scholarly journals Retracted: sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease

2017 ◽  
Vol 5 (1) ◽  
pp. 68-71 ◽  
Author(s):  
Rajnish K. Singhal ◽  
Balwant Rai
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Chronic Inflammation ◽  
Chronic Periodontitis ◽  
Apical Periodontitis ◽  
Enzyme Immunoassays ◽  
The Mean

BACKGROUND: Different studies have implicated the exposure to systemic conditions in the aetiology of cardiovascular diseases like chronic inflammation including chronic periodontitis. AIM: The present study has been conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic marker of inflammation and has been identified as risk factors for cardiovascular diseases. MATERIAL AND METHODS: sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged 20-45 years and in 20 control patients without periodontitis (M:F::10:10, aged 20-48 years). Measurement of sTNF-R1 and sTNF-R2 was carried out in duplicate with standardised, commercially available enzyme immunoassays (R&D Systems Europe, Abingdon, UK). RESULTS: The mean sTNF-R1 and sTNF-R2 levels in periodontitis were 820 (240) pg/ml (413 – 1620 pg/ml) and 1309 (403) pg/ml (540 – 2430 pg/ml), while in normal sTNF-R1 and sTNF – R2 levels were 740 (340) pg/ml (407-1240 pg/ml) and 1283 (414) pg (480 – 2340 pg/ml) respectively. Results indicated a positive high relationship between cardiovascular markers such as sTNF-R1 and sTNF – R2 and apical periodontitis. CONCLUSION: Elevated levels of sTNF-R1 and sTNF – R2 in apical periodontitis patients indicate an increased independent risk of coronary heart disease.

scholarly journals Risk factors of coronary heart disease: attitude and behaviour in family practice in Saudi Arabia

1999 ◽  
Vol 5 (1) ◽  
pp. 35-45 ◽  
Author(s):  
M. S. Khattab ◽  
M. A. Abolfotouh ◽  
W. Alakija ◽  
M. A. Al Humaidi ◽  
S. Al Wahat
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family Practice ◽  
Physical Inactivity ◽  
Fat Intake ◽  
Significant Difference ◽  
Lifestyle Questionnaire ◽  
Males And Females ◽  
The Mean

To study risk factors of attitudes and behaviour towards coronary heart disease [CHD], 280 Saudis > or = 20 years attending a family practice answered a structured health and lifestyle questionnaire and had their weight, height, blood pressure and random total cholesterol measured. Significant difference was found between males and females in the mean number of cardiovascular risk factors [t = -3.03, P < 0.01]. Few people with high dietary fat intake, obesity or physical inactivity perceived their behaviour as harmful. The number of people who perceived an associated risk to their health increased with incidence of smoking and obesity but not with high fat intake. Physically inactive people were least likely to perceive their behaviour as harmful

scholarly journals Hyperhomocysteinemia as an Independent Risk Factor for Coronary Heart Disease. Comparison with Conventional Risk Factors

2023 ◽  
Vol 83 ◽  
Author(s):  
R. Muzaffar ◽  
M. A. Khan ◽  
M. H. Mushtaq ◽  
M. Nasir ◽  
A. Khan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Logistic Regression ◽  
Risk Factor ◽  
Heart Disease ◽  
Independent Risk Factor ◽  
Plasma Homocysteine ◽  
History Of ◽  
The Mean ◽  
Conventional Risk Factors

Abstract The present study was designed to evaluate the strength of association of raised plasma homocysteine concentration as a risk factor for coronary heart disease independent of conventional risk factor. It was a case control study conducted at Punjab Institute of Cardiology Lahore. A total of 210 subjects aged 25 to 60 years comprising of 105 newly admitted patients of CHD as cases and 105 age and sex matched healthy individuals with no history of CHD as control were recruited for the study. Fasting blood samples were obtained from cases and controls. Plasma homocysteine was analyzed by fluorescence polarization immunoassay (FPIA) method on automated immunoassay analyzer (Abbott IMX). Total cholesterol, triglyceride and HDL cholesterol were analyzed using calorimetric kit methods. The concentration of LDL cholesterol was calculated using Friedewald formula. The patients were also assessed for traditional risk factors such as age, sex, family history of CVD, hypertension, smoking and physical activity, and were compared with control subjects. The collected data was entered in SPSS version 24 for analysis and interpretation.The mean age in controls and experimental groups were 43.00± 8.42 years and 44.72± 8.59 years with statistically same distribution (p- value= 0.144). The mean plasma homocysteine for cases was 22.33± 9.22 µmol/L where as it was 12.59±3.73 µmol/L in control group. Highly significant difference was seen between the mean plasma level of homocysteine in cases and controls (p˂0.001).Simple logistic regression indicates a strong association of coronary heart disease with hyperhomocysteinemia (OR 7.45), which remained significantly associated with coronary heart disease by multivariate logistic regression (OR 7.10, 95%C1 3.12-12.83, p=0.000). The present study concludes that elevated levels of Plasma homocysteine is an independent risk factor for coronary heart disease independent of conventional risk factors and can be used as an indicator for predicting the future possibility for the onset of CVD.

scholarly journals Risk Factors for Cardiovascular Diseases: a Study at National Institute of Cardiovascular Diseases (NICVD)

1970 ◽  
Vol 39 (2) ◽  
pp. 16-21
Author(s):  
S Jabeen ◽  
M Haque
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Medical Journal ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Systolic Blood Pressure ◽  
Key Words ◽  
Key Words Risk Factors

Key words: Risk factors; Coronary Heart Disease (CHD); Systolic Blood Pressure (SBP); Diastolic Blood PRessure (DBP); Body Mass Index (BMI); Waist Hip Ratio (WHR)DOI: 10.3329/bmj.v39i2.7031Bangladesh Medical Journal 2010, 39(2) pp.16-21

Relationship between Genetic Polymorphisms of Alcohol-metabolizing Enzymes and Changes in Risk Factors for Coronary Heart Disease Associated with Alcohol Consumption

2002 ◽  
Vol 48 (7) ◽  
pp. 1043-1048 ◽  
Author(s):  
Yoshiaki Hashimoto ◽  
Toshifumi Nakayama ◽  
Azusa Futamura ◽  
Miho Omura ◽  
Hideo Nakarai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Uric Acid ◽  
Heart Disease ◽  
Alcohol Consumption ◽  
Genetic Polymorphisms ◽  
Multiple Logistic Regression Analysis ◽  
Individual Variations ◽  
The Mean

Abstract Background: There are large individual variations in the responses of risk factors for coronary heart disease to alcohol consumption. To clarify the factors responsible for these individual variations, we studied the relationship between blood pressure, serum lipids, and uric acid and the genetic polymorphisms of alcohol dehydrogenase (ADH) 2 and aldehyde dehydrogenase (ALDH) 2 in alcohol drinkers. Methods: We examined 133 male workers who drank &gt;300 g of alcohol per week. Information regarding lifestyle habits was obtained by questionnaire. The ADH2 genotype was determined by PCR and subsequent digestion with MaeIII. The ALDH2 genotype was determined based on amplified product length polymorphisms. Results: When the workers were divided into three groups: the ADH21/21, ADH21/22, and ADH22/22 groups, the mean triglycerides and γ-glutamyl transpeptidase concentrations were significantly higher in the ADH22/22 group than in the ADH21/21 group. In addition, multiple logistic regression analysis showed that the frequencies of individuals whose systolic blood pressure, triglycerides, and uric acid values were in the highest one third were significantly higher in the ADH22/22 group than in the ADH21/21 group. In contrast, no difference was observed between the ALDH21/21 and (ALDH21/22 + ALDH22/22) groups with regard to the mean value of any variable and to the frequency of individuals with any variable value in the highest one third. Conclusion: Individuals with the ADH21/21 genotype might suffer fewer negative effects of drinking.

scholarly journals Cardiovascular risk factors in workers at Health Centre in Beocin

2008 ◽  
Vol 61 (5-6) ◽  
pp. 257-262 ◽  
Author(s):  
Biljana Petrovic ◽  
Zlata Jasarevic-Komljenovic ◽  
Biljana Srdic ◽  
Edita Stokic
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Family History ◽  
Cardiovascular Diseases ◽  
Cardiovascular Risk Factors ◽  
Health Workers ◽  
Health Centre

Most cardiovascular diseases are caused by atherosclerosis, which is a result of interactions between risk factors such as gender, age, blood lipid concentrations, blood pressure, glucose tolerance, adiposity, physical activity and cigarette smoking. Identification of risk factors is the first step in cardiovascular disease prevention. As health workers contribute significantly to cardiovascular morbidity, the aim of our study was to analyze prevalence of cardiovascular risk factors and to assess the level of mentioned risk in health workers employed in Health Centre Beocin. The study group consisted of 50 health workers. Obesity was evaluated according to BMI and body fat (BF%) values, while central obesity was defined using waist circumference. Serum lipid concentrations and glycaemia were used in metabolic profile definition. The level of physical activity was assessed using IPAQ, and information about smoking status and family history of cardiovascular diseases was obtained from self-report. Framingham point-scoring system was used to predict the risk for development of coronary heart disease in the 10-year period. Overweight was found in 36%, and obesity in 18% subjects. 42% of examined subjects had higher fat mass, while 24% of them had obesity. Central fat accumulation was observed in 50% subjects. We registered 56% smokers, 70% subjects with positive family history, 28% subjects with hypertension, and 56% subjects with dyslipidemia. According to IPAQ results 20% of exanimate subjects were minimally active and 70% were insufficiently active. Estimated risk of coronary heart disease was 7.38%, and 10% subjects had risk over 20%. In spite of lower cardiovascular risk level, our results showed high prevalence of overweight, smoking and physical inactivity in health workers, which suggests the importance of their own lifestyle modification. It should be the first step in increasing motivation of their patients.

scholarly journals Testosterone level in male patients with coronary heart disease and essential hypertension

2009 ◽  
Vol 55 (3) ◽  
pp. 37-39
Author(s):  
A Ya Kravchenko ◽  
V. M. Provotorov
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Essential Hypertension ◽  
Inverse Correlation ◽  
Androgen Deficiency ◽  
Blood Concentrations ◽  
Age Related ◽  
Male Patients ◽  
The Mean

The study was undertaken to ascertain the prevalence of age-related androgen deficiency in patients with coronary heart disease (CHD) and essential hypertension under the age of 60 years and its association with some risk factors. The study covered 107 patients (mean age 50.2±7.2 years). Of them 35 patients had essential hypertension and 72 had CHD, angina on exertion. The blood concentrations of testosterone and cholesterol were measured; the presence and type of adiposity and the level of depression were determined. The mean level of testosterone in patients with CHD and essential hypertension (9.2±0.96 n/mol/l) corresponded to an androgen-deficient state. There was a direct correlation of testosterone concentrations with waist circumference and an inverse correlation with the levels of atherogenic lipoproteins and depression.

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