scholarly journals D-dimer/Fibrinogen ratio and recurrent exacerbations might have a potential impact to predict 90-day mortality in patients with COPD exacerbation

2021 ◽  
Vol 33 (4) ◽  
pp. 276-280
Author(s):  
Cihan Aydin ◽  
Birsen Pınar Yıldız ◽  
Didem Görgün Hattatoğlu
Keyword(s):  
Risk Factors ◽  
Regression Model ◽  
Acute Exacerbation ◽  
Mortality Risk ◽  
World Health ◽  
Multivariable Regression Model ◽  
The World ◽  
Multivariable Regression ◽  
Predictive Risk ◽  
D Dimer

BackgroundAccording to the World Health Organisation reports (WHO), COPD is the third leading cause of overall in the World by 2020. AimWe aimed to determine the prognostic predictors of 90-day mortality after an initial exacerbation in patients with acute exacerbation of COPD (AECOPD). Results Increased Charlson Comorbidity Score(CCS) (HR:1.47; p<0.05), readmission after initial exacerbation (HR:1.47; p<0.05) were predictive risk factors for 30-day mortality in multivariable regression model. The 90-day mortality rate was %11.8. Hypertension, increased median age, nutrition risk score (NRS), CCS, CAT score, and mMRC 4th level were possible risk factors for 90-day mortality. There was a significant difference in the mortality of patients with D-dimer/Fibrinogen ratios>0.11 and ≤0.11 (HR:2.47; p<0.05). Recurrent exacerbations after discharge were predictive risk factors for 90-day mortality in the multivariable regression model (HR:2.25; p<0.001) with the increased mortality risk 4.73 times (HR:4.73; p=0.002). Furthermore, a 1-unit increment of acute exacerbation increased the mortality risk 3.39 times (HR:3.39; p<0.001). ConclusionOur study showed that D-dimer/Fibrinogen ratio but not D-dimer and recurrent exacerbations after discharge might have a critical impact on 90-day mortality

scholarly journals The Impact of Ultraviolet Radiation on the Aetiology and Development of Uveal Melanoma

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1700
Author(s):  
Melissa Chalada ◽  
Charmaine A. Ramlogan-Steel ◽  
Bijay P. Dhungel ◽  
Christopher J. Layton ◽  
Jason C. Steel
Keyword(s):  
Risk Factors ◽  
Ultraviolet Radiation ◽  
Uveal Melanoma ◽  
World Health Organisation ◽  
World Health ◽  
Genetic Mutations ◽  
High Incidence ◽  
The World ◽  
The Impact

Uveal melanoma (UM) is currently classified by the World Health Organisation as a melanoma caused by risk factors other than cumulative solar damage. However, factors relating to ultraviolet radiation (UVR) susceptibility such as light-coloured skin and eyes, propensity to burn, and proximity to the equator, frequently correlate with higher risk of UM. These risk factors echo those of the far more common cutaneous melanoma (CM), which is widely accepted to be caused by excessive UVR exposure, suggesting a role of UVR in the development and progression of a proportion of UM. Indeed, this could mean that countries, such as Australia, with high UVR exposure and the highest incidences of CM would represent a similarly high incidence of UM if UVR exposure is truly involved. Most cases of UM lack the typical genetic mutations that are related to UVR damage, although recent evidence in a small minority of cases has shown otherwise. This review therefore reassesses statistical, environmental, anatomical, and physiological evidence for and against the role of UVR in the aetiology of UM.

Prevalence of and factors associated with insufficient physical activity among adolescents: evidence from a nationwide survey in Bangladesh

2021 ◽  
pp. 1-14
Author(s):  
Md Mokbul Hossain ◽  
Fahmida Akter ◽  
Abu Abdullah Mohammad Hanif ◽  
Md Showkat Ali Khan ◽  
Abu Ahmed Shamim ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
World Health Organization ◽  
Adolescent Girls ◽  
World Health ◽  
Factors Associated ◽  
Adolescent Girls And Boys ◽  
The World ◽  
Insufficient Physical Activity ◽  
Health Organization

Abstract The World Health Organization set a target of a 15% relative reduction in the prevalence of insufficient physical activity (IPA) by 2025 among adolescents and adults globally. In Bangladesh, there are no national estimates of the prevalence of IPA among adolescents. The aim of this study was to estimate the prevalence of and risk factors associated with IPA among adolescent girls and boys. Data for 4865 adolescent girls and 4907 adolescent boys, collected as a part of a National Nutrition Surveillance in 2018–19, were analysed for this study. A modified version of the Global Physical Activity Questionnaire (GPAQ) was used to collect physical activity data. The World Health Organization recommended cut-off points were used to estimate the prevalence of IPA. Bivariate and multivariable logistic regression was performed to identify factors associated with IPA. Prevalences of IPA among adolescent girls and boys were 50.3% and 29.0%, respectively, and the prevalence was significantly higher among early adolescents (10–14 years) than late adolescents (15–19 years) among both boys and girls. The IPA prevalence was highest among adolescents living in non-slum urban areas (girls: 77.7%; boys: 64.1%). For both boys and girls, younger age, non-slum urban residence, higher paternal education and increased television viewing time were significantly associated with IPA. Additionally, residing in slums was significantly associated with IPA only among the boys. Higher maternal education was associated with IPA only among the girls. This study identified several modifiable risk factors associated with IPA among adolescent boys and girls in Bangladesh. These factors should be addressed through comprehensive public health interventions to promote physical activity among adolescent girls and boys.

scholarly journals A review of post infectious pulmonary fibrosis in the era of COVID-19 and potential treatment options

2021 ◽  
Vol 9 (40) ◽  
pp. 37-46
Author(s):  
Medha Ghose ◽  
Maehali Patel
Keyword(s):  
Risk Factors ◽  
Pulmonary Fibrosis ◽  
Treatment Options ◽  
World Health ◽  
Potential Treatment ◽  
Pulmonary Injury ◽  
The World ◽  
Health Organization ◽  
Post Infectious

On March 11, 2020, the World Health Organization (WHO) released a statement characterizing COVID-19 as a pandemic that has, as of October 2020, caused almost 36 million confirmed global cases and over 1 million deaths. One of the long-term complications suggested by researchers is fibrosis. It has been hypothesized that the combination of ongoing pulmonary injury caused by COVID-19 and the inability to promptly repair damage results in interstitial matrix widening and eventual compression and destruction of alveoli and capillaries. Here we focus on pathogenesis, risk factors, different infectious causes of fibrosis along with COVID-19, and potential treatment options that might reduce its effects. Key words: COVID-19, pulmonary fibrosis, mechanism, treatment

scholarly journals PTSD Symptoms and Risk Factors During the COVID-19 Disease Pandemic in Iran

2020 ◽  
Vol 26 (3 Special Issue on COVID-19) ◽  
pp. 394-399
Author(s):  
Seyyed Mohammad Hossein Javadi ◽  
◽  
Roya Marsa ◽  
Fahimeh Rahmani ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
World Health Organization ◽  
World Health ◽  
Chinese Government ◽  
Ptsd Symptoms ◽  
The World ◽  
Health Organization

In December 2019, the Chinese government alerted the world to a dangerous virus that spread rapidly in communities. In fact, another acute respiratory syndrome occurred in Wuhan, China, and then spread rapidly to other parts of the world. The World Health Organization (WHO) refers to this virus as nCoV-2019, where n stands for “new” and CoV stands for “coronavirus”. In general, the virus (COVID-19) is similar to acute respiratory syndrome (MERS-CoV), but they are by no means identical

NCDs: Risk factors and determinants

2017 ◽  
Author(s):  
Mike Rayner ◽  
Kremlin Wickramasinghe ◽  
Julianne Williams ◽  
Karen McColl ◽  
Shanthi Mendis
Keyword(s):  
Risk Factors ◽  
Primary Prevention ◽  
World Health ◽  
Global Burden ◽  
Health In All Policies ◽  
Socioecological Model ◽  
Life Course Approach ◽  
The World ◽  
Single Focus ◽  
Different Levels

This chapter introduces the main risk factors for non-communicable diseases (NCDs), using different causal webs. It uses the Global Burden of Disease data to describe the burden of these NCD risk factors. It uses the socioecological model and the World Health Organization’s conceptual framework for social determinants of health to show the different levels of influences relevant to NCDs. This chapter presents case studies to show how a life-course approach and health-in-all-policies approach could address these broad ranges of NCD risk factors. It discusses the importance of primary prevention efforts organized around multilevel interventions and shows that they are more likely to be more successful than single-focus efforts.

scholarly journals Short-Term Air Quality Prediction Based on Fractional Grey Linear Regression and Support Vector Machine

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Meng Dun ◽  
Zhicun Xu ◽  
Yan Chen ◽  
Lifeng Wu
Keyword(s):  
Air Quality ◽  
Regression Model ◽  
Hybrid Model ◽  
Air Pollutants ◽  
Support Vector ◽  
Support Vector Regression Model ◽  
Air Quality Prediction ◽  
Multivariable Regression Model ◽  
Multivariable Regression ◽  
The Mean

To predict the daily air pollutants, the fractional multivariable model is established. The hybrid model of the grey multivariable regression model with fractional order accumulation model (FGM(0, m)) and support vector regression model (SVR) is used to predict the air pollutants (PM10, PM2.5, and NO2) from December 31, 2018, to January 3, 2019, in Shijiazhuang and Chongqing. The absolute percentage errors (APEs) are used to determine the weights of the FGM(0, m) and SVR. Meanwhile, the Holt–Winters model is used to predict the air quality pollutants for the same location and period. When the mean absolute percent error (MAPE) is 0%–20%, it indicates that the model has good accuracy of fitting and prediction. The MAPE of the hybrid model is less than 20%. It is shown that except for the PM2.5 concentration prediction in Shijiazhuang (13.7%), the MAPE between the forecasting and actual values of the three air pollutants in Shijiazhuang and Chongqing was less than 10%.

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