Preparation of Braided Silk as a Tubular Tissue Engineering Scaffold

2011 ◽  
Vol 175-176 ◽  
pp. 95-99 ◽  
Author(s):  
Hui Jing Zhao ◽  
Ming Zhong Li
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Unit Area ◽  
Tissue Engineering Scaffold ◽  
The Other ◽  
The Novel ◽  
Ethanol Treatment ◽  
Silk Fibers ◽  
Long Time ◽  
Silkworm Silk

Silkworm silk has been recognized as a satisfactory biomaterial for long time due to its exceptional biocompatibility, biodegradability, mechanical properties etc. For example, silk fibers in the form of sutures have been used for centuries. The aim of this study is to discuss the potential usage of silk as the novel biomedical devices, such as blood vessels. In this study, cuit silks prepared from degummed raw silks were twisted as threads with four different yarn linear densities. A specific braiding machine was used to weave those threads into a tube. Subsequently two different groups of silk tubes were prepared. One was treated by ethanol and the other without. Thickness, porosity, mass per unit area of two groups of braided tubes were measured. Its mechanical properties were also studied. The influence of ethanol treatment and various yarn linear densities on its structural and mechanical properties was also studied. Results indicated that structural and mechanical properties of the tubes were significatly changed by the yarn linear densities and ethanol treatment. Conclusively, braided silk tube could be a potential blood vessel tissue engineering scaffold.

Biomineralization of Electrospun Nano-HA/PHB GTR Membrane

2007 ◽  
Vol 330-332 ◽  
pp. 695-698 ◽  
Author(s):  
Dong Hua Guan ◽  
Chun Peng Huang ◽  
Ji Liu ◽  
Kun Tian ◽  
Lin Niu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Electrospinning Process ◽  
Nanometer Scale ◽  
High Porosity ◽  
The Novel ◽  
Mineral Crystal ◽  
Novel Technology ◽  
Air Jet

Poly 3-hydroxybutyrate (PHB) as a kind of polysaccharides has been proved promising for tissue engineering because of its biocompatibility and biodegradability. But its poor mechanical properties and hydrophilicity limit its application. In order to explore a new useful porch to improve the performance of PHB-based GTR membrane, membrane composed of nano-HA / PHB composite was manufactured through the air/jet electrospinning process which can potentially generate nanometer scale diameter fibers and enlarge surface area of materials while maintaining high porosity. Successively, the biomineralization behavior of the membrane in supersaturated calcification solution (SCS) was studied. The Results of this investigation show that the successfully manufactured porous nano-HA/PHB membrane has high activity in SCS and its ability of inducing the formation of mineral crystal in vitro than that of the unfilled PHB membrane. It can be concluded that the addition of nano-HA and the novel technology could improve the performance of the PHB-based GTR membrane.

scholarly journals Chitosan/ biphasic calcium phosphate nanofibrous scaffolds for bone tissue engineering

2020 ◽  
pp. 11-17
Author(s):  
Truong Le Bich Tram Truong
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Osteogenic Differentiation ◽  
Late Stage ◽  
Biphasic Calcium Phosphate ◽  
Cell Attachment ◽  
The Novel ◽  
Osteogenic Cells ◽  
Nanofibrous Scaffolds

In this article, chitosan/biphasic calcium phosphate (CS/BCP)nanofibers were prepared by electrospinning. From the culture of osteogenic cells, the biocompatibility of CS/BCP nanofibrous substrates was identified and increased by the photocrosslinking. The enhancement in cell attachment and proliferation was caused by the improvement in nanofibers’ mechanical properties. The biocompatibility to osteoblasts was also promoted with the content of BCP. The osteogenic differentiation in early, middle and late stage was encouraged by the addition of BCP on nanofibrous substrates. The CS/BCP nanofibers were highly specific to osteogenic cells, revealed by difficulties in the growth of non-osteogenic cells on this composite nanofibrous scaffold. The novel nanofibrous scaffolds showed great potential in the tissue engineering of bones.

Finite Element Analysis of the Bionic Tissue Engineering Scaffold for the Defect Cranium

2012 ◽  
Vol 184-185 ◽  
pp. 222-226
Author(s):  
Fan Fen Peng ◽  
Shu Xian Zheng ◽  
Jia Li
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Tissue Engineering ◽  
Finite Element Analysis ◽  
Tissue Engineering Scaffold ◽  
Element Analysis ◽  
Engineering Technology ◽  
Bionic Scaffold ◽  
Bottle Neck ◽  
The Relationship

The relationship between the porosity and the mechanical property was still a bottle-neck in bone tissue engineering scaffold. Porosity increasing may reduce the scaffold strength. In order to solve the contradiction, the idea of enhancing the mechanical properties by controlling the scaffold porosity was proposed in this paper. Using reverse engineering technology, 5 different porosity cranium scaffolds were first established. Their FE models were built through FE surface preprocessing and volume fitted meshing. According to results of static analysis, the displacements and stresses of the 5 porosity scaffolds were compared and discussed and it indicated that the 36% porosity bionic scaffold have good porous level and mechanical properties.

scholarly journals Effect of Different Additives in Diets on Secondary Structure, Thermal and Mechanical Properties of Silkworm Silk

Materials ◽  
2018 ◽  
Vol 12 (1) ◽  
pp. 14 ◽  
Author(s):  
Lan Cheng ◽  
Huiming Huang ◽  
Jingyou Zeng ◽  
Zulan Liu ◽  
Xiaoling Tong ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Amino Acid ◽  
Large Scale ◽  
Fiber Composites ◽  
Metallic Ions ◽  
Silk Fibers ◽  
Random Coils ◽  
Silkworm Silk ◽  
Β Sheet

In this study, eight types of materials including nanoparticles (Cu and CaCO3), metallic ions (Ca2+ and Cu2+), and amino acid substances (serine, tyrosine, sericin amino acid, and fibroin amino acid) were used as additives in silkworm diets to obtain in-situ modified silk fiber composites. The results indicate that tyrosine and fibroin amino acids significantly increase potassium content in silk fibers and induce the transformation of α-helices and random coils to β-sheet structures, resulting in higher crystallinities and better mechanical properties. However, the other additives-modified silk fibers show a decrease in β-sheet contents and a slight increase or even decrease in tensile strengths. This finding provides a green and effective approach to produce mechanically enhanced silk fibers with high crystallinity on a large scale. Moreover, the modification mechanisms of these additives were discussed in this study, which could offer new insights into the design and regulation of modified fibers or composites with desirable properties and functions.

Fabrication and characterization of electrospinning/3D printing bone tissue engineering scaffold

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 110557-110565 ◽  
Author(s):  
Yinxian Yu ◽  
Sha Hua ◽  
Mengkai Yang ◽  
Zeze Fu ◽  
Songsong Teng ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Tissue Engineering Scaffold ◽  
Fabrication And Characterization

A composite scaffold was fabricated with a method involving both electrospinning and 3D printing to give microscale pores and good mechanical properties. Biocompatibility and cell infiltration on the scaffold was evaluated by an in vitro study.

scholarly journals Poly(lactide- co -glycolide) porous scaffolds for tissue engineering and regenerative medicine

2012 ◽  
Vol 2 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Zhen Pan ◽  
Jiandong Ding
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Porous Scaffolds ◽  
Plga Scaffold ◽  
Degradation Rates ◽  
Long Time ◽  
Facile Fabrication

Porous scaffolds fabricated from biocompatible and biodegradable polymers play vital roles in tissue engineering and regenerative medicine. Among various scaffold matrix materials, poly(lactide- co -glycolide) (PLGA) is a very popular and an important biodegradable polyester owing to its tunable degradation rates, good mechanical properties and processibility, etc. This review highlights the progress on PLGA scaffolds. In the latest decade, some facile fabrication approaches at room temperature were put forward; more appropriate pore structures were designed and achieved; the mechanical properties were investigated both for dry and wet scaffolds; a long time biodegradation of the PLGA scaffold was observed and a three-stage model was established; even the effects of pore size and porosity on in vitro biodegradation were revealed; the PLGA scaffolds have also been implanted into animals, and some tissues have been regenerated in vivo after loading cells including stem cells.

Effect of Ag Content on Electrical Conductivity and Tensile Properties of Cu-Ti-Ag Alloys

2011 ◽  
Vol 1297 ◽  
Author(s):  
Taek-Kyun Jung ◽  
Dong-Woo Joh ◽  
Hyo-Soo Lee ◽  
Hyuk-Chon Kwon
Keyword(s):  
Mechanical Properties ◽  
Electrical Conductivity ◽  
Tensile Properties ◽  
The Other ◽  
Ag Addition ◽  
Other Hand ◽  
Ageing Condition ◽  
Long Time ◽  
Short Time

ABSTRACTEffects of Ag content on microstructure, mechanical properties, and electrical conductivity in long time aged Cu-Ti-Ag alloys were investigated. In short time ageing condition, both electrical conductivity and mechanical properties were enhanced by Ag addition. On the other hand, in long time ageing condition, Ag addition showed a faster deterioration of mechanical properties than Ag free CuTi alloys.

Sign in / Sign up

Export Citation Format

Share Document