Understanding Toxicity of Nanomaterials in Biological Systems

2016 ◽  
pp. 403-427
Author(s):  
Irshad Ahmad Wani ◽  
Tokeer Ahmad
Keyword(s):  
Safety Assessment ◽  
Biological Systems ◽  
Toxicity Assessment ◽  
Applied Science ◽  
Nanoscale Materials ◽  
Energy Medicine ◽  
Wide Range ◽  
Almost All ◽  
Direct Use

Nanotechnology is a growing applied science having considerable global socioeconomic value. Nanoscale materials are casting their impact on almost all industries and all areas of society. A wide range of engineered nanoscale products has emerged with widespread applications in fields such as energy, medicine, electronics, plastics, energy and aerospace etc. While the market for nanotechnology products will have grown over one trillion US dollars by 2015, the presence of these material is likely to increase leading to increasing likelihood of exposure. The direct use of nanomaterials in humans for medical and cosmetic purposes dictates vigorous safety assessment of toxicity. Therefore this book chapter provides the detailed toxicity assessment of various types of nanomaterials.

Understanding Toxicity of Nanomaterials in Biological Systems

2017 ◽  
pp. 1533-1557
Author(s):  
Irshad Ahmad Wani ◽  
Tokeer Ahmad
Keyword(s):  
Safety Assessment ◽  
Biological Systems ◽  
Toxicity Assessment ◽  
Applied Science ◽  
Nanoscale Materials ◽  
Energy Medicine ◽  
Wide Range ◽  
Almost All ◽  
Direct Use

Nanotechnology is a growing applied science having considerable global socioeconomic value. Nanoscale materials are casting their impact on almost all industries and all areas of society. A wide range of engineered nanoscale products has emerged with widespread applications in fields such as energy, medicine, electronics, plastics, energy and aerospace etc. While the market for nanotechnology products will have grown over one trillion US dollars by 2015, the presence of these material is likely to increase leading to increasing likelihood of exposure. The direct use of nanomaterials in humans for medical and cosmetic purposes dictates vigorous safety assessment of toxicity. Therefore this book chapter provides the detailed toxicity assessment of various types of nanomaterials.

scholarly journals Understanding Toxicity of Nanomaterials in Biological Systems

2017 ◽  
pp. 1492-1516
Author(s):  
Irshad Ahmad Wani ◽  
Tokeer Ahmad
Keyword(s):  
Safety Assessment ◽  
Biological Systems ◽  
Toxicity Assessment ◽  
Applied Science ◽  
Nanoscale Materials ◽  
Energy Medicine ◽  
Wide Range ◽  
Almost All ◽  
Direct Use

Nanotechnology is a growing applied science having considerable global socioeconomic value. Nanoscale materials are casting their impact on almost all industries and all areas of society. A wide range of engineered nanoscale products has emerged with widespread applications in fields such as energy, medicine, electronics, plastics, energy and aerospace etc. While the market for nanotechnology products will have grown over one trillion US dollars by 2015, the presence of these material is likely to increase leading to increasing likelihood of exposure. The direct use of nanomaterials in humans for medical and cosmetic purposes dictates vigorous safety assessment of toxicity. Therefore this book chapter provides the detailed toxicity assessment of various types of nanomaterials.

scholarly journals Scanning Various Nanomaterials and Variable Camouflages to Evaluate the Biocompatibility in Multi-organs of Embryos

2020 ◽  
Author(s):  
Bin Zheng ◽  
Mingming Guo ◽  
Meijun Pang ◽  
Dong Ming
Keyword(s):  
Safety Assessment ◽  
Silica Coating ◽  
Toxicity Assessment ◽  
Specific Cell ◽  
Cdse Qds ◽  
Multiple Organs ◽  
Wide Range ◽  
Health And Disease

Abstract Background:Nanomaterials are under a wide range of application prospects in human health and disease, such as medical imaging and drug delivery and treatment. With the gradual advent of the nano era, the safety of nanomaterials in biology must be evaluated more widely and deeply. Therefore, superficial safety assessment based on specific cell lines in vitro is difficult to meet the current needs. Multi-organs assessment in vivo will be beneficial in establishing a more comprehensive pathway for the understanding of nanomaterials-induced biotoxicity. Results:In this work, we employed a series of genetically modified zebrafish models for nanomaterials toxicity assessment. The results demonstrated that cadmium selenide (CdSe) quantum dot (QDs) was the most toxic after scanning some popular nanomaterials. Among modified methods of silica coating, core-shell structure development and organic molecular camouflage, the polyethylene glycol camouflage method exhibits a better performance of improving the biocompatibility of CdSe QDs in multiple-organs including hearts, nerves, blood vessels, and immune system. Conclusion:Our work provides an alternative paradigm for more in-depth and sensitive preclinical validation of biocompatibility, especially in neurotoxicity and cardiotoxicity of embryos, and a guidance for reducing the toxicity of biomedical materials.

Nanoparticles Functionalized with Venom-Derived Peptides and Toxins for Pharmaceutical Applications

2020 ◽  
Vol 21 (2) ◽  
pp. 97-109 ◽  
Author(s):  
Ana P. dos Santos ◽  
Tamara G. de Araújo ◽  
Gandhi Rádis-Baptista
Keyword(s):  
Oral Absorption ◽  
Current Data ◽  
Pharmacological Activities ◽  
Venom Peptides ◽  
Essential Components ◽  
Wide Range ◽  
Different Types ◽  
Direct Use ◽  
Animal Venoms ◽  
Pharmaceutical Biotechnology

Venom-derived peptides display diverse biological and pharmacological activities, making them useful in drug discovery platforms and for a wide range of applications in medicine and pharmaceutical biotechnology. Due to their target specificities, venom peptides have the potential to be developed into biopharmaceuticals to treat various health conditions such as diabetes mellitus, hypertension, and chronic pain. Despite the high potential for drug development, several limitations preclude the direct use of peptides as therapeutics and hamper the process of converting venom peptides into pharmaceuticals. These limitations include, for instance, chemical instability, poor oral absorption, short halflife, and off-target cytotoxicity. One strategy to overcome these disadvantages relies on the formulation of bioactive peptides with nanocarriers. A range of biocompatible materials are now available that can serve as nanocarriers and can improve the bioavailability of therapeutic and venom-derived peptides for clinical and diagnostic application. Examples of isolated venom peptides and crude animal venoms that have been encapsulated and formulated with different types of nanomaterials with promising results are increasingly reported. Based on the current data, a wealth of information can be collected regarding the utilization of nanocarriers to encapsulate venom peptides and render them bioavailable for pharmaceutical use. Overall, nanomaterials arise as essential components in the preparation of biopharmaceuticals that are based on biological and pharmacological active venom-derived peptides.

First Detection of Tobacco Mosaic Virus in Tobacco Fields in Northern Lebanon

2020 ◽  
Vol 20 ◽  
Author(s):  
Rami Obeid ◽  
Elias Wehbe ◽  
Mohamad Rima ◽  
Mohammad Kabara ◽  
Romeo Al Bersaoui ◽  
...  
Keyword(s):  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Viral Genome ◽  
Virus Genome ◽  
Enzyme Linked Immunosorbent Assay ◽  
Virus Family ◽  
Crop Fields ◽  
Wide Range ◽  
Almost All ◽  
Das Elisa

Background: Tobacco mosaic virus (TMV) is the most known virus in the plant mosaic virus family and is able to infect a wide range of crops, in particularly tobacco, causing a production loss. Objectives: Herein, and for the first time in Lebanon, we investigated the presence of TMV infection in crops by analyzing 88 samples of tobacco, tomato, cucumber and pepper collected from different regions in North Lebanon. Methods: Double-antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA), revealed a potential TMV infection of four tobacco samples out of 88 crops samples collected. However, no tomato, cucumber and pepper samples were infected. The TMV+ tobacco samples were then extensively analyzed by RT-PCR to detect viral RNA using different primers covering all the viral genome. Results and Discussion: PCR results confirmed those of DAS-ELISA showing TMV infection of four tobacco samples collected from three crop fields of North Lebanon. In only one of four TMV+ samples, we were able to amplify almost all the regions of viral genome, suggesting possible mutations in the virus genome or an infection with a new, not yet identified, TMV strain. Conclusion: Our study is the first in Lebanon revealing TMV infection in crop fields, and highlighting the danger that may affect the future of agriculture.

INFLUENCE OF WEATHER ON TEMPORARY AND PERMANENT MIGRATION IN RURAL INDIA

2013 ◽  
Vol 04 (02) ◽  
pp. 1350007 ◽  
Author(s):  
K. S. KAVI KUMAR ◽  
BRINDA VISWANATHAN
Keyword(s):  
National Sample ◽  
Sample Survey ◽  
Urban Migration ◽  
Temporary Migration ◽  
Urban Migrants ◽  
Wide Range ◽  
Permanent Migration ◽  
Sample Survey Data ◽  
Almost All ◽  
Temporary Migrants

While a wide range of factors influence rural–rural and rural–urban migration in developing countries, there is significant interest in analyzing the role of agricultural distress and growing inter-regional differences in fueling such movement. This strand of research acquires importance in the context of climate change adaptation. In the Indian context, this analysis gets further complicated due to the significant presence of temporary migration. This paper analyzes how weather and its variability affects both temporary and permanent migration in India using National Sample Survey data for the year 2007–2008. The paper finds that almost all of the rural–urban migrants are permanent. Only temperature plays a role in permanent migration. In contrast, many temporary migrants are rural–rural and both temperature and rainfall explain temporary migration.

scholarly journals Engineering the Interface between Inorganic Nanoparticles and Biological Systems through Ligand Design

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1001
Author(s):  
Rui Huang ◽  
David C. Luther ◽  
Xianzhi Zhang ◽  
Aarohi Gupta ◽  
Samantha A. Tufts ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Molecular Design ◽  
Biological Systems ◽  
Ligand Design ◽  
Inorganic Nanoparticles ◽  
Organic Ligands ◽  
Biological Applications ◽  
Wide Range ◽  
Insight Into

Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight approaches to functionalize nanoparticles with ”small” organic ligands (Mw < 1000), providing insight into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.

scholarly journals VAGADRONE: Intelligent and Fully Automatic Drone Based on Raspberry Pi and Android

2021 ◽  
Vol 11 (7) ◽  
pp. 3153
Author(s):  
Saifeddine Benhadhria ◽  
Mohamed Mansouri ◽  
Ameni Benkhlifa ◽  
Imed Gharbi ◽  
Nadhem Jlili
Keyword(s):  
Remote Control ◽  
Autonomous Navigation ◽  
Object Identification ◽  
External Control ◽  
Raspberry Pi ◽  
Optimal Trajectories ◽  
Live Streaming ◽  
Wide Range ◽  
Fully Automatic ◽  
Direct Use

Multirotor drones are widely used currently in several areas of life. Their suitable size and the tasks that they can perform are their main advantages. However, to the best of our knowledge, they must be controlled via remote control to fly from one point to another, and they can only be used for a specific mission (tracking, searching, computing, and so on). In this paper, we intend to present an autonomous UAV based on Raspberry Pi and Android. Android offers a wide range of applications for direct use by the UAV depending on the context of the assigned mission. The applications cover a large number of areas such as object identification, facial recognition, and counting objects such as panels, people, and so on. In addition, the proposed UAV calculates optimal trajectories, provides autonomous navigation without external control, detects obstacles, and ensures live streaming during the mission. Experiments are carried out to test the above-mentioned criteria.

scholarly journals Quantitative linear dichroism imaging of molecular processes in living cells made simple by open software tools

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Alexey Bondar ◽  
Olga Rybakova ◽  
Josef Melcr ◽  
Jan Dohnálek ◽  
Petro Khoroshyy ◽  
...  
Keyword(s):  
Biological Systems ◽  
Linear Dichroism ◽  
Quantitative Information ◽  
Living Cells ◽  
Software Tools ◽  
Model Systems ◽  
Membrane Properties ◽  
Polarization Microscopy ◽  
Molecular Processes ◽  
Wide Range

AbstractFluorescence-detected linear dichroism microscopy allows observing various molecular processes in living cells, as well as obtaining quantitative information on orientation of fluorescent molecules associated with cellular features. Such information can provide insights into protein structure, aid in development of genetically encoded probes, and allow determinations of lipid membrane properties. However, quantitating and interpreting linear dichroism in biological systems has been laborious and unreliable. Here we present a set of open source ImageJ-based software tools that allow fast and easy linear dichroism visualization and quantitation, as well as extraction of quantitative information on molecular orientations, even in living systems. The tools were tested on model synthetic lipid vesicles and applied to a variety of biological systems, including observations of conformational changes during G-protein signaling in living cells, using fluorescent proteins. Our results show that our tools and model systems are applicable to a wide range of molecules and polarization-resolved microscopy techniques, and represent a significant step towards making polarization microscopy a mainstream tool of biological imaging.

scholarly journals Continuum modeling perspectives of non-Fourier heat conduction in biological systems

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ákos Sudár ◽  
Gergely Futaki ◽  
Róbert Kovács
Keyword(s):  
Biological Systems ◽  
Phase Lag ◽  
Dual Phase ◽  
Continuum Modeling ◽  
Biological Origin ◽  
Ultrasound Surgery ◽  
Thermal Models ◽  
Wide Range ◽  
Fourier Heat Conduction ◽  
The Continuum

Abstract The thermal modeling of biological systems is increasingly important in the development of more advanced and more precise techniques such as ultrasound surgery. One of the primary barriers is the complexity of biological materials: the geometrical, structural, and material properties vary in a wide range. In the present paper, we focus on the continuum modeling of heterogeneous materials of biological origin. There are numerous examples in the literature for non-Fourier thermal models. However, as we realized, they are associated with a few common misconceptions. Therefore, we first aim to clarify the basic concepts of non-Fourier thermal models. These concepts are demonstrated by revisiting two experiments from the literature in which the Cattaneo–Vernotte and the dual phase lag models are utilized. Our investigation revealed that these non-Fourier models are based on misinterpretations of the measured data, and the seeming deviation from Fourier’s law originates from the source terms and boundary conditions.

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