Synthesis and Application of Quaternary Ammonium-Functionalized Hyperbranched Polyester Antibacterial Agent

2013 ◽  
Vol 796 ◽  
pp. 412-415 ◽  
Author(s):  
Xiang Dong Zhou ◽  
Kun Chen ◽  
Jia Lei Guo ◽  
Yu Fang Zhang
Keyword(s):  
Escherichia Coli ◽  
Sodium Hydroxide ◽  
Quaternary Ammonium ◽  
Antibacterial Agent ◽  
Antibacterial Properties ◽  
Silk Fabric ◽  
Hyperbranched Polyester ◽  
Alkaline Catalyst ◽  
H Nmr

In the presence of alkaline catalyst sodium hydroxide, the intermediate of hyperbranched polyester (H20Cl) was prepared by the modification of hyperbranched polyester Boltorn H20 with epichlorohydrin. Then a new kind of quaternary ammonium functionalized hyperbranched polyester antibacterial agent (H20C16N) was synthesized by the reaction of H20Cl and hexadecyldimethylamine. The structures characterizations of H20C16N were characterized by 1H NMR. The application of H20C16N used as antibacterial agent of silk fabric was studied. The antibacterial ratio was 99.06% against escherichia coli and 98.24% against staphylococcus aureus.The excellent antibacterial properties of treated silk fabric were provided.

The influences of chlorhexidine and modified galactomannan additions on the physical and antibacterial properties of paper

2019 ◽  
Vol 34 (4) ◽  
pp. 467-474
Author(s):  
Bingbing Liu ◽  
Qi Yuan ◽  
Xian-Liang Song
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Citric Acid ◽  
Elemental Analysis ◽  
Antibacterial Agent ◽  
Antibacterial Properties ◽  
Inhibition Zone ◽  
Oxidation Time ◽  
Tensile Index ◽  
Folding Endurance

Abstract In the present study, antibacterial paper was prepared by mixing chlorhexidine with modified galactomannan. The effects of the oxidation time and citric acid dosages in the modification processes on the physical properties of the paper samples were examined. Also, the effects of the antibacterial agent dosages on the antibacterial properties were studied. The results showed that when the oxidation time was 5 hours, the tensile index, bursting index, and folding endurance increased by 18.4 %, 31.9 %, and 200.0 %, respectively, when compared with the control paper. Also, when the amount of citric acid was 7 %, the tensile index, bursting index, and the folding endurance increased by 20.3 %, 36.6 %, and 195.1 %, respectively, when compared with the control paper. The paper with two modified polysaccharides displayed antibacterial properties against Escherichia coli and Staphylococcus aureus. This study’s elemental analysis results indicated that when the amount of chlorhexidine was 2 %, its retention in paper with oxidized or esterified galactomannans was 1.74 % and 1.59 %, respectively. Furthermore, the SEM results showed that the structures of the bacteria around the inhibition zone were damaged and their activities had been inhibited.

Antibacterial Activities of Sirih Merah (Piper crocatum) Leaf Extracts

2019 ◽  
Vol 5 (3) ◽  
pp. 1-10
Author(s):  
Puspa Julistia Puspita ◽  
Mega Safithri ◽  
Nirmala Peni Sugiharti
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Agent ◽  
Leaf Extract ◽  
Antibacterial Activities ◽  
Leaf Extracts ◽  
Herbal Plants

Piper crocatum is one of medicinal herbal plants with a large number of benefits. Usually herbal plants have activity as antibacterial agent. Therefore, the objectives of this research were to obtain information on antibacterial activities of the leaf extracts of Piper crocatum againts four types of bacteria, in that Staphylococcus, Bacillus substilis, Escherichia coli, and Pseudomonas aeruginosa and then to analyze the phytochemistry of the leaf extracts of Piper crocatum. The leaves of Piper crocatum were extracted by maceration and reflux using ethanol 30%. The assays of the antibacterial activities and phytochemistry on the extracts were carried out using the method of Maria Bintang. Results showed that the yield of the extraction using ethanol by maceration method was 20.8%. Meanwhile, using the reflux method, the yield was obtained about 26.25%. The phytochemistry analysis showed that the leaf extracts of Piper crocatum contained alkaloid, steroid and tanin. According to this study, it was found that the leaf extract of Piper crocatum can be used to inhibit the growth of B. subtilis and P. aeuruginosa, but can not inhibit the growth of E.coli and S. aureus.

Garlic Extract (Allium sativum L.) Effectively Inhibits Staphylococcus aureus and Escherichia coli by Invitro Test

2020 ◽  
Vol 2 (2) ◽  
pp. 61-68
Author(s):  
Agnina Listya Anggraini ◽  
Ratih Dewi Dwiyanti ◽  
Anny Thuraidah
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Bacterial Infections ◽  
Allium Sativum ◽  
Antibacterial Properties ◽  
Herbal Medicines ◽  
Garlic Extract ◽  
Dilution Method ◽  
Initial Stage

Infection is a disease caused by the presence of pathogenic microbes, including Staphylococcus aureus and Escherichia coli. Garlic (Allium sativum L.) has chemical contents such as allicin, alkaloids, flavonoids, saponins, tannins, and steroids, which can function as an antibacterial against Staphylococcus aureus and Escherichia coli. This study aims to determine the antibacterial properties of garlic extract powder against Staphylococcus aureus and Escherichia coli. This research is the initial stage of the development of herbal medicines to treat Staphylococcus aureus and Escherichia coli infections. The antibacterial activity test was carried out by the liquid dilution method. The concentrations used were 30 mg/mL, 40 mg/mL, 50 mg/mL, 60 mg/mL and 70 mg/mL. The results showed that the Minimum Inhibitory Concentration (MIC) against Staphylococcus aureus and Escherichia coli was 40 mg/mL and 50 mg / mL. Minimum Bactericidal Concentration (MBC) results for Staphylococcus aureus and Escherichia coli are 50 mg/mL and 70 mg/mL. Based on the Simple Linear Regression test, the R2 value of Staphylococcus aureus and Escherichia coli is 0.545 and 0.785, so it can be concluded that there is an effect of garlic extract powder on the growth of Staphylococcus aureus and Escherichia coli by 54.5% and 78.5%. Garlic (Allium sativum L.) extract powder has potential as herbal medicine against bacterial infections but requires further research to determine its effect in vivo.

Synthesis and Antibacterial Properties of Some 4-Amino Substituted 2-Phenyl-6H-5,1,3-benzothiadiazocines

1996 ◽  
Vol 61 (11) ◽  
pp. 1681-1688 ◽  
Author(s):  
Michal Bodajla ◽  
Štefan Stankovský ◽  
Katarína Špirková ◽  
Soňa Jantová
Keyword(s):  
Mass Spectra ◽  
Antibacterial Properties ◽  
H Nmr ◽  
Antibacterial Screening

Some 4-amino substituted 2-phenyl-6H-5,1,3-benzothiadiazocines (4a-4j) were prepared by cyclization of the corresponding N1-[N-(2-chloromethylphenyl)benzimidoyl]-N2-substituted thioureas (3a-3j). The IR,1H NMR and mass spectra of the title compounds are reported together with the results of antibacterial screening.

scholarly journals Improved cytocompatibility and antibacterial properties of zinc-substituted brushite bone cement based on β-tricalcium phosphate

2021 ◽  
Vol 32 (9) ◽  
Author(s):  
Inna V. Fadeeva ◽  
Margarita A. Goldberg ◽  
Ilya I. Preobrazhensky ◽  
Georgy V. Mamin ◽  
Galina A. Davidova ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Tricalcium Phosphate ◽  
Bacterial Resistance ◽  
Antibacterial Properties ◽  
Modern Medicine ◽  
Physiological Solution ◽  
Final Phase ◽  
Bone Replacement ◽  
Challenging Tasks ◽  
Murine Fibroblast

AbstractFor bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.

scholarly journals Preparation and Performance Evaluation of Antibacterial Melt-Spun Polyurethane Fiber Loaded with Berberine Hydrochloride

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2336
Author(s):  
Ruifang Zhao ◽  
Pengfei Tan ◽  
Yanting Han ◽  
Feng Yang ◽  
Yidong Shi ◽  
...  
Keyword(s):  
Antibacterial Agent ◽  
Bacterial Infections ◽  
Antibacterial Properties ◽  
Coating Technology ◽  
Daily Lives ◽  
Berberine Hydrochloride ◽  
Comprehensive Properties ◽  
Melt Spun ◽  
And Performance ◽  
Application Prospects

(1) Background: Bacterial infections have long threatened global public safety; hence, it is significant to continuously develop antibacterial fibers that are closely related to people’s daily lives. Berberine hydrochloride is a natural antibacterial agent that has application prospects in the preparation of antibacterial fibers. (2) Methods: This study firstly verified the antibacterial properties of berberine hydrochloride and its possible antibacterial mechanism. Thereafter, berberine hydrochloride was introduced into the self-made melt-spun polyurethane fiber through optimized coating technology. The performance of coating modified polyurethane fiber has been systematically evaluated, including its antibacterial properties, mechanical properties, and surface wettability. (3) Results: Results show that the antibacterial polyurethane fiber with desirable comprehensive properties is expected to be used in the biomedical fields. (4) Conclusions: The research also provides a reference for the development and application of other natural antibacterial ingredients in fiber fields.

scholarly journals Green Accelerated Synthesis, Antimicrobial Activity and Seed Germination Test of Quaternary Ammonium Salts of 1,2-bis(4-pyridyl)ethane

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2424 ◽  
Author(s):  
Tăbăcaru ◽  
Botezatu ◽  
Horincar ◽  
Furdui ◽  
Dinică
Keyword(s):  
Escherichia Coli ◽  
Triticum Aestivum ◽  
Seed Germination ◽  
Quaternary Ammonium ◽  
Pathogenic Bacteria ◽  
Classical Method ◽  
Triticum Aestivum L ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Radicle Growth

A family of fifteen quaternary ammonium salts (QAs), bearing the 1,2-bis(4-pyridyl)ethane core, were obtained using for the first time two different green methods, such as microwave (MW) and ultrasounds (US) irradiation, with very good yields and in much shorter times compared to the classical method, and an assay on their antimicrobial action against Escherichia coli (E. coli) was carried out. While 12 to 24 hours were required for complete alkylation of 1,2-bis(4-pyridyl)ethane by reactive halogenated derivatives in anhydrous solvent under reflux conditions, MW and US irradiation reduced the reaction time and the desired products were achieved in a few min. One of the aims of this study was to evaluate the antibacterial potential of the synthesized QAs against pathogenic bacteria, along with their impact on germination activity of wheat seeds (Triticum aestivum L.). The antibacterial activity of the QAs against Escherichia coli was explored by determining the minimum inhibitory concentration (MIC). The MIC values varied from 0.312 to 2.5 mg/mL, highlighting the lowest values attained for the derivatives containing methoxy, chlorine and benzofurane functional groups. The viability of aerobic bacteria was determined with the Tetrazolium/Formazan Test, a method that was found to be the best alternative approach with respect to the difuzimetric method. Seeds of Triticum aestivum L. were used for the evaluation of the germination indicators, such as seed germination (SG), the relative seed germination (RSG), the relative radicle growth (RRG), and the seed germination index (GI). The toxicity studies of QAs 1, 4 and 7, at two different concentrations, showed no inhibitory effect on seed germination.

Anhydride und Thioanhydride von tert-Butylstibinig-und -stibonigsäuren / Anhydrides and Thioanhydrides of tert-Butylstibinous-and Stibonous Acids

1981 ◽  
Vol 36 (9) ◽  
pp. 1105-1109 ◽  
Author(s):  
Hans Joachim Breunig ◽  
Helmut Kischkel
Keyword(s):  
Sodium Hydroxide ◽  
Sodium Sulfide ◽  
H Nmr

Abstract The reactions of di-tert-butylantimony chloride with sodium hydroxide or sodium sulfide yield new anhydrides or thioanhydrides of tert-butylstibinous acids, which have structures with bridging oxygen or sulfur atoms. Analogous reactions of tert-butylantimonydichloride produce the first examples of anhydrides or thioanhydrides of tertbutylstibonous acids, which have cyclic structures (t-BuSbE)n E = O, n = 3, 4; E = S, n = 2, 3, 4, 5. Structural evidence is based on IR, 1H NMR and MS data.

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