Study on Hypolipidemic Activities of Safflower Seed Oil

2013 ◽  
Vol 275-277 ◽  
pp. 1640-1645 ◽  
Author(s):  
Jian Xia Guo ◽  
Chang Lu Wang ◽  
Zhi Jian Wu

Safflower seed oil is known to be one of the richest natural sources of linoleic acid (LA), with values of up to 69.5% of the total fatty acids. Linoleic acid is known to has important biological activity and its absence in a normal diet has been described as responsible for the development of a wide variety of diseases. This work reported purified LA from safflower seed oil could lower blood liquids level of rats with hyperlipidemia. It showed that purified LA from safflower seed oil could decrease the serum total cholesterol and triglyceride concentration significantly, as well as increase the serum high density lipoprotein cholesterol. The serum atherosclerosis index (AI) was decreased remarkably. It demonstrated purified LA from safflower seed oil could improve metabolism of serum lipids and it could play active role of preventing atherosclerosis.

2013 ◽  
Vol 634-638 ◽  
pp. 1294-1301
Author(s):  
Jian Xia Guo ◽  
Chang Lu Wang ◽  
Zhi Jian Wu

Pinus armandi franch is a unique specialty plant in China and its seed oil contains high levels of essential fatty acids (EFA), particularly linoleic acid (LA), which has several pharmaceutical properties. Pinus armandi franch seed oil is a nice resource of linoleic acid with a content of 63% of the total fatty acids. Linoleic acid is an essential fatty acid, whose absence in a normal diet is responsible for the development of various abnormal disorders. This work reported purified LA from Pinus armandi franch seed oil could lower MDA content of lipid peroxidation on rats with hyperlipidemia significantly. TAC activity of liver, heart and serum was enhanced significantly, as well as SOD activity was increased. It demonstrated purified LA from Pinus armandi franch seed oil could improve antioxidant levels of hyperlipidemia rats effectively, enhance the activity of antioxidant enzyme and reduce the content of lipid peroxide, thereby improving lipid metabolism.


2003 ◽  
Vol 89 (5) ◽  
pp. 691-694 ◽  
Author(s):  
Kazuaki Takahashi ◽  
Yukio Akiba ◽  
Toshio Iwata ◽  
Masaaki Kasai

The effect of dietary conjugated linoleic acid (CLA) isomers mixture on antibody titres against sheep blood erythrocytes (SRBC) and immunoglobulin (Ig) G concentration in plasma was studied in broiler chickens. In experiment 1, male and female broiler chicks (11 d of age, Cobb strain) were fed a diet supplemented with 10 g CLA or 10 g safflower-seed oil/kg diet for 2 weeks. An SRBC suspension (5:100, v/v) in a phosphate buffer was intravenously injected at 18 d of age and a blood sample was taken from the wing vein at 25 d of age. Chicks fed the CLA-supplemented diet had enhanced first antibody titres in plasma to SRBC as compared with those fed the safflower-seed oil-supplemented diet, irrespective of sex differences. In experiment 2, male broiler chicks (8 d of age, Ross strain) were fed a basal diet or a diet containing 10 g CLA/kg diet for 3 weeks. CLA in the CLA diet partially replaced the soyabean oil in the basal diet. The SRBC suspension was intravenously injected at 15 and 25 d of age and a blood sample was obtained at 21 and 29 d of age. The first antibody titres against SRBC were higher in chicks fed the CLA diet than those in chicks fed the basal diet, but the second titres were not. Plasma IgG concentrations in chicks fed the CLA diet were higher than those in chicks fed the basal diet on both sampling days. The results showed that dietary CLA enhanced antibody production in broiler chickens.


2009 ◽  
Vol 92 (4) ◽  
pp. 370-376 ◽  
Author(s):  
Xiaojin Han ◽  
Leming Cheng ◽  
Rong Zhang ◽  
Jicheng Bi

2013 ◽  
Vol 61 (3) ◽  
pp. 227-236 ◽  
Author(s):  
N. Mohamed ◽  
A. Mariod ◽  
S. Yagoub ◽  
Y. Dagash

The objective of this study was to determine the effect of different irrigation intervals (every 7 and every 14 days) and fertilizers (farmyard manure, pellet granules and urea) on the composition of safflower seed and its oil stability. Fertilizers have a significant effect on the carbohydrate, fat, ash and protein contents of safflower seed oil. Pellet granules slightly increased the carbohydrate content, while farmyard manure increased the fat and oil contents of safflower seed oil. On the other hand, urea and farmyard manure increased the fibre content compared with pellets, which slightly decreased it. Irrigation every 7 days increased the protein content. Farmyard manure significantly (P < 0.05) increased the mineral content (iron, potassium and calcium). The use of FTIR spectroscopy revealed that the period of storage significantly (P < 0.05) affects oil stability. The peak intensities (absorbencies) recorded for oil stored at zero time changed after storage for 1, 2 and 3 days, indicating a clear effect of storage time on the oil, and the bands 3008, 2923, 2854, 1747, 1654, 1463, 1377, 1238, 1163, 1099 and 723 exhibited a clear decrease in the intensity of the individual group vibrations, indicating a decrease in oil stability.


2011 ◽  
Vol 35 (2) ◽  
pp. 278-294 ◽  
Author(s):  
AI-JUN HU ◽  
QI-QIN FENG ◽  
JIE ZHENG ◽  
XIAO-HUA HU ◽  
CONG WU ◽  
...  

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