scholarly journals Antimicrobial activity of stigmasterol from the stem bark of Neocarya macrophylla

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Amina J. Yusuf ◽  
Musa I. Abdullahi ◽  
Godwin A. Aleku ◽  
Ilyasu A.A. Ibrahim ◽  
Celestina O. Alebiosu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
Antifungal Agent ◽  
Stem Bark ◽  
Inhibitory Effect ◽  
Chemical Diversity ◽  
Antibacterial Drug ◽  
Candida Spp ◽  
Antimicrobial Drugs ◽  
Antibacterial And Antifungal

Background: Natural products play a significant role in human therapy. They represent a huge reservoir of bioactive chemical diversity and help in understanding the cellular pathways that are essential component of drug discovery process. Objective: This study was aimed at evaluating the antimicrobial activity of stigmasterol isolated from the stem bark of Neocarya macrophylla. Methods: Stigmasterol previously isolated from the stem bark of N. macrophylla was subjected to antimicrobial screening against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), S. aureus, Streptococcus faecalis, Escherichia coli, Salmonella typhimurium, Pseudomonas fluorescens, Klebsiella pneumoniae, Candida albicans and Candida krusei using agar diffusion and broth dilution methods. Results: Susceptibility test results showed that the compound (100 μg/mL) inhibited the growth of all the test organisms with mean zone of inhibition range from 23 mm to 30 mm except the VRE, S. typhi and K. pneumoniae. The activity of stigmasterol was compared with that of ciprofloxacin (5 μg/mL), the standard antibacterial drug, and fluconazole (5 μg/mL), the antifungal agent. The test compound displayed a broad-spectrum of activity, and in many cases exhibited comparable antibacterial activity when compared to ciprofloxacin. Interestingly, the compound also showed antifungal activity against Candida spp., affording comparable inhibitory effect as fluconazole. The minimum inhibitory concentration (MIC) and the minimum bactericidal/fungicidal concentration (MBC/MFC) of stigmasterol range from 6.25 μg/mL to 25 μg/mL and from 12.5 μg/mL to 50 μg/mL, respectively. Conclusion: These properties suggest that the isolated stigmasterol is a potent and broad-spectrum antibacterial and antifungal agent and as such may serve as a lead compound in the development of novel antimicrobial drugs.

scholarly journals Antimicrobial Activity ofLippiaSpecies from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Cristiana da Purificação Pinto ◽  
Velize Dias Rodrigues ◽  
Fernanda da Purificação Pinto ◽  
Renata da Purificação Pinto ◽  
Ana Paula Trovatti Uetanabaro ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Fungal Infections ◽  
Active Species ◽  
Semiarid Region ◽  
Antimicrobial Drugs ◽  
Promising Alternative ◽  
Popular Medicine ◽  
Antibacterial And Antifungal Activities ◽  
Methanolic Extracts ◽  
Antibacterial And Antifungal

Lippia origanoidesKunth,Lippia alnifoliaSchauer, andLippia thymoidesMartius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine.L. origanoidesleaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts; this activity was also confirmed by the MIC evaluation. The fractionation ofL. origanoidescrude extracts improved the activity in spectrum and intensity. The results obtained in this study indicate thatL. origanoidesmay be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs.

IBS Therapeutic has Broad Spectrum Antimicrobial Activity

2021 ◽  
Author(s):  
Ashley L. Cunningham ◽  
Orhi Esarte Palomero ◽  
Bradley J. Voss ◽  
M. Stephen Trent ◽  
Bryan W. Davies
Keyword(s):  
Antimicrobial Activity ◽  
Irritable Bowel Syndrome ◽  
Broad Spectrum ◽  
Enteric Pathogens ◽  
Drug Resistant ◽  
Antibacterial And Antifungal Activity ◽  
Resistant Strains ◽  
Irritable Bowel ◽  
Antibacterial And Antifungal ◽  
Drug Resistant Strains

Otilonium bromide is a poorly absorbed oral medication used to control irritable bowel syndrome. It is thought to act as a muscle relaxant in the intestine. Here we show that otilonium bromide has broad-spectrum antibacterial and antifungal activity, including against multi-drug resistant strains. Our results suggest otilonium bromide could act on enteric pathogens and may offer a new scaffold for poorly absorbed intestinal antimicrobial therapy.

Synthesis, antibacterial, and antifungal activities of new pyrimidinone derivatives

2015 ◽  
Vol 21 (4) ◽  
pp. 191-194 ◽  
Author(s):  
Oussama Cherif ◽  
Fatma Masmoudi ◽  
Fatma Allouche ◽  
Fakher Chabchoub ◽  
Mohamed Trigui
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
Pathogenic Fungi ◽  
Gram Negative Bacteria ◽  
Efficient Synthesis ◽  
Gram Negative ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal

AbstractAn efficient synthesis of new pyrrolopyrimidinones 3a-d and isoxazolopyrimidinones 4a-c from the respective aminocyanopyrroles 1a-d and aminocyanoisoxazoles 2a-c is presented. The synthesized compounds were screened for antimicrobial activity against a panel of bacteria and fungi. Compound 4c exhibits remarkable activity against a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi.

Antimicrobial activity of the extracts from fruits of Rumex L. species

2011 ◽  
Vol 6 (6) ◽  
pp. 1036-1043 ◽  
Author(s):  
Magdalena Wegiera ◽  
Urszula Kosikowska ◽  
Anna Malm ◽  
Helena Smolarz
Keyword(s):  
Total Content ◽  
Trichophyton Mentagrophytes ◽  
Inhibitory Effect ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Candida Spp ◽  
Gram Positive Bacteria ◽  
Agar Dilution ◽  
Anthracene Derivatives ◽  
Antibacterial And Antifungal

AbstractThis study was designed primarily to investigate the antibacterial and antifungal activity of the extracts from fruits of six Rumex L. species: R. acetosa L., R. acetosella L., R. confertus Willd., R. crispus L., R. hydrolapathum Huds. and R. obtusifolius L. The 7 Grampositive and 7 Gram-negative bacteria strains and 5 fungal ones were tested by agar and broth dilution method. Determination of minimal inhibitory concentration (MIC) revealed that the extracts from R. confertus, R. crispus, R. hydrolapathum and R. obtusifolius exerted differential inhibitory effect on the growth of Gram-positive bacteria — staphylococci (MIC=62.5–125 µg/mL) and Gramnegative bacteria — Escherichia coli ATCC 3521, Proteus mirabilis, Pseudomonas aeruginosa (MIC=125→500 µg/mL); MIC values determined by agar dilution method were somewhat higher. The same extracts inhibited also the growth of fungi — Candida spp. or Trichophyton mentagrophytes ATCC 9533 (MIC=250–500 µg/mL), as found by agar dilution method. The total content of polyphenols (11.66–78.36 mg/g), anthracene derivatives (0.26–12.93 mg/g) and tannins (4.00–11.16%) was also determined.

scholarly journals Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.

2021 ◽  
Vol 10 (15) ◽  
pp. e35101522434
Author(s):  
Bruno Bezerra Cavalcanti ◽  
Hermes Diniz Neto ◽  
Walicyranison Plinio da Silva-Rocha ◽  
Edeltrudes de Oliveira Lima ◽  
José Maria Barbosa Filho ◽  
...  
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Antifungal Agent ◽  
Antifungal Agents ◽  
Inhibitory Concentration ◽  
Inhibitory Effect ◽  
Antifungal Drugs ◽  
Additive Effects ◽  
Candida Spp ◽  
Minimum Fungicidal Concentration ◽  
Fungicide Activity

The aim of this study was to examine the effects of (-)-myrtenol alone and combined with antifungal agents against Candida spp. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration of (-)-myrtenol and fluconazole against C. albicans and C. parapsilosis strains was obtained using CLSI guidelines. Combination of (-)-myrtenol with antifungal drugs was determined by checkboard test. The (-) myrtenol showed MIC ranging from 256 to 512 µg/mL against both species assay. And the MFC was 512 µg/mL, demonstrated nature fungicidal (MFC/MIC < 4). In addition, combination of antifungal agents (amphotericin B and fluconazole) and (-) myrtenol showed synergistic and additive effects on strains assays. Based on these results, the present study demonstrates that (-) myrtenol showed strong fungicide activity against Candida spp. In addition, Combination of antifungal agents and (-) myrtenol reduces the effective concentrations of both the agents with synergistic to additive effects. Therefore, (-) myrtenol has potential to be developed into an antifungal agent.

Chemical Composition and Antimicrobial Activity of Essential oil from Scales of Moroccan Juniperus phoenicea

2021 ◽  
Vol 1 (30) ◽  
pp. 5-11
Author(s):  
M. Achir M. Dakir
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Antifungal Agent ◽  
Antibacterial Agent ◽  
Oil Composition ◽  
High Biological Activity ◽  
Juniperus Phoenicea ◽  
Total Oil ◽  
Antibacterial And Antifungal

Abstract-The essential oil of Juniperus phoenicea was obtained by hydrodistillation method using a Clevenger-type apparatus with a yield of 1.9 % and was analyzed by gas chromatography coupled to a mass spectrometer (GC-MS). Twelve volatile compounds were identified representing 99,85% of the total oil composition, while the α-pinene (78,31%), β-Myrcene (11,92%) and limonene (3,96%) were the major compounds. This essential oil was evaluated as an antibacterial and antifungal agent. The result showed that the oil presents a high biological activity as an antibacterial agent against the three tested strains Escherichia coli, Staphylococcus aureus and Pseudomonas aeroginos. It's also active as an antifungal agent against the Candida albicans with a zone inhibition of 28 mm. Keywords: Medicinal plant, Juniperus, phoenicea, Essential oil, Chemical composition, Antimicrobial activity.

scholarly journals Antibacterial property of crude extract from stem-bark and leaves of Rhizophora apiculata against selected bacterial fish pathogens

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Jalal, K.C.A. ◽  
Zaima Azira ◽  
Kamaruzzaman B.Y ◽  
Akbar John ◽  
Said Imaddudeen
Keyword(s):  
Antimicrobial Activity ◽  
Inhibition Zone ◽  
Stem Bark ◽  
Antibacterial Drug ◽  
Fish Feed ◽  
High Concentration ◽  
Fish Pathogens ◽  
Alternative Source ◽  
Rhizophora Apiculata ◽  
Wide Range

Introduction: Recently the wide range of commercial antibiotics in fish feed for aquaculture practices has led to antibacterial resistance, environmental pollution and residue build-up in fish tissue. Therefore new sources of antibiotics from natural sources need to be investigated to circumvent these problems. Rhizophora apiculata has been reported to have high antimicrobial activity due to the high concentration of tannin in the bark of the tree. Methods: Based on these contexts, this study was conducted to measure the antimicrobial activity of ethanol, ethyl acetate and distill water extracts from the stem-bark and the leaves of R. apiculata. 9 species of bacteria consist of B. subtilis, S. aureus, S. epidermidis, P.aeruginosa, P. mirabilis, H. alvei, V. alginolyticus, V. paraheamolyticus and E. coli were tested to measure their susceptibility to the extracts. The extracts were dissolved into 2 different concentrations which were 10 mg/mL and 50 mg/mL or 10 ug/disc and 50 ug/disc respectably, to determine the inhibitory effect of the extract upon the bacterial fish pathogen. Results: 2 species of Gram-positive bacteria which were B. subtilis and S. epidermidis have shown positive results with 9.0 mm to 16.0 mm of inhibition zone respectably while the other bacteria were resistant to the extract concentration administered. Conclusions: A continuous monitoring need to be carried out to comprehend the potential of Rhizophora apiculataas and other mangrove plants, which can be applied as an alternative source for environmental friendly antibacterial drug in pharmaceutical and aquaculture industries.

scholarly journals Synthesis, antibacterial and antifungal activity of 1-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts

2019 ◽  
pp. 56-62 ◽  
Author(s):  
Y. V. Korotkii ◽  
N. A. Vrynchanu ◽  
M. L. Dronova ◽  
Z. S. Suvorova ◽  
O. A. Smertenko
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Dilution Method ◽  
The Novel ◽  
Antibacterial And Antifungal Activity ◽  
Antimicrobial Drugs ◽  
Quaternary Salts ◽  
Resistant Strains ◽  
Antibacterial And Antifungal

The emergence and spread of resistant strains of pathogens as well as reduction of the efficacy of current antimicrobial agents requires the development of novel antimicrobial compounds. The aim of the present study was synthesis and evaluation of antimicrobial activity of new arylaliphatic aminopropanols. The objects of the present study were 1-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts (compounds I–XIV). Compounds synthesis was carried out by heating of precursor epoxide and excessive amount of appropriate amines in isopropanole, followed by treatment with excess of alkyl halides. Methods of elemental analysis, IR- and PMR-spectroscopy were used for confirmation of chemical structure. Antimicrobial activity against Staphylococcus аureus АTCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa АТСС 27853 and Candida albicans NCTC 885/653 was determined by a broth dilution method and evaluated via minimum inhibitory concentration (MIC). Our investigation of antibacterial and antifungal activity of 1-[4-(1,1,3,3-tetra methylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts showed that compounds possess narrow spectrum, as well as broad spectrum action. Significant antimicrobial activity of the novel aryl aliphatic aminoalcohols indicates their potential usage as a component of new antimicrobial drugs.

scholarly journals Antimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesy

2021 ◽  
Vol 2 (3) ◽  
pp. 27-33
Author(s):  
Nina VRYNCHANU ◽  
Yurii KOROTKIJ ◽  
Nataliia HRYNCHUK ◽  
Irina BOIKO ◽  
Elena SMERTENKO ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
High Efficiency ◽  
Gentian Violet ◽  
Inhibitory Effect ◽  
Chronic Infections ◽  
E Coli ◽  
External Stresses ◽  
Antibacterial And Antifungal ◽  
New Compounds ◽  
Adsorption Desorption

Introduction. The microbial biofilm-forming ability is one of the major aspects of the emerging issue of antibiotic resistance, which makes them tolerant to antibiotics and host defense systems and other external stresses, thus contributing to persistent chronic infections. A series of relevant studies confirmed the high efficiency of aminopropanol derivatives as potential antibacterial and antifungal agents. This present study was aimed to evaluate the antimicrobial activity of new 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivatives on the planktonic bacterial/fungal cells and biofilms. Material and methods. The minimum inhibitory concentrations (MIC) of the new compounds were determined by a standard method, along with their effects on biofilms estimated via the gentian violet adsorption-desorption assay.Results. The КVM-219 compound showed the most pronounced effect on planktonic bacterial and fungal cells. The MIC values ranged between 0.78 μg/mL to 12.5 μg/mL, depending on the microbial strain. The KVM-316 compound exhibited the strongest inhibitory effect on biofilms, thus preventing their formation by S. aureus (96.1%), E. coli (57.2%), and P. aeruginosa (96.1%). Conclusions. The 15 newly synthesized 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivatives revealed marked antibacterial and antifungal effects on planktonic microorganisms. Most of these compounds showed a strain-specific inhibition of biofilm formation by at least 50% for S. aureus 222, E. coli 311, P. aeruginosa 449 and C. glabrata 404 strains.

scholarly journals SYNTHESIS AND INVESTIGATION OF ANTIMICROBIAL ACTIVITY OF THE NEW CLASS OF ACYLHYDROSONES (QUINOLIN-8-YL) OF GLYCOLIC ACID

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
V.O. Chornous ◽  
A.M. Grosav ◽  
M.K. Bratenko ◽  
S.Ye. Deineka ◽  
О.І. Gavrilyuk
Keyword(s):  
Antimicrobial Activity ◽  
Glycolic Acid ◽  
Wide Spectrum ◽  
Research Synthesis ◽  
Modern Medicine ◽  
Antifungal Drugs ◽  
Antibacterial And Antifungal Activity ◽  
Antimicrobial Drugs ◽  
New Class ◽  
Antibacterial And Antifungal

Antibiotic resistance of pathogenic strains of microorganisms is one of the most difficultproblems of modern medicine. An effective way to solve it is the synthesis of new classesof antibacterial and antifungal drugs with a wide spectrum of antiseptic action.Purpose of the research – synthesis of the new types of glycolic acid acylhydrazones(quinolin-8-yl)and investigation of their antimicrobe activity.Material and methods. The analysis of their antibacterial and antifungal activity wascarried out and the dependence of the antimicrobial action of the synthesized drugson the structure of the molecule, the type of heterocyclic fragment and the type ofmicroorganisms was investigated.Results. It was proposed a convenient method for the synthesis of new types of acylhydrosones (quinolin-8-yl) glycolic acid, which is realized by condensation ofhydrozides (quinolin-8-yl) of glycolic acid with a series of heterocyclic aldehydes.Conclusion. The results obtained indicate that this class of compounds is promising aspotential antimicrobial drugs.

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