Biomedical Imaging and Visualization Model of Mitochondrial Dysfunction and Oxidative Stress in Alzheimer Disease
2011 ◽
Vol 138-139
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pp. 1179-1182
Keyword(s):
Mitochondrial dysfunction and oxidative stress are among the earliest events linked to Alzheimer Disease and might play a causative role in disease onset and progression. In this paper, a biomedical imaging and visualization model was set to investigate the mitochondrial dysfunction and oxidative stress in Aβ/Cu2+-treated cells, which contribute in a significant manner to bioenergetic failure and mitochondrial dysfunction, by measuring mitochondrial membrane potential, Ca2+, chromatin condensation and ROS. This evaluating method opens a window for analyzing the protective effect of a certain substance in improving mitochondrial function and preventing oxidative stress in AD development.
2010 ◽
Vol 2010
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pp. 1-11
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2021 ◽
2021 ◽
Vol 771
◽
pp. 145445
2008 ◽
Vol 40
(2)
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pp. 103-109
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