Serum levels of allopregnanolone in migraine patients: A case–control study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

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Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study

The Journal of Laryngology & Otology ◽

10.1017/s0022215121001274 ◽

2021 ◽

pp. 1-4

Author(s):

D V K Irugu ◽

A Singh ◽

H Yadav ◽

H Verma ◽

R Kumar ◽

...

Keyword(s):

Serum Level ◽

Benign Paroxysmal Positional Vertigo ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Control Group ◽

Positional Vertigo ◽

The Difference ◽

Control Study ◽

Paroxysmal Positional Vertigo

Abstract Objectives This study aimed to evaluate serum otolin-1 levels in patients with benign paroxysmal positional vertigo and to compare these levels with healthy individuals. Method This was a case-control study. After obtaining institutional ethical committee clearance, the serum level of otolin-1 was calculated in adult individuals (18–75 years old) who were divided into group 1 (patients presenting with benign paroxysmal positional vertigo) and group 2 (healthy patients without benign paroxysmal positional vertigo as the control group). Data analysis was carried out to compare the serum levels in the cases and controls. A p-value less than 0.05 was considered significant. Results A total of 70 age-matched individuals (cases, n = 40; controls, n = 30) were included in the study. The mean serum level of otolin-1 was 636.8 pg/ml (range, 259–981 pg/ml) in the group of patients with benign paroxysmal positional vertigo and 236.2 pg/ml (range, 189–370 pg/ml) in the control group. The difference was statistically significant (p = 0.0000). Conclusion The serum levels of otolin-1 in patients with benign paroxysmal positional vertigo are significantly higher compared with individuals without benign paroxysmal positional vertigo.

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Low 25(OH) D serum levels are related with hip fracture in postmenopausal women: a matched case–control study

Journal of Translational Medicine ◽

10.1186/s12967-015-0756-x ◽

2015 ◽

Vol 13 (1) ◽

Cited By ~ 3

Author(s):

Xing-Mao Fu ◽

Shao-Guang Fan ◽

Shu-Liang Li ◽

Yi-Sheng Chen ◽

Hai Wu ◽

...

Keyword(s):

Hip Fracture ◽

Postmenopausal Women ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

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Serum Levels of Selenium, Zinc, Copper and Magnesium in Asthmatic Patients: a Case Control Study.

Sudan Journal of Medical Sciences ◽

10.4314/sjms.v3i1.38512 ◽

2008 ◽

Vol 3 (1) ◽

Author(s):

MM Hussein ◽

AA Yousif ◽

AM Saeed

Keyword(s):

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Asthmatic Patients ◽

Control Study

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IL-10 Promoter Genetic Polymorphisms and Risk of Kawasaki Disease in Taiwan

Disease Markers ◽

10.1155/2011/909407 ◽

2011 ◽

Vol 30 (1) ◽

pp. 51-59 ◽

Cited By ~ 11

Author(s):

Kai-Sheng Hsieh ◽

Tsung-Jen Lai ◽

Yu-Tung Hwang ◽

Ming-Wei Lin ◽

Ken-Pen Weng ◽

...

Keyword(s):

Kawasaki Disease ◽

Case Control Study ◽

Serum Levels ◽

High Plasma ◽

Case Control ◽

Healthy Children ◽

Increased Risk ◽

Family Based ◽

Control Study

Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (−1082, −819, and −592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci −819 T > C and −592 A > C for KD cases was observed (Ppermutation= 0.029 and Ppermutation= 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p= 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090–2.443; Ppermutation= 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. {The haplotype CC (−819, −592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987–1.797;p= 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant,p= 0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and −592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study.

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