scholarly journals The Association of Cytokine Genes Polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in Type 2 Diabetes Mellitus-tuberculosis

2020 ◽  
Vol 8 (A) ◽  
pp. 910-915
Author(s):  
Mutiara Indah Sari ◽  
Zaimah Z. Tala
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Control Group ◽  
P Value ◽  
Cytokine Gene Polymorphism ◽  
Cytokine Genes ◽  
Polymerase Chain

BACKGROUND: The cytokine gene polymorphism is associated with the development of metabolic disorder conditions and infectious diseases such as Type 2 diabetes mellitus (T2DM) and tuberculosis (TB) disease. AIM: The objective of the study is an attempt to examine the association of cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in T2DM-TB patients. METHODS: The cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) were investigated in 46 T2DM-TB patients, 46 T2DM patients, and 46 healthy controls. Cytokine genes polymorphism was carried out by the polymerase chain reaction-restriction fragment length polymorphism. Odds ratio (OR) with 95% confidence interval (CI) and p-value was calculated to determine the association between cytokine genes polymorphisms as the risk factor to T2DM-TB development. RESULTS: No association between genotypes and alleles of cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in T2DM-TB compared to control group (p = 0.434; OR = 0.373; 95% CI = 0.068-2.028 and p = 0.444; OR = 0.387; 95% CI = 0.073–2.046), (p = 0.833; OR = 0.915; 95% CI = 0.400–2.092 and p = 0.864; OR = 1.061; 95% CI = 0.541–2.078), and (p = 0.815; OR = 0.896; 95% CI = 0.357–2.246 and p = 0.882; OR = 0.957; 95% CI = 0.534–1.715). This study also found no association between genotypes and alleles of cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) with T2DM-TB compared to T2DM group (p = 1; OR = 0.652; 95% CI = 0.104–4.094 and p = 1; OR = 0.659; 95% CI = 0.108–4.041), (p = 0.189; OR = 1.786; 95% CI = 0.749–4.262 and p = 0.098; OR = 1.857; 95% CI = 0.887–3.889), and (p = 0.374; OR = 1.488; 95% CI = 0619–3.579 and p = 0.365; OR = 1.316; 95% CI=0.727–2.382). CONCLUSION: There is no association of the cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in T2DM-TB compared to control and T2DM groups, and all cytokine genes polymorphisms not as the risk factor to T2DM-TB development in this population.

scholarly journals A STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS

2021 ◽  
pp. 20-22
Author(s):  
Shajahan Shajahan ◽  
Koneru Sri Lahari ◽  
P. Kiranmai
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
P Value

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.

scholarly journals PROGRAM EMAS DALAM KONTROL GULA DARAH PENDERITA DIABETES MELLITUS TIPE 2

J-Dinamika ◽  
2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Arief Andriyanto ◽  
Etty Rekawati ◽  
Dwi Cahya Rahmadiyah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Behavior Change ◽  
Blood Sugar ◽  
Communicable Disease ◽  
Control Group ◽  
P Value ◽  
Nurse Specialist

Background: Diabetes mellitus is a non-communicable disease that is included in the category of chronic diseases and expected to experience an increase, so that a way to control is needed by the Ministry of Health in the form of clever management of diabetes mellitus. This study aimed to analyze the effect of EMAS (education, nutrition management, physical activity, stress management) on behavior change and adult blood sugar control with diabetes mellitus type 2. Methods: Quasi Experiment Pre-Post Test Without Control Group Design for 6 months, October 2018 to March 2019. Samples were taken by purposive sampling technique, namely adults with type 2 diabetes mellitus in Cisalak Pasar Sub-District Ciamnggis District, Depok City as many as 86 people. Results: Changes in behavior and control of adult blood sugar with type 2 diabetes mellitus through EMAS intervention (p value 0.001 <0.05). Conclusion: Changes in adult behavior with type 2 diabetes mellitus are needed to stabilize the patient's blood sugar. Therefore, it takes the role of the nurse specialist community to provide interventions according to the needs of people with diabetes mellitus to manage the disease.Keywords: Intervention EMAS; Behavior change; Glucose control; Type 2 diabetes mellitus

scholarly journals Association of serum adenosine deaminase level with atherosclerotic index in type 2 diabetes mellitus patients

Biomedicine ◽  
2021 ◽  
Vol 41 (1) ◽  
pp. 150-152
Author(s):  
M Rasheed Khan ◽  
S Vinod Babu ◽  
V. KuzhandaiVelu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Adenosine Deaminase ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
Lipid Ratio

Introduction and Aim:The atherosclerosis is the major cause of morbidity and mortality among diabetes population. Diabetes mellitus can accelerate atherosclerotic processes. Adenosine deaminase (ADA) plays a significant role in both glucose and lipid metabolism through adenosine. This study aimed to correlate the atherosclerotic index with adenosine deaminase levels in Type 2 diabetes mellitus patients. The aim of the study is to find the association between serum ADA levels with atherosclerotic index.   Materials and Methods: A cross sectional study conducted in 100 subjects (50 control and 50 T2DM patients). The following biochemical parameter were estimated:total cholesterol, triacylglycerol, HDL- C and ADA. VLDL, LDL and other atherosclerotic index were calculated using formulae. Statistical analysis such as Student’s‘t’ test and Pearson’s correlation were performed.   Results: We found significant increase (p value <0.001) in lipid profile, Non-HDL-C and lipid ratio when compared to T2DM with control group. The correlation of serum ADA with lipid profile and lipid ratio didnot show any correlation.   Conclusion: Serum ADA used as a biomarker for evaluation of glycemic status. ADA was insignificant, when correlated with dyslipidemia and atherosclerotic index.

scholarly journals The Effectiveness of Ma’tsurat Dhikr in Reducing Blood Sugar Levels in Type 2 Diabetes Mellitus Patients at Dr. Dradjat Prawiranegara Hospital Serang in 2018

2019 ◽  
Author(s):  
Ernawati . ◽  
Agus Sustiyono ◽  
Mulyati .
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Exercise Intervention ◽  
Control Group ◽  
P Value ◽  
Glucose Levels ◽  
Sugar Levels

Background: DM (Diabetes Mellitus) is a chronic/chronic metabolic disorder characterized by an increase in blood glucose levels (hyperglycemia) caused by insufficient amounts of insulin or insufficient amounts of insulin, sometimes even more effective, this condition is called insulin resistence. Objective: This study aims to determine the effectiveness of ma’tsurat dhikr therapy in reducing blood sugar levels in type 2 diabetes mellitus patients at dr. Dradjat Prawiranegara Hospital Serang in 2018. Methods: The number of samples of this study was 34 respondents and the method was quasi-experimental. The data was analyzed by independent T-Test. The respondents of experimental group received DM exercise and morning-evening dhikr intervention, while the control group only received DM exercise intervention. Results:The results of the study showed that ma’tsurat dhikr affects significantly on the decrease of bloods ugarlevelsinpatienntswithtype2DMatdr.DradjatPrawiranegara Hospital Serang with p value<0.005. Conclusion: Intervention of ma’tsurat dhikr can be recommended for type 2 DM patients with elevated blood sugar levels in patients.

scholarly journals glucose reducing effects of a physical regimen combining putu sila and tai chi in individuals with type 2 diabetes mellitus in the public health center of bima

2021 ◽  
Vol 7 (2) ◽  
pp. 63-70
Author(s):  
A. Haris ◽  
Jubair Jubair ◽  
Julhana Julhana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Tai Chi ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Glucose Levels

Diabetes mellitus hyperglycemia is a chronic disease characterized by the absence of insulin or a relative decrease in cell insensitivity to insulin that requires continuous treatment and ongoing self-management to prevent acute complications and reduce the risk of chronic complications. Type 2 diabetes mellitus is particularly by physical activity. This study aims to understand the difference between two exercise regimens on blood glucose levels reduction in patients with type 2 diabetes mellitus. This was a quasi-experimental study with a pre-test post-test control group design. 60 respondents were selected via random sampling and divided evenly into two groups of 30 individuals: 1) the treatment group; and 2) the control group. A Wilcoxon test performed on the treatment group yielded P-value = 0,005 < ? = 0,05 and a Wilcoxon test performed on the control group yielded P-value = 0,046 < ? = 0,05. The conclusion that can be drawn from this study is that physical activity has an effect of reducing blood glucose levels in patients with type 2 diabetes mellitus, and, when comparing the differences in blood glucose level reduction, a combined regimen of putu sila and Tai Chi is more effective than Tai Chi alone.

scholarly journals Correlation between OSAHS and Early Peripheral Atherosclerosis Indices in Patients with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xin Zhao ◽  
Xiaofeng Yu ◽  
Sixu Xin ◽  
Wei Zhang ◽  
Xiaomei Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Risk Factor ◽  
Lower Extremity ◽  
Control Group ◽  
Multivariate Logistic Regression ◽  
Early Atherosclerosis

Objective: To analyze the differences of early atherosclerosis indices in type 2 diabetes mellitus (T2DM) patients with different degrees of obstructive sleep apnea-hypopnea syndrome (OSAHS) and explore the correlation between them, so as to provide a new clinical basis for the prevention and treatment of early atherosclerosis in patients with T2DM and OSAHS. Methods. A prospective study was conducted in 312 patients with T2DM and snoring who were hospitalized in the Department of Endocrinology, Peking University International Hospital from January 2017 to January 2020. According to the monitoring results, 312 patients were divided into 4 groups including the control group (208 cases), mild OSAHS group (18 cases), moderate OSAHS group (38 cases), and severe OSAHS group (48 cases). Multivariate logistic regression analysis was used to analyze the early atherosclerosis indices including brachial-ankle pulse wave velocity (PWV) and ankle-brachial index (ABI) in patients with T2DM coexistence with different degrees of OSAHS. Results. (1) As the degree of OSAHS increased, ABI decreased gradually and was lower than that in the control group, but PWV increased and was higher than that in the control group ( p < 0.05 , respectively). (2) The apnea-hypopnea index (AHI) positively correlated with PWV ( r = 0.36 , p < 0.05 ) and negatively correlated with ABI ( r = − 0.37 , p < 0.05 ). (3) Multivariate logistic regression showed that after adjusting for age, gender, duration, BMI, blood pressure, blood glucose, blood lipid, and other factors, OSAHS was a risk factor of lower extremity arterial disease (LEAD) in patients with T2DM. With the increase of degree of OSAHS, the risk of lower extremity atherosclerosis gradually increased. Conclusion. OSAHS is an independent risk factor of LEAD in patients with T2DM, and with the increase of AHI, the ABI and PWV have changed, which provides a new clinical basis for the prevention and the treatment of early atherosclerosis in patients with T2DM and OSAHS.

scholarly journals Study of the effect of gallic acid and cold plasma on the levels of inflammatory factors and antioxidants in the serum sample of subjects with type 2 diabetes mellitus

2021 ◽  
Vol 4 (8) ◽  
pp. 167
Author(s):  
Danik Martirosyan ◽  
Hamid Ghomi ◽  
Mohammad Reza Ashoori ◽  
Alireza Rezaeinezhad ◽  
Afsaneh Seyed Mikaeili ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glutathione Reductase ◽  
Gallic Acid ◽  
Atmospheric Plasma ◽  
Inflammatory Factors ◽  
Control Group ◽  
P Value

Background: Uncontrolled type 2 diabetes mellitus can have devastating consequences. The role of functional foods in controlling and even preventing diabetes mellitus is prominent, and adjunct therapies can be helpful in controlling some of the consequences of diabetes.Objective: The aim of this study was to investigate whether gallic acid, as a functional food, as well as cold atmospheric plasma, as an adjunct therapy, have an effect on the levels of some antioxidant enzymes, inflammatory factors, and the levels of oxidizing agent and blood glucose.Methods: In this study, 30 healthy individuals, as the control group, and 30 individuals with type 2 diabetes mellitus were selected. Samples of people with diabetes were examined before and after treatment with gallic acid and cold atmospheric plasma (cold argon plasma jet for 10 minutes). Levels of interleukin 2 and 13 and NF-κB, as inflammatory factors, glutathione reductase, paraoxonase, and lipoprotein lipase, as antioxidants, hydrogen peroxide and blood glucose were assessed in untreated and treated diabetic groups and control group according to kit instructions.Results: Comparison of the results of the levels of inflammatory factors, antioxidants, blood glucose, and hydrogen peroxide showed a significant difference (P value < 0.05) between the diabetic and control groups. Treatment of diabetic specimens with plasma and gallic acid showed a significant increase (P value < 0.05) in glutathione reductase, paraoxonase, and NF-κB levels compared to the untreated diabetic group.Conclusions: The results showed that concomitant use of gallic acid, as well as plasma therapy, could be effective on NF-κB, glutathione reductase, and paraoxonase levels.Keywords: Diabetes mellitus, Cold plasma, Inflammatory factors, Gallic acid

scholarly journals Association between Adiponectin and Insulin Resistance among Sudanese Males with Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Eman Ahamed Almakey ◽  
Ahmed Mohamed Makeen ◽  
Osman Khalafalla Saeed ◽  
Khalid Abdelsamea Mohamedahmed
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Adiponectin ◽  
Control Group ◽  
P Value ◽  
Model Assessment ◽  
Positive Effects

Abstract Background Adiponectin is associated with improved systemic insulin sensitivity and profound positive effects in adipose tissue, such as increasing mitochondrial density in adipocytes, reducing adipocyte size, and effective esterification of free fatty acids on lipid storage The factor performs forward transcriptional regulation. Diabetes and its complications are considered to be one of the main causes of morbidity and mortality worldwide. Objectives The aim of this study was to correlate serum levels of adiponectin with insulin resistance in Sudanese males' type 2 diabetes mellitus. Methodology: A case-control community-based study carried out among 126 patients with T2DM as cases group (mean ages 45.2 ± 5.4 years); and 126 normal healthy individuals as controls group (mean ages 44.7 ± 5.4 years as) in Aldaraga Diabetic Center, Wad Medani, Gezira State, Sudan. About Five mL of fasting venous blood was obtained from all participants. HbA1c, FPG, FPI, serum Adiponectin, and (HOMA)-IR were analyzed. SPSS (v 20.0) was used for data analysis. Results The mean of serum adiponectin in the cases group (3.03 ± 0.90µg/ml) was lower than the control group (6.02 ± 4.24µg/ml) giving highly significant differences -between them (P = value ≤ 0.000). HbA1c and Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR) differed significantly between the two groups (P-value ≤ 0.000). Serum adiponectin concentrations correlated significantly negative with HOMA IR (r = -0.149, P-value = 0.002). Conclusion We concluded that low plasma adiponectin level was predictive of future development of Insulin resistance in Sudanese males.

scholarly journals Study of Urinary Calprotectin Levels in Type 2 Diabetics with Peripheral Arterial Disease

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M R Halawa ◽  
M M Abushady ◽  
M M Abdelsalam ◽  
N R Mohamed ◽  
A S S Basabbea ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Control Group ◽  
P Value ◽  
Calprotectin Level ◽  
Peripheral Arterial

Abstract Objective The aim of the present study is to investigate the association of urinary calprotectin levels with lower extremities peripheral arterial disease (LEPAD) in patients with type 2 diabetes mellitus (T2DM). Background calprotectin is formed by two different calcium- binding proteins; it constitutes about 40% of neutrophils all cytosolic proteins. Calprotectin or its components (S100A8/S100A9) consider as a potential therapeutic target in inflammatory conditions including diabetes mellitus. The ankle-brachial index of less than 0.9 was applied for LEPAD diagnosis. Method we recruited 60 patients with T2DM; half of them had LEPAD and a healthy control group consists of 30 participants. Urinary Calprotectin and high sensitivity CRP (hsCRP) were measured by enzyme-linked immunoassay kit. Results Urinary calprotectin level was statistically significant higher among the three participating groups (p value &lt;0.001), however, in post-hoc analysis there was no difference between patients with type 2 diabetes mellitus with or without LEPAD (p value =0.993). However, urinary calprotectin was weakly associated with LEPAD severity (p value = 0.175, p value = 0.06 respectively).There was a statistically significant positive correlation between urinary calprotectin level and hsCRP (r = 0.65, p value 0.001). Conclusion Urinary calprotectin cannot be used as a biomarker for LEPAD in T2DM.

scholarly journals Foot reflexology in feet impairment of people with type 2 diabetes mellitus: randomized trial

2015 ◽  
Vol 23 (4) ◽  
pp. 603-610 ◽  
Author(s):  
Natália Chantal Magalhães da Silva ◽  
Érika de Cássia Lopes Chaves ◽  
Emilia Campos de Carvalho ◽  
Leonardo César Carvalho ◽  
Denise Hollanda Iunes
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treated Group ◽  
Control Group ◽  
P Value ◽  
Fisher Exact Test ◽  
Significance Level ◽  
Exact Test

AbstractObjective: to evaluate the effect of foot reflexology on feet impairment of people with type 2 diabetes mellitus.Method: this is a randomized, controlled and blind clinical trial. The sample was comprised by people with type 2 diabetes mellitus who, after being randomized into Treated group (n = 21) and Control group (n = 24), received guidelines on foot self-care. To the Treated Group it was also provided 12 sessions of foot reflexology. The scores of impairment indicators related to skin and hair, blood circulation, tissue sensitivity and temperature were measured by means of the instrument for assessing tissue integrity of the feet of people with diabetes mellitus. Chi-square test, Fisher exact test, Mann-Whitney test and regression analyzes were applied to the data, considering a significance level of 5% (P value <0.05).Results: participants who received the therapy showed better scores in some impairment indicators related to skin and hair (hair growth, elasticity/turgor, hydration, perspiration, texture and integrity of the skin/ skin peeling).Conclusion: the foot reflexology had a beneficial effect on feet impairment of people with type 2 diabetes mellitus, which makes it a viable therapy, deserving investment. This study was registered in the Brazilian Registry of Clinical Trials - RBR-8zk8sz.

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