Rethinking J. G. A. Pocock’s Research Methodology in the History of Historiography : With Special Focus on Barbarism and Religion in Six Volumes

2021 ◽  
Vol 45 (3) ◽  
pp. 179-204
Author(s):  
Seok-Min Yun
Keyword(s):  
Research Methodology ◽  
Special Focus ◽  
History Of

Tanaka Kinuyo

2018 ◽  
Keyword(s):  
Industrial Development ◽  
Japanese Woman ◽  
Cultural Construction ◽  
Public Image ◽  
Special Focus ◽  
Japanese History ◽  
Female Subjectivity ◽  
Japanese Cinema ◽  
Close Analysis ◽  
History Of

This is the first book in English dedicated to the actress and director Tanaka Kinuyo. Praised as amongst the greatest actors in the history of Japanese cinema, Tanaka’s career spanned the industrial development of cinema - from silent to sound, monochrome to colour. Alongside featuring in films by Ozu, Mizoguchi, Naruse and Kurosawa, Tanaka was also the only Japanese woman filmmaker between 1953 and 1962, and her films tackled distinctly feminine topics such as prostitution and breast cancer. Because her career overlaps with a transformative period in Japan, especially for women, this close analysis of her fascinating life and work offers new perspectives into the Japanese history of women and classical era of national cinema. The first half of the book focuses on Tanaka as actress and analyses the elements and meanings associated with her star image, and her powerful embodiment of diverse, at times contradictory, ideological discourses. The second half is dedicated to Tanaka as director and explores her public image as filmmaker and her depiction of gender and sexuality against the national history in order to reflect on her role and style as author. With a special focus on the melodrama genre and on the sociopolitical and economic contexts of film production, the book offers a revision of theories of stardom, authorship, and women’s cinema. In examining Tanaka’s iconic reification of femininities in relation to politics, national identity, and memory, the chapters shed light on the cultural construction of female subjectivity and sexuality in Japanese popular culture.

Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

2018 ◽  
Vol 18 (10) ◽  
pp. 857-880 ◽  
Author(s):  
Salma E. Ahmed ◽  
Nahid Awad ◽  
Vinod Paul ◽  
Hesham G. Moussa ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Special Focus ◽  
Nano Drug Delivery ◽  
Medical Researchers ◽  
History Of ◽  
Overall Performance ◽  
Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

scholarly journals Different Within-Host Viral Evolution Dynamics in Severely Immunosuppressed Cases with Persistent SARS-CoV-2

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 808
Author(s):  
Laura Pérez-Lago ◽  
Teresa Aldámiz-Echevarría ◽  
Rita García-Martínez ◽  
Leire Pérez-Latorre ◽  
Marta Herranz ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Evolutionary Dynamics ◽  
Viral Evolution ◽  
Special Focus ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
New Variant ◽  
History Of ◽  
Evolution Dynamics ◽  
The Uk

A successful Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant, B.1.1.7, has recently been reported in the UK, causing global alarm. Most likely, the new variant emerged in a persistently infected patient, justifying a special focus on these cases. Our aim in this study was to explore certain clinical profiles involving severe immunosuppression that may help explain the prolonged persistence of viable viruses. We present three severely immunosuppressed cases (A, B, and C) with a history of lymphoma and prolonged SARS-CoV-2 shedding (2, 4, and 6 months), two of whom finally died. Whole-genome sequencing of 9 and 10 specimens from Cases A and B revealed extensive within-patient acquisition of diversity, 12 and 28 new single nucleotide polymorphisms, respectively, which suggests ongoing SARS-CoV-2 replication. This diversity was not observed for Case C after analysing 5 sequential nasopharyngeal specimens and one plasma specimen, and was only observed in one bronchoaspirate specimen, although viral viability was still considered based on constant low Ct values throughout the disease and recovery of the virus in cell cultures. The acquired viral diversity in Cases A and B followed different dynamics. For Case A, new single nucleotide polymorphisms were quickly fixed (13–15 days) after emerging as minority variants, while for Case B, higher diversity was observed at a slower emergence: fixation pace (1–2 months). Slower SARS-CoV-2 evolutionary pace was observed for Case A following the administration of hyperimmune plasma. This work adds knowledge on SARS-CoV-2 prolonged shedding in severely immunocompromised patients and demonstrates viral viability, noteworthy acquired intra-patient diversity, and different SARS-CoV-2 evolutionary dynamics in persistent cases.

WHY STUDYING THE HISTORY OF PHILOSOPHY MATTERS

Think ◽  
2021 ◽  
Vol 21 (60) ◽  
pp. 5-20
Author(s):  
Anna Marmodoro
Keyword(s):  
Ancient Philosophy ◽  
History Of Philosophy ◽  
Special Focus ◽  
The Past ◽  
History Of ◽  
The One

The debate over whether and how philosophers of today may usefully engage with philosophers of the past is nearly as old as the history of philosophy itself. Does the study of the history of philosophy train or corrupt the budding philosopher's mind? Why study the history of philosophy? And, how to study the history of philosophy? I discuss some mainstream approaches to the study of the history of philosophy (with special focus on ancient philosophy), before explicating the one I adopt and commend.

THE FORMATION OF THE HISTORICAL AND LITURGICAL RESEARCH AREA IN RUSSIAN ACADEMIC SCHOLARSHIP IN THE LATE 19TH – EARLY 20TH CENTURY. A COMPARATIVE ANALYSIS OF METHODOLOGICAL APPROACHES OF N.V. POKROVSKY AND I.A. KARABINOV

2021 ◽  
pp. 30-49
Author(s):  
Zoya M. Dashevskaya ◽  
Keyword(s):  
Research Methodology ◽  
Research Area ◽  
Academic Science ◽  
Scientific School ◽  
Academic Scholarship ◽  
Academic Courses ◽  
History Of ◽  
Christian Worship ◽  
The Subject ◽  
The 19Th Century

n the second half of the 19th century – especially in the period following the introduction of the Academic Constitution of 1869, and in the 1880s and continuing until the forced closure of Theological Academies after the Revolutionary coup – the historical and liturgical research area in Russian academic science experienced a period of its formation and flourishing. The subject of the article is a comparison of approaches to the study of the worship service history and analysis of the formation of the research methodology for teaching Liturgics by professors N.V. Pokrovsky and I.A. Karabinov of the St. Petersburg Theological Academy, where they taught the history of Christian worship from the 1880’s until its forced closure in 1918. Analysis and juxtapos- ing of academic courses in Liturgics allows defining the boundaries and content of the discipline in the period of its formation as well as considering the evolu- tion in research methodology and, more broadly, the formation of the Russian historical and liturgical scientific school. A comparison of the courses reveals the authors attitudes towards histori- cal sources material and its studies. Their own ideas about the provenance of various rites used in church worship characterize their views on the develop- ment of the liturgical tradition, expressing their approaches to its study and thereby form our picture of the establishment of historical Liturgics as a field of researchable knowledge.

scholarly journals Echinocandins: structural diversity, biosynthesis, and development of antimycotics

2020 ◽  
Vol 105 (1) ◽  
pp. 55-66
Author(s):  
Wolfgang Hüttel
Keyword(s):  
Isotope Labeling ◽  
Current Knowledge ◽  
Complex Structure ◽  
Hydrolytic Stability ◽  
Structural Diversity ◽  
Gene Clusters ◽  
Special Focus ◽  
Key Points ◽  
Invasive Mycosis ◽  
History Of

Abstract Echinocandins are a clinically important class of non-ribosomal antifungal lipopeptides produced by filamentous fungi. Due to their complex structure, which is characterized by numerous hydroxylated non-proteinogenic amino acids, echinocandin antifungal agents are manufactured semisynthetically. The development of optimized echinocandin structures is therefore closely connected to their biosynthesis. Enormous efforts in industrial research and development including fermentation, classical mutagenesis, isotope labeling, and chemical synthesis eventually led to the development of the active ingredients caspofungin, micafungin, and anidulafungin, which are now used as first-line treatments against invasive mycosis. In the last years, echinocandin biosynthetic gene clusters have been identified, which allowed for the elucidation but also engineering of echinocandin biosynthesis on the molecular level. After a short description of the history of echinocandin research, this review provides an overview of the current knowledge of echinocandin biosynthesis with a special focus of the diverse structural elements, their biosynthetic background, and structure−activity relationships. Key points • Complex and highly oxidized lipopeptides produced by fungi. • Crucial in the design of drugs: side chain, solubility, and hydrolytic stability. • Genetic methods for engineering biosynthesis have recently become available.

scholarly journals THE APPROACHES OF THE ROMANIAN AUTHORS REGARDING THE CSR CONCEPT

2020 ◽  
Vol 5 (2) ◽  
pp. 63-71
Author(s):  
Nicoleta-Daniela Milu
Keyword(s):  
Corporate Social Responsibility ◽  
Social Responsibility ◽  
Research Methodology ◽  
Business Environment ◽  
Significant Progress ◽  
Analysis And Synthesis ◽  
History Of ◽  
Corporate Social ◽  
Development Prospects ◽  
Great Development

In Romania, large companies, most of which are multinationals, have made significant progress in integrating the concept of corporate social responsibility (CSR) into their activity. The concept of CSR in small and medium-sized companies is still in the early stages of reporting, but with great development prospects. Romanian companies have gradually begun to develop their own culture in terms of social responsibility. The main objective of this article is to analyze how Romanian authors approach CSR theories in their research. The CSR action is seen by the authors as an interdependent relationship between corporations and society. Social requirements are generally considered to be a way in which society interacts with the business environment and gives it a certain legitimacy and prestige. Given that the history of the concept of CSR is long and diverse, I must emphasize that this article focuses on the publications of Romanian authors who based their work on a theory of CSR, providing an original perspective and understanding of the concept of CSR. The research methodology approached involves analysis and synthesis appeal. The study shows that integrative theories are the most common, based on the papers of Romanian authors regarding the concept of CSR. Most articles are based on the idea that the business depends on society to continue its activity and to develop, there is an interdependent relationship between the company and society.

scholarly journals Kitabistyka: źródła, metodologia i perspektywy badawcze

2018 ◽  
Vol 24 (2) ◽  
pp. 111-124
Author(s):  
Czesław Łapicz
Keyword(s):  
Research Methodology ◽  
16Th Century ◽  
Major Research ◽  
Historical Texts ◽  
Slavic Languages ◽  
History Of ◽  
Vilnius University ◽  
Grand Duchy Of Lithuania ◽  
Grand Duchy ◽  
Oriental Language

The paper contains a synthetic discussion of original and little known philological manuscripts which had been created since the 16th century by Tatars – Muslims of the Grand Duchy of Lithuania – as characteristic Slavic aljamiado. The preserved manuscripts in which Slavic languages – Polish and Belarusian – were recorded in the Arabic alphabet are enormously important for the history of both languages and the Slavic-Oriental language relations. Various types of these historical texts (kitabs, chamails, tajweeds, etc.) contain the first, that is the oldest (16th century), translation of the Quran into a Slavic language (Polish) recorded in the Arabic alphabet (so-called tafsir). These sources are studied within the framework of an original philological sub-discipline of Kitab Studies whose origin and development should be credited to Professor Anton Antonovich from Vilnius University. The author of the paper discusses the research methodology pertaining to these sources, particularly the transliteration of Slavic texts recorded in the Arabic alphabet into the Latin alphabet, and introduces prospective major research tasks for Kitab Studies.

Saint Theophan the Recluse in the Struggle with Shtunda

2020 ◽  
pp. 230-242
Author(s):  
Варвара Викторовна Каширина
Keyword(s):  
Research Methodology ◽  
Bible Study ◽  
Active Participation ◽  
Scientific Methods ◽  
History Of ◽  
The Subject ◽  
Xix Century

Объектом исследования в статье является переписка святителя Феофана с Н. В. Елагиным, протоиереем Николаем Флоринским и протоиереем Димитрием Ждановым. Тематика переписки - религиозно-нравственные братства («штунды») для изучения Библии, возникшие в начале XIX в. в южных областях Украины и быстро увеличивавшие своё влияние среди православных христиан. Методология исследования базируется на комплексном применении традиционных научных методов: источниковедческого, историко-логического и сравнительно-исторического. В результате исследования была реконструирована история издания сочинения А. Д. Ушинского «Вероучение малорусских штундистов, разобранное на основании Священного Писания в беседах православного мирянина с сектантами» против штундистов и выявлено участие в подготовке издания святителя Феофана Затворника. Труд А. Д. Ушинского, написанный при деятельном участии и поддержке святителя Феофана, явился одним из первых, посвящённых штунде. В книге были опубликованы и подробно разобраны вероучительные положения штундистов, которые ходили в рукописном виде или же распространялись только устно. The object of research in the article was the correspondence of Saint Theophan with N. V. Elagin, Archpriest Nikolai Florinsky and Archpriest Dimitri Zhdanov. The subject of the correspondence is religious and moral fraternities («shtund») for Bible study, which appeared in the early XIX century in the southern regions of Ukraine and quickly increased their influence among Orthodox Christians. The research methodology is based on the complex application of traditional scientific methods: source-based, historical-logical and comparative-historical. The study was reconstructed history of editions of works by A. D. Ushinsky «a little Creed of Stundists, dismantled on the basis of Holy Scripture in the conversations of an Orthodox layman with zealots» against Stundists identified and involved in the preparation of the edition of St. Theophan the Recluse. The work of A.D. Ushinsky, written with the active participation and support of Saint Theophan, was one of the first dedicated to shtunda. The book published and analyzed in detail the doctrinal statements of the shtundists, which went in handwritten form or were distributed only orally.

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