Electrochemical Deposition of Fluoridated Calcium Phosphate Thin Film on Titanium Substrates

2008 ◽  
Vol 47-50 ◽  
pp. 1387-1390 ◽  
Author(s):  
Xiang Ge ◽  
Fu Zeng Ren ◽  
Yang Leng
Keyword(s):  
Thin Film ◽  
Calcium Phosphate ◽  
Dental Implants ◽  
Titanium Substrate ◽  
Titanium Implants ◽  
Connective Tissues ◽  
Percutaneous Device ◽  
Fluorine Ions ◽  
Film Synthesis ◽  
Titanium Substrates

Percutaneous type of orthopedic and dental implants requires not only a good adhesion with bone, but also the ability to form good attachment and seal with connective tissues and skins. Currently, the skin-seal of such implants still remains as a problem to be resolved. Electrochemical processing was used to modify the surface of titanium implants in order to improve the ability of anti-bacteria infection and skin seal around the implants by synthesizing a fluoridated calcium phosphate thin film on titanium substrate. The surface of titanium was cathodically treated in an electrochemical cell. A thin film of about 80 nm thickness was deposited on the titanium surface by controlling the treatment parameters. The dense and gel-like film was composed of calcium phosphate and fluorine ions. Fluorine ion has the anti-bacteria property and could help to improve the skin seal around the percutaneous device. The electrochemical method of fluoridated calcium phosphate thin film synthesis will provide an alternative method for surface treatment of orthopedic and dental implants.

scholarly journals Biomimetic Collagen/Zn2+-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE

Nanomaterials ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 692 ◽  
Author(s):  
Ionela Andreea Neacsu ◽  
Laura Vasilica Arsenie ◽  
Roxana Trusca ◽  
Ioana Lavinia Ardelean ◽  
Natalia Mihailescu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Comparative Study ◽  
Spin Coating ◽  
Composite Coatings ◽  
Titanium Implants ◽  
Laser Evaporation ◽  
Mineralization Process ◽  
Ftir Microscopy ◽  
Titanium Substrates

Synthesis of biomimetic materials for implants and prostheses is a hot topic in nanobiotechnology strategies. Today the major approach of orthopaedic implants in hard tissue engineering is represented by titanium implants. A comparative study of hybrid thin coatings deposition was performed by spin coating and matrix-assisted pulsed laser evaporation (MAPLE) onto titanium substrates. The Collagen-calcium phosphate (Coll-CaPs) combination was selected as the best option to mimic natural bone tissue. To accelerate the mineralization process, Zn2+ ions were inserted by substitution in CaPs. A superior thin film homogeneity was assessed by MAPLE, as shown by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) microscopy. A decrease of P-O and amide absorbance bands was observed as a consequence of different Zn2+ amounts. A variety of structural modifications of the apatite layer are then generated, which influenced the confinement process towards the collagen template. The in-vitro Simulated Body Fluid (SBF) assay demonstrated the ability of Coll/Zn2+-CaPs coatings to stimulate the mineralization process as a result of synergic effects in the collagen-Zn2+ substituted apatite. For both deposition methods, the formation of droplets associated to the growth of CaPs particulates inside the collagen matrix was visualized. This supports the prospective behavior of MAPLE biomimetic coatings to induce mineralization, as an essential step of fast implant integration with vivid tissues.

Development of Titanium Implants with a Rough Calcium Phosphate Surface to Control the Morphofunctional State of Stem Cells

2021 ◽  
Vol 887 ◽  
pp. 40-45
Author(s):  
K.A. Yurova ◽  
Igor A. Khlusov ◽  
L.S. Litvinova
Keyword(s):  
Stem Cells ◽  
Calcium Phosphate ◽  
Bone Cells ◽  
Titanium Implants ◽  
New Class ◽  
Physicochemical Features ◽  
Mineral Substance ◽  
Titanium Substrates

Experimental titanium implants with a rough calcium phosphate (CР) coating with bio-inspired properties have been developed. The role of roughness (in the range Ra = 2.4 - 4.6 μm) of the surface CP simulating the physicochemical features of the mineral substance of regenerating bone tissue to change the growth and morphofunctional activity of mesenchymal stem cells (MSCs) was evaluated. Titanium substrates with a microrelief CP coating bearing artificial niches for stem cells was shown in vitro to have an epigenomic effect on MSCs, that contributes to their differentiation and maturation in bone cells. The results show the promise of developing and introducing a new class of medical devices with bio-inspired surfaces into clinical practice for traumatology and orthopedics.

Calcium Phosphate Precipitation by Galvanic Current between Titanium and Gold in Pseudo-Body Fluid

2007 ◽  
Vol 539-543 ◽  
pp. 653-656
Author(s):  
Equo Kobayashi ◽  
Masa Ogo ◽  
Hisashi Doi ◽  
T. Yoneyama ◽  
K. Noda ◽  
...  
Keyword(s):  
Surface Modification ◽  
Calcium Phosphate ◽  
Body Fluid ◽  
Bone Growth ◽  
Titanium Substrate ◽  
Titanium Implants ◽  
Gold Coating ◽  
Galvanic Current ◽  
Hydroxy Apatite ◽  
Calcium Phosphate Precipitation

For commercialized dental implants, to enhance the bone bonding of the artificial tooth roots, several kinds of surface modification techniques, such as hydroxy-apatite coating, anodic oxidation and sand-blasting, have been developed. Apart from the surface modification, it is known that the bone growth is accelerated by electric stimulations in the living body. In the present study, the galvanic current between titanium substrate and gold coating partially on the titanium implants was applied to enhance calcium phosphate precipitation in a pseudo-body fluid namely Hanks’ solution. The galvanic current between titanium specimens and gold electrode jumped up approximately 0.2 s after put into Hanks’ solution and the current has decreased asymptotically. With such consideration, the desirable conditions of surface modification by gold coating were presented to provide suitable galvanic current density enhancing calcium phosphate precipitation.

scholarly journals Protruding Nanostructured Surfaces for Antimicrobial and Osteogenic Titanium Implants

Coatings ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 756
Author(s):  
Mohd I. Ishak ◽  
Xiayi Liu ◽  
Joshua Jenkins ◽  
Angela H. Nobbs ◽  
Bo Su
Keyword(s):  
Bacterial Infection ◽  
Dental Implants ◽  
High Throughput ◽  
Rapid Development ◽  
Titanium Substrate ◽  
Titanium Implants ◽  
Bacterial Colonisation ◽  
Nanostructured Surfaces ◽  
Novel Technologies ◽  
Advantages And Disadvantages

Protruding nanostructured surfaces have gained increasing interest due to their unique wetting behaviours and more recently their antimicrobial and osteogenic properties. Rapid development in nanofabrication techniques that offer high throughput and versatility on titanium substrate open up the possibility for better orthopaedic and dental implants that deter bacterial colonisation while promoting osteointegration. In this review we present a brief overview of current problems associated with bacterial infection of titanium implants and of efforts to fabricate titanium implants that have both bactericidal and osteogenic properties. All of the proposed mechano-bactericidal mechanisms of protruding nanostructured surfaces are then considered so as to explore the potential advantages and disadvantages of adopting such novel technologies for use in future implant applications. Different nanofabrication methods that can be utilised to fabricate such nanostructured surfaces on titanium substrate are briefly discussed.

Creation and Characterization of Doped Hydroxyapatite With Strontium Carbonate Thin Film Coating on Titanium Substrates Using Pulse Laser Deposition for Biological Applications

2013 ◽  
Author(s):  
Cindy Waters ◽  
Stephen Ajinola ◽  
Dhannajay Kumar ◽  
Kwadwo-mensah Darkwa ◽  
Ahmadreza Sedighi
Keyword(s):  
Thin Film ◽  
Pulse Laser Deposition ◽  
Pulse Laser ◽  
Elastic Moduli ◽  
High Vacuum ◽  
Titanium Substrate ◽  
Surface Hardness ◽  
Strontium Carbonate ◽  
Laser Deposition ◽  
Titanium Substrates

The main purpose of this paper is to investigate mechanical properties of thin films of strontium carbonate (Sr2CO3) doped with hydroxyapatite (HA) on titanium substrates using nanoindentation techniques. The variation in the weight percentages of strontium carbonate of 0 wt %, 2.5 wt % and 100 wt % of Sr2CO3 in hydroxyapatite on a titanium substrate were used to investigate the effect of strontium carbonate on the surface modification for biological application. The hope is to use these results to improve the surface hardness of dentures and boost cavity prevention, and to improve menopause bone loss and help in its remodeling. The hardness and elastic moduli of different weight percents of variation in the compositions of strontium carbonate in Sr2CO3 - HA thin film layers deposited at 600 °C on titanium substrates using Pulse Laser Deposition (PLD) at high vacuum of 10−6 Torr were measured. The effect of varying Sr2CO3 in HA on the crystallinity, on the microstructure and on film thickness was determined using X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM) and stylus profilometer respectively. The Sr2CO3 - HA with the composition of 2.5 wt. % of Sr2CO3 has average film thicknesses of each composition of the film were also recorded and a hardness performance of 3.89 GPa, good peak broadening was also observed in the 2.5 wt % composition Sr2CO3 using XRD. The variations in the composition of strontium Carbonate in Hydroxyapatite in term of hardness and elastic moduli were reported.

Study of Titanium Surface Topography Influence on Biomimetic Coating Deposition

2012 ◽  
Vol 727-728 ◽  
pp. 1622-1627
Author(s):  
Roseli Marins Balestra ◽  
Alexandre Antunes Ribeiro ◽  
M.C. Andrade ◽  
Luiz Carlos Pereira ◽  
Marize Varella
Keyword(s):  
Powder Metallurgy ◽  
Calcium Phosphate ◽  
Calcium Phosphates ◽  
Titanium Implants ◽  
Precipitation Method ◽  
Phosphate Coatings ◽  
Biomimetic Coating ◽  
Simplified Solution ◽  
Calcium Phosphate Coatings ◽  
Titanium Substrates

Studies show that calcium phosphate coatings on titanium implants improve osseointegration at the implant-bone interface, due to the mineral biocompatibility. Titanium implants can be coated with calcium phosphates by a biomimetic precipitation method. This work studied a biomimetic method under a simplified solution with calcium and phosphorus ions. As substrates, commercially dense titanium sheet and macroporous titanium samples produced by powder metallurgy were used, both ASTM F67 grade 2. The substrates were submitted to chemical and heat treatment and then immersed in the solution for 10 days. Samples characterization was performed by Optical Microscopy (OM), Scanning Electron Microscopy/Energy Dispersive Spectroscopy (SEM/EDS), low angle X-ray Diffractometry (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). Powder metallurgy successfully produced macroporous titanium substrates. Calcium phosphate coatings were deposited on both substrates, confirmed by FTIR bands. Such results indicated the potential of this methodology for calcium phosphate coatings on titanium substrates.

Calcium Phosphate Films Coated on Titanium by RF Magnetron Sputtering for Medical Applications

2007 ◽  
Vol 539-543 ◽  
pp. 551-556 ◽  
Author(s):  
Takayuki Narushima ◽  
Kyosuke Ueda ◽  
Takashi Goto ◽  
Tomoyuki Katsube ◽  
Hiroshi Kawamura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Calcium Ion ◽  
Pure Titanium ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Apatite Formation ◽  
Commercially Pure Titanium ◽  
Commercially Pure ◽  
Titanium Substrates

Calcium phosphate films were coated on commercially pure titanium substrates by radiofrequency magnetron sputtering using β-tricalcium phosphate targets. The films consisted of amorphous calcium phosphate and oxyapatite phases. Immersion tests of the films were carried out in Hanks’ solution and PBS(-), and apatite formation and calcium ion elution from the films were investigated. The titanium cylinders coated with calcium phosphate films were implanted into the mandibles of beagle dogs. These results suggest that coating with calcium phosphate improves the biocompatibility of titanium implants with bone tissue.

scholarly journals Macrophagic Inflammatory Response Next to Dental Implants with Different Macro- and Micro-Structure: An In Vitro Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5324
Author(s):  
Maria Menini ◽  
Francesca Delucchi ◽  
Domenico Baldi ◽  
Francesco Pera ◽  
Francesco Bagnasco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Implants ◽  
In Vitro Study ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
Optimal Outcomes ◽  
Negative Controls ◽  
Inflammatory Effect

(1) Background: Intrinsic characteristics of the implant surface and the possible presence of endotoxins may affect the bone–implant interface and cause an inflammatory response. This study aims to evaluate the possible inflammatory response induced in vitro in macrophages in contact with five different commercially available dental implants. (2) Methods: one zirconia implant NobelPearl® (Nobel Biocare) and four titanium implants, Syra® (Sweden & Martina), Prama® (Sweden & Martina), 3iT3® (Biomet 3i) and Shard® (Mech & Human), were evaluated. After 4 h of contact of murine macrophage cells J774a.1 with the implants, the total RNA was extracted, transcribed to cDNA and the gene expression of the macrophages was evaluated by quantitative PCR (qPCR) in relation to the following genes: GAPDH, YWHAZ, IL1β, IL6, TNFα, NOS2, MMP-9, MMP-8 and TIMP3. The results were statistically analyzed and compared with negative controls. (3) Results: No implant triggered a significant inflammatory response in macrophages, although 3iT3 exhibited a slight pro-inflammatory effect compared to other samples. (4) Conclusions: All the samples showed optimal outcomes without any inflammatory stimulus on the examined macrophagic cells.

Calcium Phosphate-Coated Titanium Implants in the Mandible: Limitations of the in vivo Minipig Model

2020 ◽  
Vol 61 (6) ◽  
pp. 177-187
Author(s):  
Till Kämmerer ◽  
Tony Lesmeister ◽  
Victor Palarie ◽  
Eik Schiegnitz ◽  
Andrea Schröter ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Statistical Difference ◽  
Surface Modifications ◽  
Titanium Implants ◽  
In Vivo Model ◽  
Implant Surface ◽  
Press Fit ◽  
Endosseous Implant ◽  
Bone To Implant Contact

Introduction: We aimed to compare implant osseointegration with calcium phosphate (CaP) surfaces and rough subtractive-treated sandblasted/acid etched surfaces (SA) in an in vivo minipig mandible model. Materials and Methods: A total of 36 cylindrical press-fit implants with two different surfaces (CaP, n = 18; SA, n = 18) were inserted bilaterally into the mandible of 9 adult female minipigs. After 2, 4, and 8 weeks, we analyzed the cortical bone-to-implant contact (cBIC; %) and area coverage of bone-to-implant contact within representative bone chambers (aBIC; %). Results: After 2 weeks, CaP implants showed no significant increase in cBIC and aBIC compared to SA (cBIC: mean 38 ± 5 vs. 16 ± 11%; aBIC: mean 21 ± 1 vs. 6 ± 9%). Two CaP implants failed to achieve osseointegration. After 4 weeks, no statistical difference between CaP and SA was seen for cBIC (mean 54 ± 15 vs. 43 ± 16%) and aBIC (mean 43 ± 28 vs. 32 ± 6). However, we excluded two implants in each group due to failure of osseointegration. After 8 weeks, we observed no significant intergroup differences (cBIC: 18 ± 9 vs. 18 ± 20%; aBIC: 13 ± 8 vs. 16 ± 9%). Again, three CaP implants and two SA implants had to be excluded due to failure of osseointegration. Conclusion: Due to multiple implant losses, we cannot recommend the oral mandibular minipig in vivo model for future endosseous implant research. Considering the higher rate of osseointegration failure, CaP coatings may provide an alternative to common subtractive implant surface modifications in the early phase post-insertion.

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