Simultaneous Incorporation of 5-Fluorouracil and Leucovorin into Chitosan Nanoparticle as Drug Carrier and Its Characterization
2010 ◽
Vol 654-656
◽
pp. 2265-2268
Keyword(s):
A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.
2018 ◽
Vol 18
(2)
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pp. 302-311
Keyword(s):
2019 ◽
Vol 11
(06)
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2019 ◽
Vol 9
(3)
◽
pp. 212-221
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2019 ◽
2020 ◽
Vol 27
(22)
◽
pp. 3665-3685
◽
Keyword(s):
2020 ◽
Vol 10
(1)
◽
pp. 53-57
Keyword(s):
2021 ◽
Vol 21
(2)
◽
pp. 1184-1189
Keyword(s):