Reduced Weight Scatter with Bonded Powder Mixes

2007 ◽  
Vol 534-536 ◽  
pp. 309-312
Author(s):  
Daniel Edman ◽  
Luigi Alzati ◽  
Giovanni Pozzi ◽  
Carlo Frediani ◽  
Riccardo Crosa
Keyword(s):  
Cost Effective ◽  
Key Factors ◽  
Dimensional Control ◽  
Dimensional Properties ◽  
The Stability ◽  
Manufacturing Technologies ◽  
Filling Characteristics

Organically bonded P/M mixes have been developed to improve the stability of dimensional properties by reducing the segregation of the mix constituents and improving the filling characteristics. Robustness and reliability are key factors for the promotion of P/M as cost effective substitute of competing manufacturing technologies. Based on the production of four different belt pulleys, this paper presents the achievement of reduced weight scatter and close dimensional control realizable by using a StarmixTM that is organically bonded.

scholarly journals IS MORE MEMORY IN EVOLUTIONARY SELECTION (DE)STABILIZING?

2011 ◽  
Vol 16 (3) ◽  
pp. 335-357 ◽  
Author(s):  
Cars Hommes ◽  
Tatiana Kiseleva ◽  
Yuri Kuznetsov ◽  
Miroslav Verbic
Keyword(s):  
Asset Pricing ◽  
Multinomial Logit Model ◽  
Heterogeneous Beliefs ◽  
Pricing Model ◽  
Key Factors ◽  
Evolutionary Selection ◽  
Asset Pricing Model ◽  
Economic Fundamentals ◽  
Selection Dynamics ◽  
The Stability

We investigate the effects of memory on the stability of evolutionary selection dynamics based on a multinomial logit model in a simple asset pricing model with heterogeneous beliefs. Whether memory is stabilizing or destabilizing depends in general on three key factors: (1) whether or not the weights on past observations are normalized; (2) the ecology or composition of forecasting rules, in particular the average trend extrapolation factor and the spread or diversity in biased forecasts; and (3) whether or not costs for information gathering of economic fundamentals have to be incurred.

CRITICAL REVIEW OF EMULSION STABILITY AND CHARACTERIZATION TECHNIQUES IN OIL PROCESSING

2021 ◽  
pp. 1-36
Author(s):  
Vahideh Angardi ◽  
Ali Ettehadi ◽  
Özgün Yücel
Keyword(s):  
Separation Efficiency ◽  
Petroleum Industry ◽  
Cost Effective ◽  
Downstream Processing ◽  
Physical Factors ◽  
Comprehensive Review ◽  
Factors Affecting ◽  
Mathematical Explanations ◽  
The Stability ◽  
The Right

Abstract Effective separation of water and oil dispersions is considered a critical step in the determination of technical and economic success in the petroleum industry over the years. Moreover, a deeper understanding of the emulsification process and different affected parameters is essential for cost-effective oil production, transportation, and downstream processing. Numerous studies conducted on the concept of dispersion characterization indicate the importance of this concept, which deserves attention by the scientific community. Therefore, a comprehensive review study with critical analysis on significant concepts will help readers follow them easily. This study is a comprehensive review of the concept of dispersion characterization and conducted studies recently published. The main purposes of this review are to 1) Highlight flaws, 2) Outline gaps and weaknesses, 3) Address conflicts, 4) Prevent duplication of effort, 5) List factors affecting dispersion. It was found that the separation efficiency and stability of dispersions are affected by different chemical and physical factors. Factors affecting the stability of the emulsions have been studied in detail and will help to look for the right action to ensure stable emulsions. In addition, methods of ensuring stability, especially coalescence are highlighted, and coalescence mathematical explanations of phenomena are presented.

scholarly journals Two Electrode ECG And EOG System For Monitoring Applications

2019 ◽  
Vol 8 (11) ◽  
pp. 262-265
Keyword(s):  
Reference Electrode ◽  
Cost Effective ◽  
Electrode System ◽  
Ecg Signal ◽  
Biomedical Signal ◽  
Ecg Signals ◽  
Arm Position ◽  
The Stability ◽  
Electrocardiogram Ecg ◽  
Total Gain

Heart and Eye are two vital organs in the human system. By knowing the Electrocardiogram (ECG) and Electro-oculogram (EOG), one will be able to tell the stability of the heart and eye respectively. In this project, we have developed a circuit to pick the ECG and EOG signal using two wet electrodes. Here no reference electrode is used. EOG and ECG signals have been acquired from ten healthy subjects. The ECG signal is obtained from two positions, namely wrist and arm position respectively. The picked-up biomedical signal is recorded and heart rate information is extracted from ECG signal using the biomedical workbench. The result found to be promising and acquired stable EOG and ECG signal from the subjects. The total gain required for the arm position is higher than the wrist position for the ECG signal. The total gain necessary for the EOG signal is higher than the ECG signal since the ECG signal is in the range of millivolts whereas EOG signal in the range of microvolts. This two-electrode system is stable, cost-effective and portable while still maintaining high common-mode rejection ratio (CMRR).

scholarly journals The Instability of Dimeric Fc-Fusions Expressed in Plants Can Be Solved by Monomeric Fc Technology

2021 ◽  
Vol 12 ◽  
Author(s):  
Pia Gattinger ◽  
Shiva Izadi ◽  
Clemens Grünwald-Gruber ◽  
Somanath Kallolimath ◽  
Alexandra Castilho
Keyword(s):  
Monoclonal Antibodies ◽  
Fusion Proteins ◽  
Degradation Products ◽  
Therapeutic Proteins ◽  
Cost Effective ◽  
Full Length ◽  
Peptide Sequence ◽  
Reporter Protein ◽  
The Stability

The potential therapeutic value of many proteins is ultimately limited by their rapid in vivo clearance. One strategy to limit clearance by metabolism and excretion, and improving the stability of therapeutic proteins, is their fusion to the immunoglobulin fragment crystallizable region (Fc). The Fc region plays multiple roles in (i) dimerization for the formation of “Y”-shaped structure of Ig, (ii) Fc-mediated effector functions, (iii) extension of serum half-life, and (iv) a cost-effective purification tag. Plants and in particular Nicotiana benthamiana have proven to be suitable expression platforms for several recombinant therapeutic proteins. Despite the enormous success of their use for the production of full-length monoclonal antibodies, the expression of Fc-fused therapeutic proteins in plants has shown limitations. Many Fc-fusion proteins expressed in plants show different degrees of instability resulting in high amounts of Fc-derived degradation products. To address this issue, we used erythropoietin (EPO) as a reporter protein and evaluated the efforts to enhance the expression of full-length EPO-Fc targeted to the apoplast of N. benthamiana. Our results show that the instability of the fusion protein is independent from the Fc origin or IgG subclass and from the peptide sequence used to link the two domains. We also show that a similar instability occurs upon the expression of individual heavy chains of monoclonal antibodies and ScFv-Fc that mimic the “Y”-shape of antibodies but lack the light chain. We propose that in this configuration, steric hindrance between the protein domains leads to physical instability. Indeed, mutations of critical residues located on the Fc dimerization interface allowed the expression of fully stable EPO monomeric Fc-fusion proteins. We discuss the limitations of Fc-fusion technology in N. benthamiana transient expression systems and suggest strategies to optimize the Fc-based scaffolds on their folding and aggregation resistance in order to improve the stability.

scholarly journals Demulsification of Liquid Membrane Emulsion using High Voltage Glass Coated Electrode in Batch System

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
N. Othman ◽  
A. Ahmad ◽  
M. A. Piramali
Keyword(s):  
High Voltage ◽  
Liquid Membrane ◽  
Alternate Current ◽  
Cost Effective ◽  
Electrical Field ◽  
Electrical Field Strength ◽  
Oil Emulsion ◽  
Internal Phase ◽  
The Stability ◽  
Time Required

Demulsification is one of the key processes in emulsion liquid membrane application. This study involved the effect of electrical field on demulsification of water in oil using batch high voltage demulsifier system. This technique widely used because of its advantages of easy manipulation of applied field direction and strength, offers cost–effective separation and minimal environmental impact combined with mechanical simplicity. Influence of various values of frequency (400–1500 Hz) and voltage was studied experimentally using Alternate Current (AC) High Voltage Demulsifier with insulated electrode. The emulsion consists of kerosene as organic phase, sulfuric acid as internal phase and span 80 (3 and 5 w/v %) as a surfactant. The effect of emulsion preparation such as homogenizer speed, internal phase and surfactant concentrations on the stability of water–in–oil emulsion was also investigated. The results showed that the attractive forces between the water droplets under an electrical field increase by raising the applied electrical field strength. Meanwhile, the time required for the emulsion to separate and coalescence under electrical field increased when the stability of emulsion increased.

Development and Assembly of a MEMS Based High-Sensitivity Relative Gravimeter for Multi-Pixel Imaging Applications 

2021 ◽  
Author(s):  
Karl Toland ◽  
Abhinav Prasad ◽  
Andreas Noack ◽  
Kristian Anastasiou ◽  
Richard Middlemiss ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Cost Effective ◽  
Mount Etna ◽  
Earth Tides ◽  
Gravity Measurements ◽  
Stepper Motors ◽  
Long Term Monitoring ◽  
The Stability ◽  
Term Monitoring

<p>The manufacture and production of a high-sensitivity cost-effective gravimeter has the potential to change the methodology and efficiency of gravity measurements. Currently, the most common method to conduct a survey is by using a single gravimeter, usually costing tens of thousands of Dollars, with measurements taken at multiple locations to obtain the required data. The availability of a cost-effective gravimeter however would allow the user to install multiple gravimeters, at the same cost of a single gravimeter, to increase the efficiency of surveys and long-term monitoring.  </p><p> </p><p>Since the previous reporting on a low-drift relative MEMS gravimeter for multi-pixel imaging applications (Prasad, A. et al, EGU2020-18528), significant progress has been made in the development and assembly of the previously reported system. Field prototypes have been manufactured and undergone significant testing to investigate the stability and robustness of the system in preparation for the deployment of multiple devices as part of the gravity imager on Mount Etna. The device, known as Wee-g, has several key features which makes it an attractive prospect in the field of gravimetry. Examples of these features are that the Wee-g is small and portable with the ability to connect to the device remotely, can be powered through a mains connected power supply, or through portable batteries, weighs under 4kg, has a low power consumption during normal use of 5W, correct for tilt through manual adjustments or remotely through integrated stepper motors with a total tilt correction range of 5 degrees, the ability to read out tilt of the device through an inclinometer for either alignment or long term monitoring and numerous temperature sensors and heater servos to control the temperature of the MEMS to <1mK.</p><p> </p><p>This presentation aims to report on the progress that has been achieved in the development and manufacturing of the prototype devices, various testing of the devices under various laboratory conditions (such as the measurements of the Earth tides, and a relative measurement of gravity at various floor levels), as well as additional applications that are to be explored in 2021. </p>

scholarly journals Gliadin Nanoparticles Pickering Emulgels for β-Carotene Delivery: Effect of Particle Concentration on the Stability and Bioaccessibility

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4188
Author(s):  
Ce Cheng ◽  
Yi Gao ◽  
Zhihua Wu ◽  
Jinyu Miao ◽  
Hongxia Gao ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Active Ingredient ◽  
Functional Foods ◽  
Particle Concentration ◽  
Storage Conditions ◽  
Key Factors ◽  
Food Grade ◽  
The Stability ◽  
Thermal Stability Of ◽  
Β Carotene

β-carotene is a promising natural active ingredient for optimum human health. However, the insolubility in water, low oral bioavailability, and instability in oxygen, heat, and light are key factors to limit its application as incorporation into functional foods. Therefore, gliadin nanoparticles (GNPs) Pickering emulgels were chosen as food-grade β-carotene delivery systems. The objectives of the present study were to investigate the influence of GNPs concentration on the rheological properties, stability, and simulated gastrointestinal fate of β-carotene of Pickering emulgels. The formulations of Pickering emulgels at low GNPs concentration had better fluidity, whereas at high GNPs concentration, they had stronger gel structures. Furthermore, the thermal stability of β-carotene loaded in Pickering emulgels after two pasteurization treatments was significantly improved with the increase of GNPs concentration. The Pickering emulgels stabilized with higher GNPs concentration could improve the protection and bioaccessibility of β-carotene after different storage conditions. This study demonstrated the tremendous potential of GNPs Pickering emulgels to carry β-carotene.

scholarly journals Scientific Approaches on Extraction, Purification and Stability for the Commercialization of Fucoxanthin Recovered from Brown Algae

Foods ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1113
Author(s):  
Catarina Lourenço-Lopes ◽  
Paula Garcia-Oliveira ◽  
Maria Carpena ◽  
Maria Fraga-Corral ◽  
Cecilia Jimenez-Lopez ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Scientific Community ◽  
High Performance ◽  
Cost Effective ◽  
Free Molecule ◽  
Neuroprotective Effects ◽  
Natural Sources ◽  
Future Production ◽  
Efficient Extraction ◽  
The Stability

The scientific community has corroborated the numerous beneficial activities of fucoxanthin, such as its antioxidant, anti-inflammatory, anticancer or neuroprotective effects, among others. These properties have attracted the attention of nutraceutical, cosmetic and pharmacological industries, giving rise to various possible applications. Fucoxanthin may be chemically produced, but the extraction from natural sources is considered more cost-effective, efficient and eco-friendly. Thus, identifying suitable sources of this compound and giving a general overview of efficient extraction, quantification, purification and stabilization studies is of great importance for the future production and commercialization of fucoxanthin. The scientific research showed that most of the studies are performed using conventional techniques, but non-conventional techniques begin to gain popularity in the recovery of this compound. High Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) and spectroscopy techniques have been employed in the quantification and identification of fucoxanthin. The further purification of extracts has been mainly accomplished using purification columns. Finally, the stability of fucoxanthin has been assessed as a free molecule, in an emulsion, or encapsulated to identify the variables that might affect its further industrial application.

scholarly journals Performance Analysis of Cost-Effective Miniature Microphone Sound Intensity 2D Probe

Sensors ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 271
Author(s):  
Witold Mickiewicz ◽  
Michał Raczyński ◽  
Arkadiusz Parus
Keyword(s):  
Free Field ◽  
Sound Intensity ◽  
Cost Effective ◽  
Acoustic Power ◽  
Metrological Analysis ◽  
Architectural Acoustics ◽  
Advantages And Disadvantages ◽  
Directional Characteristics ◽  
The Stability ◽  
Prototype Measurement

This article presents the functional properties of modified versions of the 2D pressure–pressure intensity probe allowing us to determine the vector of sound intensity on a plane using a mechatronic system with one or two miniature electret microphones. The introduction contains basic information about the application areas of the sound intensity and its measurement problems. Next, the principle of operation of the probes and the construction of the prototype measurement system are described. It was subjected to comparative analysis for the stability of obtained results and accuracy of directional characteristics in free field conditions. For this purpose, experiments were conducted to analyze the flow of acoustic power in an anechoic chamber using both (one- and two-microphone) probes. The results were used for a comparative metrological analysis of the described methods and to indicate the advantages and disadvantages of both constructions. The next part of the article presents an experiment concerning the measurement of the sound intensity impulse response of a room, which is an example of practical use of the probe to analyze reflections in the room, which can be used in sound engineering and architectural acoustics.

scholarly journals Bioreactor Parameters for Microcarrier-Based Human MSC Expansion under Xeno-Free Conditions in a Vertical-Wheel System

2020 ◽  
Vol 7 (3) ◽  
pp. 73 ◽  
Author(s):  
Josephine Lembong ◽  
Robert Kirian ◽  
Joseph D. Takacs ◽  
Timothy R. Olsen ◽  
Lye Theng Lock ◽  
...  
Keyword(s):  
Cost Effective ◽  
Population Doubling ◽  
Bioreactor Culture ◽  
Lot Size ◽  
Fed Batch ◽  
The Media ◽  
Manufacturing Technologies ◽  
Suspension Bioreactor ◽  
Culture Protocol ◽  
Bioreactor Process

Human mesenchymal stem/stromal cells (hMSCs) have been investigated and proven to be a well-tolerated, safe therapy for a variety of indications, as shown by over 900 registered hMSC-based clinical trials. To meet the commercial demand for clinical manufacturing of hMSCs, production requires a scale that can achieve a lot size of ~100B cells, which requires innovative manufacturing technologies such as 3D bioreactors. A robust suspension bioreactor process that can be scaled-up to the relevant scale is therefore crucial. In this study, we developed a fed-batch, microcarrier-based bioreactor process, which enhances media productivity and drives a cost-effective and less labor-intensive hMSC expansion process. We determined parameter settings for various stages of the culture: inoculation, bioreactor culture, and harvest. Addition of a bioreactor feed, using a fed-batch approach, was necessary to replenish the mitogenic factors that were depleted from the media within the first 3 days of culture. Our study resulted in an optimized hMSC culture protocol that consistently achieved hMSC densities between 2 × 105–6 × 105 cells/mL within 5 days with no media exchange, maintaining the final cell population doubling level (PDL) at 16–20. Using multiple hMSC donors, we showed that this process was robust and yielded hMSCs that maintained expansion, phenotypic characteristic, and functional properties. The developed process in a vertical-wheel suspension bioreactor can be scaled to the levels needed to meet commercial demand of hMSCs.

Sign in / Sign up

Export Citation Format

Share Document