Influence of vitamin K2 on bone metabolism in hemodialysis patients. Bone metabolism marker before and after administration of vitamin K2.

Abstract Background Hyperphosphatemia is a common complication in patients on maintenance hemodialysis. Patients’ adherence to phosphorus control can be improved by consistent education. However, few studies have focused on the model construction and effects of health education on phosphate control for hemodialysis patients. Objective To develop an intensive education program focusing on phosphate control among hemodialysis patients and to analyze the effectiveness of this program. Design A non-randomized, single-arm, single-center trial lasting for 6 months. Setting This program was conducted in a hemodialysis center in a teaching hospital in Zhuhai, China. Participants Patients on maintenance hemodialysis with hyperphosphatemia. Methods An intensive hyperphosphatemia control education program lasting for 6 months was conducted among 366 hemodialysis patients applying the First Principles of Instruction model, which focused on mastering four stages: (a) activation of prior experience, (b) demonstration of skills, (c) application of skills and (d) integration of these skills into real-world activities. The controlled percentage of serum phosphorus, knowledge of hyperphosphatemia, and adherence to phosphate binders before and after the education program were assessed. Results The proportion of controlled serum phosphorus was significantly increased from 43.5 to 54.9% (P<0.001). The scores on the knowledge of phosphate control were improved significantly from 59.0 ± 18.9 to 80.6 ± 12.4 (P < 0.001). The proportion of high adherence to phosphate binders was increased dramatically from 21.9 to 44.5% (P < 0.001). Conclusion The intensive education program can effectively improve serum phosphorus, knowledge of hyperphosphatemia, and adherence to phosphate binders among hemodialysis patients. Trial registration Chinese Clinical Trial Registry, ChiCTR2100042017. Retrospectively registered January 12th, 2021.

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Bone metabolism marker in an elderly patient with osteoarthritis of the knee joint

Bone Reports ◽

10.1016/j.bonr.2021.101052 ◽

2021 ◽

Vol 14 ◽

pp. 101052

Author(s):

Hiroshi Yonezu

Keyword(s):

Elderly Patient ◽

Knee Joint ◽

Bone Metabolism ◽

Osteoarthritis Of The Knee ◽

Bone Metabolism Marker

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Bone and Mineral Metabolism Phenotypes in MEN1-Related and Sporadic Primary Hyperparathyroidism, before and after Parathyroidectomy

Cells ◽

10.3390/cells10081895 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1895

Author(s):

Francesca Marini ◽

Francesca Giusti ◽

Federica Cioppi ◽

Davide Maraghelli ◽

Tiziana Cavalli ◽

...

Keyword(s):

Primary Hyperparathyroidism ◽

Bone Mass ◽

Bone Metabolism ◽

Mineral Metabolism ◽

Parathyroid Tissue ◽

Young Patients ◽

Surgical Removal ◽

Mineral Density ◽

Bone Mass Loss ◽

Before And After

Primary hyperparathyroidism (PHPT) is the most common endocrinopathy in multiple endocrine neoplasia type 1 (MEN1). Persistent levels of increased parathyroid hormone (PTH) result in a higher incidence of osteopenia and osteoporosis compared to the general population. Surgical removal of hyper-functioning parathyroid tissue is the therapy of choice. This retrospective study evaluated the effect of parathyroidectomy (PTX) on bone metabolism and bone mass in two series of patients with MEN1 PHPT and sporadic PHPT (sPHPT) by comparing bone metabolism-related biochemical markers and bone mineral density (BMD) before and after surgery. Our data confirmed, in a higher number of cases than in previously published studies, the efficacy of PTX, not only to rapidly restore normal levels of PTH and calcium, but also to normalize biochemical parameters of bone resorption and bone formation, and to improve spine and femur bone mass, in both MEN1 PHPT and sPHPT. Evaluation of single-patient BMD changes after surgery indicates an individual variable bone mass improvement in a great majority of MEN1 PHPT patients. In MEN1 patients, PTX is strongly suggested in the presence of increased PTH and hypercalcemia to prevent/reduce the early-onset bone mass loss and grant, in young patients, the achievement of the bone mass peak; routine monitoring of bone metabolism and bone mass should start from adolescence. Therapy with anti-fracture drugs is indicated in MEN1 patients with BMD lower than the age-matched normal values.

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Mineral-bone metabolism markers in young hemodialysis patients

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2011.08.1143 ◽

2011 ◽

Vol 44 (17-18) ◽

pp. 1425-1428 ◽

Cited By ~ 10

Author(s):

Alvaro Osorio ◽

Esperanza Ortega ◽

Jesús M. Torres ◽

Pilar Sanchez ◽

Estrella Ruiz-Requena

Keyword(s):

Bone Metabolism ◽

Hemodialysis Patients ◽

Bone Metabolism Markers

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Time-Dependent Effects of Vitamin K2 (Menatetrenone) on Bone Metabolism in Postmenopausal Women.

Endocrine Journal ◽

10.1507/endocrj.49.363 ◽

2002 ◽

Vol 49 (3) ◽

pp. 363-370 ◽

Cited By ~ 32

Author(s):

RIEKO OZURU ◽

TOSHITSUGU SUGIMOTO ◽

TOHRU YAMAGUCHI ◽

KAZUO CHIHARA

Keyword(s):

Bone Metabolism ◽

Postmenopausal Women ◽

Vitamin K2 ◽

Time Dependent

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THE EFFECT OF DHIKR ON ANXIETY AND DEPRESSION LEVEL IN HEMODIALYSIS PATIENTS AT PURWOKERTO ISLAMIC HOSPITAL

International Journal of Islamic Medicine ◽

10.37275/ijim.v2i1.17 ◽

2021 ◽

Vol 2 (1) ◽

pp. 15-25

Author(s):

Muhammad Anggun ◽

Titik Kusumawinakhyu ◽

Irma Finurina Mustikawati ◽

Wiharto Wiharto

Keyword(s):

Intervention Group ◽

Depression Scale ◽

Sampling Technique ◽

Hemodialysis Patients ◽

Anxiety And Depression ◽

Control Group ◽

Control Group Design ◽

Hemodialysis Unit ◽

Before And After ◽

The Mean

Hemodialysis is a routinely performed therapy on chronic kidney patients, leading to psychological problems among subjects who undergo hemodialysis, such as anxiety and depression. One of the efforts to overcome anxiety and depression is with the dhikr intervention. Dhikr presents hearts to remember and be obedient to Allah followed by the words and actions in various conditions. Discover dhikr's influence on the level of anxiety and depression in patients on hemodialysis in Purwokerto Islamic Hospital. It was a quantitative study using quasi experiment with a non-quivalent control group design. The number of samples was 12 subjects consisting of 6 subjects in the control group and six subjects in the intervention group with the purposive sampling technique. Instruments were used to measure anxiety and depression are the HADS ( Hospital Anxiety and Depression Scale ) before and after dhikr intervention as much as 12 times. Research is carried out in Hemodialysis Unit of Purwokerto Islamic Hospital. Test statistics on research are used paired t-test and independent t-tests. This study showed a decrease in the mean level of anxiety from 5, 83 to 1.67 in the experimental group ( p = 0.003). The mean level of depression experienced a decline of 9, 67 becomes 4.67 on a group experiment ( p = 0.003). Dhikr reduces the level of anxiety and depression in hemodialysis patients at the Purwokerto Islamic Hospital.

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Association of habitual physical activity with bone metabolism in hemodialysis patients

Physiotherapy ◽

10.1016/j.physio.2015.03.109 ◽

2015 ◽

Vol 101 ◽

pp. e1699-e1700

Author(s):

K. Yoneki ◽

A. Matsunaga ◽

J. Kitagawa ◽

Y. Abe ◽

M. Harada ◽

...

Keyword(s):

Physical Activity ◽

Bone Metabolism ◽

Hemodialysis Patients ◽

Habitual Physical Activity

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Usefulness of foot-to-foot bioimpedance analysis for assessing volume status in chronic hemodialysis patients at the Aristide Le Dantec University Hospital (Senegal)

Journal of Clinical Nephrology ◽

10.29328/journal.jcn.1001075 ◽

2021 ◽

Vol 5 (2) ◽

pp. 056-060

Author(s):

Keita Niakhaleen ◽

Faye Maria ◽

Seck Sidy Mouhamed ◽

Ndong Boucar ◽

Faye Moustapha ◽

...

Keyword(s):

Bioelectrical Impedance ◽

Dry Weight ◽

Impedance Analysis ◽

Cross Sectional Study ◽

Hemodialysis Patients ◽

Chronic Hemodialysis ◽

University Hospital ◽

Single Frequency ◽

Cross Sectional ◽

Before And After

Introduction: Determination of dry weight is one of the daily goals to achieve in hemodialysis. The aim of this study was to validate the use of bioelectrical impedance analysis (BIA) in estimation of dry weight in a population of Senegalese chronic hemodialysis patients. Patients and methods: A 9-week cross-sectional study was carried out at the hemodialysis unit of Aristide Le Dantec University Hospital. Adult patients with no previous hospital history were included. The total body water (TBW) was measured with a single frequency bioelectric impedance foot-to-foot analyzer, before and after six successive hemodialysis sessions. These results were compared with those from clinical measurements with the Watson equation using a Student’s t-test and Bland-Altman analysis. Results: 264 measurements were made in 22 patients (46.6 years, 54.5% men, 92.3 months on dialysis, 62.7 kg mean dry weight). A significant reduction in weight (ΔWeight = 2.0 ± 1.1 kg; p < 0.0001) and in TBW measured by the BIA (ΔTBWBIA = 3.3 ± 1.0 liters; p < 0.0001)) or calculated by Watson’s equation (ΔTBWWatson = 0.5 ± 0.2 liter; p = 0.0001) was observed. There was a strong linear correlation and agreement between the 2 TBW measurements in pre-dialysis. In post-dialysis the concordance diagram indicated a bias = –2.2 and wide agreement limits. Conclusion: The BIA allows reproducible and reliable measurements and a fair estimate of the TBW in pre-dialysis.

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Higher Serum Bisphenol A Levels in Diabetic Hemodialysis Patients

Blood Purification ◽

10.1159/000445203 ◽

2016 ◽

Vol 42 (1) ◽

pp. 77-82 ◽

Cited By ~ 5

Author(s):

Faruk Turgut ◽

Sana Sungur ◽

Ramazan Okur ◽

Mustafa Yaprak ◽

Muge Ozsan ◽

...

Keyword(s):

Bisphenol A ◽

High Performance ◽

Patient Characteristics ◽

Hemodialysis Patients ◽

Chronic Hemodialysis ◽

Dialysis Session ◽

Laboratory Parameters ◽

Hemodialysis Session ◽

Before And After ◽

Patients With Diabetes

Background: Bisphenol A (BPA) has been implicated as an ‘endocrine disruptor'. We aimed at exploring the association between serum BPA levels and patient characteristics, particularly the presence of diabetes mellitus, and laboratory parameters in hemodialysis patients. Methods: This study included 47 chronic hemodialysis patients. Patient characteristics were recorded. Blood was drawn before and after hemodialysis session. Serum BPA levels were measured by the high-performance-liquid-chromatography and laboratory parameters were measured by using standard methods. Results: In hemodialysis patients, postdialysis serum BPA levels were significantly higher than predialysis after a single hemodialysis session (5.57 ± 1.2 vs. 4.06 ± 0.73, p < 0.0001). Predialysis serum BPA levels were significantly higher in patients with diabetes than non-diabetics (4.4 ± 0.6 vs. 3.9 ± 0.7, p = 0.025). No association was found between serum BPA levels and patient characteristics, and particularly laboratory parameters. Conclusion: Serum BPA levels were rising significantly after a single dialysis session. Diabetic hemodialysis patients had higher predialysis serum BPA levels.

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