the cyanotic heart diseases tetralogy of Fallot was the most frequent cyanotic heart disease seen in 15 (6.4%) patients.Conclusions: Authors observed high prevalence of CHD in our population. The pattern and spectrum of CHD were comparable to national and international data.

scholarly journals Hubungan penyakit jantung bawaan pada anak dengan status pendidikan orang tua

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Kimberly Munaiseche ◽  
Herdy Munayang ◽  
Erling D. Kaunang
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Educational Status ◽  
Developed Countries ◽  
Chi Square ◽  
Cross Sectional ◽  
Live Births ◽  
Education Levels

Abstract: Congenital heart disease (CHD) has an incidence of 30% of all congenital abnormalities. The incidences of CHDs in developed countries and developing countries range from 6-10 cases per 1000 live births, with an average of 8 per 1,000 live births. Education and knowledge of parents play important roles in the treatment of CHD. This study was aimed to determine the relationship between CHD in children and the educational status of parents. This was an analytical observational study with a cross sectional design. Subjects were all children admitted to the Pediatrics Department Prof. Dr. R. D. Kandou Manado in 2014-2015 due to heart diseases. Data consisted of sex, age, and the last education of the parents. Data were analyzed by using the Chi-Square test. The results showed that there were 100 children with heart diseases consisted of 53 males and 47 females. There were 38 males (52.8%) with positive CHD and the highest percentage of positive CHD was at 7-12 years as many as 17 children (60.7%). Based on education level, most of the children’s fathers were senior high school (42.9%) as well as the children’s mother (53.6%). The Chi-Square showed p= 0.776 and p= 0.532 for the relationships between the fathers’ as well as the mothers’ education levels and congenital heart disease in children. Conclusion: There was no significant relationship between parents’ educational level and congenital heart disease in children.Keywords: congenital heart disease, education. Abstrak: Penyakit jantung bawaan (PJB) merupakan kelainan bawaan yang sering dijumpai, dengan angka kejadian 30% dari seluruh kelainan bawaan. Insiden PJB dinegara maju maupun negara berkembang berkisar 6-10 kasus per 1000 kelahiran hidup, dengan rata-rata 8 per 1000 kelahiran hidup. Pendidikan, pengetahuan, dan pekerjaan orang tua berperan penting dalam penanganan PJB. Penelitian ini bertujuan untuk mengetahui adanya hubungan antara PJB pada anak dengan status pendidikan orang tua. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Subjek penelitian ialah semua anak dengan penyakit jantung yang dirawat di Instalasi Rawat Inap di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado tahun 2014-2015. Data diambil dari Bagian Rekam Medik berupa jenis kelamin anak, usia anak, serta pendidikan terakhir ayah dan ibu. Analisis data dilakukan dengan uji Chi-Square. Hasil penelitian mendapatkan jumlah subjek penelitian sebanyak 100 anak terdiri dari 53 anak laki-laki dan 47 anak perempuan. Berdasarkan jenis kelamin yang terbanyak positif PJB ialah laki-laki sebanyak 38 orang (52,8%). Berdasarkan usia yang terbanyak positif PJB ialah 7-12 tahun sebanyak 17 anak (60,7%). Pendidikan terbanyak ialah SLTA yaitu pada ayah 42,9% dan pada ibu sebesar 53,6%. Uji Chi-Square, mendapatkan p = 0,776 dan p = 0,532 untuk hubungan tingkat pendidikan ayah dan ibu dengan PJB. Simpulan: Tidak terdapat hubungan bermakna antara tingkat pendidikan orang tua dengan penyakit jantung bawaan pada anak. Kata kunci: penyakit jantung bawaan, pendidikan

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