scholarly journals Surgical approach dilemmas of periglabellar malformations in children

2015 ◽  
Vol 62 (4) ◽  
pp. 391-394
Author(s):  
Dan Cristian Gheorghe ◽  
◽  
A. Zamfir-Chiru-Anton ◽  
◽  
Keyword(s):  
Postoperative Complications ◽  
Surgical Approach ◽  
Point Of View ◽  
Diagnosis And Treatment ◽  
Monitoring Point ◽  
Clinical Appearance ◽  
Patients Âgés

Objectives. Diagnosis and treatment challenges in similar clinical appearance nasal malformations. The authors present 2 nasal external malformations. Material. Patients admitted, evaluated and operated into the pediatric ENT department. Results. The evolution of operated patients was fine, with no postoperative complications. Discussions. 2 clinically similar malformations were compared mostly from the surgical perspective. Imagistics failed to fully delineate the extent of the disease in one case. Surgical approach was differently decided, considering patients ages. The main surgical issues and dilemmas were analyzed. Conclusion. The investigation and surgery for nasal malformations in children can be challenging from the decision and the monitoring point of view.

scholarly journals Radiological Parameters Review for Choanal Atresia

2021 ◽  
Vol 13 (2) ◽  
pp. 302-311
Author(s):  
Daniela Messineo ◽  
Maryia Chernikava ◽  
Valeria Pasquali ◽  
Serena Bertin ◽  
Mario Ciotti ◽  
...  
Keyword(s):  
Retrospective Study ◽  
High Resolution ◽  
Surgical Approach ◽  
Choanal Atresia ◽  
Point Of View ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
Imaging Parameters ◽  
Multiplanar Imaging

(1) Background: The study aims to identify which imaging parameters are necessary for a new correct surgical approach in the study of choanal atresia, and which anatomical findings are essential for correct planning of endoscopic treatment in choanal atresia. (2) Methods: In this retrospective study, 19 patients with choanal atresia had high-resolution multiplanar imaging (14 cases aged ≤1 year and 5 cases aged 1 to 3 years) and 35 patients in the control group similarly distributed by age. Fourteen variables, the most relevant from a surgical point of view, were selected and measured. A comparison was made between the averages of the study group and the different control groups, either directly observed or selected from the literature, using Pearson’s correlation. (3) Results: In 14 out of 26 cases, the differences were statistically significant. There was a correlation between the structures assessed, such as choanal height, rostrum height, and age. (4) Conclusions: Thanks to volumetric reformatting, this work identified and provided the clinician with useful information that helped choose the correct surgical approach. Furthermore, it focused on which imaging parameters are necessary to improve the planning of the surgical correction of choanal atresia.

A Study on the Influence of Cysteine and Magnesium Ions on Brain Dementia

2014 ◽  
Vol 487 ◽  
pp. 161-164
Author(s):  
Lu Yin ◽  
Shuang Yue Zhu
Keyword(s):  
Vascular Dementia ◽  
Plasma Homocysteine ◽  
Diagnosis And Treatment ◽  
Magnesium Ion ◽  
Disease Development ◽  
Mechanism Analysis ◽  
Magnesium Ions ◽  
Patients Âgés ◽  
Dementia Patients ◽  
Relationship Of

As the population ages, dementia disease is increasingly becoming the most concerned social problems. According to the cause of dementia, it can be divided into many kinds class, among them with Alzheimer's Disease (Alzheimers diseases, AD) and Vascular Dementia (Vascular Dementia, VD) are common. Data shows it accounts for nearly 60% of total AD dementia patients, VD (20%), but only 2% of patients could get timely diagnosis and treatment, make its cognitive damage to a certain extent suppress and improve. for untimely diagnosis and treatment, most patients makes the disease development worse. In recent years, studies have shown that plasma Homocysteine,Hcy levels associated with AD. And studies show that from the power of the risk factors to the mechanism analysis, dementia disease level correlation with magnesium ions. On this basis, this study of plasma homocysteine in patients with AD,VD and magnesium ion detection results were analyzed retrospectively. Discuss their levels between the distributio relationship of patients ages in AD and VD.

scholarly journals Exploiting Clonal Evolution to Improve the Diagnosis and Treatment Efficacy Prediction in Pediatric AML

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1995
Author(s):  
Salvatore Nicola Bertuccio ◽  
Laura Anselmi ◽  
Riccardo Masetti ◽  
Annalisa Lonetti ◽  
Sara Cerasi ◽  
...  
Keyword(s):  
Treatment Efficacy ◽  
Clonal Evolution ◽  
Poor Response ◽  
Point Of View ◽  
Diagnosis And Treatment ◽  
Preclinical Model ◽  
Therapeutic Protocols ◽  
Pediatric Aml ◽  
Patients Experience ◽  
Efficacy Prediction

Despite improvements in therapeutic protocols and in risk stratification, acute myeloid leukemia (AML) remains the leading cause of childhood leukemic mortality. Indeed, the overall survival accounts for ~70% but still ~30% of pediatric patients experience relapse, with poor response to conventional chemotherapy. Thus, there is an urgent need to improve diagnosis and treatment efficacy prediction in the context of this disease. Nowadays, in the era of high throughput techniques, AML has emerged as an extremely heterogeneous disease from a genetic point of view. Different subclones characterized by specific molecular profiles display different degrees of susceptibility to conventional treatments. In this review, we describe in detail this genetic heterogeneity of pediatric AML and how it is linked to relapse in terms of clonal evolution. We highlight some innovative tools to characterize minor subclones that could help to enhance diagnosis and a preclinical model suitable for drugs screening. The final ambition of research is represented by targeted therapy, which could improve the prognosis of pediatric AML patients, as well as to limit the side toxicity of current treatments.

An overview on the concept of “Aam” and its significance as mentioned in Ayurvedic texts.

2020 ◽  
Vol 8 (01) ◽  
Author(s):  
Tejaswini Katare ◽  
Disha Sharma ◽  
Ganesh Puradkar ◽  
Arun Dudhamal
Keyword(s):  
Point Of View ◽  
The Body ◽  
Diagnosis And Treatment ◽  
Important Concept ◽  
Root Cause ◽  
Causative Factors ◽  
Undigested Food ◽  
Unhealthy Diet ◽  
Lack Of Exercise ◽  
All Diseases

Aam is an important concept described by Ayurvedic Acharyas which is responsible for many diseases. According to Ayurvedic point of view, all diseases are originated from aamdosh, vitiation of Agni i.e malfunction of Agni produces Aam. Aam is unripe, undigested food which is caused due to Agnimandya. Agnimandya produces aam and viceversa. We all know that all diseases are caused due to Agnimandya. Therefore as agnimandya and aam are the causative factors of each other, aam is the root cause of all diseases. Hence aam and agnimandya plays an important role in diagnosis and treatment of disease. Nowadays due to lack of exercise, unhygienic and unhealthy diet, incapability to obey the rules of sound body maintenance and increasing pollution results in agnimandya and aam production in the body and decrease in immunity resulting into various diseases. The concept of aam is the most important fundamental principal of Ayurveda in understanding the physio- pathology of the disease.

scholarly journals Monitoring of Grid Scientific Workflows

2008 ◽  
Vol 16 (2-3) ◽  
pp. 205-216
Author(s):  
Bartosz Balis ◽  
Marian Bubak ◽  
Bartłomiej Łabno
Keyword(s):  
Real Life ◽  
Scientific Workflow ◽  
Point Of View ◽  
Scientific Workflows ◽  
Monitoring Data ◽  
Monitoring Point ◽  
Loosely Coupled ◽  
Provenance Data ◽  
On Line ◽  
Monitoring Architecture

Scientific workflows are a means of conducting in silico experiments in modern computing infrastructures for e-Science, often built on top of Grids. Monitoring of Grid scientific workflows is essential not only for performance analysis but also to collect provenance data and gather feedback useful in future decisions, e.g., related to optimization of resource usage. In this paper, basic problems related to monitoring of Grid scientific workflows are discussed. Being highly distributed, loosely coupled in space and time, heterogeneous, and heavily using legacy codes, workflows are exceptionally challenging from the monitoring point of view. We propose a Grid monitoring architecture for scientific workflows. Monitoring data correlation problem is described and an algorithm for on-line distributed collection of monitoring data is proposed. We demonstrate a prototype implementation of the proposed workflow monitoring architecture, the GEMINI monitoring system, and its use for monitoring of a real-life scientific workflow.

scholarly journals Unstable Hemostasis and Specific Postoperative Complications (Literature Review)

2020 ◽  
Vol 5 (4) ◽  
pp. 98-102
Author(s):  
D. V. Lebedeva ◽  
E. A. Ilyicheva
Keyword(s):  
Postoperative Complications ◽  
Rapid Development ◽  
Point Of View ◽  
The Body ◽  
Cost Of Treatment ◽  
Duration Of Hospital Stay ◽  
Technical Errors ◽  
Perioperative Bleeding ◽  
The Cost

Perioperative bleeding occupies a leading place among all surgical complications and, despite the rapid development of surgery, remains relevant to this day. In addition to an increase in mortality, bleeding can cause the development of other postoperative complications, which lead to disability of patients and to a decrease in the quality of life in all age groups. Most perioperative bleeding are caused by technical errors. This article reviews the problem of perioperative bleeding from the point of view of impaired coagulation capabilities of the body. The main etiopathogenetic features of hemostasis during the development of this complication are considered. The analysis of postoperative complications, which were directly or indirectly caused by bleeding during or after surgery, is presented. The prevalence of these complications in various areas of surgery has been demonstrated. More detailed study of the hemostasis system and the identification of predictors of hemostasis difficulties before the surgery may cause an improvement in the results of surgical treatment and reduce the number of postoperative complications and the duration of hospital stay. Accordingly, this will lead to a decrease in the cost of treatment and an increase in patient satisfaction with the medical care. In connection with the above, there is a great interest among surgeons and anesthesiologists in preventing the development of perioperative bleeding.

Hammer-Chisel Technique in Endoscopic Dacryocystorhinostomy

2003 ◽  
Vol 112 (5) ◽  
pp. 444-449 ◽  
Author(s):  
Yasar Cokkeser ◽  
Mustafa Tercan ◽  
Cem Evereklioglu ◽  
Ibrahim F. Hepsen
Keyword(s):  
Postoperative Complications ◽  
Success Rate ◽  
External Approach ◽  
Prospective Evaluation ◽  
Lacrimal Sac ◽  
Successful Completion ◽  
Patients Âgés ◽  
Minimal Morbidity ◽  
Patient Tolerance

We performed a prospective evaluation of endoscopic hammer-chisel dacryocystorhinostomy (DCR) procedures on 62 eyes of 44 patients (40 female and 4 male) with chronic epiphora or dacryocystitis (26 unilateral and 18 bilateral). The technique included chisel removal of bone over the lacrimal sac. The follow-up period was 12 to 54 months (mean, 28 months), and the patients' ages ranged from 17 to 67 years (mean, 35.5 years). The success rate of the consecutive endoscopic hammer-chisel DCR procedures was 87%. During operation, 8 patients had mild mucosal hemorrhage, which did not prevent the successful completion of the operation. Excellent patient tolerance was observed, with minimal morbidity and no major complications. As compared to the external approach, endoscopic hammer-chisel DCR is less traumatic, is less time-consuming, and is practical and cosmetically convenient, with minimal perioperative and postoperative complications. It also allows the simultaneous correction of any intranasal disease. It requires minimal instrumentation and is a relatively easy and fast technique.

scholarly journals Novel abdominal approach for dissection of advanced type II/III adenocarcinoma of the esophagogastric junction: a new surgical option

2018 ◽  
Vol 47 (1) ◽  
pp. 398-410 ◽  
Author(s):  
Can Hu ◽  
Hao-te Zhu ◽  
Zhi-yuan Xu ◽  
Jian-fa Yu ◽  
Yi-an Du ◽  
...  
Keyword(s):  
Lymph Node ◽  
Survival Rate ◽  
Postoperative Complications ◽  
Total Gastrectomy ◽  
Surgical Approach ◽  
Esophagogastric Junction ◽  
Abdominal Cavity ◽  
Type Ii ◽  
Siewert Type ◽  
Siewert Type Ii

Objective The optimal surgical approach for Siewert type II adenocarcinoma of the esophagogastric junction (AEG) is controversial. In this study, we evaluated the outcomes of total gastrectomy for Siewert type II/III AEG via the left thoracic surgical approach that is used at our center. Methods We identified 41 patients with advanced AEG in our retrospective database and analyzed their 3-year survival rate, upper surgical margin, postoperative complications, and index of estimated benefit from lymph node dissection. Results The 3-year overall survival rate of the whole group was 63%, but no difference was observed between Siewert type II and III AEGs. Esophageal exposure and lymphadenectomy were sufficient. Eight patients developed postoperative complications, but none of the patients developed anastomotic leakage. Dissection of lymph node station Nos. 19 and 110 may be necessary for patients with Siewert type II AEG. Multivariate analysis revealed that the cT category was the only independent risk factor. Conclusions Total gastrectomy via an approach from the abdominal cavity into the thoracic cavity may be an optimal surgical technique for advanced Siewert type II AEG.

Nasal Reconstruction of a Frontonasal Dysplasia via Septal L-Strut Reconstruction Using Costal Cartilage

2021 ◽  
pp. 105566562110366
Author(s):  
Yong Bae Kim ◽  
Seung Min Nam ◽  
Eun Soo Park ◽  
Chang Yong Choi ◽  
Han Gyu Cha ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
General Anesthesia ◽  
Retrospective Review ◽  
Costal Cartilage ◽  
Point Of View ◽  
Nasal Reconstruction ◽  
Open Rhinoplasty ◽  
Frontonasal Dysplasia ◽  
Congenital Condition

Objective Frontonasal dysplasia (FND) is a rare congenital condition. Its major features include hypertelorism, a large and bifid nasal tip, and a broad nasal root. We present our technique of septal L-strut reconstruction using costal cartilage. Design Retrospective review from June 2008 and August 2017. Methods Under general anesthesia, 6 patients with FND underwent septal reconstruction using costal cartilage via open rhinoplasty. We reconstructed the nasal and septal cartilaginous framework by placing columellar struts and cantilever-type grafts. Results The patients ranged in age from 6 to 13 years old. All were female. The follow-up period ranged from 8 months to 2 years; we encountered no postoperative complications (infection, nasal obstruction, or recurrence). All patients were satisfied with their nasal appearance. Conclusions Although the results were not entirely satisfactory from an esthetic point of view, we found that FND can be treated via septal reconstruction with costal cartilage and that the clinical outcomes are reliable and satisfactory. Our approach is a useful option for FND patients.

scholarly journals Comparison between LigaSure™ and Harmonic® in Laparoscopic Sleeve Gastrectomy: A Single-Center Experience on 422 Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
N. Velotti ◽  
M. Manigrasso ◽  
K. Di Lauro ◽  
A. Vitiello ◽  
G. Berardi ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Postoperative Complications ◽  
Operative Time ◽  
Intraoperative Complications ◽  
Hospital Costs ◽  
Point Of View ◽  
Morbidly Obese ◽  
Biomedical Sciences ◽  
Single Center Experience ◽  
User Friendly

Background. New laparoscopic devices, such as electrothermal bipolar-activated devices (LigaSure™ (LS)) or ultrasonic systems (Harmonic® scalpel (HS)), have been applied recently to bariatric surgery allowing to reduce blood loss and surgical risks. The aim of this study was to retrospectively compare intraoperative performance of HS and LS, postoperative results, and clinical outcomes in a large cohort of patients undergoing LSG. Methods. Data from 422 morbidly obese patients undergoing LSG in our Bariatric Unit at the Advanced Biomedical Sciences Department of the “Federico II” University of Naples (Italy) between January 2009 and December 2017 were retrospectively analyzed. Subjects were divided into two groups (HS and LS), and operative time, intraoperative complications, and postoperative (within 30 days from surgery) complications were compared. Bleeding from the omentum or from the staple line, use of hemostatic clips, and absorbable hemostat were recorded as intraoperative complications; hemorrhages, abscess formation, gastric leaks, fever, and mortality were considered as postoperative complications. Results. Statistical analysis showed no difference in terms of baseline demographics between the two cohorts. Operative time (48 ± 9 vs 49 ± 6 min, p=0.646) and the rates of intraoperative and postoperative complications did not significantly differ between groups. Conclusion. Harmonic® and LigaSure™ are both useful tools in bariatric surgery, and these two advanced power devices are user-friendly and can facilitate surgeon work; from this point of view, the choice of the energy device should be based on the preference of the surgeon and on the hospital costs policy and availability.

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