Vitamin D, Parathyroid Hormone, and Heart Failure in a Chinese Elderly Population

Background: Previous studies have indicated that parathyroid hormone (PTH) has been linked to post-myocardial infarction (MI) development. The aim of this cross-sectional study was to evaluate the relationship between PTH level and heart failure due to post infarction remodeling during the first 72 hours of hospitalization. Methods: Seventy patients with a diagnosis of acute MI (age ≥18 years, 22 females and 48 males) were enrolled. Patients were admitted to the Imam Raza Educational, Research and Treatment Center, Mashhad University of Medical Sciences, Iran between July 2014 to September 2015. We measured PTH and vitamin D level. Blood samples were taken after 24 hours and 72 hours. Results: During the first 72 hours, the PTH level significantly increased in patients with Post-MI heart failure. 68% of the subjects had an inappropriate vitamin D level at the time of admission. Mean levels of vitamin D and PTH increased compared with the baselines (95% CI, 0.15 to 10.03, P: 0.044), (95% CI, 6.5 to 24.8, P:0.001) respectively. Conclusion: Acute elevations of serum PTH levels increased early remodeling heart failure after MI. Serum vitamin D status was independent of high serum PTH level. Based on the current evidence, PTH excess may be a risk factor for heart failure, so early treatment and omitting risk factors are the most effective strategies for the patients with acute myocardial infarction. J Pharm Care 2020; 8(1): 11-15.

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Association of vitamin D and cardiovascular health

Nepalese Heart Journal ◽

10.3126/njh.v15i1.19706 ◽

2018 ◽

Vol 15 (1) ◽

pp. 17-21

Author(s):

Hridaya Bibhu Ghimire ◽

Chandra Mani Adhikari

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Vitamin D ◽

Acute Coronary Syndrome ◽

Elderly Population ◽

Cardiovascular Health ◽

Sun Exposure ◽

Vitamin D Insufficiency ◽

Coronary Syndrome ◽

The Relationship

Vitamin D insufficiency or deficiency is highly prevalent due to limited sun exposure especially in urban and elderly population. Vitamin D is now increasingly recognized as a hormone responsible for numerous physiologic functions in different cells and tissues of the human body including heart. Vitamin D has been shown to be linked with hypertension, acute coronary syndrome, heart failure, and atrial fibrillation. This review briefly overviews the relationship between vitamin D deficiency, its supplementation and outcome in cardiovascular health.Nepalese Heart Journal 2018; 15(1): 17-21.

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Seasonal Variance in Serum Levels of Vitamin D Determines a Compensatory Response by Parathyroid Hormone: Study in an Ambulatory Elderly Population in Quebec

Gerontology ◽

10.1159/000089823 ◽

2006 ◽

Vol 52 (1) ◽

pp. 33-39 ◽

Cited By ~ 18

Author(s):

Concepción Vecino-Vecino ◽

Miren Gratton ◽

Richard Kremer ◽

Leocadio Rodriguez-Mañas ◽

Gustavo Duque

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Elderly Population ◽

Serum Levels ◽

Compensatory Response

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Parathyroid hormone and vitamin D-markers for cardiovascular and all cause mortality in heart failure

European Journal of Heart Failure ◽

10.1093/eurjhf/hfr016 ◽

2011 ◽

Vol 13 (6) ◽

pp. 626-632 ◽

Cited By ~ 81

Author(s):

Louise Lind Schierbeck ◽

Torben Slott Jensen ◽

Ulrich Bang ◽

Gorm Jensen ◽

Lars Køber ◽

...

Keyword(s):

Heart Failure ◽

Vitamin D ◽

Parathyroid Hormone ◽

All Cause Mortality

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Study of Parathyroid Hormone as an Independent Risk Marker of Heart Failure

Indian Journal of Medical Biochemistry ◽

10.5005/jp-journals-10054-0041 ◽

2017 ◽

Vol 21 (2) ◽

pp. 157-161

Author(s):

Krishna M Iyyapu ◽

Sreekanth Yerram ◽

Kompella SS Sai Baba

Keyword(s):

Heart Failure ◽

Vitamin D ◽

Parathyroid Hormone ◽

Odds Ratio ◽

Nyha Class ◽

Clinical Syndrome ◽

Study Group ◽

Risk Marker ◽

High Concentration ◽

Cross Sectional

ABSTRACT Introduction Heart failure (HF) is a clinical syndrome characterized by cardiac pump failure with signs and symptoms arising from salt and water retention. Heart failure is associated with considerable mortality and morbidity. Identification of modifiable risk factors may reduce incidence of HF and its complications. The aim of our study is to assess parathyroid hormone (PTH) as a risk marker for HF and its association with severity of HF. Materials and methods In this cross-sectional study, 120 subjects with HF were recruited and they were compared with 60 age- and sex-matched controls. Along with the routine parameters, N-terminal pro B-type natriuretic peptide (NT-proBNP), intact PTH, and vitamin D were estimated. The study group was divided into quartiles depending on PTH value. Results The median PTH (81.5 pg/mL) and NT-proBNP (3753 pg/mL) in HF patients are found to be significantly higher (p < 0.0001) when compared with control subjects. The median vitamin D concentration (18 ng/mL) though low in cases is not statistically significant when compared with controls. Demographic, clinical, and laboratory characteristics are compared across the quartiles of PTH. Highest number of New York Heart Association (NYHA) class IV HF cases are found in highest quartiles of PTH. Logistic regression analysis demonstrated that high concentration of PTH [odds ratio of 1.1113; 95% confidence interval (CI) 1.07—1.14; p < 0.0001] and low levels of vitamin D (odds ratio of 1.053; 95% CI 1.0079—1.1009) are significantly associated with HF. Conclusion This study has demonstrated that higher concentration of PTH is associated with severe form of HF. Vitamin D deficiency is also seen in the study group. How to cite this article Khan SA, Iyyapu KM, Sai Baba KSS, Yerram S. Study of Parathyroid Hormone as an Independent Risk Marker of Heart Failure. Indian J Med Biochem 2017;21(2):157-161.

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Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.682521 ◽

2021 ◽

Vol 8 ◽

Author(s):

Bianca Dahlen ◽

Felix Müller ◽

Sven-Oliver Tröbs ◽

Marc William Heidorn ◽

Andreas Schulz ◽

...

Keyword(s):

Heart Failure ◽

Vitamin D ◽

Platelet Count ◽

Parathyroid Hormone ◽

Ejection Fraction ◽

Vitamin D Status ◽

Linear Regression Models ◽

Platelet Indices ◽

Reduced Ejection Fraction ◽

Potential Marker

Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF.Aim: This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF.Methods and Results: PTH and platelet indices (MPV and platelet count) were available in 1,896 participants from the MyoVasc study in Mainz, Germany. Multivariable linear regression models, adjusted for age, sex, season, vitamin D status, cardiovascular risk factors, comorbidities, estimated glomerular filtration rate, and medication, were used to assess the associations between platelet indices and PTH. The results showed distinct sex-specific associations between PTH and platelet indices. A positive association between PTH and MPV was found in females with symptomatic HF with reduced ejection fraction (HFrEF) only [β = 0.60 (0.19; 1.00)]. Platelet count was inversely associated with PTH in male HFrEF individuals [β = −7.6 (−15; −0.30)] and in both males and females with HF with preserved ejection fraction (HFpEF).Conclusion: This study reports differential, sex-specific relationships between PTH and platelet indices in HF individuals independent of vitamin D status and clinical profile. Particularly in phenotypes of symptomatic HF, distinct associations were observed, suggesting a sex-specific mechanism involved in the interaction between PTH and platelets.

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