Basal cell carcinoma trends in Thailand: a 10-year retrospective study of demographic, clinical and histopathological features

Background: Basal cell carcinoma (BCC) is the most common skin cancer with globally increasing incidence. To date, the information regarding BCC in Thailand is limited.Objective: To evaluate the demographic, clinical, histopathological trends of BCC and other contributing factors.Methods: We retrospectively reviewed the demographic, clinical and histological data of all BCC outpatients from January 2009 to December 2018.Results: From 278 BCC patients recruited to this study, most of them (71.6%) were older than 60 years old. The most common histological subtype was nodular BCC (63.3%). A statistically significant association was observed between histological variant and location of the tumor; H and M area were associated with nodular BCC, L area was related to superficial subtype (p-value < 0.001). Misdiagnosis of BCC was observed in 53 cases, mostly as melanocytic nevus (30.2%), and about quarter (26.4%) was made by board-certified dermatologists.Conclusions: Nodular BCC is significantly associated with H and M area, while superficial subtype is related to L location. Quarter of the patients already have large tumors at their first presentation. Misdiagnosis of BCC is not uncommon.

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Use of Cytology in the Diagnosis of Basal Cell Carcinoma Subtypes

Journal of Clinical Medicine ◽

10.3390/jcm9030612 ◽

2020 ◽

Vol 9 (3) ◽

pp. 612

Author(s):

Paola Pasquali ◽

Gonzalo Segurado-Miravalles ◽

Mar Castillo ◽

Ángeles Fortuño ◽

Susana Puig ◽

...

Keyword(s):

Retrospective Study ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Inverse Correlation ◽

Basal Cells ◽

White Population ◽

First Line ◽

Common Skin ◽

Cytological Features

Background: Basal cell carcinoma (BCC) is the most common skin cancer in the white population. Nonsurgical treatments are first-line alternatives in superficial BCC (sBCC); therefore, differentiating between sBCC and non-sBCC is of major relevance for the clinician. Scraping cytology possesses several advantages, such as an earlier diagnosis and scarring absence, in comparison to a biopsy. Nevertheless, previous studies reported difficulties in differentiating the different BCC subtypes. The objective of this study was to determine the capability and accuracy of scraping cytology to differentiate between sBCC and non-sBCC. Methods: In this retrospective study, cytological samples of histologically confirmed BCC were examined. Select cytological features were correlated to BCC subtypes (sBCC or non-sBCC). Results: A total of 84 BCC samples were included (29 sBCC; 55 non-sBCC). An inverse correlation between the diagnosis of sBCC and the presence of mucin, dehiscence, and grade of atypia in the basal cells was observed. The presence of medium and large basal cell clusters correlated directly to a sBCC diagnosis. The presence of clear cells is strongly associated with sBCC. Therefore, Conclusion: Scraping cytology is reliable in differentiating sBCC from other BCC subtypes.

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Histopathological spectrum of skin diseases in a tertiary skin health and referral centre

Journal of Pathology of Nepal ◽

10.3126/jpn.v9i1.23172 ◽

2019 ◽

Vol 9 (1) ◽

pp. 1434-1440 ◽

Cited By ~ 1

Author(s):

Ram Chandra Adhikari ◽

Mahesh Shah ◽

Anjani Kumar Jha

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Skin Diseases ◽

Fungal Infections ◽

Melanocytic Nevus ◽

Skin Tumors ◽

Referral Centre ◽

Common Skin ◽

Frequent Site

Background: Skin diseases are very much prevalent in the developing countries. The pattern of skin diseases varies from country to country and even region to region within a country. The histological diagnosis is used by clinicians to aid in the management of patients & most appropriate clinical interventions. Materials and methods: The study included a total of 1040 skin biopsies from January 2016 to December 2018 in the department of pathology, DI skin health and referral centre, Kathmandu, Nepal. Results: The majority of the patients were in the age group of 31-40 years. The most common skin disease is non-infectious vesicobullous and vesicopustular disease (28.6%), followed by non-infectious erythematous papular and squamous disease (25.9%). The most common vesicobullous disease is spongiotic dermatitis (84.8%). Erythema dyschromicum perstans (31.8%) is the commonest non-infectious erythematous papular and squamous disease. The most common microbial disease is fungal infection, followed by leprosy. Among the neoplastic diseases of skin, tumors of epidermis are commonest diseases and the most common epidermal tumor is basal cell carcinoma. The commonest tumor of skin is melanocytic nevus. The most frequent site is upper extremities. Conclusions: Eczema is predominating non-infectious vesicobullous and vesicopustular disease. A relatively higher, prevalence of fungal infections was observed. Basal cell carcinoma is the commonest epidermal tumor and melanocytic nevus is commonest of all skin tumors.

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BOWENOID BASAL CELL CARCINOMA OF THE THUMB: A CASE REPORT AND REVIEW OF THE LITERATURE

Hand Surgery ◽

10.1142/s0218810402001060 ◽

2002 ◽

Vol 07 (02) ◽

pp. 295-298 ◽

Cited By ~ 3

Author(s):

M. Galeano ◽

M. Colonna ◽

M. Lentini ◽

F. Stagno D'Alcontres

Keyword(s):

Case Report ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Basal Layer ◽

Rare Entity ◽

Review Of The Literature ◽

Skin Malignancy ◽

Root Sheath ◽

Common Skin

Basal cell carcinoma (BCC) is the most common skin malignancy arising from cells of the basal layer of the epithelium or from the external root sheath of the hair follicle. BCC of the digit is a rare entity. The article presents one such case of bowenoid BCC of the thumb which required amputation at the MP joint.

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Agreement between histological subtype on punch biopsy and surgical excision in primary basal cell carcinoma

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/j.1468-3083.2012.04608.x ◽

2012 ◽

Vol 27 (7) ◽

pp. 894-898 ◽

Cited By ~ 33

Author(s):

M.H. Roozeboom ◽

K. Mosterd ◽

V.J.L. Winnepenninckx ◽

P.J. Nelemans ◽

N.W.J. Kelleners-Smeets

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Surgical Excision ◽

Punch Biopsy ◽

Histological Subtype

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Basal Cell Carcinoma on the Sole: An Easily Missed Cancer

Case Reports in Dermatology ◽

10.1159/000450697 ◽

2016 ◽

Vol 8 (3) ◽

pp. 283-286 ◽

Cited By ~ 4

Author(s):

Natalie L. Hone ◽

Radhika Grandhi ◽

Adam A. Ingraffea

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Significant Risk ◽

Significant Risk Factor ◽

The Sun ◽

Common Skin ◽

Ultraviolet Ray ◽

Solar Ultraviolet ◽

Sole Of The Foot

Basal cell carcinoma (BCC) is the most common skin cancer, and solar ultraviolet ray exposure is the most significant risk factor for its development. The plantar foot is infrequently exposed to the sun, thus the presence of BCC on the sole is rare. We report a case of BCC on the sole of the foot and its treatment in the hope to facilitate its detection.

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Basal cell carcinoma- a prospective clinico epidemiological and pathological study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20172475 ◽

2017 ◽

Vol 5 (6) ◽

pp. 2712 ◽

Cited By ~ 2

Author(s):

V. Ammasaigoundan ◽

V. N. S. Ahamed Shariff ◽

A. Ramesh

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Health Workers ◽

Tertiary Care ◽

Malignant Tumour ◽

Care Hospital ◽

Female Ratio ◽

Histological Variant ◽

Public Health Workers

Background: Basal cell carcinoma is the most common malignant tumour of the skin worldwide. The objective was to find out the age and sex incidence of basal cell carcinoma in patients attending the outpatient department of dermatology and to find out the various clinical and histopathological features of basal cell carcinoma.Methods: It was a prospective observational study carried out in a tertiary care hospital, Chennai, Tamilnadu, India. Patients with clinical diagnosis of basal cell carcinoma were included in the study after thorough history, clinical examination, routine and special investigations like skin biopsy.Results: Out of 20 patients with basal cell carcinoma 6 were males and 14 were females with a male to female ratio of 1:2.33. Most commonly affected age group was 50-70 years (70%). Distribution of BCC in our study was confined to head and neck area. Most common morphological subtype encountered in this study was nodular/nodulo-ulcerative BCC (70%), followed by pigmented type (25%) and superficial BCC (5%). The most common histological variant observed in present study was nodular type (55%), followed by pigmented variant (25%), adenoid (5%), basisquamous (5%), superficial BCC (5%) and BCC with sebaceous differentiation (5%).Conclusions: This study highlights a paradoxically increasing trend of BCC with female predilection. Early detection and treatment of lesions are crucial to decrease the functional and cosmetic disfigurement and also this study highlights the importance of improving awareness among general practitioners, public health workers and general population.

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Dermoscopic Features of Basal Cell Carcinoma

Acta Facultatis Medicae Naissensis ◽

10.2478/afmnai-2018-0029 ◽

2018 ◽

Vol 35 (4) ◽

pp. 273-281

Author(s):

Danica Tiodorović ◽

Andrija Jović ◽

Danijela Popović ◽

Hristina Kocić ◽

Aleksandra Ignjatović ◽

...

Keyword(s):

Retrospective Study ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Basal Cell ◽

Skin Tumors ◽

Clinical Type ◽

Reliable Diagnosis ◽

The Moment

Abstract The aim of this study was to analyze the dermoscopic features in patients with pathohistologically confirmed basal cell carcinoma (BCC). Our retrospective study included 54 patients with 76 BCCs in total, diagnosed in 2016 and 2017. All lesions were classified into four clinical types: nodular, pigmented, superficial and infiltrative. Digital dermoscopic images were evaluated by three observers. We selected five dermoscopic features for analysis, including: the absence of pigment network, the presence of arborizing vessels, blue-gray globules and ovoid nests, leaf-like areas and ulcerations. In the total of 54 patients, there were 22 females and 32 males. At the moment of establishing the diagnosis, the patients’ age was in the range from 31 to 84 years (median age 67 years). The most frequent clinical type was the nodular type with 28 confirmed diagnoses. Nodular BCC was more frequently localized on the head and neck areas compared to the trunk and limbs (p < 0.01). Dermoscopically, the absence of pigmented network was verified in all cases. Arborizing vessels were present in 71 (93.4%) lesions, blue-gray globules and ovoid nests in 33 (42.1%), ulcerations in 44 (57.9%), and leaf-like areas in 5 (6.6%) lesions. Blue-gray globules and ovoid nests were significantly frequent in pigmented BCC in comparison to other clinical types of BCC (p < 0.01). In conclusion, using dermoscopy, it is entirely possible to make a reliable diagnosis of BCC as well as to differentiate it from others skin tumors.

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Single versus Multiple Level Sectioning for the Subtyping of Basal-Cell Carcinoma: A Retrospective Study

Dermatology ◽

10.1159/000503320 ◽

2019 ◽

Vol 236 (3) ◽

pp. 237-240 ◽

Cited By ~ 1

Author(s):

Lieke C.J. van Delft ◽

Patty J. Nelemans ◽

Myrurgia Abdul Hamid ◽

Nicole W.J. Kelleners-Smeets

Keyword(s):

Retrospective Study ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Primary Outcome ◽

Punch Biopsy ◽

Appropriate Treatment ◽

Treatment Objective ◽

Optimal Approach ◽

Single Versus

Background: The histological subtype of basal-cell carcinoma (BCC) is often based on a punch biopsy; only a small part is evaluated, possibly leading to misclassification. Consensus on the optimal approach to process punch biopsies is lacking, though accurate subtyping is important for appropriate treatment. Objective: The aim is to investigate whether evaluating 4 levels of a punch biopsy instead of 1 or 2 levels leads to more accurate subtyping of BCC. Methods: In a retrospective study we evaluated 87 punch biopsies of histologically confirmed BCCs. The primary outcome was the proportion of “more aggressive” BCCs (nonsuperficial vs. superficial, infiltrative vs. nodular subtype) that was missed by evaluation on 1 or 2 levels, using 4-level diagnosis as reference standard. Results: Eighty-five cases were available for analysis. Subtyping based on 1 level resulted in discrepancies with 4-level diagnosis in 16.5% of all cases. Underdiagnosis occurred in 14 of 58 nonsuperficial BCCs (24.1%, 95% CI: 13.9–37.2). Seven of 38 nodular BCCs (18.4%, 95% CI: 7.74–34.3) were diagnosed as superficial in 1 level, and 7 of 20 infiltrative BCCs (35%, 95% CI: 15.4–59.2) were diagnosed as superficial (n = 2) or nodular (n = 5) in 1 level. Conclusion: In order to maximize correct subtyping and plan appropriate treatment, we advise to evaluate at least 2, but preferably more, levels of a punch biopsy to determine the BCC subtype.

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