Study of Electrospun PLLACL Nanofibrous Mats for Drug Delivery System

2009 ◽  
Vol 610-613 ◽  
pp. 1319-1322 ◽  
Author(s):  
Shui Ping Liu ◽  
Xiao Qiang Li ◽  
Yan Su ◽  
Lian Jiang Tan ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery System ◽  
Wound Dressing ◽  
Coaxial Electrospinning ◽  
Release Behavior ◽  
The Core ◽  
Vis Spectroscopy ◽  
Long Time

In the present study an innovative tissue engineering scaffold was developed which can be used on wound dressing with a controllable drug-releasing capability. By coaxial electrospinning a coaxial nanofibrous mats were obtained which was made from Poly(L-lactid-co-ε-caprolactone) (PLLACL) and Tetracycline Hydrochloride (TCH), with P(LLA-CL) as the shell and TCH as the core. The TCH release behavior of the coaxial nanofibrous mats was measured by ultraviolet-visible (UV-vis) spectroscopy in vitro environment of 37°C for a maximum 180 hours. To compare with the method of mix electrospinning, TCH without any other material could encapsulated in P(LLA-CL) nanofibers very well and released for a long time.

An Implantable Immunosuppressive Cyclosporine Drug Delivery System

2005 ◽  
Vol 288-289 ◽  
pp. 125-128 ◽  
Author(s):  
Shen Guo Wang ◽  
Qing Cai ◽  
Jian Zhong Bei ◽  
Wei Yun Shi ◽  
Li Xin Xie
Keyword(s):  
Drug Delivery ◽  
Anterior Chamber ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Immunosuppressive Agent ◽  
Drug Preparation ◽  
Long Time ◽  
Clinically Significant

In the article a kind biodegradable drug carrier (glycolide-co-lactide-co-caprolactone) tricomponent copolymer (PGLC) was synthesized by ring opening copolymerization of glycolide (GA), lactide (LA) and ε-caprolactone (CL), and was used to manufacture an implantable drug preparation---Cyclosporine-PGLC drug delivery system (Cs-PGLC DDS).The Cs could slowly release from the Cs-PGLC DDS near linearly and last for a long time in vitro. A clinically significant Cs concentration in the cornea and anterior chamber could be achieved by implanting the Cs-PGLC DDS in anterior chamber. It was demonstrated that the Cs-PGLC DDS is a long-effective intraocular immunosuppressive agent for remaining corneal allograft clear and significantly prolong its survival time.

scholarly journals Fabrication of Injectable Chitosan-Chondroitin Sulfate Hydrogel Embedding Kartogenin-Loaded Microspheres as an Ultrasound-Triggered Drug Delivery System for Cartilage Tissue Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1487
Author(s):  
Fu-Zhen Yuan ◽  
Hu-Fei Wang ◽  
Jian Guan ◽  
Jiang-Nan Fu ◽  
Meng Yang ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Chondroitin Sulfate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
In Vitro Degradation

Ultrasound-responsive microspheres (MPs) derived from natural polysaccharides and injectable hydrogels have been widely investigated as a biocompatible, biodegradable, and controllable drug delivery system and cell scaffolds for tissue engineering. In this study, kartogenin (KGN) loaded poly (lactide-co-glycolic acid) (PLGA) MPs (MPs@KGN) were fabricated by premix membrane emulsification (PME) method which were sonicated by an ultrasound transducer. Furthermore, carboxymethyl chitosan-oxidized chondroitin sulfate (CMC-OCS) hydrogel were prepared via the Schiff’ base reaction-embedded MPs to produce a CMC-OCS/MPs scaffold. In the current work, morphology, mechanical property, porosity determination, swelling property, in vitro degradation, KGN release from scaffolds, cytotoxicity, and cell bioactivity were investigated. The results showed that MPs presented an obvious collapse after ultrasound treatment. The embedded PLGA MPs could enhance the compressive elastic modulus of soft CMC-OCS hydrogel. The cumulative release KGN from MPs exhibited a slow rate which would display an appropriate collapse after ultrasound, allowing KGN to maintain a continuous concentration for at least 28 days. Moreover, the composite CMC-OCS@MPs scaffolds exhibited faster gelation, lower swelling ratio, and lower in vitro degradation. CCK-8 and LIVE/DEAD staining showed these scaffolds did not influence rabbit bone marrow mesenchymal stem cells (rBMMSCs) proliferation. Then these scaffolds were cultured with rBMMSCs for 2 weeks, and the immunofluorescent staining of collagen II (COL-2) showed that CMC-OCS hydrogel embedded with MPs@KGN (CMC-OCS@MPs@KGN) with ultrasound had the ability to increase the COL-2 synthesis. Overall, due to the improved mechanical property and the ability of sustained KGN release, this injectable hydrogel with ultrasound-responsive property is a promising system for cartilage tissue engineering.

scholarly journals Correction: In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 3623-3623
Author(s):  
Junyan Yao ◽  
Shijie Zhang ◽  
Wudan Li ◽  
Zhi Du ◽  
Yujie Li
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
System P

Correction for ‘In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system’ by Junyan Yao et al., RSC Adv., 2016, 6, 515–521.

scholarly journals FUNCTIONALIZATION OF 3D FIBROUS SCAFFOLDS PREPARED USING CENTRIFUGAL SPINNING WITH LIPOSOMES AS A SIMPLE DRUG DELIVERY SYSTEM

2017 ◽  
Vol 8 ◽  
pp. 24-26 ◽  
Author(s):  
Michala Rampichová ◽  
Matej Buzgo ◽  
Věra Lukášová ◽  
Andrea Míčková ◽  
Karolína Vocetková ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Drug Delivery System ◽  
Delivery System ◽  
Supporting Cell ◽  
Platelet Lysate ◽  
Centrifugal Spinning

3D materials supporting cell adhesion, infiltration and proliferation are crucial for bone tissue engineering. In the current study we combined PCL fibers prepared using centrifugal spinning with adhered liposomes filled with platelet lysate as a natural source of growth factors. The scaffold was seeded with MG-63 cells and tested in vitro as a potential drug delivery system for bone tissue engineering.

Electrospun MWCNTs/Poly(lactic-co-glycolic acid) Composite Nanofibrous Drug Delivery System

2012 ◽  
Vol 424-425 ◽  
pp. 1220-1223 ◽  
Author(s):  
Rui Ling Qi ◽  
Hui Juan Liu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Mouse Fibroblast ◽  
Burst Release ◽  
Vis Spectroscopy ◽  
Multi Walled Carbon Nanotubes ◽  
Model Drug

In this study, nanotubular materials multi-walled carbon nanotubes (MWCNTs) were used to encapsulate a model drug, doxorubicine hydrochloride (DOX). Then, the drug-loaded nanotubes (DOX/CNTs) with an optimized drug encapsulation percentage were mixed with poly (lactide-co-glycolide) (PLGA) polymer solution for subsequent electrospinning to form drug-loaded composite nanofibrous mats. The morphology was characterized using scanning electron microscopy (SEM). The proliferation of mouse fibroblast cells cultured on both PLGA and CNTs-doped PLGA fibrous scaffolds were compared through 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyl tetrazolium bromide (MTT) assay of cell viability and SEM observation of cell morphology. In vitro drug release behavior was examined using UV-vis spectroscopy. We show that the incorporation of CNTs and DOX/CNTs within the nanofibrous mats does not significantly change the morphology of the mats. In addition, our results indicate that this double-container drug delivery system (both PLGA polymer and CNTs are drug carriers) is beneficial to avoid the burst release of the drug. The drug loaded elctrospinning composite nanofibrous mats developed in this study may find various applications in tissues engineering and pharmaceutical sciences.

scholarly journals A two pulse drug delivery system for amoxicillin: An attempt to counter the scourge of bacterial resistance against antibiotics

2011 ◽  
Vol 61 (3) ◽  
pp. 313-322 ◽  
Author(s):  
Habban Akhter ◽  
Nitin Saigal ◽  
Sanjula Baboota ◽  
Shah Faisal ◽  
Javed Ali
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Microcrystalline Cellulose ◽  
Bacterial Resistance ◽  
Lag Time ◽  
Pore Former ◽  
The Core ◽  
Core Tablet

A two pulse drug delivery system for amoxicillin: An attempt to counter the scourge of bacterial resistance against antibiotics Bearing in mind the present scenario of the increasing biological tolerance of bacteria against antibiotics, a time controlled two pulse dosage form of amoxicillin was developed. The compression coating inlay tablet approach was used to deliver the drug in two pulses to different parts of the GIT after a well defined lag time between the two releases. This was made possible by formulating a core containing one of the two drug fractions (intended to be delivered as the second pulse), which was spray coated with a suspension of ethyl cellulose and a hydrophilic but water insoluble agent as a pore former (microcrystalline cellulose). Coating of up to 5 % (m/m) was applied over the core tablet, giving a corresponding lag of 3, 5, 7 and 12 h. Increasing the level of coating led to retardation of the water uptake capacity of the core, leading to prolongation of the lag time. Microcrystalline cellulose was used as a hydrophilic but water insoluble porosity modifier in the barrier layer, varying the concentration of which had a significant effect on shortening or prolongation of the lag time. This coated system was further partially compression coated with the remaining drug fraction (to be released as the first immediate release pulse) with a disintegrant, giving a final tablet. The core tablet and the final two pulse inlay tablet were further investigated for their in vitro performance.

scholarly journals A Comprehensive Review on the Applications of Exosomes and Liposomes in Regenerative Medicine and Tissue Engineering

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2529
Author(s):  
Mojtaba Shafiei ◽  
Mohamed Nainar Mohamed Ansari ◽  
Saiful Izwan Abd Razak ◽  
Muhammad Umar Aslam Khan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Comprehensive Review ◽  
Absorption Potential ◽  
Substantial Degree

Tissue engineering and regenerative medicine are generally concerned with reconstructing cells, tissues, or organs to restore typical biological characteristics. Liposomes are round vesicles with a hydrophilic center and bilayers of amphiphiles which are the most influential family of nanomedicine. Liposomes have extensive research, engineering, and medicine uses, particularly in a drug delivery system, genes, and vaccines for treatments. Exosomes are extracellular vesicles (EVs) that carry various biomolecular cargos such as miRNA, mRNA, DNA, and proteins. As exosomal cargo changes with adjustments in parent cells and position, research of exosomal cargo constituents provides a rare chance for sicknesses prognosis and care. Exosomes have a more substantial degree of bioactivity and immunogenicity than liposomes as they are distinctly chiefly formed by cells, which improves their steadiness in the bloodstream, and enhances their absorption potential and medicinal effectiveness in vitro and in vivo. In this review, the crucial challenges of exosome and liposome science and their functions in disease improvement and therapeutic applications in tissue engineering and regenerative medicine strategies are prominently highlighted.

scholarly journals Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1862
Author(s):  
Emily Dosmar ◽  
Gabrielle Vuotto ◽  
Xingqi Su ◽  
Emily Roberts ◽  
Abigail Lannoy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
3D Model ◽  
Release Behavior ◽  
Drug Diffusion ◽  
Release Drug ◽  
Antibiotic Drug

The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartmental and four COMSOL models of the eye were developed to describe transport into the vitreous originating from a DDS placed topically, in the subconjunctiva, subretinally, and intravitreally. The concentration of the simulated DDS was assumed to be the initial concentration of the hydrogel DDS. The simulation was executed over 1500 and 100 h for the compartmental and COMSOL models, respectively. Based on the MATLAB model, topical, subconjunctival, subretinal and vitreous administration took most (~500 h to least (0 h) amount of time to reach peak concentrations in the vitreous, respectively. All routes successfully achieved therapeutic levels of drug (0.007 mg/mL) in the vitreous. These models predict the relative build-up of drug in the vitreous following DDS administration in four different points of origin in the eye. Our model may eventually be used to explore the minimum loading dose of drug required in our DDS leading to reduced drug use and waste.

Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

2020 ◽  
Vol 14 (4) ◽  
pp. 351-359
Author(s):  
Shubham Shrestha ◽  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Structure ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Carrier System ◽  
Current Review ◽  
Long Time ◽  
Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

Sign in / Sign up

Export Citation Format

Share Document