scholarly journals Vascular anomalies in the mesenteric circulation of patients with Crohn’s disease: a pilot study

2017 ◽  
Vol 6 (2) ◽  
Author(s):  
Matilde Zamboni ◽  
Maria Grazia Sibilla ◽  
Roberto Galeotti ◽  
Massimo Pedriali ◽  
Simona Ascanelli
Keyword(s):  
Crohn’S Disease ◽  
Pilot Study ◽  
Crohn's Disease ◽  
Vascular System ◽  
Current Treatment ◽  
Small Sample ◽  
Vascular Anomalies ◽  
Chronic Inflammatory Bowel Disease ◽  
Mesenteric Circulation ◽  
Inflammatory Bowel

Crohn’s disease (CD) is a chronic inflammatory bowel disease and its pathogenesis is still not well understood. Previous studies suggested the possibility of the involvement of vascular system, but, todate, the mesenteric circulation has poor been investigated, especially in complicated CD cases requiring colectomy. We investigated the mesenteric circulation in a case-control pilot study, including 19 controls and 7 patients affected by complicated cases of CD. Cases and controls underwent selective angiography of both superior and inferior mesenteric district. Transit time was found either significantly shortened in 2/7 cases (29%), or prolonged 5/7 (71%) (P=0.0034 in the superior mesenteric district; P=0.0079 in the inferior mesenteric district), respectively due to the presence of A-V malformations and of a miscellaneous of venous abnormalities, which included thrombosis, hypoplasia and extra-truncular venous malformations. Our study demonstrates the presence of congenital or acquired vascular anomalies in a small sample of CD patients not responder to current treatment and with severe complications. The present pilot study warrants further investigations.

scholarly journals Crohn’s Disease Remission with a Plant-Based Diet: A Case Report

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1385 ◽  
Author(s):  
Kelsea Sandefur ◽  
Hana Kahleova ◽  
Alan N. Desmond ◽  
Eden Elfrink ◽  
Neal D. Barnard
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Remission ◽  
Chronic Inflammatory Bowel Disease ◽  
Standard Medical Therapy ◽  
Westernized Diet ◽  
Inflammatory Bowel ◽  
Maintenance Of Remission ◽  
Vegetables And Fruits ◽  
Diet And Lifestyle

Crohn’s disease (CD) is a form of chronic inflammatory bowel disease (IBD). The etiology of CD is thought to be multi-factorial; genetic factors, dietary and environmental exposures, immune events, and dysfunction of the gut microbiome are all though to play a role. The prevalence of CD is increasing globally and is higher in countries with a Westernized diet and lifestyle. Several human trials have demonstrated that plant-based dietary therapies may have utility in both the treatment of acute CD flares and the maintenance of remission. This case study describes a young adult male with newly diagnosed CD who failed to enter clinical remission despite standard medical therapy. After switching to a diet based exclusively on grains, legumes, vegetables, and fruits, he entered clinical remission without need for medication and showed no signs of CD on follow-up colonoscopy.

scholarly journals Exercise and Crohn’s Disease: Speculations on Potential Benefits

2006 ◽  
Vol 20 (10) ◽  
pp. 657-660 ◽  
Author(s):  
Victor Ng ◽  
Wanda Millard ◽  
Constance Lebrun ◽  
John Howard
Keyword(s):  
Physical Activity ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gastrointestinal Symptoms ◽  
The United States ◽  
Chronic Inflammatory Bowel Disease ◽  
Potential Benefits ◽  
Patient Groups ◽  
Inflammatory Bowel ◽  
Low Intensity Exercise

Crohn’s disease (CD) is a chronic inflammatory bowel disease that affects nearly one million people in the United States and Canada. While current pharmaceutical treatments are effective in controlling symptoms, patients continue to experience a reduced quality of life (QOL). Based on preliminary studies, QOL in CD patients may be improved by engaging in physical activity. Exercise may decrease CD activity and reduce psychological stress. Current research also suggests that low-intensity exercise does not exacerbate gastrointestinal symptoms and does not lead to flare-ups. Furthermore, exercise appears to reduce CD symptoms and improve QOL. In summary, physical activity may be beneficial to certain patient groups, but more studies are needed before broad recommendations can be made.

scholarly journals Nutritional Treatment in Crohn’s Disease

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1628
Author(s):  
Giacomo Caio ◽  
Lisa Lungaro ◽  
Fabio Caputo ◽  
Eleonora Zoli ◽  
Fiorella Giancola ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Recent Progress ◽  
Chronic Inflammatory Bowel Disease ◽  
Nutritional Treatment ◽  
Research Fields ◽  
Wide Range ◽  
Inflammatory Bowel ◽  
Chronic Inflammatory Bowel

Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) which can affect any part of the whole gastrointestinal tract (from mouth to anus). Malnutrition affects 65–75% of CD patients, and it is now well acknowledged that diet is of paramount importance in the management of the disease. In this review, we would like to highlight the most recent findings in the field of nutrition for the treatment of CD. Our analysis will cover a wide range of topics, from the well-established diets to the new nutritional theories, along with the recent progress in emerging research fields, such as nutrigenomics.

scholarly journals Herb-partitioned moxibustion alleviates colonic inflammation in Crohn’s disease rats by inhibiting hyperactivation of the NLRP3 inflammasome via regulation of the P2X7R-Pannexin-1 signaling pathway

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252334
Author(s):  
Ji Zhang ◽  
Xue-jun Wang ◽  
Li-jie Wu ◽  
Ling Yang ◽  
Yan-ting Yang ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Signaling Pathway ◽  
Nlrp3 Inflammasome ◽  
Chronic Inflammatory Bowel Disease ◽  
Colonic Inflammation ◽  
Pannexin 1 ◽  
Inflammatory Bowel ◽  
First Time ◽  
Chronic Inflammatory Bowel

Crohn’s disease is a chronic inflammatory bowel disease and the NLRP3 inflammasome plays an important role in Crohn’s disease. Previous studies have shown that Herb-partitioned moxibustion treating (at Qihai (CV 6) and Tianshu (ST 25)) prevented the excessive activation of the NLRP3 inflammasome and repaired damaged colonic mucosa in Crohn’s disease. However, the mechanism by which Herb-partitioned moxibustion (at CV 6 and ST 25) regulates NLRP3 remains unclear. In this study, we treated Crohn’s disease rats with herb-partitioned moxibustion (at CV 6 and ST 25) to investigate the mechanism by which Herb-partitioned moxibustion regulates the colonic NLRP3 inflammasome by observing colon length, the colon macroscopic damage indexes, and the expression of ATP, P2X7R, Pannexin-1, NF-κBp65, NLRP3, ASC, caspase-1, IL-1β and IL-18 in the colon in Crohn’s disease. Here, this study shows that herb-partitioned moxibustion (at CV 6 and ST 25) can reduce colon macroscopic damage indexes and colon histopathological scores, alleviate colon shortening and block the abnormal activation of the NLRP3 inflammasome by inhibiting the ATP content and the expression of P2X7R, Pannexin-1 and NF-κBp65, thereby reducing the release of the downstream inflammatory cytokine IL-1β and ultimately suppressing colonic inflammation in Crohn’s disease rats. This study for the first time identifies the mechanism by which herb-partitioned moxibustion (at CV 6 and ST 25) may inhibit the abnormal activation of the NLRP3 inflammasome by inhibiting the P2X7R-Pannexin-1 signaling pathway in Crohn’s disease rats.

scholarly journals The role of TNF-alpha gene (-238G/A and -308G/A) polymorphisms in the etiology and pathogenesis of inflammatory bowel diseases in various ethnic groups

2019 ◽  
Vol 47 (6) ◽  
pp. 548-558
Author(s):  
I. V. Zhilin ◽  
E. Yu. Chashkova ◽  
A. A. Zhilina ◽  
B. S. Pushkarev ◽  
N. S. Korotaeva
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gene Polymorphism ◽  
Ethnic Groups ◽  
Small Sample ◽  
Tnf Α ◽  
Study Results ◽  
Inflammatory Bowel

This literature review deals with specifics of the natural course of inflammatory bowel disease (IBD) in patients from various ethnic groups and -308G/A and -238G/A promoter polymorphisms in tumor necrosis factor-alpha (TNF-α) gene. The search in PubMed, Medline, Еlibrary.ru databases has led to identify in total 20 studies, including 2 meta-analyses, on the role of TNF-α-308G/A and -238G/A gene polymorphism in the etiology and pathophysiology of IBD. The TNF-α-308G/A polymorphism is associated with increased secretion of this proinflammatory cytokine, whereas the TNF-α-238G/A genotype is characterized by reduced TNF-α secretion. A  number of studies have shown an association between TNF-α-308G/A gene polymorphism and severe course of IBD, requiring more active treatment of patients (cytostatics, corticosteroids, biological agents). Some investigators have found that the patients carriers of TNF-α-308G/A had a  higher probability of surgical interventions. The association between TNF-α-308G/A and the phenotypic characteristics of IBD has been identified in studies performed in Europe, Asia, and Russia. The association of this polymorphism with the prevalence of ulcerative colitis has been proven in some studies, in particular, in the Asian population. Similar associations have been noted in few publications originating from Europe and North America, while some studies have found no links between TNF-α-308G/A, -238G/A, and the course of IBD. TNF-α-238G/A gene polymorphism has not shown any significance for the prevalence and course of ulcerative colitis and Crohn's disease. One can assume that the differences in the study results arising from one and the same geographical area are related to genetic heterogeneity of the study groups, phenotypic variances between the study subjects, as well as relatively small sample sizes. Currently, the search for genetic, biochemical and other prognostic criteria for IBD course is in progress. There are studies in progress to investigate the mechanisms of transformation of the genetic information into the particulars of ulcerative colitis and Crohn's disease manifestations, with consideration of ethnicity.

P061 VALUE OF US AND MRE IMAGES IN THE DIAGNOSTICS OF ACTIVE CROHN’S DISEASE IN CHILDREN

2020 ◽  
Vol 26 (Supplement_1) ◽  
pp. S15-S16
Author(s):  
Monika Zbroja ◽  
Weronika Cyranka ◽  
Maryla Kuczynska ◽  
Monika Piekarska ◽  
Karolina Siejka ◽  
...  
Keyword(s):  
Small Intestine ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Active Phase ◽  
Chronic Inflammatory Bowel Disease ◽  
Inflammatory Infiltration ◽  
Inflammatory Reactions ◽  
Linear Probe ◽  
The Us ◽  
Inflammatory Bowel

Abstract Introduction Crohn’s disease is classified as chronic inflammatory bowel disease. The incidence of it in Europe ranges from 1 to almost 11.4 per 100,000 population per year. Ultrasound and magnetic resonance enterography examinations play an important role in imaging diagnostics of inflammatory bowel lesions. They allow for recognising and monitoring changes during therapy as well as assessing complications such as fistula or abscess. Materials and Methods 36 children were included in the study: 16 boys and 20 girls with an active phase of Crohn’s disease. Each patient underwent intestinal ultrasound examination with a high frequency 7–12 Mhz linear probe and MRE with intravenous administration of a contrast agent. Results All patients showed a significant correlation between ultrasound and MRE. In the US examination all children had thickened, low echogenic wall showing varying degrees of vascular flow signals. Additionally, in 8 patients Bauhin’ valve edema was visible. In 16 children, inflammatory infiltration of the periintestinal fat around the affected segment of the intestine was found. In all patients a mesenteric lymphadenopathy in the short axis of 10-15mm was visible. MRE confirmed the presence of the confirmed ideal lesions and Bauhin’ valve edema in all 36 children. In addition, in 4 patients small intestine fistulas were found whereas abscess was observed in another 4 patients. In contrast-enhanced images, a vivid enhancement of the affected bowel section was revealed and in 10 children inflammatory reactions of peri-intestinal fat was demonstrated. Conclusion US and MRE are reliable tools in diagnosis of enteric inflammatory disease of the small intestine, evaluation of disease activity and assessment of potential complications. They are complementary elements in diagnostics of Crohn’s disease.

scholarly journals Complete Genome Sequence of a Parabacteroides distasonis Strain (CavFT hAR46) Isolated from a Gut Wall-Cavitating Microlesion in a Patient with Severe Crohn’s Disease

2019 ◽  
Vol 8 (36) ◽  
Author(s):  
Falong Yang ◽  
Anand Kumar ◽  
Karen Walston Davenport ◽  
Julia Mae Kelliher ◽  
Jessica C. Ezeji ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Fistulous Tract ◽  
Chronic Inflammatory Bowel Disease ◽  
Content Type ◽  
Inflammatory Bowel ◽  
Chronic Inflammatory Bowel

Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) of the digestive tract in humans. There is evidence that Parabacteroides distasonis could contribute to IBD. Here, we present the complete genome sequence of a strain designated CavFT-hAR46, which was isolated from a gut intramural cavernous fistulous tract (CavFT) microlesion in a CD patient.

scholarly journals Kono-S Anastomosis for Crohn's Disease: Report of Two Cases

2017 ◽  
Author(s):  
Shohei Eto ◽  
Kozo Yoshikawa ◽  
Takashi Iwata ◽  
Jun Higashijima ◽  
Takuya Tokunaga ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Chronic Inflammatory Bowel Disease ◽  
Ileocecal Resection ◽  
Retroperitoneal Abscess ◽  
Anastomotic Site ◽  
Case Presentation ◽  
Handsewn Anastomosis ◽  
Inflammatory Bowel ◽  
The Stability

Introduction: Crohn's disease (CD) is a chronic inflammatory bowel disease, which affect the entire gastrointestinal tract. Treatment basis for CD is medication to control the inflammation and relieve the symptoms. CD patients often require surgery at some points of their lifetime for complications, treatment-resistant, and side effects of medication. However, the postoperative recurrences are common. To reduce the anastomotic troubles, several types of anastomosis were investigated. Kono-S anastomosis, an antimesenteric functional end-to-end handsewn anastomosis, was introduced in order to prevent the restenosis caused by the recurrence of CD in 2010. Kono-S anastomosis is expected lower susceptibility to mechanical distortions due to the stability provided by the "supporting column". We herein report the two cases of CD which was performed Kono-S anastomosis. The important of these cases are that Kono-S anastomosis is useful to prevent the restenosis caused by the recurrence. Case presentation: The first patient was 26-year-old man, who had suffered from CD for 9 years. Computed tomography (CT) showed inflammation and stenosis at ileocecum, fistula between terminal ileum and sigmoid colon, and 3cm of intraperitoneal abscess. We performed ileocecal resection and Kono-S anastomosis. The second patient was 25-year-old woman who had suffered from CD for 8 years. CT showed inflammation and stenosis at ileocecum, and retroperitoneal abscess. We performed ileocecal resection and Kono-S anastomosis. Both patients don't have the recurrence after surgery. Conclusion: Kono-S anastomosis may be effective for preventing the recurrence at anastomotic site in CD patients.

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