scholarly journals Acute Hypoglycaemic Activities and Fatty Acid Profile of Seed Oil of Moringa oleifera Lam

2019 ◽  
Vol 60 (2) ◽  
pp. 55-62
Author(s):  
M. B. Busari ◽  
H. L. Muhammad ◽  
E. O. Ogbadoyi ◽  
F. O. Badmos
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Moringa Oleifera ◽  
Seed Oil ◽  
Unsaturated Fatty Acids ◽  
Glucose Solution ◽  
Oil Extract ◽  
Moringa Oleifera Seed

The adverse effect of oral hypoglycaemic drugs necessitated the search for efficient and safer antidiabetic drugs from herbal formulation. As such, the fatty acids profile and acute antidia­betic activities of Moringa oleifera seed oil extract of petroleum ether (PEEMO) and Moringa oleifera seed oil extract of dichloromethane (DCMMO) were investigated. The 2.0 mL/kg body weight (kg.bw) of both oils, 500 μg/kg.bw of glibenclimide and 2.0 mL/kg.bw of dimethyl sulphoxide (DMSO) were given orally to rats in their respective groups after induction with 2 g/kg.bw of glucose solution orally. Unsaturated fatty acids contents were in high proportion in both oils when compared to saturated fatty acids content. Administration of glucose solution significantly elevated the blood glucose level to 24.71, 47.83, 44.05, 44.78 and 30.86% for normoglycaemic, control, glibenclimide, DCMMO and PEEMO respectively at 30 minutes from their respective basal blood glucose level. However, the blood glucose level of the glib­enclimide, PEEMO, DCMMO treated groups were significantly (p<0.05) reduced at 60 (24.57, 15.61 and 10.69%), 90 (43.87, 30.08 and 15.45%) and 120 (57.98, 19.82 and 41.33%) minutes respectively when compared with that of 30 minutes’ blood glucose levels. Therefore, Moringa oleifera seed oil extracts demonstrated acute hypoglycaemic effects in glucose fed rats. Keywords: Moringa oleifera, glibenclimide, antidiabetic, diabetes, unsaturated fatty acids.

scholarly journals Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs

2002 ◽  
Vol 282 (2) ◽  
pp. E402-E411 ◽  
Author(s):  
Chang An Chu ◽  
Stephanie M. Sherck ◽  
Kayano Igawa ◽  
Dana K. Sindelar ◽  
Doss W. Neal ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Free Fatty Acids ◽  
Glucose Level ◽  
Conscious Dogs ◽  
Arterial Blood ◽  
Plasma Ffa ◽  
Arterial Plasma ◽  
Arterial Blood Glucose

The aim of this study was to determine the effect of high levels of free fatty acids (FFA) and/or hyperglycemia on hepatic glycogenolysis and gluconeogenesis. Intralipid was infused peripherally in 18-h-fasted conscious dogs maintained on a pancreatic clamp in the presence (FFA + HG) or absence (FFA + EuG) of hyperglycemia. In the control studies, Intralipid was not infused, and euglycemia (EuG) or hyperglycemia (HG) was maintained. Insulin and glucagon were clamped at basal levels in all four groups. The arterial blood glucose level increased by 50% in the HG and FFA + HG groups. It did not change in the EuG and FFA + EuG groups. Arterial plasma FFA increased by ∼140% in the FFA + EuG and FFA + HG groups but did not change significantly either in the EuG or HG groups. Arterial glycerol levels increased by ∼150% in both groups. Overall (3-h) net hepatic glycogenolysis was 196 ± 26 mg/kg in the EuG group. It decreased by 96 ± 20, 82 ± 16, and 177 ± 22 mg/kg in the HG, FFA + EuG, and FFA + HG groups, respectively. Overall (3-h) hepatic gluconeogenic flux was 128 ± 22 mg/kg in the EuG group, but it was suppressed by 30 ± 9 mg/kg in response to hyperglycemia. It was increased by 59 ± 12 and 56 ± 10 mg/kg in the FFA + EuG and FFA + HG groups, respectively. In conclusion, an increase in plasma FFA and glycerol significantly inhibited hepatic glycogenolysis and markedly stimulated hepatic gluconeogenesis.

Effect of an α-Glucosidase Inhibitor on Intestinal Fermentation and Faecal Lipids in Diabetic Patients

1993 ◽  
Vol 21 (5) ◽  
pp. 257-267 ◽  
Author(s):  
T Nakamura ◽  
K Takebe ◽  
K Kudoh ◽  
A Terada ◽  
Y Tandoh ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Bile Acids ◽  
Glucose Level ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Acid Excretion ◽  
Intestinal Transit Time ◽  
Glucosidase Inhibitor

Eight non-insulin-dependent diabetes mellitus patients, in whom oral hypoglycaemic agents were not effective, were treated with an α-glucosidase inhibitor, AO-128 (0.9 mg/day) for 6 months. After 6 months of treatment there was a statistically significant decrease in the blood glucose level 1 and 2 h postprandially. The 2 h blood glucose level was also significantly reduced after 2 months' treatment. The insulin and HbAlC levels after 2 and 6 months' treatment were lower than those before administration. Faecal weight, the frequency of bowel movements, the ratio of hydroxy fatty acids to total fatty acids, and faecal short-chain carboxylic acid content were all increased significantly during treatment. The initially hard stools became normal or soft, although no actual diarrhoea developed. Both faecal bile-acid excretion and the ratio of primary bile acids to total bile acids were increased significantly after 2 months, but they showed some recovery towards the pretreatment levels after 6 months' treatment. There was no distinct change in neutral sterol and fatty acid excretion. Breath hydrogen excretion showed a slight increase after treatment. These results suggest that intestinal fermentation was promoted and the intestinal transit time was shortened by AO-128 administration.

scholarly journals Physicochemical Properties and Fatty Acids Composition of Sudanese Moringa Oleifera Seed Oil

2020 ◽  
Vol 7 (3) ◽  
pp. 911-920
Author(s):  
Abeer IDRIS ◽  
Azhari NOUR ◽  
Omer ISHAG ◽  
Mahmoud ALİ ◽  
Ibrahim ERWA ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Physicochemical Properties ◽  
Moringa Oleifera ◽  
Seed Oil ◽  
Fatty Acids Composition ◽  
Moringa Oleifera Seed

Jew's Mellow Leaves (Corchorus olitorius) Suppress Elevation of Postprandial Blood Glucose Levels in Rats and Humans

2005 ◽  
Vol 75 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Satoshi Innami ◽  
Hiroshi Ishida ◽  
Kahoru Nakamura ◽  
Mika Kondo ◽  
Kimiko Tabata ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Solution ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Intestinal Membrane ◽  
Freeze Dried ◽  
Postprandial Blood Glucose Level

The study was performed to explore the suppressive effect of Jew's mellow leaves (JML) on postprandial blood glucose levels in rats and humans. A soluble dietary fiber (SDF) was extracted from the freeze-dried JML powder. An elevation of the postprandial blood glucose level in rats given 1% or 2% JML-SDF solution orally together with 20% glucose solution was significantly suppressed as compared with that observed in the control rats given only glucose solution. When seven healthy young male adults ingested 225 mL of JML mixed juice containing 15 g of freeze-dried powder with 75 g of glucose in the fasting state in the morning, the elevation of the postprandial blood glucose level was significantly suppressed as compared with the control subjects. The diffusion rate of glucose and the permeation rate of glucose in the cultured Caco-2 cells were both significantly reduced by the addition of appropriate amounts of JML-SDF when compared to the controls. These results indicate that the effective substance in JML for suppressing blood glucose elevation is a kind of mucilaginous SDF. The mechanism by which this suppression occurs may be largely attributable to the delayed absorption of glucose from the intestinal membrane in the upper digestive tract by viscous SDF.

scholarly journals Ameliorative Effect of <i>Moringa Oleifera</i> Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats

2021 ◽  
Vol 9 (1) ◽  
pp. 6
Author(s):  
Ibrahim Maina Hassan ◽  
Bashir Saidu ◽  
Ja’afaru Abdullahi Ishaq ◽  
Ashiru Dahiru ◽  
Nafisat Abdulazeez ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Biochemical Constituents ◽  
Ameliorative Effect

scholarly journals REGULATION OF ETHYL ACETATE FRACTION FROM MORINGA OLEIFERA LEAVES TO IMPROVE LIPID METABOLISM AND INSULIN SENSITIVITY IN TYPE 2 DIABETES

2018 ◽  
Vol 10 (10) ◽  
pp. 78
Author(s):  
Sholihatil Hidayati ◽  
Rini Sulistyawati ◽  
Laela Hayu Nurani
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Moringa Oleifera ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethyl Acetate Fraction ◽  
Diabetic Rats ◽  
Moringa Oleifera Leaves

Objective: Moringa oleifera is a medicinal plant species that has potential as an antidiabetic. The present study was designed to evaluated molecullar mechanism antidiabetic ethyl acetate fraction of Moringa oleifera leaves (EAFML).Methods: The study was conducted on 30 male wistar rats which were induced with the combination of streptozotocin and nicotinamide by intraperitoneal administration to make a model of type 2 diabetes. After the diabetic induction, all rats were divided into six group and once daily administered orally EAFML in doses standardized quercetine. The treatment was given for ten days, and on the final treatment, all rats were checked their blood glucose level and lipid profile. The skeletal muscles and liver were taken to examine glucose transporter-4 (GLUT4) expression by immunohistochemistry.Results: The result of this study shows that the blood glucose level in diabetic rats with the treatment of EAFML decreased significantly from 355.8±83.7 mg/dL to 177.5±89.3 mg/dL. The cholesterol decreased significantly from 105.2±47.4 mg/dL to 58.6±6.9 mg/dL and low-density lipoprotein (LDL) in diabetic rats with the treatment of EAFML decreased significantly compared to control group from 175.6±41.9 mg/dL to 95.3±8.0 mg/dL. The expression of GLUT4 in skeletal muscles increased from 0.7±1.0 to 3.9±1.1 and in the liver increased significantly from 1.8±1.3 to 2.9±1.9.Conclusion: The EAFML can decrease blood glucose level, cholesterol and low-density lipoprotein in type 2 diabetic rat model. Other than that, this fraction can improve insulin sensitivity by the increase of GLUT4 expressions.

scholarly journals PENGARUH SEREAL BERBAHAN SAGU DAN Moringa oleifera TERHADAP KADAR GLUKOSA DARAH TIKUS YANG DIINDUKSI ALOKSAN - IN PRESS -

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Melin Novidinisa Herada Putri ◽  
A'immatul Fauziyah ◽  
Taufik Maryusman
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Moringa Oleifera ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
White Rats

The Effects of Cereal Made From Sagu and Moringa oleifera on the Blood Glucose Level of Alloxan-Induced RatsDiabetes Mellitus (DM) type 2 could increase oxidative stress and blood glucose level. Resistant starch compounds in Cersa Mori have an antidiabetic properties.This research aimed to analyze the effect of Cersa Mori on fasting blood glucose (FBG) level of diabetic white rats induced by alloxan. This is a true experimental study with a randomized pre-post control group design using 27 male Wistar strain rats divided into 3 groups randomly, i.e (KN) feed and aquades, (KP) glibenclamide 0.126mg/200gBB/day, (P) Cersa Mori 5g/200gBB/day. KP and P groups were given alloxan 125 mg/KgBB subcutaneously and the intervention was carried out for 30 days. FBG level was measured using the GOD-PAP method. The results of Paired T-Test showed the effect of Cersa Mori on lowering FBG level in hyperglycemic rats (P=0,006). One-Way ANOVA test showed that Cersa Mori reduced FBG level, which was equalent to those given glibenclamide (P=0,366). It can be concluded that giving Cersa Mori 5g/200gBB/day for 30 days had a significant effect on lowering FBG level. Keywords: alloxan; Cersa Mori; diabetic rats; fasting blood glucose level; resistant strachABSTRAKDiabetes Mellitus (DM) tipe 2 dapat memicu stres oksidatif dan meningkatkan kadar glukosa darah puasa (GDP). Senyawa pati resisten dalam sereal siap saji Cersa Mori memiliki sifat antidiabetik. Penelitian ini bertujuan menganalisis pengaruh pemberian Cersa Mori terhadap kadar glukosa darah tikus putih diabetes yang diinduksi aloksan. Penelitian true-experimental ini menggunakan randomized pre-post control group design. Sampel sebanyak 27 ekor tikus jantan galur Wistar dibagi menjadi 3 kelompok secara acak yaitu; (KN) pakan dan akuades, (KP) glibenklamid 0,126 mg/200gBB/hari, (P) Cersa Mori 5g/200gBB/hari. KP sampai P diberikan aloksan 125 mg/KgBB secara subkutan dan intervensi dilakukan selama 30 hari. Pengukuran GDP menggunakan metode GOD-PAP. Hasil Uji-T menunjukkan pengaruh Cersa Mori dalam menurunkan GDP tikus hiperglikemia (P=0,006). Uji ANOVA satu arah menunjukkan penurunan GDP pada kelompok Cersa Mori (P) setara dengan tikus yang diberi glibenklamid (P=0,366). Dengan demikian dapat disimpulkan bahwa pemberian Cersa Mori dosis 5g/200gBB/hari selama 30 hari berpengaruh terhadap penurunan GDP secara signifikan. 

scholarly journals Effects of Moringa oleifera Leaves Methanolic Extract on Alloxan- Induced Diabetic Albino Rats

2019 ◽  
pp. 1-8
Author(s):  
C. Udeogu ◽  
C. C. Ejiofor ◽  
A. Nwakulite
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Moringa Oleifera ◽  
Albino Rats ◽  
High Blood Glucose ◽  
Before And After ◽  
Moringa Oleifera Leaves ◽  
Group 2 ◽  
Wistar Albino Rats

Moringa oleifera, popularly known as “miracle tree” belongs to the family, Moringaceae. It is a medicinal plant in which the leaves are the most nutritious part, being a significant source of vitamins and protein among others. This study was conceived and designed based on the gaps in the research that has been performed and what is known about the plant. In this study, the effect of Moringa oleifera leaves extract on alloxan induced diabetes in Wistar albino rats was investigated. A total of forty five (45) rats were acclimatized for a period of two weeks, then randomly divided into five (5) groups (1, 2, 3, 4, and 5) of  nine (9) rats each and fed with standard feed and water. Group 1 which is the control was fed with just water and standard feed while Hyperglycemia was induced in groups 2, 3, 4, & 5 intra-peritoneally after an over-night fasting using alloxan at a concentration of 130 mg/kg b.w. and allowed for 48hours which resulted in a high blood glucose level between 300 mg/dl and 600 mg/dl. Group 2 was not given any treatment while Groups 3, 4, & 5 were treated with doses 100 mg/kg b.w., 200 mg/kg bw, and 400 mg/kgbw of Moringa oleifera leaf extract respectively for a period of four weeks. A glucometer was used to check the blood glucose level of the animals before and after treatment. The results of Groups 3, 4, & 5 (172.0±4.75 mg/dl, 142.9±47.25 mg/dl, 70.6±24.46 mg/dl respectively) showed a significant decrease (p< 0.05) in blood glucose level of the induced rats when compared with Group 2 (316±47.17 mg/dl) which was induced only alloxan. It can therefore be concluded that this study has shown that the extract of Moringa oleifera leaves offers an anti-diabetic effect in Wistar albino rats.

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