Colour and qualia

Author(s):  
Joseph Levine

There are two basic philosophical problems about colour. The first concerns the nature of colour itself. That is, what sort of property is it? When I say of the shirt that I am wearing that it is red, what sort of fact about the shirt am I describing? The second problem concerns the nature of colour experience. When I look at the red shirt I have a visual experience with a certain qualitative character – a ‘reddish’ one. Thus colour seems in some sense to be a property of my sensory experience, as well as a property of my shirt. What sort of mental property is it? Obviously, the two problems are intimately related. In particular, there is a great deal of controversy over the following question: if we call the first sort of property ‘objective colour’ and the second ‘subjective colour’, which of the two, objective or subjective colour, is basic? Or do they both have an independent ontological status? Most philosophers adhere to the doctrine of physicalism, the view that all objects and events are ultimately constituted by the fundamental physical particles, properties and relations described in physical theory. The phenomena of both objective and subjective colour present problems for physicalism. With respect to objective colour, it is difficult to find any natural physical candidate with which to identify it. Our visual system responds in a similar manner to surfaces that vary along a wide range of physical parameters, even with respect to the reflection of light waves. Yet what could be more obvious than the fact that objects are coloured? In the case of subjective colour, the principal topic of this entry, there is an even deeper puzzle. It is natural to think of the reddishness of a visual experience – its qualitative character – as an intrinsic property of the experience. Intrinsic properties are distinguished from relational properties in that an object’s possession of the former does not depend on its relation to other objects, whereas its possession of the latter does. If subjective colour is intrinsic, then it would seem to be a neural property of a brain state. But what sort of neural property could explain the reddishness of an experience? Furthermore, reduction of subjective colour to a neural property would rule out even the possibility that forms of life with different physiological structures, or intelligent robots, could have experiences of the same qualitative type as our experiences of red. While some philosophers endorse this consequence, many find it quite implausible. Neural properties seem best suited to explain how certain functions are carried out, and therefore it might seem better to identify subjective colour with the property of playing a certain functional role within the entire cognitive system realized by the brain. This allows the possibility that structures physically different from human brains could support colour experiences of the same type as our own. However, various puzzles undermine the plausibility of this claim. For instance, it seems possible that two people could agree in all their judgments of relative similarity and yet one sees green where the other sees red. If this ‘inverted spectrum’ case is a genuine logical possibility, as many philosophers advocate, then it appears that subjective colour must not be a matter of functional role, but rather an intrinsic property of experience. Faced with the dilemmas posed by subjective colour for physicalist doctrine, some philosophers opt for eliminativism, the doctrine that subjective colour is not a genuine, or real, phenomenon after all. On this view the source of the puzzle is a conceptual confusion; a tendency to extend our judgments concerning objective colour, what appear to be intrinsic properties of the surfaces of physical objects, onto the properties of our mental states. Once we see that all that is happening ‘inside’ is a perceptual judgment concerning the properties of external objects, we will understand why we cannot locate any state or property of the brain with which to identify subjective colour. The controversy over the nature of subjective colour is part of a wider debate about the subjective aspect of conscious experience more generally. How does the qualitative character of experience – what it is like to see, hear and smell – fit into a physicalist scientific framework? At present all of the options just presented have their adherents, and no general consensus exists.

Author(s):  
Joseph Levine

There are two basic philosophical problems about colour. The first concerns the nature of colour itself. That is, what sort of property is it? When I say of the shirt that I am wearing that it is red, what sort of fact about the shirt am I describing? The second problem concerns the nature of colour experience. When I look at the red shirt I have a visual experience with a certain qualitative character – a ‘reddish’ one. Thus colour seems in some sense to be a property of my sensory experience, as well as a property of my shirt. What sort of mental property is it? Obviously, the two problems are intimately related. In particular, there is a great deal of controversy over the following question: if we call the first sort of property ‘objective colour’ and the second ‘subjective colour’, which of the two, objective or subjective colour, is basic? Or do they both have an independent ontological status? Most philosophers adhere to the doctrine of physicalism, the view that all objects and events are ultimately constituted by the fundamental physical particles, properties and relations described in physical theory. The phenomena of both objective and subjective colour present problems for physicalism. With respect to objective colour, it is difficult to find any natural physical candidate with which to identify it. Our visual system responds in a similar manner to surfaces that vary along a wide range of physical parameters, even with respect to the reflection of light waves. Yet what could be more obvious than the fact that objects are coloured? In the case of subjective colour, the principal topic of this entry, there is an even deeper puzzle. It is natural to think of the reddishness of a visual experience – its qualitative character – as an intrinsic and categorical property of the experience. Intrinsic properties are distinguished from relational properties in that an object’s possession of the former does not depend on its relation to, or even the existence of, other objects, whereas its possession of the latter does. Categorical properties are distinguished from dispositional ones. A dispositional property is one that an object has by virtue of its tendency to behave in certain ways, or cause certain effects, in particular circumstances. So being brittle is dispositional in that it involves being liable to break under slight pressure, whereas being six feet tall, say, is categorical. If subjective colour is intrinsic and categorical, then it would seem to be a neural property of a brain state. But what sort of neural property could explain the reddishness of an experience? Furthermore, reduction of subjective colour to a neural property would rule out even the possibility that forms of life with different physiological structures, or intelligent robots, could have experiences of the same qualitative type as our experiences of red. While some philosophers endorse this consequence, many find it quite implausible. Neural properties seem best suited to explain how certain functions are carried out, and therefore it might seem better to identify subjective colour with the property of playing a certain functional role within the entire cognitive system realized by the brain. This allows the possibility that structures physically different from human brains could support colour experiences of the same type as our own. However, various puzzles undermine the plausibility of this claim. For instance, it seems possible that two people could agree in all their judgements of relative similarity and yet one sees green where the other sees red. If this ‘inverted spectrum’ case is a genuine logical possibility, as many philosophers advocate, then it appears that subjective colour must not be a matter of functional role, but rather an intrinsic property of experience. Another possibility is that qualitative character is just a matter of features the visual system, in the case of colour, is representing objects in the visual field to have. Reddish experiences are just visual representations of red. But this view too has problems with spectrum-inversion scenarios, and also entails some counterintuitive consequences concerning our knowledge of our own qualitative states. Faced with the dilemmas posed by subjective colour for physicalist doctrine, some philosophers opt for eliminativism, the doctrine that subjective colour is not a genuine, or real, phenomenon after all. On this view the source of the puzzle is a conceptual confusion; a tendency to extend our judgements concerning objective colour, what appear to be intrinsic and categorical properties of the surfaces of physical objects, onto the properties of our mental states. Once we see that nothing qualitative is happening ‘inside’, we will understand why we cannot locate any state or property of the brain with which to identify subjective colour. The controversy over the nature of subjective colour is part of a wider debate about the subjective aspect of conscious experience more generally. How does the qualitative character of experience – what it is like to see, hear and smell – fit into a physicalist scientific framework? At present all of the options just presented have their adherents, and no general consensus exists.


2019 ◽  
Author(s):  
Florent Meyniel

AbstractLearning in a changing and uncertain environment is a difficult problem. A popular solution is to predict future observations and then use surprising outcomes to update those predictions. However, humans also have a sense of confidence that characterizes the precision of their predictions. Bayesian models use this confidence to regulate learning: for a given surprise, the update is smaller when confidence is higher. We explored the human brain dynamics sub-tending such a confidence-weighting using magneto-encephalography. During our volatile probability learning task, subjects’ confidence reports conformed with Bayesian inference. Several stimulus-evoked brain responses reflected surprise, and some of them were indeed further modulated by confidence. Confidence about predictions also modulated pupil-linked arousal and beta-range (15-30 Hz) oscillations, which in turn modulated specific stimulus-evoked surprise responses. Our results suggest thus that confidence about predictions modulates intrinsic properties of the brain state to amplify or dampen surprise responses evoked by discrepant observations.


2020 ◽  
Vol 20 (3) ◽  
pp. 174-183
Author(s):  
Bushra Nabi ◽  
Saleha Rehman ◽  
Faheem Hyder Pottoo ◽  
Sanjula Baboota ◽  
Javed Ali

: NeuroAIDS, a disease incorporating both infectious and neurodegenerative pathways, is still a formidable challenge for the researchers to deal with. The primary concern for the treatment of neuroAIDS still remains the inaccessibility of the viral reservoir, making it indispensable for novel techniques to be continuously innovated. Since the brain serves as a reservoir for viral replication, it is pragmatic and a prerequisite to overcome the related barriers in order to improve the drug delivery to the brain. The current treatment ideology is based on the combinatorial approach of a mocktail of antiretroviral drugs. However, complete eradication of the disease could not be achieved. Thereby the arena of gene-based cellular delivery is trending and has created a niche for itself in the present scenario. To establish the supremacy of gene delivery, it is advisable to have a better understanding of the molecular mechanism involved in the due process. The mechanism associated with the activity of the anti-HIV gene lies in their intrinsic property to impart resistance to the HIV infection by targeting the viral entry channels. This review principally emphasizes on different types of gene therapies explored so far for the management of AIDS and its associated neurological conditions. Therefore it could rightly be said that we are at the crossroad where the need of the hour is to develop novel strategies for curbing AIDS and its associated neurological conditions.


Author(s):  
Anil K. Seth

Consciousness is perhaps the most familiar aspect of our existence, yet we still do not know its biological basis. This chapter outlines a biomimetic approach to consciousness science, identifying three principles linking properties of conscious experience to potential biological mechanisms. First, conscious experiences generate large quantities of information in virtue of being simultaneously integrated and differentiated. Second, the brain continuously generates predictions about the world and self, which account for the specific content of conscious scenes. Third, the conscious self depends on active inference of self-related signals at multiple levels. Research following these principles helps move from establishing correlations between brain responses and consciousness towards explanations which account for phenomenological properties—addressing what can be called the “real problem” of consciousness. The picture that emerges is one in which consciousness, mind, and life, are tightly bound together—with implications for any possible future “conscious machines.”


2013 ◽  
Vol 26 (1-2) ◽  
pp. 98
Author(s):  
Achille Pasqualotto ◽  
Michael J. Proulx ◽  
Martin I. Sereno

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1118
Author(s):  
Jan Homolak ◽  
Ana Babic Perhoc ◽  
Ana Knezovic ◽  
Jelena Osmanovic Barilar ◽  
Melita Salkovic-Petrisic

The gastrointestinal system may be involved in the etiopathogenesis of the insulin-resistant brain state (IRBS) and Alzheimer’s disease (AD). Gastrointestinal hormone glucagon-like peptide-1 (GLP-1) is being explored as a potential therapy as activation of brain GLP-1 receptors (GLP-1R) exerts neuroprotection and controls peripheral metabolism. Intracerebroventricular administration of streptozotocin (STZ-icv) is used to model IRBS and GLP-1 dyshomeostasis seems to be involved in the development of neuropathological changes. The aim was to explore (i) gastrointestinal homeostasis in the STZ-icv model (ii) assess whether the brain GLP-1 is involved in the regulation of gastrointestinal redox homeostasis and (iii) analyze whether brain-gut GLP-1 axis is functional in the STZ-icv animals. Acute intracerebroventricular treatment with exendin-3(9-39)amide was used for pharmacological inhibition of brain GLP-1R in the control and STZ-icv rats, and oxidative stress was assessed in plasma, duodenum and ileum. Acute inhibition of brain GLP-1R increased plasma oxidative stress. TBARS were increased, and low molecular weight thiols (LMWT), protein sulfhydryls (SH), and superoxide dismutase (SOD) were decreased in the duodenum, but not in the ileum of the controls. In the STZ-icv, TBARS and CAT were increased, LMWT and SH were decreased at baseline, and no further increment of oxidative stress was observed upon central GLP-1R inhibition. The presented results indicate that (i) oxidative stress is increased in the duodenum of the STZ-icv rat model of AD, (ii) brain GLP-1R signaling is involved in systemic redox regulation, (iii) brain-gut GLP-1 axis regulates duodenal, but not ileal redox homeostasis, and iv) brain-gut GLP-1 axis is dysfunctional in the STZ-icv model.


2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
D. E. Johnson ◽  
A. Hudmon

Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly concentrated in the brain where its activation by the Ca2+sensor CaM, multivalent structure, and complex autoregulatory features make it an ideal translator of Ca2+signals created by different patterns of neuronal activity. We provide direct evidence that graded levels of kinase activity and extent of T287(T286αisoform) autophosphorylation drive changes in catalytic output and substrate selectivity. The catalytic domains of CaMKII phosphorylate purified PSDs much more effectively when tethered together in the holoenzyme versus individual subunits. Using multisubstrate SPOT arrays, high-affinity substrates are preferentially phosphorylated with limited subunit activity per holoenzyme, whereas multiple subunits or maximal subunit activation is required for intermediate- and low-affinity, weak substrates, respectively. Using a monomeric form of CaMKII to control T287autophosphorylation, we demonstrate that increased Ca2+/CaM-dependent activity for all substrates tested, with the extent of weak, low-affinity substrate phosphorylation governed by the extent of T287autophosphorylation. Our data suggest T287autophosphorylation regulates substrate gating, an intrinsic property of the catalytic domain, which is amplified within the multivalent architecture of the CaMKII holoenzyme.


2021 ◽  
Author(s):  
Sophia Wienbar ◽  
Gregory Schwartz

The output of spiking neurons depends both on their synaptic inputs and on their intrinsic properties. Retinal ganglion cells (RGCs), the spiking projection neurons of the retina, comprise over 40 different types in mice and other mammals, each tuned to different features of visual scenes. The circuits providing synaptic input to different RGC types to drive feature selectivity have been studied extensively, but there has been substantially less research aimed at understanding how the intrinsic properties of RGCs differ and how those differences impact feature selectivity. Here, we introduce an RGC type in the mouse, the Bursty Suppressed-by-Contrast (bSbC) RGC, whose contrast selectivity is shaped by its intrinsic properties. Surprisingly, when we compare the bSbC RGC to the OFF sustained alpha (OFFsA) RGC that receives similar synaptic input, we find that the two RGC types exhibit starkly different responses to an identical stimulus. We identified spike generation as the key intrinsic property behind this functional difference; the bSbC RGC undergoes depolarization block in conditions where the OFFsA RGC maintains a high spike rate. Pharmacological experiments, imaging, and compartment modeling demonstrate that these differences in spike generation are the result of differences in voltage-gated sodium channel conductances. Our results demonstrate that differences in intrinsic properties allow these two RGC types to detect and relay distinct features of an identical visual stimulus to the brain.


2019 ◽  
Author(s):  
Jarno Tuominen ◽  
Sakari Kallio ◽  
Valtteri Kaasinen ◽  
Henry Railo

Can the brain be shifted into a different state using a simple social cue, as tests on highly hypnotisable subjects would suggest? Demonstrating an altered brain state is difficult. Brain activation varies greatly during wakefulness and can be voluntarily influenced. We measured the complexity of electrophysiological response to transcranial magnetic stimulation (TMS) in one “hypnotic virtuoso”. Such a measure produces a response outside the subject’s voluntary control and has been proven adequate for discriminating conscious from unconscious brain states. We show that a single-word hypnotic induction robustly shifted global neural connectivity into a state where activity remained sustained but failed to ignite strong, coherent activity in frontoparietal cortices. Changes in perturbational complexity indicate a similar move toward a more segregated state. We interpret these findings to suggest a shift in the underlying state of the brain, likely moderating subsequent hypnotic responding. [preprint updated 20/02/2020]


Sign in / Sign up

Export Citation Format

Share Document