Introduction to Olfaction

2012 ◽  
pp. 1-43
Author(s):  
Graeme Lowe
Keyword(s):  
Olfactory Bulb ◽  
Olfactory Cortex ◽  
Neural Systems ◽  
Chemical Stimulus ◽  
Anatomy And Physiology ◽  
Cellular Architecture ◽  
Detection And Identification ◽  
Processing Pathways ◽  
Research Findings ◽  
And Function

This chapter introduces the basic anatomy and physiology of the neural systems involved in the detection and identification of odors by vertebrate animals. It describes the cellular architecture and function of these systems, tracing the path of sensory signals from the initial steps of sniffing and chemical stimulus transduction in the nose, through to the synaptic processing pathways in the circuits of the olfactory bulb and major areas of olfactory cortex. Included are reviews of the latest research findings and hypotheses shaping our fundamental understanding of olfactory mechanisms, with particular emphasis on mammalian olfaction.

CD38 as an immunomodulator in cancer

2020 ◽  
Vol 16 (34) ◽  
pp. 2853-2861
Author(s):  
Yanli Li ◽  
Rui Yang ◽  
Limo Chen ◽  
Sufang Wu
Keyword(s):  
Multiple Myeloma ◽  
Cell Activation ◽  
Human Tissues ◽  
Transmembrane Glycoprotein ◽  
Cell Activation Marker ◽  
Research Findings ◽  
A Cell ◽  
And Function ◽  
Human Molecule

CD38 is a transmembrane glycoprotein that is widely expressed in a variety of human tissues and cells, especially those in the immune system. CD38 protein was previously considered as a cell activation marker, and today monoclonal antibodies targeting CD38 have witnessed great achievements in multiple myeloma and promoted researchers to conduct research on other tumors. In this review, we provide a wide-ranging review of the biology and function of the human molecule outside the field of myeloma. We focus mainly on current research findings to summarize and update the findings gathered from diverse areas of study. Based on these findings, we attempt to extend the role of CD38 in the context of therapy of solid tumors and expand the role of the molecule from a simple marker to an immunomodulator.

HISTORIAN ON SOCIAL NETWORKS: SOME METHODOLOGICAL CONSIDERATIONS

2020 ◽  
pp. 223-227
Author(s):  
Vasily Syrov
Keyword(s):  
Social Networks ◽  
Decisive Role ◽  
Professional Community ◽  
Historical Knowledge ◽  
Main Attention ◽  
Web Technologies ◽  
Research Findings ◽  
Methodological Considerations ◽  
And Function

The article discusses some of the research findings related to the topic of the place and function of histori-ans on social networks. The main attention is paid to identifying the role of web technologies in the con-ventional practices of creating historical knowledge creation of historical knowledge. It is emphasized that the thesis about blurring the boundaries between the professional community and users in general does not mean rejection of the recognition of the decisive role of the professional community in the production of knowledge. The ways and methods of historians' actions in social networks and their advantages over traditional methods of knowledge production are revealed.

The Endocrine System: Thyroid and Parathyroid

2019 ◽  
Author(s):  
Samantha J. Baker ◽  
John R. Porterfield Jr
Keyword(s):  
Venous Blood ◽  
Endocrine System ◽  
Superior Laryngeal Nerve ◽  
Central Compartment ◽  
Lymphatic Drainage ◽  
Laryngeal Nerve ◽  
Thyroid Disorders ◽  
Hormone Synthesis ◽  
Anatomy And Physiology ◽  
And Function

In the adult, the thyroid gland is located in the central compartment of the neck on the anterolateral aspect of the cervical trachea between the carotid sheaths. Patients with thyroid disorders require attentive care, and safe, successful surgery of the thyroid is dependent on an intimate knowledge of the anatomy and physiology of the gland. This review discusses nerve branches and function; arterial and venous blood supply; lymphatic drainage; histology; physiology; and thyroid hormone synthesis, secretion, and regulation. Nerve injuries and postoperative complications are summarized, as are functions of thyroid hormones. A thorough understanding of these relationships is imperative for proper medical recommendations, surgical procedure selection, and meticulous surgical technique to avoid complications. To provide safe care of patients with thyroid disorders, treating physicians must embrace the intricate details of the anatomy and physiology of this unique gland to avoid potentially devastating complications. This review contains 5 figures, 3 tables, and 29 references. Key Words: brachial cleft, lymphatic zones, recurrent laryngeal nerve, superior laryngeal nerve, nerve injury, thyroglossal duct cysts, thyroid, thyroidectomy

Retronasal Smell

Neuroenology ◽  
2016 ◽  
pp. 128-134
Author(s):  
Gordon M. Shepherd
Keyword(s):  
Olfactory Bulb ◽  
Olfactory Receptors ◽  
Olfactory Cortex ◽  
Initial Experience

We compare the initial experience of the aroma of the wine in the glass with the experience of the retronasal aroma as it contributes to the full flavor of the wine in the mouth and throat. We discuss the controversy over whether retronasal smell is less sensitive than orthonasal smell, and what could be the reasons. The processing of retronasal smell images is described from the olfactory receptors to the olfactory bulb, olfactory cortex, and highest cortical levels.

Parallel Tufted Cell and Mitral Cell Pathways from the Olfactory Bulb to the Olfactory Cortex

2014 ◽  
pp. 133-160 ◽  
Author(s):  
Shin Nagayama ◽  
Kei M. Igarashi ◽  
Hiroyuki Manabe ◽  
Kensaku Mori
Keyword(s):  
Olfactory Bulb ◽  
Mitral Cell ◽  
Olfactory Cortex ◽  
Tufted Cell

Disorders of the Cranial Nerves and Brainstem

2021 ◽  
pp. 851-861
Author(s):  
Kelly D. Flemming
Keyword(s):  
Olfactory Bulb ◽  
Olfactory Receptor ◽  
Cranial Nerves ◽  
Olfactory Nerve ◽  
Mitral Cell ◽  
Olfactory Cortex ◽  
Olfactory Receptor Cells ◽  
Receptor Cells ◽  
Clinical Disorders ◽  
Primary Olfactory Cortex

This chapter briefly repeats key anatomic characteristics and then reviews clinical disorders affecting each cranial nerve in addition to the brainstem. More specifically, this chapter covers cranial nerves I, V, VII, and IX through XII plus the brainstem. The olfactory nerve is a special visceral afferent nerve that functions in the sense of smell. The axons of the olfactory receptor cells within the nasal cavity extend through the cribriform plate to the olfactory bulb. These olfactory receptor cell axons synapse with mitral cells in the olfactory bulb. Mitral cell axons project to the primary olfactory cortex and amygdala. The olfactory cortex interconnects with various autonomic and visceral centers.

scholarly journals Role of Axonal Odorant Receptors in Olfactory Topography

2020 ◽  
Vol 15 ◽  
pp. 263310552092341
Author(s):  
Claudia Lodovichi
Keyword(s):  
Olfactory Bulb ◽  
Sensory Neurons ◽  
Axon Terminal ◽  
Internal Representation ◽  
Dual Role ◽  
Odorant Receptors ◽  
Topographic Map ◽  
And Function ◽  
Guidance Molecule

A unique feature in the organization of the olfactory system is the dual role of the odorant receptors: they detect odors in the nasal epithelium and they play an instructive role in the convergence of olfactory sensory neuron axons in specific loci, ie, glomeruli, in the olfactory bulb. The dual role is corroborated by the expression of the odorant receptors in 2 specific locations of the olfactory sensory neurons: the cilia that protrude in the nostril, where the odorant receptors interact with odors, and the axon terminal, a suitable location for a potential axon guidance molecule. The mechanism of activation and function of the odorant receptors expressed at the axon terminal remained unknown for almost 20 years. A recent study identified the first putative ligand of the axonal odorant receptors, phosphatidylethanolamine-binding protein1, a molecule expressed in the olfactory bulb. The distinctive mechanisms of activation of the odorant receptors expressed at the opposite locations in sensory neurons, by odors, at the cilia, and by molecules expressed in the olfactory bulb, at the axon terminal, explain the dual role of the odorant receptors and link the specificity of odor perception with its internal representation, in the topographic map.

scholarly journals Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation

2020 ◽  
Vol 10 (6) ◽  
pp. 367
Author(s):  
Sarah M. Keesom ◽  
Laura M. Hurley
Keyword(s):  
Hearing Loss ◽  
Social Isolation ◽  
Human Subjects ◽  
Brain Regions ◽  
Neural Systems ◽  
Depression And Anxiety ◽  
Auditory Cognition ◽  
Regulatory Systems ◽  
Two Factors ◽  
And Function

For social animals that communicate acoustically, hearing loss and social isolation are factors that independently influence social behavior. In human subjects, hearing loss may also contribute to objective and subjective measures of social isolation. Although the behavioral relationship between hearing loss and social isolation is evident, there is little understanding of their interdependence at the level of neural systems. Separate lines of research have shown that social isolation and hearing loss independently target the serotonergic system in the rodent brain. These two factors affect both presynaptic and postsynaptic measures of serotonergic anatomy and function, highlighting the sensitivity of serotonergic pathways to both types of insult. The effects of deficits in both acoustic and social inputs are seen not only within the auditory system, but also in other brain regions, suggesting relatively extensive effects of these deficits on serotonergic regulatory systems. Serotonin plays a much-studied role in depression and anxiety, and may also influence several aspects of auditory cognition, including auditory attention and understanding speech in challenging listening conditions. These commonalities suggest that serotonergic pathways are worthy of further exploration as potential intervening mechanisms between the related conditions of hearing loss and social isolation, and the affective and cognitive dysfunctions that follow.

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