scholarly journals Bacterial aetiology and antimicrobial resistance pattern in culture positive enteric fever in a private hospital in Sri Lanka

2019 ◽  
Vol 6 (1) ◽  
pp. 82
Author(s):  
Suchetha Charukeshi Illapperuma ◽  
Enoka Marie Corea ◽  
Suneth Buddika Agampodi
Keyword(s):  
Sri Lanka ◽  
Antimicrobial Resistance ◽  
Enteric Fever ◽  
Private Hospital ◽  
Resistance Pattern ◽  
Bacterial Aetiology ◽  
Culture Positive

scholarly journals Is Antimicrobial Resistance Pattern of Enteric Fever Changing in Kathmandu Valley?

2013 ◽  
Vol 32 (3) ◽  
pp. 221-228
Author(s):  
Ganesh Kumar Rai ◽  
Subhana Karki ◽  
Bina Prajapati
Keyword(s):  
Antimicrobial Resistance ◽  
Nalidixic Acid ◽  
Enteric Fever ◽  
Public Health Problem ◽  
Salmonella Typhi ◽  
Resistance Pattern ◽  
Kathmandu Valley ◽  
Sensitivity Testing ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern

Introduction: Enteric fever is a public health problem in developing countries including Nepal. Antimicrobial sensitivity pattern of Salmonella sp causing enteric fever is changing over time and also differs according to geographical location. Periodic surveillance of antimicrobial resistance of Salmonella sp is mandatory for management of enteric fever rationally. The objective of this study was to analyze the resistance pattern of Salmonella sp to commonly used antimicrobials. Materials and Methods: This was a retrospective study undertaken reviewing the records of blood isolates of Salmonella sp over one year period at Kanti Children’s Hospital, Nepal. Antimicrobial sensitivity testing was done following Kirby Bauer’s disk diffusion technique using Muller Hinton agar. Results: Salmonella typhi was found to be 100% resistance to ampicillin and resistance to nalidixic acid and ciprofloxacin was also high. The resistance to chloramphenicol and ofloxacin was low. No resistance was found to amoxicillin, ceftriaxone, cefotaxime and amikacin. However, among the sensitive isolates of Salmonella typhi intermediate sensitivity to ceftriaxone and ceftazidime was reported to be high. Among the isolates of S paratyphi A, the resistance to nalidixic acid was 100% followed by 75% to ciprofloxacin. No resistance was found to chloramphenicol, ceftriaxone, cefixime, amikacin and low resistance to amoxicillin and ofloxacin. Among the sensitive isolates of S paratyphi A, majority of them were only moderately sensitive to cefotaxime and ceftazidime and about 1/3 of the organisms had only intermediate sensitivity to ceftriaxone. Conclusiion: Commonly used parenteral third generation cephalosporins, first line drugs like chloramphenicol and amoxicillin and ofloxacin among fluoroquinolones were found to be effective in vitro in treating enteric fever. However, Salmonella typhi was found to be highly resistant to the most frequently used drugs like ciprofloxacin and cefixime and Salmonella paratyphi A to ciprofloxacin. A comparative chart of antimicrobial sensitivity of enteric fever in children over 10 year period from different hospitals of Kathmandu valley is also presented in the study. DOI: http://dx.doi.org/10.3126/jnps.v32i3.6625 J. Nepal Paediatr. SocVol.32(3) 2012 221-228

scholarly journals Antimicrobial Resistance ofSalmonella entericaSerovars Typhi and Paratyphi Isolates from a General Hospital in Karawaci, Tangerang, Indonesia: A Five-Year Review

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Nata Pratama Hardjo Lugito ◽  
Cucunawangsih
Keyword(s):  
Antimicrobial Resistance ◽  
General Hospital ◽  
Enteric Fever ◽  
Adult Population ◽  
Public Health Problem ◽  
Resistance Pattern ◽  
Global Public Health ◽  
Prevalent Disease ◽  
Paratyphoid Fever ◽  
Resistance Rates

Typhoid and paratyphoid fever known as enteric fever pose important global public health problem, with 21.6 million cases and approximately 250,000 deaths annually. It is a prevalent disease in Indonesia, but data on the antimicrobial resistance pattern is limited. This study aim was to provide data on the antimicrobial resistance pattern ofS.Typhi andS.Paratyphi bloodstream isolates in a general hospital in Karawaci, Tangerang, Banten, Indonesia, during the period of January 2011 to December 2015. Susceptibility against antimicrobials was detected according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI). Out of a total of 168 isolates 55.4% wereS.Typhi and 44.6%S.Paratyphi A. Most of the isolates, 92.9%, were from children aged 6–18 years and adult population. There was low resistance ofS.Typhi against ampicillin, trimethoprim-sulfamethoxazole, ceftriaxone, ciprofloxacin, and levofloxacin, similar to previous studies in Indonesia. In the 2011–2015 period, resistance rates against most antimicrobials and MDR rate ofS.Typhi andS.Paratyphi were low, emphasizing that there is a distinct epidemiological dynamic of the enteric fever in Indonesia.

scholarly journals Epidemiology of Typhoid and Paratyphoid Fever in Kathmandu : Two Years Study and Trends of Antimicrobial Resistance

2005 ◽  
Vol 44 (157) ◽  
Author(s):  
S Malla ◽  
P Kansakar ◽  
Serichantalergs Serichantalergs ◽  
M Rahman ◽  
S Basnet
Keyword(s):  
Antimicrobial Resistance ◽  
Enteric Fever ◽  
Tetracycline Resistance ◽  
Salmonella Typhi ◽  
Multidrug Resistant ◽  
Resistance Pattern ◽  
Drug Resistant ◽  
Diffusion Technique ◽  
Plasmid Analysis ◽  
Paratyphoid Fever

Enteric fever is prevalent in developing countries including Nepal, where it still remains as a major healthproblem. Appropriate antibiotics are essential for the treatment of typhoid and paratyphoid fever. Aprospective study was carried out to characterize the epidemiological features of enteric fever in Kathmandu,Nepal and to analyse the recent trend of antimicrobial resistance pattern of the Salmonella isolated from thecases of enteric fever from different hospitals in Kathmandu during June, 2002 to June, 2004. A total of 1469Salmonella typhi and Salmonella paratyphi ‘A’ isolates collected during this period from five different hospitallaboratories situated in Kathmandu were studied. The antimicrobial susceptibilities of the isolates towardsAmpicillin (10mcg), Chloramphenicol (30mcg), Cotrimoxazole (25mcg), Ciprofloxacin (5mcg) and Ceftriaxone(5mcg) were determined by standard disc diffusion technique and Agar dilution technique were used todetermine the minimum inhibitory concentration (MIC) for Ampicillin, Ciprofloxacin, Chloramphenicoland Ceftriaxone. All the isolates tested were found to be sensitive to Ceftriaxone and Ciprofloxacin, the mostcommonly used antibiotic for treatment of enteric fever in Nepal. Of the total isolates studied, 15.5% from2002, 8% from 2003 and 3.45% from 2004 were found to be multidrug resistant (exhibiting resistance towardsAmpicillin, Chloramphenicol and Cotrimoxazole). Of the total multi drug resistant Salmonella isolates, 92%were Salmonella typhi. All the multidrug resistant isolates were also further tested for susceptibilities towardsTetracycline (30mcg), Nalidixic acid (30 mcg), Streptomycin (10units), Gentamycin (25mcg), Azithromycin(15mcg), Kanamycin (30mcg), Neomycin (30mcg). 50% of the multi drug resistant Salmonella typhi werealso resistant to Tetracycline. Plasmid analysis revealed that all of the Mutidrug resistant Salmonella typhiisolates with Tetracycline resistance harbored a large molecular weight (147 Kb) plasmid.Key Words: Enteric fever, Salmonella, Antibiotic, Plasmid, Multidrugresistant

Bacterial aetiology and antimicrobial resistance of community-acquired pneumonia in the elderly and younger adults

2010 ◽  
Vol 40 (2) ◽  
pp. 89-91 ◽  
Author(s):  
Seyyed Hamid Hashemi ◽  
Golnoosh Soozanchi ◽  
Shirin Jamal-Omidi ◽  
Rasoul Yousefi-Mashouf ◽  
Mojgan Mamani ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
General Trend ◽  
The Elderly ◽  
Community Acquired Pneumonia ◽  
Resistance Pattern ◽  
Age Group ◽  
Younger Adults ◽  
Streptococcus Pneumonia ◽  
Bacterial Aetiology ◽  
And Staphylococcus Aureus

This study was undertaken in order to compare the frequency of bacterial agents of community-acquired pneumonia (CAP) and their antimicrobial resistance in the elderly and younger adults admitted to a teaching hospital in Hamedan, Iran. A total of 150 cases of CAP, including 81 elderly and 69 younger adults, were evaluated. The most frequently identified pathogens in younger adults were Moraxella catarralis (11.5%), Streptococcus pneumonia (10.1%) and Staphylococcus aureus (10.1%); while in the elderly the most frequent were S. pneumonia (12.3%), S. aureus (6.1%) and Pseudomonas aeruginosa (6.1%). No significant differences were observed between the frequency and antimicrobial resistance pattern of isolated pathogens in either age group. We concluded that the cause of CAP in the elderly follows the general trend of infection in the younger population. Increased resistance of isolated bacteria to the current antibiotics highlights the need for further investigation of newer antibiotics for the treatment of CAP.

scholarly journals Trends in Epidemiology, Susceptibility Pattern and Serotypes of Salmonellae at a Tertiary Care Hospital, India: An Eight-Year Study (2011 – 2018)

2019 ◽  
pp. 1-6
Author(s):  
Swati Mudshingkar ◽  
Meghna Palewar ◽  
Vaishali Kongre ◽  
Anju Kagal ◽  
Renu Bhardwaj ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Enteric Fever ◽  
Tertiary Care ◽  
Salmonella Typhi ◽  
Etiological Agent ◽  
Resistance Pattern ◽  
Central Research ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Paratyphi B

Background: Enteric fever is a global disease. In India, Enteric fever is endemic with Salmonella enterica serovar typhi being the predominant etiological agent. Due to changing antimicrobial resistance patterns, knowledge of local epidemiology, antimicrobial resistance pattern helps in the initiation of appropriate empiric therapy. Methodology: A prospective study on Salmonellae isolated from blood and stool specimens over an 8 year period was conducted. Antimicrobial susceptibility was done as per The Clinical & Laboratory Standards Institute (CLSI) guidelines. Serotyping was done by using commercial antisera and later confirmed at Central Research Institute, Kasauli. Results: Out of 52 salmonellae, 43 (82.6%) were from blood and 8 (15.3%) from stool and 1 (1.9%) from pus specimen. We observed a change in spectrum and susceptibility pattern of salmonellae the 8 year study period. In 2011, 2013, 2016 and 2018, Salmonella typhi (serotype-9,12,vi:d:-) was the predominant etiological agent accounting for 81.8% , 66.6%, 51% and 80% of the total cases of salmonella respectively. Salmonella Paratyphi B (4,12:b:1,2) was predominant in 2012 (100% of cases). Salmonella Serotype Typhimurium (4,12;i:1,2) was predominant in 2014 (50%) while Salmonella typhi and S. paratyphi B contributed equally to infections in 2015 (40% each). From 2011, Non-typhoidal salmonellae (NTS) steadily increased. 19 (36.6%).The most effective antimicrobials against typhoidal salmonellae were chloramphenicol, ceftriaxone and co-trimoxazole with all most 100% sensitivity from 2011 to 2018. Ciprofloxacin maintained good sensitivity in 2013, 2014 and 2015, 2016 and 2018 but ampicillin was ineffective in our set-up. Conclusions: Due to changing trends in spectrum and sensitivity of salmonellae, continuous monitoring is essential.

scholarly journals Antimicrobial Resistance in Typhoidal Salmonella in Nepal: Surveillance for Enteric Fever, 2016-2019

2021 ◽  
Vol 19 (1) ◽  
pp. 162-169
Author(s):  
Rajeev Shrestha ◽  
Navin Adhikari ◽  
Sailesh Pradhan ◽  
Ritu Amatya ◽  
Basudha Shrestha ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Enteric Fever ◽  
Current Trend ◽  
Salmonella Typhi ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Asian Countries ◽  
First Line ◽  
The Status ◽  
Culture Positive

Background: Enteric fever (caused by Salmonella enterica) has been associated with poor hygiene and is endemic in the South-Asian countries. The increase in resistance to first line antimicrobials has been observed, while the emergence of multi/extremely drug resistance cases have been identified in several countries. The objective of this study is to analyze the current trend of antimicrobial resistance in Salmonella isolates in Nepal, and to identify the status of multi- and extremely- drug resistant isolates.Methods: We recruited individuals at study hospitals with suspected enteric fever between September 2016 and August 2019 and performed blood cultures. The Salmonella isolates were tested for antimicrobial susceptibility and the antimicrobial resistance trend was evaluated.Results: 1438 positive blood culture isolates were studied for antimicrobial resistance. 88% were culture positive for Salmonella Typhi and 12% for Salmonella Paratyphi. Multidrug resistant S. Typhi cases appeared mostly in December 2018 and January 2019, while there were no multidrug resistant S. Paratyphi cases. Also, extremely drug resistant S. Typhi cases were not observed during the study period. Conclusions: The Salmonella isolates were mostly susceptible to first-line antimicrobials, cephalosporins and others. Many fluoroquinolones non-susceptible Salmonella were obtained, nevertheless their overall trend seems to be declining. In addition, the S. Paratyphi total cases are reducing since September 2017. Among S. Typhi isolates, only few were multidrug resistant and there were no extremely drug resistant isolates. Keywords: Antimicrobial resistance; enteric fever; multi-drug resistant; Nepal; Salmonella; typhoid

ANTIMICROBIAL SUSCEPTIBILITY IN CULTURE POSITIVE ENTERIC FEVER

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Manish Kulshrestha ◽  
Dr. Anjali Kulshrestha
Keyword(s):  
Bone Marrow ◽  
Blood Culture ◽  
Nalidixic Acid ◽  
Antimicrobial Susceptibility ◽  
Salmonella Enterica ◽  
Enteric Fever ◽  
Multidrug Resistant ◽  
Bone Marrow Culture ◽  
Diffusion Method ◽  
Culture Positive

INTRODUCTION: Enteric fever includes typhoid and paratyphoid fever. Peak incidence is seen in children 5–15 years of age; but in regions where the disease is highly endemic, as in India, children younger than 5 years of age may have the highest infection rates. There are about 22 million new typhoid cases occur each year. Young children in poor, resource limited areas, who make up the majority of the new cases and there is a mortality figures of 215,000 deaths annually. A sharp decline in the rates of complications and mortality due to typhoid fever is observed as a result of introduction of effective antibiotic therapy since 1950s. MDR-ST became endemic in many areas of Asia, including India soon after multidrug-resistant strains of Salmonella enterica serotype typhi (MDR-ST) that were resistant to all the three first-line drugs then in use, namely chloramphenicol, amoxycillin and co-trimoxazole emerged in early 1990s. MATERIAL AND METHODS: Only blood culture or bone marrow culture positive cases were included. The patients with culture isolated enteric fever were included in the study. Antimicrobial susceptibility testing was carried out by disk diffusion method using antibiotic discs. The analysis of the antimicrobial susceptibility was carried out as per CLSI interpretative guidelines. RESULTS: A total of 82 culture positive cases were included in the present study. 80 culture isolates were from blood culture and 2 from the bone marrow culture. Salmonella entericasubspecies enterica serovartyphi (S typhi) was isolated from 67 (81.70%) patients while Salmonella enterica subspecies entericaserovarparatyphi (S paratyphi A) was isolated from 13 (15.85%) cases and 2 (2.44%) were Salmonella enterica subspecies entericaserovarschottmuelleri (S paratyphi B). Of the 82 cases 65(79.3%) isolates were resistant to ciprofloxacin, 17 (20.7%) were resistant to nalidixic acid, one (1.2%) case each was resistant to Cefotaxime and ceftriaxone, 2 (2.4%) were resistant to chloramphenicol, 10 (12.2%) were resistant and to cotrimoxazole 3 (3.7%) were resistant. CONCLUSION: In a culture positive cases 65(79.3%) isolates were resistant to ciprofloxacin and 17 (20.7%) were resistant to nalidixic acid. Multidrug resistant isolates were 65(79.3%).

Pharyngeal gonorrhoea in men who have sex with men

2021 ◽  
pp. 095646242097562
Author(s):  
Daniel Richardson ◽  
Alice Pickering ◽  
Daniel Trotman ◽  
Kayleigh Nichols ◽  
Zoe Buss ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Sore Throat ◽  
Routine Screening ◽  
Transmission Dynamics ◽  
Hiv Status ◽  
Sex With Men ◽  
Culture Positive

Pharyngeal gonorrhoea is important in the transmission dynamics of gonorrhoea, and generation of antimicrobial resistance and the performing of culture remains vital. We reviewed the notes of men who have sex with men (MSM) presenting to our clinic with a positive pharyngeal NAAT for gonorrhoea between January and December 2019. There were 383 cases of NAAT-positive pharyngeal gonorrhoea, and 28 (7%, 95% CI = 5.11–10.36) reported sore throat at presentation. Pharyngeal cultures were taken from 270/383 (70%), and 73/270 (27%) were culture positive with available antimicrobial sensitivities. Overall, the presence of pharyngeal symptoms was not associated with pharyngeal chlamydia (OR = 1.6, CI = 0.19–13.32, p = 0.7), HIV status (OR = 1.1, CI = 0.47–2.57, p = 0.8), positive cultures (OR = 1.9, CI = 0.78–4.62, p = 0.2) or age ( p = 0.3). Routine screening of MSM for pharyngeal gonorrhoea is important to maintain surveillance and measures need to be taken to improve pharyngeal culture sampling from MSM.

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