scholarly journals Correlation between OSAHS and Early Peripheral Atherosclerosis Indices in Patients with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xin Zhao ◽  
Xiaofeng Yu ◽  
Sixu Xin ◽  
Wei Zhang ◽  
Xiaomei Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Risk Factor ◽  
Lower Extremity ◽  
Control Group ◽  
Multivariate Logistic Regression ◽  
Early Atherosclerosis

Objective: To analyze the differences of early atherosclerosis indices in type 2 diabetes mellitus (T2DM) patients with different degrees of obstructive sleep apnea-hypopnea syndrome (OSAHS) and explore the correlation between them, so as to provide a new clinical basis for the prevention and treatment of early atherosclerosis in patients with T2DM and OSAHS. Methods. A prospective study was conducted in 312 patients with T2DM and snoring who were hospitalized in the Department of Endocrinology, Peking University International Hospital from January 2017 to January 2020. According to the monitoring results, 312 patients were divided into 4 groups including the control group (208 cases), mild OSAHS group (18 cases), moderate OSAHS group (38 cases), and severe OSAHS group (48 cases). Multivariate logistic regression analysis was used to analyze the early atherosclerosis indices including brachial-ankle pulse wave velocity (PWV) and ankle-brachial index (ABI) in patients with T2DM coexistence with different degrees of OSAHS. Results. (1) As the degree of OSAHS increased, ABI decreased gradually and was lower than that in the control group, but PWV increased and was higher than that in the control group ( p < 0.05 , respectively). (2) The apnea-hypopnea index (AHI) positively correlated with PWV ( r = 0.36 , p < 0.05 ) and negatively correlated with ABI ( r = − 0.37 , p < 0.05 ). (3) Multivariate logistic regression showed that after adjusting for age, gender, duration, BMI, blood pressure, blood glucose, blood lipid, and other factors, OSAHS was a risk factor of lower extremity arterial disease (LEAD) in patients with T2DM. With the increase of degree of OSAHS, the risk of lower extremity atherosclerosis gradually increased. Conclusion. OSAHS is an independent risk factor of LEAD in patients with T2DM, and with the increase of AHI, the ABI and PWV have changed, which provides a new clinical basis for the prevention and the treatment of early atherosclerosis in patients with T2DM and OSAHS.

scholarly journals The Relationship Between Serum Vitamin D Level and Type 2 Diabetes Mellitus

2021 ◽  
Vol 8 (2) ◽  
pp. 79-85
Author(s):  
Habibe İnci ◽  
Fatih İnci
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Risk Factor ◽  
Control Group ◽  
Healthy Individuals ◽  
The Relationship

Objective: Vitamin D (VD) could play a role in pathogenesis of Type 2 Diabetes Mellitus (T2DM) by affecting either insulin sensitivity or pancreatic β-cell function. This article is about the relationship between T2DM and VD levels. Material and Methods: The 4678 individuals were included in the study. Of these, 1764 were T2DM patients and 2914 were healthy individuals. Correlation analysis was carried out between VD, age, Body Mass Index (BMI), Hemoglobin A1c (HbA1c), and duration of illness in the T2DM patients. Logistic regression analysis was used to determine the independent predictors. Results: VD levels were significantly lower in the T2DM patients compared to the control group. The VD level of T2DM patients with HbA1c >7% was lower than those with HbA1c <7%. The VD level of T2DM patients using insulin was found to be significantly lower compared to those not using insulin. Among the T2DM patients, VD level was found to be the highest in those without complications and the lowest in those with nephropathy. The cut-off value for VD was calculated as 16.95 ng/mL. According to the logistic regression test, low serum VD levels were found to be an independent risk factor for the development of T2DM and its complications. Conclusion:  VD deficiency may be a risk factor for the development of T2DM. In our study, VD levels were significantly lower in the T2DM patients and those having complications of T2DM than the healthy individuals.

scholarly journals Use and effectiveness of dapagliflozin in patients with type 2 diabetes mellitus: a multicenter retrospective study in Taiwan

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9998
Author(s):  
Jung-Fu Chen ◽  
Yun-Shing Peng ◽  
Chung-Sen Chen ◽  
Chin-Hsiao Tseng ◽  
Pei-Chi Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Body Weight ◽  
Retrospective Study ◽  
Multivariate Logistic Regression

Aims/Introduction To investigate the clinical outcomes of patients with type 2 diabetes mellitus (T2DM) who initiated dapagliflozin in real-world practice in Taiwan. Materials and Methods In this multicenter retrospective study, adult patients with T2DM who initiated dapagliflozin after May 1st 2016 either as add-on or switch therapy were included. Changes in clinical and laboratory parameters were evaluated at 3 and 6 months. Baseline factors associated with dapagliflozin response in glycated hemoglobin (HbA1c) were analyzed by univariate and multivariate logistic regression. Results A total of 1,960 patients were eligible. At 6 months, significant changes were observed: HbA1c by −0.73% (95% confidence interval [CI] −0.80, −0.67), body weight was -1.61 kg (95% CI −1.79, −1.42), and systolic/diastolic blood pressure by −3.6/−1.4 mmHg. Add-on dapagliflozin showed significantly greater HbA1c reduction (−0.82%) than switched therapy (−0.66%) (p = 0.002). The proportion of patients achieving HbA1c <7% target increased from 6% at baseline to 19% at Month 6. Almost 80% of patients experienced at least 1% reduction in HbA1c, and 65% of patients showed both weight loss and reduction in HbA1c. Around 37% of patients had at least 3% weight loss. Multivariate logistic regression analysis indicated patients with higher baseline HbA1c and those who initiated dapagliflozin as add-on therapy were associated with a greater reduction in HbA1c. Conclusions In this real-world study with the highest patient number of Chinese population to date, the use of dapagliflozin was associated with significant improvement in glycemic control, body weight, and blood pressure in patients with T2DM. Initiating dapagliflozin as add-on therapy showed better glycemic control than as switch therapy.

scholarly journals Assessment of Risk of Type 2 Diabetes Mellitus with Stress as a Risk Factor using Classification Algorithms

2019 ◽  
Vol 8 (4) ◽  
pp. 11273-11277
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Risk Factor ◽  
Random Forest ◽  
Health Concern ◽  
Support Vector

Rising prevalence of type 2 diabetes mellitus is a vital health concern today, not only in India but across the world. Several factors including dietary habits, genetics, lack of physical exercise and stress are known to affect the risk of type 2 diabetes. Although awareness has increased to some extent, many people with diabetes have limited knowledge about the risk factors before the diagnosis of disease. For chronic disease prevention there is a necessity to find out such risk factors and manage them appropriately. Statistical techniques can be employed to understand the risk of type 2 diabetes in different age group of people. The objective of the research was to evaluate relationship among stress and type 2 diabetes in people with different age groups by a statistical tool. The proposed method uses three machine learning classifiers namely Support Vector Machine (SVM), Logistic Regression and Random Forest (RF) to detect type 2 diabetes at an early stage. To develop an adaptive model the preprocessing step has been applied. The accuracy of predicting diabetes using SVM, Random Forest and Logistic Regression was 80.17%, 79.37%, 78.67% respectively. The results suggest that as compared to Random Forest and Logistic Regression, SVM is better in predicting occurrence and progress of type 2 diabetes mellitus with stress as a risk factor.

scholarly journals Association of Lower Extremity Vascular Disease, Coronary Artery, and Carotid Artery Atherosclerosis in Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Zheng Yang ◽  
Bing Han ◽  
Hongguang Zhang ◽  
Guohui Ji ◽  
Liang Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lower Extremity ◽  
Carotid Stenosis ◽  
Vascular Diseases ◽  
Control Group ◽  
Diabetes Mellitus Group

The motive of this article is to present the case study of patients to investigate the association between the ultrasonographic findings of lower extremity vascular disease (LEAD) and plaque formation. Secondly, to examine the association between the formation of coronary artery and carotid artery atherosclerosis in patients with type 2 diabetes mellitus. 124 patients with type 2 diabetes (64 males and 60 females with the age group 25-78 years) are considered for the research studies who have registered themselves in the Department of Endocrinology and Metabolism from April 2017 to February 2019. All participants have reported their clinical information regarding diabetes, alcohol consumption, smoking status, and medication. The blood samples from subjects are collected for measurement of HbA1c, total cholesterol, triglycerides, HDL-c, and LDL-c levels. Two-dimensional ultrasound has been used to measure the inner diameter, peak flow velocity, blood flow, and spectral width of the femoral artery, pop artery, anterior iliac artery, posterior tibial artery, and dorsal artery and to calculate the artery stenosis degree. Independent factors of atherosclerosis are determined by multivariate logistic regression analysis. The results are evaluated within the control group and it is found that there is no significant impact of gender, age, and body mass index ( P > 0.05 ) on the lower extremity vascular diseases. Those with smoking, alcohol consumption, hypertension, and dyslipidemia have higher positive rate ( P < 0.05 ). The type 2 diabetes mellitus group has higher diastolic blood pressure and lower triglyceride ( P < 0.05 ). Diastolic blood pressure, HbA1C, total cholesterol, HDL-c, and LDL-C are not remarkably dissimilar between the type 2 diabetes mellitus group and the control group ( P > 0.05 ). Compared with the control group, the type 2 diabetes mellitus group has higher frequency of lower extremity vascular diseases in the dorsal artery than in the pop artery ( P < 0.05 ). The blood flow of type 2 diabetes mellitus group is found to be lower than that of the control group, especially in the dorsal artery ( P < 0.05 ). The blood flow velocity of the dorsal artery is accelerated ( P < 0.01 ). Among 117 patients of type 2 diabetes mellitus (94.35%) with a certain degree of injury, there are 72 cases of type I carotid stenosis (58.06%), 30 cases of type II carotid stenosis (24.19%), and 15 cases of type III carotid stenosis (12.10%). Out of 108 subjects in the control group, there are 84 cases of type 0 carotid stenosis (77.78%), 19 cases of type I carotid stenosis (17.59%), 5 cases of type II carotid stenosis (4.63%), and 0 case of type III carotid stenosis (0.00%). Compared with the control group, carotid stenosis is more common in patients with type 2 diabetes mellitus ( P < 0.05 ). Age, smoking, duration of diseases, systolic blood pressure, and degree of carotid stenosis are found to be associated with atherosclerosis. The findings suggest that the color Doppler ultrasonography can give early warning when applied in patients with carotid and lower extremity vascular diseases to delay the incidence of diabetic macroangiopathy and to control the development of cerebral infarction, thus providing an important basis for clinical diagnosis and treatment.

scholarly journals Glucose-6-Phosphate Dehydrogenase (G6PD) status in Female Type 2 Diabetes Mellitus and its Relationship with HbA1C

1970 ◽  
Vol 5 (2) ◽  
pp. 60-65 ◽  
Author(s):  
Nadira Akter ◽  
Noorzahan Begum ◽  
Sultana Ferdousi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
G6pd Deficiency ◽  
Glycosylated Hemoglobin ◽  
Health Science ◽  
Control Group ◽  
Glucose 6 Phosphate Dehydrogenase

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency may be one of the risk factor for type 2 diabetes mellitus. Objective: To observe erythrocyte G6PD status in type 2 female diabetic patients and also to find out its relationship with glycosylated hemoglobin. Methods: This cross sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka from January to December 2009. For this, 60 female patients with type 2 diabetes mellitus, age ranged from 40 to 60 years were included in the study group (group B). On the basis of glycosylated hemoglobin level (HbA1C) they were further subdivided into group B1, consisting of 30 controlled diabetics (HbA1C 4.8-6%) and group B2, consisting of 30 uncontrolled diabetic (HbA1C>6%) patients. They were selected from Out Patient Department of Bangladesh Institute of Health Science Hospital. For comparison, age & sex matched 30 apparently healthy non diabetic females (group A) were also studied. Erythrocyte G6PD level was measured by Spectrophotometer, HbA1C level by Flex reagent cartridge and serum bilirubin, Hb%, total count of RBC and reticulocyte% were measured by standard laboratory techniques. For statistical analysis ANOVA, independent sample t test, χ2 test and Pearson's correlation coefficient test were performed as applicable. Results: In this study, erythrocyte G6PD level was significantly lower in both the diabetic groups (p <0.001) than those of control group but their difference when compared between B1 and B2 was not statistically significant. In controlled diabetics 20% and in uncontrolled diabetics 6.7% patients were found G6PD deficients. No G6PD deficient subjects were found in control group. HbA1C showed negative correlation with Erythrocyte G6PD which was only significant for uncontrolled diabetes (p < 0.05) Conclusion: This study concludes that G6PD deficiency may be one of the risk factor for type 2 diabetes mellitus irrespective of blood glucose control status.Key words: Glucose-6-PD; Diabetes; Female.DOI: 10.3329/jbsp.v5i2.6778J Bangladesh Soc Physiol. 2010 December; 5(2): 60-65

scholarly journals Identification of independent risk factors for diabetic neuropathy progression in patients with type 2 diabetes mellitus

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110443
Author(s):  
Linjing Huang ◽  
Ximei Shen ◽  
Lingning Huang ◽  
Sunjie Yan ◽  
Peiwen Wu
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Diabetic Nephropathy ◽  
Multivariate Logistic Regression ◽  
History Of ◽  
Independent Risk Factors

Objective To identify independent risk factors for diabetic neuropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Methods We retrospectively analyzed 376 patients with T2DM at the First Affiliated Hospital of Fujian Medical University, China between January 2013 and October 2016. Multivariate logistic regression was used to explore potential risk factors for progression of DN in patients with T2DM. Effect sizes were estimated using odds ratios (ORs) and 95% confidence intervals (CIs). Results The prevalence of DN in patients with T2DM was 43.1%. Multivariate logistic regression indicated that retinopathy (OR: 2.755, 95% CI: 1.599–4.746); diabetic nephropathy (OR: 2.196, 95% CI: 1.279–3.772); longer duration of T2DM (OR: 1.081, 95% CI: 1.045–1.120); use of insulin (OR: 1.091, 95% CI: 1.018–1.170); longer history of alcohol consumption (OR: 1.034, 95% CI: 1.010–1.059); and higher blood urea nitrogen (OR: 1.081, 95% CI: 1.009–1.159) were associated with increased risk of DN in patients with T2DM. Conclusions Retinopathy, diabetic nephropathy, longer duration of T2DM, use of insulin, longer history of alcohol consumption, and higher blood urea nitrogen were independent risk factors for DN. These findings should be verified in large-scale prospective studies.

scholarly journals The Association of Cytokine Genes Polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in Type 2 Diabetes Mellitus-tuberculosis

2020 ◽  
Vol 8 (A) ◽  
pp. 910-915
Author(s):  
Mutiara Indah Sari ◽  
Zaimah Z. Tala
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Control Group ◽  
P Value ◽  
Cytokine Gene Polymorphism ◽  
Cytokine Genes ◽  
Polymerase Chain

BACKGROUND: The cytokine gene polymorphism is associated with the development of metabolic disorder conditions and infectious diseases such as Type 2 diabetes mellitus (T2DM) and tuberculosis (TB) disease. AIM: The objective of the study is an attempt to examine the association of cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in T2DM-TB patients. METHODS: The cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) were investigated in 46 T2DM-TB patients, 46 T2DM patients, and 46 healthy controls. Cytokine genes polymorphism was carried out by the polymerase chain reaction-restriction fragment length polymorphism. Odds ratio (OR) with 95% confidence interval (CI) and p-value was calculated to determine the association between cytokine genes polymorphisms as the risk factor to T2DM-TB development. RESULTS: No association between genotypes and alleles of cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in T2DM-TB compared to control group (p = 0.434; OR = 0.373; 95% CI = 0.068-2.028 and p = 0.444; OR = 0.387; 95% CI = 0.073–2.046), (p = 0.833; OR = 0.915; 95% CI = 0.400–2.092 and p = 0.864; OR = 1.061; 95% CI = 0.541–2.078), and (p = 0.815; OR = 0.896; 95% CI = 0.357–2.246 and p = 0.882; OR = 0.957; 95% CI = 0.534–1.715). This study also found no association between genotypes and alleles of cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) with T2DM-TB compared to T2DM group (p = 1; OR = 0.652; 95% CI = 0.104–4.094 and p = 1; OR = 0.659; 95% CI = 0.108–4.041), (p = 0.189; OR = 1.786; 95% CI = 0.749–4.262 and p = 0.098; OR = 1.857; 95% CI = 0.887–3.889), and (p = 0.374; OR = 1.488; 95% CI = 0619–3.579 and p = 0.365; OR = 1.316; 95% CI=0.727–2.382). CONCLUSION: There is no association of the cytokine genes polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in T2DM-TB compared to control and T2DM groups, and all cytokine genes polymorphisms not as the risk factor to T2DM-TB development in this population.

Influence of Retinopathy on Plasma Concentrations of total Homocysteine and other Biochemical Parameters in Algerian Patients with Type 2 Diabetes Mellitus

Pteridines ◽  
2012 ◽  
Vol 23 (1) ◽  
pp. 96-103 ◽  
Author(s):  
Mounira Amrane ◽  
Zahira Houcher ◽  
Samia Begag ◽  
Bakhouche Houcher ◽  
Cherifa Benlatreche ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Folic Acid ◽  
Plasma Concentrations ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Folic Acid Deficiency

Abstract Homocysteine (HCY) has been identified as a risk factor for vascular disease in the general population. Diabetic retinopathy (DR) itself rather than hyperhomocysteinemia is the leading cause of blindness among patients with type 2 diabetes mellitus (T2DM). Our study was conducted with 60 healthy control subjects and 178 subjects with T2DM. They were enrolled in the Diabetes Prevention Program from September 2007 to December 2008. Of the 178 patients, 121 cases (68%) had DR Mean plasma total HCY (tHCY) levels were found to be higher in T2DM patients compared to controls (p <0.001), and were also higher than that of the DR group (p <0.001). Plasma folic acid levels were lower in the DR group compared with T2DM without DR and the control group (p <0.001), but there were no significant differences between the latter and the controls. Moderate hyperhomocysteinemia was significantly associated with lower vitamin B12 and folic acid concentrations and older age. Concentrations of serum total cholesterol, LDL-cholesterol (LDL-C), and triglycerides (TG) were significantly raised (p <0.001) whereas the level of HDL-cholesterol (HDL-C) was decreased (p <0.001) in diabetic subjects as compared to controls. Logistic regression analysis showed that DR after adjustment was significantly associated with the following factors: cholesterol, HDL-C and TG. The analysis in DR patients after controlling for cholesterol and TG was independent of plasma tHCY concentrations (OR = 28.5 and OR = 11.9; respectively). In conclusion, results suggest a possible association between moderate hyperhomocysteinemia, traditional risk factors and folic acid deficiency could be an independent risk factor for DR.

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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