scholarly journals Antimicrobial Activity ofLippiaSpecies from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Cristiana da Purificação Pinto ◽  
Velize Dias Rodrigues ◽  
Fernanda da Purificação Pinto ◽  
Renata da Purificação Pinto ◽  
Ana Paula Trovatti Uetanabaro ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Fungal Infections ◽  
Active Species ◽  
Semiarid Region ◽  
Antimicrobial Drugs ◽  
Promising Alternative ◽  
Popular Medicine ◽  
Antibacterial And Antifungal Activities ◽  
Methanolic Extracts ◽  
Antibacterial And Antifungal

Lippia origanoidesKunth,Lippia alnifoliaSchauer, andLippia thymoidesMartius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine.L. origanoidesleaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts; this activity was also confirmed by the MIC evaluation. The fractionation ofL. origanoidescrude extracts improved the activity in spectrum and intensity. The results obtained in this study indicate thatL. origanoidesmay be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs.

scholarly journals Antimicrobial activity of aqueous methanolic extracts of Algerian cultivars of sorghum (Sorghum bicolor (L.) Moench)

2020 ◽  
Vol 7 (1) ◽  
pp. 71-85
Author(s):  
Kadri Farida ◽  
Boudjeniba Messaoud ◽  
Wathelet Bernard ◽  
Akkal Salah
Keyword(s):  
Antimicrobial Activity ◽  
Sorghum Bicolor ◽  
Diffusion Method ◽  
Minimal Inhibition Concentration ◽  
Antibacterial And Antifungal Activities ◽  
Microdilution Method ◽  
Methanolic Extracts ◽  
Mrsa Strains ◽  
Antibacterial And Antifungal ◽  
Sorghum Bicolor L

AbstractCertain phenolics have been recognized to possessing antibacterial and antifungal activities and high levels of flavonoids and tannins have been reported in several varieties of Sorghum bicolor (L.) Moench. Antimicrobial activity and phenolics contents were investigated in five Algerian sorghum seeds. AS20 sorghum extract showed the highest levels of: total phenolics (3214.46±263.64 mg/100 g), flavonoids (32.03±1.64 mg/100 g) and tannins (615.35±6.10 mg/g) contents; however, comparable flavonoids content was recorded in I27 extract. FZ40 and AS12 flavonoids contents were comparable. Screening for antimicrobial activity, carried out by the disc’s diffusion method revealed an antimicrobial potential of sorghum crude extracts against Gram-positive and Gram-negative bacteria and candida albicans yeast. Minimal inhibition concentration determined by microdilution method varied between 0.2 and 2 mg/ml. the lowest value was recorded with F11 and FZ40 extract against Streptococcus pneumoniae and F11 against Escherichia coli. Bacillus subtilis, Staphylococcus aureus ATTCC6538 and MRSA strains showed sensitivity to all extracts. The results show these sorghums as a potential source of natural anti-streptococcal, anti-staphylococcal and anti-candida substances.

In vitro Antimicrobial Activity of Plants used in Cambodian Traditional Medicine

2007 ◽  
Vol 35 (05) ◽  
pp. 867-873 ◽  
Author(s):  
Aun Chea ◽  
Marie-Caroline Jonville ◽  
Sok-Siya Bun ◽  
Michèle Laget ◽  
Riad Elias ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Traditional Medicine ◽  
Bactericidal Effect ◽  
Gram Positive Bacteria ◽  
Antibacterial And Antifungal Activities ◽  
Methanolic Extracts ◽  
Disk Diffusion Assay ◽  
Antibacterial And Antifungal ◽  
Diffusion Assay

The purpose of the present study was to screen 27 plant species used in the traditional medicine of Cambodia for in vitro antibacterial and antifungal activities. Thirty-three methanolic extracts were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium smegmatis and Candida albicans. Screened by disk diffusion assay, the extracts showed antimicrobial activity especially on Gram-positive bacteria. None of the crude methanolic extracts showed activity against P. aeruginosa. Twenty-five selected extracts were evaluated using a micro-dilution test. Harrisonia perforata (roots) and Hymenodictyon excelsum (bark) exhibited a bactericidal effect against S. aureus at a concentration of 500 μg/ml. Azadirachta indica (bark), Harrisonia perforata (roots and stem) and Shorea obtusa (roots) exhibited a bactericidal effect against M. smegmatis at 250 μg/ml.

scholarly journals Antimicrobial Activity of Polyphenols and Natural Polyphenolic Extracts on Clinical Isolates

Antibiotics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 46
Author(s):  
Tamara Manso ◽  
Marta Lores ◽  
Trinidad de Miguel
Keyword(s):  
Antimicrobial Activity ◽  
Antibiotic Resistance ◽  
Antimicrobial Agents ◽  
Fungal Infections ◽  
Clinical Isolates ◽  
World Health ◽  
Supporting Evidence ◽  
Promising Alternative ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities

Antibiotic resistance is a growing global problem that affects people, animals, the environment, and the economy. Many clinically relevant bacteria have become resistant to antibiotics, and this fact is emerging as one of the major threats to public health. The lack of new antibiotics, which is due to their time-consuming and costly development, exacerbates the problem. Therefore, it is necessary to identify new antimicrobial agents to treat bacterial and fungal infections. Plant extracts, which are valuable sources of bioactive compounds, mainly polyphenols, play an important role as a new strategy to combat pathogenic microorganisms. There is an extensive body of supporting evidence for the potent antibacterial and antifungal activities of polyphenols. Furthermore, some polyphenols show a synergistic effect when combined with antibiotics and antifungals, suggesting a promising alternative for therapeutic strategies against antibiotic resistance. However, only a few articles are found when searching the antibacterial or antifungal activities of polyphenols employing clinical isolates. Hence, this review focuses on the antimicrobial activity of polyphenols and extracts rich in polyphenols on clinical isolates, organized according to the World Health Organization priority pathogens classification.

scholarly journals Synthesis, Antibacterial, and Antifungal Activities of Hybrid Molecules Based on Alzheimer Disease Drugs and Bearing an Amino Acid Fragment

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 23 ◽  
Author(s):  
Radoslav Chayrov ◽  
Aleksandra Tencheva ◽  
Hristina Sbirkova-Dimitrova ◽  
Boris Shivachev ◽  
Anna Kujumdzieva ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Alzheimer Disease ◽  
Fungal Infections ◽  
Biological Properties ◽  
X Ray ◽  
Antibacterial And Antifungal Activities ◽  
Acid Fragment ◽  
Hybrid Molecules ◽  
Antibacterial And Antifungal

The objective of the current study was to develop novel compounds–memantine derivatives with antimicrobial activity designed for application in treatment of bacterial and fungal infections in patients suffering from Alzheimer’s disease. To realize this objective, a series of six memantine hybrid molecules were synthesized, characterized by 1H NMR, 13C NMR, MS, X-ray, and tested for their biological properties as anti-Alzheimer agents and their antimicrobial potential.

scholarly journals Design, Synthesis, and Antibacterial and Antifungal Activities of Novel Trifluoromethyl and Trifluoromethoxy Substituted Chalcone Derivatives

2020 ◽  
Vol 13 (11) ◽  
pp. 375
Author(s):  
Surendra Babu Lagu ◽  
Rajendra Prasad Yejella ◽  
Richie R. Bhandare ◽  
Afzal B. Shaik
Keyword(s):  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Fungal Infections ◽  
Normal Liver ◽  
Dilution Method ◽  
Spectroscopic Techniques ◽  
Normal Liver Cell ◽  
Olefinic Carbon ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Despite the availability of many drugs to treat infectious diseases, the problems like narrow antimicrobial spectrum, drug resistance, hypersensitivities and systemic toxicities are hampering their clinical utility. Based on the above facts, in the present study, we designed, synthesized and evaluated the antibacterial and antifungal activity of novel fluorinated compounds comprising of chalcones bearing trifluoromethyl (A1–A10) and trifluoromethoxy (B1–B10) substituents. The compounds were characterized by spectroscopic techniques and evaluated for their antimicrobial activity against four pathogenic Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Bacillus subtilis) bacterial and fungal (Candida albicans and Aspergillus niger) strains. In this study, the compounds with trifluoromethoxy group were more effective than those with trifluoromethyl group. Among the 20 fluorinated chalcones, compound A3/B3 bearing an indole ring attached to the olefinic carbon have been proved to possess the most antimicrobial activity compared to the standard drugs without showing cytotoxicity on human normal liver cell line (L02). Further, the minimum inhibitory concentration (MIC) for A3/B3 was determined by serial tube dilution method and showed potential activity. These results would provide promising access to future study about the development of novel agents against bacterial and fungal infections.

scholarly journals Screening of antibacterial and antifungal activities of selected Macedonian wild mushrooms

2013 ◽  
pp. 333-340 ◽  
Author(s):  
Daniela Nikolovska-Nedelkoska ◽  
Natalija Atanasova-Pancevska ◽  
Haris Amedi ◽  
Dafina Veleska ◽  
Emilija Ivanova ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Inhibitory Concentration ◽  
Methanolic Extract ◽  
Antimicrobial Properties ◽  
Inhibitory Effects ◽  
Antibacterial And Antifungal Activities ◽  
Microdilution Method ◽  
Methanolic Extracts ◽  
Antibacterial And Antifungal

Regarding the development of novel safe antimicrobials of natural origin, macrofungi became attractive for the researchers in the last decade. In this study, antimicrobial potential of methanolic extracts of six wild macromycetes (Boletus lupinus, Flammulina velutypes, Phellinus igniarius, Sarcodon imbricatus, Tricholoma aurantium, Xerocomus ichnusanus) was evaluated. In vitro antimicrobial activity was investigated by the microdilution method and minimum inhibitory concentration (MIC) was determined. Testing was conducted against eleven microorganisms, including six strains of bacteria and five species of fungi. Extracts showed selective antimicrobial properties while the activities depended both on the species of microorganism and on the type and concentration of extract. The evaluated extracts demonstrated antimicrobial activity, exhibiting more potent inhibitory effects on the growth of bacteria than on fungi. The highest antibacterial and antifungal activity was observed in methanolic extract of polypore fungus P. igniarius.

scholarly journals Chemical Composition and Antimicrobial Activity of the Essential Oil from Flowers of Eryngium triquetrum (Apiaceae) Collected Wild in Sicily

2016 ◽  
Vol 11 (7) ◽  
pp. 1934578X1601100
Author(s):  
Simona Casiglia ◽  
Maurizio Bruno ◽  
Sergio Rosselli ◽  
Felice Senatore
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Art Works ◽  
Main Components ◽  
Antibacterial And Antifungal ◽  
Historical Art

The chemical composition of the essential oil from flowers of Eringium triquetrum Vahl. collected in Sicily was evaluated by GC and GC-MS. The main components were pulegone (50.6%), piperitenone (30.5%) and menthone (7.0%). Comparison of this oil with other studied oils of Eringium species is discussed. The oil showed good antibacterial and antifungal activities against some microorganisms that infest historical art works.

scholarly journals Phytochemical investigation and in vitro antimicrobial activity of Richardia scabra

2016 ◽  
Vol 11 (2) ◽  
pp. 248 ◽  
Author(s):  
Kathirvel Poonkodi ◽  
Subban Ravi
Keyword(s):  
Antimicrobial Activity ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Weed Species ◽  
Antibacterial And Antifungal Activities ◽  
Agar Plug ◽  
Phytochemical Investigation ◽  
Antibacterial And Antifungal ◽  
Simple Sugar

<p class="Abstract">The present study was aimed to evaluate the phytochemical screening and antimicrobial activity of the petroleum ether and methanol extracts from the mature leaves of <em>Richardia scabra</em> from India. Disc diffusion method was used to determine the zone inhibition of the tested samples for antibacterial and agar plug method was used to determine the antifungal activity, while the microtube-dilution technique was used to determine the minimum inhibitory concentration. Both extracts showed significant antibacterial and antifungal activities when tested against 10 bacterial and four fungal strains. The minimum inhibitory concentrations of the methanol extract of<em> R. scabra</em> ranged between 12.5–100 μg/mL for bacterial strains. Alkaloids, steroids, flavonoids, fatty acids, terpenoids and simple sugar were detected as phytoconstituents of extracts. To the best of our knowledge, this is the first report against antimicrobial activity of common weed species <em>R. scabra</em> found in India.</p><p> </p>

scholarly journals Phytochemical study and antimicrobial activity of Algerian Marrubium vulgare leaf and stem extracts

2020 ◽  
Vol 10 (5) ◽  
pp. 70-74
Author(s):  
Nadia BENZIDANE ◽  
Ridha SMAHI ◽  
Boudjemaa ZABOUCHE ◽  
Abdelhalim MAKROUF ◽  
Lekhmici ARRAR
Keyword(s):  
Antimicrobial Activities ◽  
Hplc Method ◽  
Basic Material ◽  
Antimicrobial Drugs ◽  
Phytochemical Study ◽  
Methanolic Extracts ◽  
Staphyloccocus Aureus ◽  
Marrubium Vulgare ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal

Marrubium vulgare is used worldwide as a source of food flavor and for medicinal purposes. The aim of this study is to investigate polyphenol and flavonoid contents of M. vulgare extracts and their antimicrobial activities. Extraction was conducted using methanol and hexane. The determination of polyphenol content was realized with folin ciocalteu method and flavonoids using AlCl3. Rouph characterization of these compounds was done with HPLC method. Activity against bacteria and fungi was also studied. Results showed that methanolic extracts of leaves (LME) and stems SME) contain relatively high levels of polyphenols ad flavonoids.  Except for hexane extract, all extracts from leaves and stems possess antibacterial and antifungal effects especially against Staphyloccocus aureus and Candida albicans. This finding suggests that M. vulgare methanolic extracts could serve as a basic material for the preparation of antimicrobial drugs. Keywords: Marrubium vulgare, polyphenols, flavonoids, antibacterial, antifungal activities.

scholarly journals Synthesis and Antimicrobial Activity of Some Chalcone Derivatives

2008 ◽  
Vol 5 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Y. Rajendra Prasad ◽  
A. Lakshmana Rao ◽  
R. Rambabu
Keyword(s):  
Aqueous Solution ◽  
Antimicrobial Activity ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Antimicrobial Agents ◽  
Aromatic Aldehydes ◽  
Plate Method ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR,1H-NMR spectral data and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

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