WARMING EFFECT OF BLANKETS WITH HIGH FAR-INFRARED EMISSIVITY ON SKIN MICROCIRCULATION IN TYPE 2 DIABETIC PATIENTS

Vascular complications are responsible for most of the morbidity and mortality in diabetic patients. Effective strategies to improve circulation appear to be another important issue in addition to the interventions of blood glucose control. Previous studies have shown that the biological effects on humans after using the materials containing ceramic particles emits far infrared radiation (FIR). The present study is to investigate the warming effect of the fabrics containing specified metals in diabetic patients. A total of 28 diabetic patients were blinded and randomly assigned to treatment group ([Formula: see text]) and control group ([Formula: see text]), respectively. The subjects of treatment group were ministered with the blankets with fibers containing the specified metals, while the subjects of control group were provided with blankets of ordinary material. The skin temperature and microcirculatory perfusion were monitored before and after 20-min use of the blankets at shoulder and bilateral calves. After warming with blankets, the treatment group revealed a higher increased ratio of skin perfusion than control ([Formula: see text]), while there was no prominent variation on the wavelet spectrum of the perfusion signal. Although it is already a known fact that passive FIR warming has the advantages of safety and convenience, our results suggest that warming by wearing the textiles containing the specified metals with high FIR emissivity is a solution for daily skin care of diabetic patients.

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Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus

Clinical & Investigative Medicine ◽

10.25011/cim.v34i3.15189 ◽

2011 ◽

Vol 34 (3) ◽

pp. 163 ◽

Cited By ~ 71

Author(s):

Omur Tabak ◽

Remise Gelisgen ◽

Hayriye Erman ◽

Fusun Erdenen ◽

Cüneyt Muderrisoglu ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Dna Damage ◽

Oxidative Dna Damage ◽

Vascular Complications ◽

Diabetic Group ◽

Control Group ◽

Diabetic Patients ◽

Serum Samples ◽

Type 2 Diabetic Patients

Purpose: The purpose of this study was to determine the effects of diabetic complications on oxidation of proteins, lipids, and DNA and to investigate the relationship between oxidative damage markers and clinical parameters. Methods: The study group consisted of 69 type 2 diabetic patients (20 patients without complication, 49 patients with complication) who attended internal medicine outpatient clinics of Istanbul Education and Research Hospital and 19 healthy control subjects. In serum samples of both diabetic patients and healthy subjects, 8-hydroxy-2’deoxyguanosine (8-OHdG), as a marker of oxidative DNA damage, Nε-(hexanoyl)lysine (HEL) and 15-F2t-iso-prostaglandin (15-F2t-IsoP). as products of lipooxidative damage, advanced oxidation protein products (AOPP), as markers of protein damage, and paraoxonase1 (PON1) as antioxidant were studied. Results: 15-F2t-IsoP (p < 0.005) and AOPP (p < 0.001) levels were significantly higher in diabetic group than control group while there were no significant differences in levels of 8-OHdG and HEL between the two groups. AOPP (p < 0.001) and 8-OHdG (p < 0.001) were significantly higher in diabetic group with complications compared to diabetic group without complications. Conclusions: Increased formation of free radicals and oxidative stress, under conditions of hyperglycaemia, is one of the probable causes for evolution of complications in diabetes mellitus. Our study supports the hypothesis that oxidant/antioxidant balance is disturbed in diabetic patients.

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Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia

10.21203/rs.2.20116/v1 ◽

2020 ◽

Author(s):

Xiaomeng Sun ◽

Jia Liu ◽

Guang Wang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Treatment Group ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Control Group ◽

Diabetic Patients ◽

Type 2 Diabetic Patients

Abstract Background: This study was to research the efficacy of fenofibrate in the treatment of microalbuminuria in the patients with type 2 diabetes mellitus (T2DM) and hypertriglyceridemia.Methods: Type 2 diabetic patients (56) with microalbuminuria and hypertriglyceridemia aged 30 to 75 were randomly divided into the fenofibrate treatment group(n=28) and the control group (n=28) for 180 days. Urinary microalbumin /creatinine ratio (UACR) and other metabolic parameters were compared at baseline, during treatment and after treatment.Results: After 180 days, the reduction of levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in two groups were no differences. In treatment group, uric acid (UA) (296.42 ± 56.41 vs 372.46 ± 72.78), triglyceride (TG) [1.51(1.17, 2.06) vs 3.04(2.21, 3.29)], and UACR [36.45 (15.78,102.41) vs 129.00 (53.00, 226.25)] were significantly decreased compared with the baseline. The high-density lipoprotein cholesterol (HDL-C) levels were significantly increased (1.22 ± 0.26 vs 1.09 ± 0.24) compared with the baseline. The decrease in UACR [-44.05(-179.47, -12.16) vs -8.15(-59.69, 41.94)]in treatment group was significantly higher compared with the control group. The decrease in UACR was positively associated with the decreases in TG ( r = 0.447, P = 0.042) and UA ( r = 0.478, P = 0.024) after fenofibrate treatment.Conclusion: In the patients with hypertriglyceridemia and type 2 diabetes mellitus, fenofibrate can improve microalbuminuria and do not increase the deterioration of glomerular filtration rate

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The Effects of Information and Support on Individuals Awaiting Cadaveric Kidney Transplantation

Progress in Transplantation ◽

10.1177/152692480201200308 ◽

2002 ◽

Vol 12 (3) ◽

pp. 201-207 ◽

Cited By ~ 2

Author(s):

Cynthia L. Russell ◽

Kristi Brown

Keyword(s):

Kidney Transplantation ◽

Treatment Group ◽

Nursing Intervention ◽

Control Group ◽

Body Of Knowledge ◽

Phone Calls ◽

Growing Body ◽

Before And After ◽

Cadaveric Kidney ◽

Cadaveric Kidney Transplantation

Context No empirical studies exist to direct nursing interventions for individuals during the long period of waiting for a transplant. Objective To measure the effect of information and support on hope and uncertainty for individuals awaiting cadaveric kidney transplantation. Design Randomized, controlled study. Setting A university-affiliated hospital in the Midwest from 1997 to 1999. Patients Fifty participants awaiting cadaveric kidney transplantation. Interventions The control group received no intervention phone calls or mailings, which was the current standard of care. The treatment group received phone calls and mailings once every month for 6 months. Main Outcome Measures Hope, measured by the Herth Hope Index, and uncertainty, measured by the Mishel's Uncertainty in Illness Scale for Adults, were evaluated at the beginning of the study and 6 months later. Results No statistically significant effect of the nursing intervention was found on hope and uncertainty in this sample (F = 0.5322, P = .81). Hope was found to be negatively related to uncertainty both before ( r = $0.53, P = .0001) and after ( r = $0.59, P = .0001) intervention. No significant change was found between hope before and after intervention, and uncertainty before and after intervention in the treatment group (F = 1.10, P = .40) or the control group. Conclusion The individuals indicated that definite needs were met by the information and support intervention even though the results did not statistically support the effect of the nursing intervention. Conclusions Several conclusions can be drawn from the findings of this study. First, even though the nursing intervention of providing information and support did not have a statistically significant effect on levels of hope and uncertainty in individuals awaiting kidney transplantation, anecdotal reports from the respondents indicated that the phone calls and mailed information were helpful and appreciated. Valuable information, potentially impacting the outcomes of kidney transplantation, was gathered by the researchers and shared with the transplant team. Secondly, levels of hope were relatively high, whereas levels of uncertainty were moderate in this sample of individuals waiting for cadaveric kidney transplantation. Furthermore, in this sample, the average time since diagnosis of ESRD was more than 4 years and the average waiting time was more than 1 year. There may have been a change over time from viewing the waiting experience as a negative experience to a positive opportunity. Thirdly, the finding of a negative relationship between hope and uncertainty provided support to the growing body of knowledge of this association. Finally, time on the waiting list, gender, and marital status were not associated with levels of hope or uncertainty. Generally, the findings of this study are consistent with existing literature and add to the growing body of knowledge related to the midrange theories of hope and uncertainty.

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The Significance of Urinary Markers in the Evaluation of Diabetic Nephropathy

Journal of Medical Biochemistry ◽

10.2478/v10011-008-0019-y ◽

2008 ◽

Vol 27 (3) ◽

pp. 376-382 ◽

Cited By ~ 5

Author(s):

Tatjana Cvetković ◽

Predrag Vlahović ◽

Vidosava đorđević ◽

Lilika Zvezdanović ◽

Dušica Pavlović ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Urine Concentration ◽

Control Group ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Urinary Markers ◽

Stress Markers

The Significance of Urinary Markers in the Evaluation of Diabetic Nephropathy Oxidative stress is considered to be a unifying link between diabetes mellitus (DM) and its complications, including nephropathy (DN). The aim of this study was to determine the parameters of oxidative injury of lipids and proteins as well as the activity of ectoenzymes in the urine of DN patients. The study included 40 individuals: 10 patients with type 2 diabetes mellitus and microalbuminuria (DMT2-MIA), 10 type 2 diabetic patients with macroalbuminuria (DMT2-MAA), 10 patients with type 1 diabetes and microalbuminuria (DMT1-MIA) and 10 age- and sex-matched healthy subjects (control). In the urine we determined TBA reactive substances (TBARS), reactive carbonyl groups (RCG), and the activity of ectoenzymes N-acetyl-β-d-glucosaminidase (NAG), plasma cell differentiation antigen (PC-1), aminopeptidase N (APN) and dipeptidyl peptidase IV (DPP IV). A higher concentration of TBARS in the urine was found in DMT2-MIA and DMT1-MIA, compared to the control group (p<0.001 and P<0.05). The urine concentration of RCD shows similar results with a significant elevation in the groups with DMT2-MAA and DMT1-MIA, compared to the DMT2-MIA (p<0.001) and control group (p<0.001). Activities of NAG, APN and DPPIV were significantly higher in the urine of DMT2-MAA, compared to the control (p<0.01). The activity of PC-1 was slightly increased in that group, but not significantly. In conclusion, the level of oxidative stress markers and activities of brush border ectoenzymes in the urine may be a useful non-invasive and easily repeatable test in DN.

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Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

Global Journal of Health Science ◽

10.5539/gjhs.v9n5p234 ◽

2016 ◽

Vol 9 (5) ◽

pp. 234

Author(s):

Zahra Heidari ◽

Zahra Sepehri ◽

Aleme Doostdar

Keyword(s):

Type 2 Diabetes ◽

Serum Level ◽

Control Group ◽

Diabetic Patients ◽

Diabetes Incidence ◽

Serum Selenium ◽

Type 2 Diabetic Patients ◽

Significant Difference ◽

The Mean

<p>In addition to known risk factors, the role of different micronutrients such as selenium in diabetes incidence has been proposed. Some previous studies have shown an association of selenium deficiency and type 2 diabetes mellitus, while other studies have not confirmed such a relationship. The aim of this study was to evaluate serum level of selenium in patients with Type 2 diabetes compared with the control group. This cross-sectional study was carried out on patients with type 2 diabetes in Zahedan, southeastern Iran. One hundred newly diagnosed type 2 diabetic patients were evaluated for serum selenium level. One hundred subjects from the general population who had normal fasting blood sugar levels were selected as the control group. The control group subjects were matched in pairs with each of patients on the basis of sex, age (± one year), and body mass index (±1). Serum level of selenium was determined by spectrometry method. Results were compared using t-test. The mean serum level of selenium in patients was 94.47±18.07 µg/L whereas in control group was 142.79±23.67 µg/L. The mean serum level of selenium was significantly different between the two groups (P<0.001). Serum levels of selenium in diabetic patients with significant difference statistically were lower than the control group. In order to evaluate serum level of selenium in patients with diabetes, studies with larger sample size are required. Likewise, prospective studies along with selenium supplementation and investigating its effect on incidence of diabetes are accordingly needed.</p>

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Ethnic Foods Diet Program Improve Self-Efficacy and Diet Compliance Among Type 2 Diabetic Patients

Jurnal NERS ◽

10.20473/jn.v14i2.16642 ◽

2020 ◽

Vol 14 (2) ◽

pp. 155

Author(s):

Eka Mishbahatul Mar'ah Has ◽

Amira Aulia ◽

Tiyas Kusumaningrum ◽

Ferry Efendi

Keyword(s):

Treatment Group ◽

Self Efficacy ◽

Dietary Guidelines ◽

Rank Test ◽

Control Group ◽

Diabetic Patients ◽

Post Test ◽

Diet Compliance ◽

And Control

A well-balanced diet is one of the four pillars of diabetes self-management. Patient's culture strongly influences intake food. Diabetic dietary guidelines which fit with the patient's culture is expected to improve patient's self-efficacy and diet compliance. This study was aimed to analyze the effect of ethnic foods diet program in improving self-efficacy and diet compliance among Type-2 Diabetes Mellitus (T2DM) patients. This was quasy experiment research with pre and post-test control design. The population was 112 T2DM patients from Sasak Tribes, West Nusa Tenggara. Samples were 36 respondents, divided into intervention (18) and control (18) groups. The independent variable was the ethnic food diet (EFD) program, while the dependent variables were patient's self-efficacy and diet compliance. Data were collected using self-efficacy questionnaire and a 24-hour dietary recall form. Data were then analyzed using Wilcoxon Signed Rank Test and Mann Whitney U Test. The result showed differences in self-efficacy between pre and post-test in the treatment group (p=0,001), but there were no differences in the control group. There were differences in diet compliance in the treatment group (p=0,001), but there were no differences in the control group. There were differences between treatment and control groups on self-efficacy (p=0,000) and diet compliance (p=0,000). Ethnic foods diet program can improve self-efficacy and diet compliance among T2DM patients because more comfortable and easier to be applied. Nurses can apply ethnic foods diet program as an intervention to promote healthy diet for T2DM patients.

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Influence of Nutrition Education with Calendar Method in Diabetic Patients' Blood Glucose

NurseLine Journal ◽

10.19184/nlj.v3i2.6627 ◽

2018 ◽

Vol 3 (2) ◽

pp. 72

Author(s):

Setyoadi Setyoadi ◽

Heri Kristianto ◽

Siti Nur Afifah

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Nutrition Education ◽

Community Health Center ◽

Control Group ◽

P Value ◽

Diabetic Patients ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Before And After

Diabetes mellitus is a disease that required good self-management. Noncompliance in diet and meal plans cause the instability of blood glucose levels. Nutrition education calendar method can improve knowledge and ability to consume food that matches the number, hours and types with dietary adjustments listed in the calendar diet. This study aimed to determine the effect of nutrition education calendar method on blood glucose levels of patients with type 2 diabetes mellitus in Community Health Center Pakis Malang. Pre-experimental design one group pretest-posttest with purposive sampling was conducted in this study and sample obtained as many as 21 people. Blood glucose levels were measured before and after the nutrition education calendar methods. Compliance in using calendar method with the observation sheet. Statistical analysis values obtained by Wilcoxon, the p-value of 0.007 (p <0.05). The results of the analysis, 16 respondents showed a decrease in blood glucose levels and 5 respondents experienced an increase in blood glucose levels after the given intervention. It can be concluded that there are differences between blood glucose levels before and after nutrition education calendar method. Differences in blood glucose levels can be influenced by controlling diet respondent in accordance with the calendar method in education, but also antidiabetic drugs, and sports. Should be added to the control group to determine objectively the effect of nutrition education on the calendar method.

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Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia

10.21203/rs.2.20116/v2 ◽

2020 ◽

Author(s):

Xiaomeng Sun ◽

Jia Liu ◽

Guang Wang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Treatment Group ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Control Group ◽

Diabetic Patients ◽

Fenofibrate Treatment

Abstract Background: This study was to research the efficacy of fenofibrate in the treatment of microalbuminuria in the patients with type 2 diabetes mellitus (T2DM) and hypertriglyceridemia. Methods: Type 2 diabetic patients (56) with microalbuminuria and hypertriglyceridemia aged 30 to 75 were randomly divided into the fenofibrate treatment group(n=28) and the control group (n=28) for 180 days. Urinary microalbumin /creatinine ratio (UACR) and other metabolic parameters were compared at baseline, during treatment and after treatment. Results: After 180 days, the reduction of levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in two groups were no differences. In treatment group, uric acid (UA) (296.42 ± 56.41 vs 372.46 ± 72.78), triglyceride (TG) [1.51(1.17, 2.06) vs 3.04(2.21, 3.29)], and UACR [36.45 (15.78,102.41) vs 129.00 (53.00, 226.25)] were significantly decreased compared with the baseline. The high-density lipoprotein cholesterol (HDL-C) levels were significantly increased (1.22 ± 0.26 vs 1.09 ± 0.24) compared with the baseline. The decrease in UACR [-44.05(-179.47, -12.16) vs -8.15(-59.69, 41.94)]in treatment group was significantly higher compared with the control group. The decrease in UACR was positively associated with the decreases in TG ( r = 0.447, P = 0.042) and UA ( r = 0.478, P = 0.024) after fenofibrate treatment. Conclusion: In the patients with hypertriglyceridemia and type 2 diabetes mellitus, fenofibrate can improve microalbuminuria and do not increase the deterioration of glomerular filtration rate

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Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne

Frontiers in Medicine ◽

10.3389/fmed.2021.662640 ◽

2021 ◽

Vol 8 ◽

Author(s):

Hongyu Zhong ◽

Xiang Li ◽

Wanqi Zhang ◽

Xiaoxiao Shen ◽

Yuangang Lu ◽

...

Keyword(s):

Treatment Group ◽

Side Effects ◽

Combined Therapy ◽

Aloe Vera ◽

Physical Method ◽

Control Group ◽

Severe Acne ◽

Aloe Vera Gel ◽

Before And After ◽

Acne Therapy

Background: Acne is a chronic disorder that affects almost 80% of adolescents and young adults, causing psychological and emotional distress. However, the current treatments for acne are either ineffective or have many side effects. This study was designed to confirm and objectively quantify the effect of a new non-drug combined therapy on acne.Methods: This study innovatively utilized ultrasound, which enhanced the absorption of aloe vera gel, and soft mask to make a purely physical method without any drugs. In both the treatment group and control group, the number of papules/pustules and the area of hyperpigmented lesions were counted, and a smart mirror intelligent face system was used before and after the combined therapy. Alterations in the skin functional index were recorded and analyzed statistically.Results: In the treatment group, the combined therapy significantly reduced the number of papules and the area of hyperpigmented lesions and improved skin roughness and local blood circulation. In the control group, there was no obvious improvement over 2 months.Conclusion: This study suggests that the new non-drug combined therapy significantly improved acne, which provided experimental evidence and treatment guidance for patients with mild to severe acne, especially patients with moderate acne. This new therapy may possibly be an appropriate method for patients who seek topical treatments with mild side effects and low antibiotic resistance rates.

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OHIS Differences on Primary School Students in Relation to Little Dentist Training

10.31219/osf.io/uxbks ◽

2021 ◽

Author(s):

Asep Arifin Senjaya ◽

Ni Made Sirat ◽

I Nyoman Wirata ◽

Ni Ketut Ratmini

Keyword(s):

Treatment Group ◽

Primary School ◽

Oral Hygiene ◽

Dental Health ◽

Control Group ◽

Primary School Students ◽

School Students ◽

Significant Difference ◽

Before And After ◽

The Difference

Dental healthcare is very important since dental and oral hygiene should be maintained. Statistics showed that more than 80% of children in developed and developing countries suffer from dental disease. This study aimed to see the safety of OHIS (Oral Hygiene Index Simplified) in primary school students who got and did not get little dentist cadre training in Bangli Regency in 2019. The study was done in an experimental design: pre and post-test with control design, which was conducted in August-September 2019. The sample in this study is 366 students. The difference in OHIS scores before and after treatment in the control group and treatment group was carried out by the bivariate Mann Whitney U Test. The results of the study showed that before dental health training was conducted, there were 54.3% of primary school students in the treatment group with good OHIS score criteria, and after the training was carried out as many as 98.4% of the students in the treatment group had a good OHIS. Additionally, prior to the training, 57.5% of the control group had fair OHIS criteria score. Then, after the training was carried out, 73.7% of the control group had good OHIS score. Hence, the study concluded that there was a significant difference in the OHIS of primary school students who got little doctor training prior to and after the training. Also, there was a significant difference in the OHIS of the students who did not get such treatment before and after the training.

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