Suppressive Effect of Auto-Polymerized Surgical Obturator Resin Incorporated with Vanillin on Microbial Biofilm

2020 ◽  
Vol 862 ◽  
pp. 130-134
Author(s):  
Sroisiri Thaweboon ◽  
Pakpoom Kedcharoen ◽  
Natthamet Wongsirichat ◽  
Boonyanit Thaweboon
Keyword(s):  
Surgical Treatment ◽  
Psychological Health ◽  
Biofilm Formation ◽  
Antimicrobial Property ◽  
Antimicrobial Properties ◽  
Suppressive Effect ◽  
Cell Counting ◽  
Microbial Biofilm ◽  
Scar Contracture ◽  
Pmma Resin

Surgical obturators are important oral prostheses given to patients after surgical treatment to minimize scar contracture and esthetic disfigurement that may affect patients’ functional appearance and psychological health. Poly-methyl methacrylate (PMMA) resin has been the material generally used for fabrication of surgical obturator. However, wearing of this resin appliance can raise a condition for microbial biofilm accumulation and infection of the patients due to the rough surfaces and internal porosities of the resin. Vanillin-incorporated heat-cured and auto-polymerized PMMA resin have been developed and demonstrated to have antimicrobial activity against several types of microorganisms. This study aimed to examine antimicrobial properties of vanillin-incorporated auto-polymerized surgical obturator resin on the biofilm formation of Streptococcus mutans and Candida glabrata. The auto-polymerized PMMA resin samples (Orthocryl® EQ, Germany) were prepared with vanillin incorporation (0.1% and 0.5% vanillin). All samples were coated with sterile saliva and incubated at 37 °C for 60 min. The suspensions of S. mutans ATCC 25715 and C. glabrata ATCC 15126 (107 colony forming unit/mL) were prepared using McFarland standard No.1. Microbial biofilm formation was done in 96-well plate at 37°C for 24 h. The total vital biofilm formation was evaluated by Cell Counting Kit WST-8 (Dojindo Molecular Technologies, USA) at 450 nm. All tests were done in triplicate on three separate circumstances. One-way ANOVA and Tukey’s test were applied for the statistical analysis. A significant decrease of S. mutans biofilm mass was noticed in 0.5% vanillin incorporated resin group compared with a control, resin without vanillin. The percentage of biofilm reduction was 40.8%. No different effect was observed in 0.1% vanillin group. In the case of C. glabrata, no significant biofilm reduction was examined among all groups. In conclusion, the adding of 0.5% vanillin to surgical obturator resin could significantly inhibit biofilm formation of S. mutans, however, the effect was not demonstrated on 0.1% vanillin. C. glabrata was observed to be resistant to vanillin. Using PMMA resin incorporated with 0.5% vanillin, an obturator with antimicrobial property can be applied to prevent dental caries and other systemic diseases in patients after surgical treatment.

Microbial Biofilm Formation on Vanillin Incorporated Surgical Obturator Resin

2020 ◽  
Vol 853 ◽  
pp. 51-55
Author(s):  
Pakpoom Kedcharoen ◽  
Boonyanit Thaweboon ◽  
Natthamet Wongsirichat ◽  
Sroisiri Thaweboon
Keyword(s):  
Biofilm Formation ◽  
Opportunistic Infections ◽  
Antimicrobial Property ◽  
Cell Counting ◽  
Control Group ◽  
Surgical Removal ◽  
Microbial Biofilm ◽  
Heat Cure ◽  
Increased Risk ◽  
Pmma Resin

Self-cure poly-methyl methacrylate (PMMA) resin has been the material commonly used for fabrication of surgical obturator. The appliance is used in the cancer patient after surgical removal of the affected maxillofacial tissues. However, wearing of this resin appliance can enhance a condition for microbial biofilm aggregation and put patients at increased risk of infection. Vanillin-incorporated heat-cure PMMA resin and self-cure PMMA resin have been developed and demonstrated to have antimicrobial activity. This study aimed to evaluate antimicrobial property of vanillin-incorporated self-cure PMMA obturator resin on the biofilm formation of C. albicans and S. aureus. The resin samples (Orthocryl® EQ, Dentaurum, Germany) were prepared with vanillin incorporation (0.1% and 0.5% vanillin). All samples were coated with sterile saliva and incubated at 37 °C for 60 min. The Staphylococcus aureus ATCC 5638 and Candida albicans ATCC 10231 suspensions (107 colony forming unit/mL) were prepared and microbial biofilm formation was done in 96-well plate at 37°C for 24 h. The amount of biofilm was quantified by Cell Counting Kit WST-8 (Dojindo Molecular Technologies, USA) at 450 nm. All tests were performed in triplicate on three separate occasions. One-way ANOVA and Tukey’s test were used for the statistical analysis. It was found that approximately 52% and 48% biofilm reductions were observed in 0.1% and 0.5% vanillin groups against S.aureus compared with 0% vanillin (control group) whereas 46% and 54% biofilm reductions were seen against C. albicans biofilm. In conclusion, the incorporation of vanillin in surgical obturator PMMA resin was demonstrated to have antimicrobial property against biofilm formation of S. aureus and C. albicans. This can help the patient who wears surgical obturator for the prevention of opportunistic infections.

Biofilm Formation of Cariogenic Bacteria on Vanillin-Incorporated Orthodontic Retainer PMMA Resin

2020 ◽  
Vol 853 ◽  
pp. 31-35
Author(s):  
Sroisiri Thaweboon ◽  
Mari Fujita ◽  
Keiji Nagano ◽  
Boonyanit Thaweboon
Keyword(s):  
Dental Caries ◽  
Biofilm Formation ◽  
Antimicrobial Property ◽  
Suppressive Effect ◽  
Inhibitory Effect ◽  
Cell Counting ◽  
Orthodontic Appliances ◽  
Cariogenic Bacteria ◽  
The Right ◽  
Pmma Resin

Orthodontic retainers made of poly methyl methacrylate (PMMA) resin are generally used after finished orthodontic treatment to hold teeth in the right position and avoid the shift out from the alignment. The use of these devices can place patients at greater risk of dental caries through the biofilm accumulation of caries-associated bacteria and food debris on the rough surfaces or inherent porosities of PMMA surfaces of appliances themselves. Vanillin, the major component of flavoring agent vanilla, has been demonstrated to have antimicrobial activity against many types of microorganisms. This study aimed to evaluate antimicrobial property of vanillin-incorporated orthodontic retainer PMMA resin on the biofilm formation of cariogenic bacteria. The self-curing orthodontic retainer PMMA resin samples were produced according to the percentage of vanillin adding (0%, 0.1% and 0.5% vanillin) (SCG Chemicals, Thailand). All samples were coated with sterile unstimulated saliva. Then the cariogenic bacterial suspensions of Streptococcus mutans ATCC 25715, Streptococcus sobrinus ATCC 33478, Lactobacillus casei ATCC 334 and Lactobacillus acidophilus ATCC 314 were added and incubated at 37°C in 5% CO2 atmosphere for 48 h to allow the biofilm formation. The amount of vital biofilm was determined by WST Microbial Cell Counting Kit (Dojindo Molecular Technologies, USA) at 460 nm. One-way ANOVA and Turkey’s test were employed for the statistical analysis. A significant inhibitory effect against all tested bacteria was observed in 0.5% vanillin incorporated samples compared with 0% vanillin. The percentage of biofilm reduction was 23-45%. The adding of 0.1% vanillin showed suppressive effect only on Lactobacillus spp. In conclusion, the incorporation of 0.5% vanillin to self-curing orthodontic retainer PMMA resin could significantly inhibit biofilm formation of cariogenic bacteria (S. mutans, S. sobrinus, L. casei and L. acidophilus). Using this PMMA resin, removable orthodontic appliances with antimicrobial property can be applied to prevent dental caries or tooth demineralization in orthodontic patients.

In Vitro Study of Streptococcus mutans Biofilm Formation on Vanillin-Incorporated Orthodontic PMMA Resin

2019 ◽  
Vol 801 ◽  
pp. 9-14 ◽  
Author(s):  
Sroisiri Thaweboon ◽  
Boonyanit Thaweboon
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Biofilm Formation ◽  
Antimicrobial Property ◽  
Cell Counting ◽  
Bacterial Suspension ◽  
Orthodontic Appliances ◽  
Increased Risk ◽  
Removable Orthodontic Appliances ◽  
Pmma Resin

Removable orthodontic appliances made of poly methyl methacrylate (PMMA) resin are commonly used after complete orthodontic treatment to keep teeth in the right position and prevent the shift out from the alignment. The use of these appliances can place patients at increased risk of dental caries through the biofilm accumulation ofStreptococcus mutans, caries-associated bacteria, on the surfaces of appliance themselves. Moreover, their rough surfaces or intrinsic porosities of PMMA enhance a condition for plaque aggregation, altering the oral microflora and limiting the washing out action of saliva on teeth and mucosal tissues, subsequently bringing about enamel demineralization and gingival inflammation. Cleaning by brushing or using chemical disinfectants is necessary for hygiene maintenance of the appliances, but requires patient cooperation, which is uncertain. Vanillin is a natural phenolic aldehyde which is used widely as a flavoring agent in various foods. It has been reported by many studies to exhibit antimicrobial activity. The aim of the present study was to evaluate antimicrobial property of vanillin-incorporated orthodontic PMMA resin onS. mutansbiofilm formation. The self-curing orthodontic PMMA resin samples (SCG Chemicals, Thailand) were prepared according to the percentage of vanillin incorporation (0%, 0.1% and 0.5% vanillin). Another group of commercial resin samples without vanillin (Dentsply Caulk, USA) was prepared in the same manner. All samples were coated with sterile unstimulated saliva collected from three healthy adult volunteers at 37 °C for 60 min. TheS. mutansbiofilm formation was done with the 107colony forming unit (CFU)/m of bacterial suspension in 96-well plate and incubated at 37°C in 5% CO2 atmosphere for 24 h. The amount of biofilm was quantified by Cell Counting Kit WST-8 (Dojindo Molecular Technologies, USA) at 450 nm. All tests were performed in triplicate on three separate occasions. One-way ANOVA and Turkey’s test were used for the statistical analysis. A significant inhibitory effect was observed in 0.5% vanillin incorporated samples at 48 h compared with 0% vanillin and commercial samples. The percentage of biofilm reduction was 30%. In conclusion, the incorporation of vanillin to self-curing orthodontic PMMA resin could significantly inhibit biofilm formation ofS. mutans. Using this PMMA resin, removable orthodontic appliances with antimicrobial property can be applied to prevent dental caries or tooth demineralization in orthodontic patients.

Biofilm Formation of Respiratory Pathogens on Vanillin-Incorporated Denture Base Resin

2019 ◽  
Vol 801 ◽  
pp. 3-8 ◽  
Author(s):  
Sroisiri Thaweboon ◽  
Boonyanit Thaweboon ◽  
Futoshi Nakazawa
Keyword(s):  
Respiratory Infection ◽  
Biofilm Formation ◽  
Antimicrobial Property ◽  
Respiratory Pathogens ◽  
Denture Base ◽  
Commercial Resin ◽  
Base Materials ◽  
Base Resin ◽  
Pmma Resin ◽  
Denture Base Resin

The adherence of microorganisms to denture base materials and the consequent formation of biofilms on these surfaces are contributing factors to biofilm-related oral and systemic diseases. Aspiration pneumonia is a potentially life-threatening respiratory infection associated with the entry of foreign materials into the bronchi. Vanillin-incorporated polymethyl methacrylate (PMMA) resin has been developed for the use in dentistry and demonstrated to have antimicrobial activity. Objective: To evaluate antimicrobial property of vanillin-incorporated PMMA denture base resin on biofilm formation of respiratory pathogens. Materials and methods: The heat polymerized PMMA denture base resin samples (Siam Cement Group, Thailand) were prepared according to the percentage of vanillin incorporation (0%, 0.1% and 0.5% vanillin). Another group of commercial resin samples without vanillin (Triplex®, Ivoclar Vivadent, USA) was prepared in the same manner. All samples were coated with sterile unstimulated saliva collected from three healthy adult volunteers at 37 °C for 60 min. The respiratory pathogenic bacteria used in this study were Staphylococcus aureus ATCC 5638, Streptococcus pneumoniae ATCC 49619, and Pseudomonas aeruginosa ATCC 27853. They were prepared to a concentration of approximately 107 colony forming unit (CFU)/mL. The bacterial biofilm formation was done in 96-well plate and incubated at 37°C for 24-48 h. The amount of biofilm was quantified by Cell Counting Kit WST-8 (Dojindo Molecular Technologies, USA) at 420 nm. All tests were performed in triplicate on three separate occasions. One-way ANOVA and Turkey’s test were used for the statistical analysis. Results: The vanillin-incorporated resin groups (0.1% and 0.5% vanillin) had a significant reduction of S. aureus and P. aeruginosa biofilm mass compared with resins without vanillin (0% vanillin and commercial resin groups). No significant difference was observed in the S. pneumonia biofilm formation. Up to 80% and 33% reductions of biofilm mass were demonstrated on P. aeruginosa and S. aureus, respectively. Conclusion: The incorporation of vanillin to denture base PMMA resin could significantly inhibit biofilm formation of respiratory pathogens. Using this PMMA resin, denture base materials with antimicrobial property can be applied to reduce a risk of respiratory infection in denture wearing patients.

Formation of Cariogenic Bacterial Biofilm on Vanillin-Incorporated Resin-Based Dental Sealant

2021 ◽  
Vol 889 ◽  
pp. 107-111
Author(s):  
Boonyanit Thaweboon ◽  
Sroisiri Thaweboon
Keyword(s):  
Dental Caries ◽  
Biofilm Formation ◽  
Antimicrobial Agents ◽  
Antimicrobial Property ◽  
Bacterial Biofilm ◽  
Cell Counting ◽  
Cariogenic Bacteria ◽  
Tooth Structure ◽  
Dental Sealants ◽  
Dental Sealant

Tooth decay or dental caries is an important oral health problem involving people of all age groups. The disease is the outcome of the demineralize process in which aciduric and acidogenic bacteria in a biofilm decompose tooth structure. Dental sealant, a resin material, which is applied on the occlusal pit and fissure surfaces of the teeth as a protective layer has been commonly used to prevent dental caries. However, the microbial effect on food residue is found to be a major cause of microleakage of sealant and secondary caries. Several types of antimicrobial agents were introduced to increase the caries preventive effect of dental sealants. Vanillin, the main component of flavoring agent vanilla, has been found to have antimicrobial property against Gram-positive and Gram-negative bacteria. The objective of this study was to investigate the antimicrobial effect of vanillin-incorporated dental sealant against biofilm formation of cariogenic bacteria. Dental sealant resin samples (Clinpro; 3M ESPE, USA) were prepared in 96-well plate in accordance with the amount of vanillin adding (0%, 0.5%, 1% and 5% vanillin). The cariogenic bacterial suspensions of Streptococcus mutans ATCC 25175 and Lactobacillus casei ATCC 334 were added to saliva-coated samples and incubated at 37°C in 5% CO2 atmosphere for 48 h to allow the biofilm formation. The quantity of vital biofilm was determined by WST Microbial Cell Counting Kit (Dojindo Molecular Technologies, USA) at 460 nm. One-way ANOVA and Tukey’s test were applied to the statistical analysis. A significant inhibitory effect against L. casei biofilm was observed in all vanillin incorporated samples (0.5%, 1% and 5% vanillin) compared with samples without vanillin. The percentage of biofilm reduction was 32-39%. For S. mutans, the suppressive effect was noticed only at >1% vanillin with 18-25% biofilm reduction. In conclusion, the incorporation of vanillin to dental sealants could decrease biofilm formation of cariogenic bacteria (S. mutans and L. casei). The use of dental sealants containing vanillin could be a promising measure to prevent dental caries due to their antibacterial biofilm formation property.

Anti-Biofilm Formation of an Adhesive Containing Calcium Salts of Acidic Monomers against Oral Candida Related to Root Caries

2021 ◽  
Vol 904 ◽  
pp. 282-286
Author(s):  
Sroisiri Thaweboon ◽  
Takashi Saito ◽  
Boonyanit Thaweboon
Keyword(s):  
Candida Albicans ◽  
Biofilm Formation ◽  
Antimicrobial Property ◽  
Antimicrobial Effect ◽  
Cell Counting ◽  
Root Caries ◽  
Flat Bottom ◽  
Calcium Salts ◽  
Oral Candida

The proportion of older people within the general population is expanding due to the decline of birth rate and the increase of life expectancy. Increasing elderly populations, which is retaining its teeth longer, leads to oral health problems, for example, root caries. The main etiological factor for the initiation and development of root caries is the appearance of cariogenic biofilm. The acid-producing and acid-tolerant bacteria and oral yeast, such as Candida albicans are the major contributors in root caries formation. A new generation of adhesives is developed with several modifications for the prevention of dental caries by incorporating antimicrobial components. The aim of this study was to investigate the antimicrobial effect of adhesive containing calcium salt of acidic monomers on the biofilm formation of oral Candida related to root caries. In the experiments, the flat-bottom surfaces of 96-well plate were painted with an adhesive containing calcium salts of 4-methacryloxyethyl trimellitic acid (CMET) and 10-methacryloyloxydecyl dihydrogen calcium phosphate (MDCP) (Bio-Coat, CA, Sun Medical, Japan). Then they were LED light-cured and coated with sterile saliva at 37 °C for 60 min. The biofilm formation was made by adding of Candida albicans (ATCC 10238 and two clinical strains) suspensions (107 colony forming unit/mL) and incubated at 37°C for 24 h. The amount of vital biofilm was determined by WST-8 Microbial Cell Counting Kit (Dojindo Molecular Technologies, USA). All experiments were done in triplicate and repeated three times. Statistical analysis was performed using Student’s t-test. The results clearly showed that adhesive could significantly inhibit biofilm formation of all tested Candida compared with a control. This suppressive effect was not different among the strains of Candida. The percentages of vital biofilm reduction were 25% to 40%. The ability of this adhesive to suppress biofilm of oral yeast may be its antimicrobial property of acidic monomer or the effect of calcium ion within the adhesive, which can alter Candida cell morphology, and influence their structures or process of biofilm formation. In conclusion, an adhesive containing calcium salts of acidic monomers could significantly inhibit biofilm formation of C. albicans. This adhesive could be effectively applied to exposed root surfaces to prevent or inhibit the progression of root caries. Further studies are necessary to clarify the effect on multispecies biofilm, on long-term activity, and in vivo conditions.

scholarly journals Polydopamine-Inspired Surface Modification of Polypropylene Hernia Mesh Devices via Cold Oxygen Plasma: Antibacterial and Drug Release Properties

Coatings ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 164 ◽  
Author(s):  
Xiakeer Saitaer ◽  
Noor Sanbhal ◽  
Yansha Qiao ◽  
Yan Li ◽  
Jing Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Plasma Treatment ◽  
Oxygen Plasma ◽  
Antimicrobial Property ◽  
Antimicrobial Properties ◽  
Major Complication ◽  
Inhibition Zone ◽  
Repair Process ◽  
Hernia Surgery ◽  
Maximum Inhibition

Mesh infection is a major complication of hernia surgery after polypropylene (PP) mesh implantation. Modifying the PP mesh with antibacterial drugs is an effective way to reduce the chance of infection, but the hydrophobic characteristic of PP fibers has obstructed the drug adhesion. Therefore, to prepare antimicrobial PP mesh with a stable drug coating layer and to slow the drug release property during the hernia repair process has a great practical meaning. In this work, PP meshes were coated by bio-inspired polydopamine (PDA), which can load and release levofloxacin. PP meshes were activated with cold oxygen plasma and then plasma activated PP fibers were coated with PDA. The PDA coated meshes were further soaked in levofloxacin. The levofloxacin loaded PP meshes demonstrate excellent antimicrobial properties for 6 days and the drug release has lasted for at least 24 h. Moreover, a control PP mesh sample without plasma treatment was also prepared, after coating with PDA and loading levofloxacin. The antimicrobial property was sustained only for two days. The maximum inhibition zone of PDA coated meshes with and without plasma treatment was 12.5 and 9 mm, respectively. On all accounts, the modification strategy can facilely lead to long-term property of infection prevention.

scholarly journals Silver-Derived Antimicrobial Coatings for the Prevention of Microbial Biofilms in Metal Pipes

2021 ◽  
Vol 232 (8) ◽  
Author(s):  
M. Vela-Cano ◽  
C. Garcia-Fontana ◽  
F. Osorio ◽  
A. González-Martinez ◽  
J. González-López
Keyword(s):  
Biofilm Formation ◽  
Antimicrobial Properties ◽  
Pilot Scale ◽  
Biological Factors ◽  
Antimicrobial Coatings ◽  
Microbial Biofilms ◽  
Physical Chemical ◽  
Silver Zeolite ◽  
Metal Pipes ◽  
Pipeline Corrosion

AbstractBiodeterioration is one of the most important processes in metal pipeline corrosion, and it can be due to physical, chemical, and biological factors. Coatings rich in silver have been used to inhibit this undesirable phenomenon. In this study, the antimicrobial properties of several silver-containing products used as a coating in pipelines were determined on a pilot scale in order to evaluate the ability of silver to inhibit biofilm formation. The results showed that the coating with silver zeolite at a concentration of 2000 mg L–1 inhibited the formation of a microbial biofilm and prevented the biodeterioration process. Therefore, from our study, it can be concluded that silver zeolite shows greater protection capacity than other silver preparations and presents advantages in relation to other silver coatings that are currently available

Uji Ekstrak Bawang Bombay sebagai Anti Bakteri Gram Positif Staphylococcus aureus dengan Metode Difusi Cakram

2012 ◽  
Vol 12 (2) ◽  
pp. 68
Author(s):  
Wuryanti Wuryanti ◽  
Nies Suci Mulyani ◽  
Mukhammad Asy'ari ◽  
Purbowatiningrum Ria Sarjono
Keyword(s):  
Allium Cepa ◽  
Human Life ◽  
Antimicrobial Property ◽  
Antimicrobial Properties ◽  
Living Organism ◽  
Inhibition Zone ◽  
Antimicrobial Test ◽  
Allium Cepa L ◽  
Paper Disc

Microbe is a microscopic living organism which is closely linked to human life. One of pathogenic microorganisms such as Staphylococcus aureu,. may cause diseases. Sulfure of several plants are bioactive as antimicrobial. The properties of sulfure in Allium cepa L leads to an assumption that it has antimicrobial properties. Therefore, this study involved the antimicrobial test. The determination steps of antimicrobial Allium cepa L extract consisted of the Allium cepa L extract preparation, microbial regeneration and antimicrobial test. The antibacterial determination were performed by paper disc method. Based on the research data, determination of antimicrobial Allium cepa L extract resulted in inhibition zone area showed that the extract owned antimicrobial property.

scholarly journals Effect of Coriander Oil (Coriandrum sativum) on Planktonic and Biofilm Cells of Acinetobacter baumannii

2013 ◽  
Vol 8 (5) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Andreia F. Duarte ◽  
Susana Ferreira ◽  
Rosário Oliveira ◽  
Fernanda C. Domingues
Keyword(s):  
Essential Oil ◽  
Acinetobacter Baumannii ◽  
Biofilm Formation ◽  
Antimicrobial Properties ◽  
Hospital Acquired Infections ◽  
Microtiter Plates ◽  
Crystal Violet Assay ◽  
Hospital Acquired ◽  
Microdilution Broth ◽  
Susceptibility Assay

The increasing incidence of hospital-acquired infections caused by multi-drug resistant pathogens, such as Acinetobacter baumannii, coupled with the low efficacy of drugs and rising treatment costs has created interest in the potential antimicrobial properties of natural products. The main objective of this work was to determine the effect of coriander essential oil on Acinetobacter baumannii in different growth phases, as well as its ability to inhibit the formation or eradication of biofilms. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of coriander oil using a microdilution broth susceptibility assay was determined. The effects of different concentrations of coriander oil (ranging from 0.125 to 4×MIC) on biofilm formation and on established biofilm were tested using 96-well microtiter plates. Crystal violet assay was used as indicator of total biofilm biomass and the biofilm viability was assessed with a XTT staining method. It was found that coriander oil presented significant antibacterial activity against all tested strains of A. baumannii, with MIC values between 1 and 4 μL/mL. The MBC values were the same as the MIC, being an indicator of the bactericidal activity of this essential oil. In what concerns the effect of this essential oil on biofilm formation inhibition was observed of at least 85% of biomass formation by all A. baumannii strains using 2×MIC of coriander oil, in addition to a decrease in the metabolic activity of the cells. After exposure to coriander oil, a decrease in 24 h and 48 h-old biofilm biomass and metabolism was seen for all tested concentrations, even with sub-inhibitory concentrations. Coriander essential oil proved to have a significant antibacterial and anti-biofilm activity and should be considered in the development of future disinfectants to control A. baumannii dissemination.

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