scholarly journals The application of 1,3-dioxolane in synthesis of disubstituted 3,4-dihydroquinazolines, diarylmethane or methylenediamine

2019 ◽  
Vol 58 (4) ◽  
pp. 48-52
Author(s):  
Lidia P. Yunnikova ◽  
◽  
Victoria V. Esenbaeva ◽  
Tatiana А. Akentieva ◽  
◽  
...  
Keyword(s):  
Aromatic Amine ◽  
Mass Spectrometry Data ◽  
Pathogenic Microorganism ◽  
Microbiological Activity ◽  
Medicinal Products ◽  
Primary Aromatic Amine ◽  
X Ray ◽  
Heterocyclic Series ◽  
The Russian Federation ◽  
Sulfonamide Group

The interaction between 1,3-dioxolane with primary aromatic amine- sulfanilamide (streptocide), secondary aromatic amine-N-benzylaniline and also with amine of heterocyclic series – 4-aminopyridine. It is found that, sulfanilamide (streptocide), which has an electron withdrawing sulfonamide group in para position, reacts with 1,3-dioxolane in an atmosphere of benzol and trifluoroacetic acid producing 3-(4-sulfamoylphenyl)-3,4-dihydroquinazoline-6-sulphonamide, that is corresponding to the previous result obtained when 1,3-dioxolane reacts with para-nitroaniline (which also contains electron-withdrawing nitrogroup) resulting in 3-(p-nitrophenyl)-6-nitro-3,4-dihydroquinazoline. Under the same conditions the interaction between 1,3-dioxolane and N-benzylaniline results in producing 4,4'-bis(phenylmethyleneamino)diphenylmethane, which refers to a different class of compounds – diphenylmethane derivative. A primary amine of heterocyclic series 4-aminopyridine reacts with 1,3-dioxolane in the presence of concentrated hydrochloric acid producing N,Nʹ-di-(4-pyridinyl)methylenediamine. Antimicrobic properties of received compounds were studied on museum potentially pathogenic microorganism strains: Staphylococcusaureus (strain 906), Candid aalbicans (АТСС 24433), in FSBI «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation. Only N,Nʹ-di-(4-pyridyl)methylenediamine out of three investigated compounds showed microbiological activity. This compound inhibits growth of Staphylococcus aureus at concentration 62.5 µg/ml, culture death comes from the effect of concentration 125.0 µg/ml. The morphology of compounds was established according to mass spectrometry data, 1Н NMR spectroscopy, the structure of N,Nʹ-di-(4-pyridyl)methylenediamine in the form of chloride was proved using X-ray structural analysis.

Determination of primary aromatic amine in quality control of X-ray contrast media by flow-injection analysis

Talanta ◽  
1996 ◽  
Vol 43 (6) ◽  
pp. 951-955 ◽  
Author(s):  
Gro Johansen ◽  
Kjersti Grini ◽  
Karina Langseth-Manrique ◽  
Kre Helge Karstensenb
Keyword(s):  
Quality Control ◽  
Contrast Media ◽  
Aromatic Amine ◽  
Flow Injection ◽  
Flow Injection Analysis ◽  
Primary Aromatic Amine ◽  
X Ray

scholarly journals Synthesis, Characterization and Study of the Biological activity of Some Aldimines Derivatives

2006 ◽  
Vol 3 (4) ◽  
pp. 257-261 ◽  
Author(s):  
Mohamed N. Ibrahim ◽  
Hazem K. Al - Deeb
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
Aromatic Aldehyde ◽  
Aromatic Amine ◽  
Elemental Analysis ◽  
Primary Aromatic Amine ◽  
H Nmr

A number of imines derivatives have been synthesized, they were obtained by condensation of aromatic aldehyde derivatives with primary aromatic amine derivatives. Their structures have been characterised by IR,1H NMR in addition to the elemental analysis. The biological activity of these imines (which are also known as Schiff bases) were examined against different type of microorganisms and they found to have considerable activity in comparison with the most commonly used antibiotics.

THE PROGRESSIVE PHENOTYPE OF PNEUMOCONIOSIS

2021 ◽  
Author(s):  
Y.Y. Gorblyansky ◽  
◽  
M.A. Panova ◽  
O.P. Ponamareva
Keyword(s):  
Computed Tomography ◽  
Silicon Dioxide ◽  
Retrospective Analysis ◽  
Russian Federation ◽  
Medical Examination ◽  
X Ray ◽  
Radiological Parameters ◽  
Rostov Region ◽  
The Russian Federation

Abstract: The prevalence of progressive forms of pneumoconiosis in the Russian Federation has been little studied. At the same time, the number of workers exposed to silicon dioxide, both in our country and abroad, is not decreasing. The purpose of our research to determine the criteria for the progression of pneumoconiosis in miners. A retrospective analysis of the results of a comprehensive medical examination of 150 miners of the Rostov region, observed in the center of occupational pathology, was carried out. All patients underwent radiography, computed tomography of the chest organs, and spirometry. X-ray description of the changes was carried out in accordance with the recommendations of the ILO. As a result, 24.5% had statistically significant signs of negative dynamics of functional and radiological indicators, which we referred to the criteria of progression. Thus, the progression of pneumoconiosis is determined by the negative dynamics of clinical and radiological parameters.

scholarly journals Ways to optimize the assessment of lean body mass in hemodialysis patients

2019 ◽  
Vol 9 (1) ◽  
pp. 23-28
Author(s):  
Juliia V. Lavrishcheva ◽  
Aleksandr A. Jakovenko
Keyword(s):  
Comparative Analysis ◽  
Lean Body Mass ◽  
Body Mass ◽  
Hemodialysis Patients ◽  
Dual Energy ◽  
European Part ◽  
X Ray ◽  
Bland Altman Method ◽  
Total Lean Body Mass ◽  
The Russian Federation

The aim. To conduct a comparative analysis of the effectiveness of methods for assessing lean body mass in haemodialysis patients. Patients and methods. A total of 317 patients receiving treatment with programmatic bicarbonate haemodialysis in 9 haemodialysis centers in 5 regions of the European part of the Russian Federation were examined for 8.2 ± 5.1 years, among them 171 women and 146 men, the average age was 57.1 ± 11.3 years. Dual-energy X-ray absorptiometry and bioimpedancemetry were used to assess lean body mass. Results. The results of determining the total lean body mass obtained from the results of dual-energy X-ray absorptiometry and bioimpedancemetry were compared using the Bland-Altman method. The correlation coefficient between the indicators was r = 0.994, p < 0.0001, delta (M ± σ) was –0.48 ± 0.91 kg, CI 95% (–0.71)–(–0.26) kg. Conclusion. Dual-energy X-ray absorptiometry has no significant advantages compared with bioimpedancemetry when evaluating lean body mass in haemodialysis patients.

Nanomaterials for detection of primary aromatic amine derivatives based on a fluorescent probe

2020 ◽  
Vol 704 (1) ◽  
pp. 57-65
Author(s):  
Yu Jeong Lee ◽  
In Soo Kang ◽  
Yo Seob Shin ◽  
Seung Woo Lee
Keyword(s):  
Fluorescent Probe ◽  
Aromatic Amine ◽  
Primary Aromatic Amine

A Novel Example of X-Ray-Radiation-Induced Chemical Reduction of an Aromatic Nitro-Group-Containing Thin Film on SiO2 to an Aromatic Amine Film

ChemPhysChem ◽  
2003 ◽  
Vol 4 (8) ◽  
pp. 884-889 ◽  
Author(s):  
Paula Mendes ◽  
Maura Belloni ◽  
Mark Ashworth ◽  
Chris Hardy ◽  
Kirill Nikitin ◽  
...  
Keyword(s):  
Thin Film ◽  
Nitro Group ◽  
Aromatic Amine ◽  
Chemical Reduction ◽  
X Ray ◽  
Radiation Induced ◽  
Aromatic Nitro

scholarly journals Recommendations for the Contents of the “Glycan Profile” Part of a Product Specification File

2021 ◽  
Vol 11 (4) ◽  
pp. 273-275
Author(s):  
O. A. Vaganova
Keyword(s):  
Test Procedure ◽  
Federal State ◽  
Expert Evaluation ◽  
Medicinal Products ◽  
Active Ingredients ◽  
Glycan Profile ◽  
Additional Information ◽  
Batch Release ◽  
The Russian Federation ◽  
Product Specification

“Glycan Profile” is a necessary part of manufacturers’ product specification files for monoclonal antibody active ingredients or final products and erythropoietin active ingredients. The expert of the Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products” of the Ministry of Health of the Russian Federation provides recommendations for a step-by-step presentation of the test procedure, which will allow applicants to align product specification files for Russian- and foreign-produced medicinal products, help experts to minimise or eliminate the need to request additional information from applicants, and will contribute to timely batch release of medicinal products.

scholarly journals Analysis of doctors of different specialties staffing in the Russian Federation and abroad

2020 ◽  
pp. 96-101
Author(s):  
I.V. Shakhabov ◽  
◽  
Y.Y. Melnikov ◽  
A.V. Smyshlyaev ◽  
◽  
...  
Keyword(s):  
Exercise Therapy ◽  
Russian Federation ◽  
National Health System ◽  
Medical Personnel ◽  
X Ray ◽  
Foreign Countries ◽  
Healthcare It ◽  
Leading Position ◽  
The Russian Federation ◽  
Quantitative Indicators

The aim of the research is to analyze the indicators of medical personnel of various specialties staffing in the Russian Federation and abroad. Material and methods. The data from Rosstat in the field of healthcare were used. The proportion of doctors of various specialties was calculated. Descriptive statistics method was used; indicators trend analysis was carried out. Results. The indicator of staffing by doctors of all specialties per 10,000 population in the studied period had a downward trend (-4.3%). The largest decrease occurred among pediatricians (-36.0%). Less decrease concerns obstetricians and gynecologists (-1.7%), psychiatrists and psychiatrists and narcologists (-11.7%), phthisiatricians (-16.6%). An increase was registered among therapeutists (except GP) (+ 1.8%), (family) GP (+ 14.2%), surgeons except anesthesiologists and resuscitators (+ 4.0%), X-ray specialists and radiologists (+15, 3%), and dentists (+ 2.3%). The indicator was stable among ophthalmologists, otorhinolaryngologists, neurologists, dermato-venereologists, and exercise therapy doctors. The proportion of therapeutists (except GPs) and GPs tended to increase and amounted 1.7% and 22.8%, respectively, by the end of the studied period. The indicator increased among surgeons except anesthesiologists and resuscitators, obstetricians and gynecologists, ophthalmologists, otorhinolaryngologists, neurologists, X-ray specialists and radiologists, exercise therapy doctors, and dentists. The decrease was registered in pediatricians, psychiatrists and psychiatrists and narcologists, phthisiatricians, dermato-venereologists. The Russian Federation occupies a leading position compared to foreign countries in terms of staffing by doctors (per 100,000 population). Conclusion. To implement personnel policy in healthcare, it is necessary to pay attention not only to quantitative indicators providing population with doctors, but to qualitative ones as well. It is necessary to balance the ratio of doctors of different specialties to form a sustainable national health system. Scientifically based mechanism for specialist’s distribution should be developed.

scholarly journals MEDICINES: CONSTITUTIONAL AND LEGAL REGULATION ON RESTRICTION OF THE PROPERTY RIGHT CONCERNING TECHNOLOGY TRANSFER SUBJECTS AND THE RIGHT TO CONDUCT ENTREPRENEURSHIP ON IMPORT OF MEDICINAL PRODUCTS IN CONDITIONS OF CONFLICT AND TEMPORARY OCCUPATION

2021 ◽  
pp. 6-13
Author(s):  
Юрій Бисага
Keyword(s):  
Technology Transfer ◽  
Russian Federation ◽  
Legal Regulation ◽  
Democratic Society ◽  
Medicinal Products ◽  
Public Values ◽  
European Court ◽  
The Russian Federation ◽  
The Law ◽  
The Right

  The purpose of this article is to identify the features of restriction of ownership on the subjects of technology transfer regarding production of medicines and the right to run business on the import of medicines in conditions of conflict and temporary occupation. The methodological basis of the conducted research is the general methods of scientific cognitivism as well as concerning those used in legal science: methods of analysis and synthesis, formal logic, comparative law etc. When determining the legitimate purpose of restriction, it is necessary to apply the principle of proportionality, which is the concordance of measures applied to the above entities in order to limit the exercise of their rights with those public values that are protected by such restriction. On the procedural level, the State having realized the right for withdrawal has to comprehensively inform the General Secretary of the Council of Europe as for the measures taken and the reasons for them, as well as the time when those measures have ceased to apply and the provisions of the Convention are profoundly applied again. As the case law of the European Court of Human Rights shows, the derogation from the obligations under the Convention must have territorial and temporal specifications. The following features of the constitutional and legal regulation of restriction of property rights for subjects of technology transfer to the production of medicines are revealed: 1) restrictions on the implementation of these rights should be provided by the law, which must meet the following requirements: clarity, accuracy, accessibility; 2) the measure is a temporal one; 3) the range of entities in respect of which it is applied to are the subjects of technology transfer being residents of the aggressor country; 4) legitimate purpose of implementation is protection of public values (national security, life and health of persons staying on the territory of Ukraine, territorial integrity, etc.); 5) necessary in democratic society. The following features of the constitutional and legal regulation of restrictions on the right for running business activities regarding import of medicines during conflict and temporary occupation of the part of the territory of Ukraine by the Russian Federation are revealed: 1) restrictions on the exercise of these rights are provided by the Law of Ukraine “On Foreign Economic Activity” from 04.07.2017 №18.1-07/18369, which meets the following requirements: clarity, accuracy, accessibility; 2) the measure is temporal one; 3) the range of entities in respect of which it is applied to is addressed to the applicants of medicinal products, alternative and/or potential manufacturers, applicants-holders of registration certificates of which are the subjects of the Russian Federation; 4) legitimate purpose of implementation is protection of life and health of persons staying on the territory of Ukraine in connection with the impossibility of providing Ukraine with proper control over the quality of production of medicines within the Russian Federation; 5) necessary in democratic society.    

scholarly journals Radiological and nuclear medicine examinations in breastfeeding women. A novel protocol of the Academy of Breastfeeding

2021 ◽  
Vol 4 (3) ◽  
pp. 238-242
Author(s):  
Y.L. Gerashchenko ◽  
◽  
◽  
Keyword(s):  
Nuclear Medicine ◽  
Review Paper ◽  
Imaging Techniques ◽  
Reproductive Technologies ◽  
Lactating Women ◽  
X Ray ◽  
Breast Examination ◽  
The Russian Federation ◽  
Second Period ◽  
And Child Health

This paper discusses a particular time in woman’s life, breastfeeding, that takes from 4 months to 2 years. Mean age of pregnant women increases every year, while reproductive technologies allow for realizing childbearing function in the second period of adulthood. Many diseases those diagnosis requires multiple examinations occur with age. When the mother is forced to stop breastfeeding in view of the need for examination, it is essential for her to get a reasoned rationale and to know the duration of limitations. Unfortunately, no regulations covering the use of modern nuclear medicine and X-ray technologies in breastfeeding women are available in the Russian Federation. Foreign experience may address the existing lack of knowledge. In the future, these data may provide guidance to develop national recommendations. This review paper summarizes the studies on imaging techniques and nuclear medicine procedures in lactating women and limitations of breastfeeding in their use. KEYWORDS: lactation, breastfeeding, breast examination, nuclear medicine, mammologist. FOR CITATION: Gerashchenko Y.L. Radiological and nuclear medicine examinations in breastfeeding women. A novel protocol of the Academy of Breastfeeding. Russian Journal of Woman and Child Health. 2021;4(3):238–242 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-238-242.

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