scholarly journals The potential effect of the green coffee extract on reducing atherogenic index in hyperlipidemic rats

2021 ◽  
pp. 126-131
Author(s):  
Fransiska Maria Christianty ◽  
Fifteen Aprila Fajrin ◽  
Andrean Roni
Keyword(s):  
Cardiovascular Disease ◽  
Serum Lipid ◽  
Potential Effect ◽  
Research Data ◽  
Atherogenic Index ◽  
Green Coffee ◽  
High Fat ◽  
Atherogenic Index Of Plasma ◽  
High Prevalence ◽  
Cardiac Histopathology

Introduction: Dyslipidemia is a risk factor for atherosclerosis and cardiovascular disease. The high prevalence of dyslipidemia triggers the development of green coffee supplement products, which are claimed as cholesterol-lowering and slimming agents. Nonetheless, research data on the effect of taking green coffee supplement products, especially regarding cardiovascular function, is limited. Aims: To determine the potential effect of green coffee extract (GCE) on improving atherogenic index of plasma (AIP) and cardiac histopathology in hyperlipidemic rats. Methods: 24 rats were induced by high-fat feed for 21 days. Then, the rats were treated with a GCE, dose of 200, 400, and 800 mg/kg bodyweight for 14 days. The next day, blood was collected from the rats to take measurements of their serum lipid profile and calculating their AIP. The heart organ was created by using histopathological preparations. Results: Administration of GCE in all doses significantly reduced the AIP and improved cardiac histopathology in the hyperlipidemic rats. Conclusions: GCE can be developed as a cardio-protector.

Evidence for the atherogenic index of plasma as a potential biomarker for cardiovascular disease in schizophrenia

2021 ◽  
pp. 026988112110264
Author(s):  
Sinay Onen ◽  
Ibrahim Taymur
Keyword(s):  
Cardiovascular Disease ◽  
Serum Lipid ◽  
Risk Index ◽  
Atherogenic Index ◽  
Healthy Controls ◽  
Cvd Risk ◽  
Atherogenic Index Of Plasma ◽  
Atherogenic Indices ◽  
And Control ◽  
Drug Free

Background: Schizophrenia is known to be accompanied with increased cardiovascular mortality, which causes reduced life expectancy. Aim: The aim of the current study was to investigate if atherogenic index of plasma (AIP) could be a good marker in assessing cardiovascular disease (CVD) risk in patients with schizophrenia. Methods: Patients with schizophrenia ( n = 328) and healthy controls ( n = 141) were recruited. Schizophrenia patients were evaluated according to the presence of antipsychotic (AP) drug use as AP(+)Sch group and AP(−)Sch group. Atherogenic indices, such as AIP, Castelli’s risk index-I (CRI-I), Castelli’s risk index-II (CRI-II), and atherogenic coefficient (AC), were calculated according to the laboratory examination of serum lipid parameters. Results: According to the comparison of serum lipid levels, triglyceride (TG) levels were found to be highest and high-density lipoprotein–cholesterol levels were lowest in AP(+)Sch group than AP(−)Sch group and control group (CG) ( p < 0.001). AIP, CRI-I, and CRI-II scores were found to be significantly higher in AP(+)Sch group than AP(−)Sch group, and in AP(−)Sch than healthy controls ( p < 0.001). Mean AC scores were higher in AP(+)Sch group than both AP(−)Sch and CG and were similar in AP(−)Sch and control subjects ( p < 0.001). According to the correlation analysis, AIP scores were positively correlated with duration of disease ( r = 0.235; p = 0.002) and age ( r = 0.226; p = 0.003) in AP(+)Sch group but not in drug-free subjects. In all groups, atherogenic indices of CRI-I, CRI-II, and AC scores were found to be positively correlated with AIP scores ( p < 0.001). Conclusion: Our results suggest that AIP is an easily calculable and reliable marker for determining the CVD risk in both drug-free schizophrenia patients and patients under AP treatment.

scholarly journals The Apolipoprotein B/Apolipoprotein A-I Ratio as a Potential Marker of Plasma Atherogenicity

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Anastasiya M. Kaneva ◽  
Natalya N. Potolitsyna ◽  
Evgeny R. Bojko ◽  
Jon Ø. Odland
Keyword(s):  
Cardiovascular Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Fasting Period ◽  
Apo B ◽  
Atherogenic Index Of Plasma ◽  
Potential Marker ◽  
Atherogenic Lipid Profile

Background.The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting the presence or absence of cardiovascular disease, less is known about apoB/apoA-I ratio as a marker of plasma atherogenicity.Methods.A total of 157 normolipidemic men aged 20–59 years were included in the study. The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apoA-I, apoB, and apoE were determined after a 12 h fasting period.Results. The median of the apoB/apoA-I ratio in the studied normolipidemic subjects was 0.52, with values ranging from 0.19 to 2.60. The percentage of subjects with the apoB/apoA-I ratio exceeding 0.9 (the accepted risk value of cardiovascular disease) was 19.1%. The subjects with apoB/apoA-I>0.9 were characterized by higher TG levels and atherogenic index of plasma (AIP) and lower values of ratio of low-density lipoprotein cholesterol (LDL-C) to apoB (LDL-C/apoB) and apoE levels compared with men with apoB/apoA-I<0.9.Conclusion. Despite normolipidemia, the subjects with the unfavorable apoB/apoA-I ratio had more atherogenic lipid profile.

scholarly journals Understanding the Relationship between Atherogenic Index of Plasma and Cardiovascular Disease Risk Factors among Staff of an University in Malaysia

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Myat Su Bo ◽  
Whye Lian Cheah ◽  
Soe Lwin ◽  
Tin Moe Nwe ◽  
Than Than Win ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Visceral Fat ◽  
Blood Pressure Measurement ◽  
Measurement Data ◽  
Atherogenic Index ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Atherogenic Index Of Plasma

Background. Atherogenic index of plasma (AIP) was found to be one of the strongest markers in predicting the cardiovascular disease (CVD) risk. This study was to determine the AIP and its relationship with other CVD risk factors. Materials and Methods. This cross-sectional study was done among 349 staff of a public university in Sarawak. Data were collected using questionnaire, blood sampling, and anthropometric and blood pressure measurement. Data were analyzed using IBM SPSS version 20. Results. A total of 349 respondents participated with majority females (66.8%), aged 38.5 ± 7.82 years. Nearly 80% of the respondents were overweight and obese, 87.1% with high and very high body fat, and 46.9% with abnormal visceral fat. For AIP category, 8.9% were found to be in intermediate and 16.4% were at high risk. Elevated lipid profile showed that total cholesterol (TC) is 15.5%, low density lipoprotein (LDL) is 16.1%, and triglyceride (TG) is 10.6%. AIP was significantly correlated with body mass index (r=0.25), visceral fat (r=0.37), TC (r=0.22), LDL (0.24), HDL (r=−0.72), TG (r=0.84), glucose (r=0.32), systolic blood pressure (r=0.22), and diastolic blood pressure (r=0.28). Conclusion. It indicated that AIP is associated with other CVD risk factors. Modification of lifestyle is strongly recommended.

scholarly journals Atherogenic Index of Plasma in Obstructive Sleep Apnoea

2021 ◽  
Vol 10 (3) ◽  
pp. 417
Author(s):  
Andras Bikov ◽  
Martina Meszaros ◽  
Laszlo Kunos ◽  
Alina Gabriela Negru ◽  
Stefan Marian Frent ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Disease Severity ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Atherogenic Index ◽  
Clinical Value ◽  
Sleep Study ◽  
Atherogenic Index Of Plasma ◽  
Obstructive Sleep ◽  
Cardiovascular Morbidity And Mortality

Background: Dyslipidaemia is well recognised in obstructive sleep apnoea (OSA) and could contribute to the development of cardiovascular disease (CVD). Atherogenic index of plasma (AIP) predicts cardiovascular morbidity and mortality better than the individual lipid levels. The aim of this study was to investigate the AIP in patients with OSA in relation with disease severity. Methods: Four hundred sixty-one patients with OSA and 99 controls participated in this study. AIP was assessed in the morning following a diagnostic sleep study. The association between lipid values and OSA were adjusted for age, gender, and body mass index. Results: Patients with OSA had higher AIP and triglyceride, and lower high-density lipoprotein cholesterol (HDL-C) levels (all p < 0.05). AIP significantly correlated with the Epworth Sleepiness Scale score (ρ = 0.19), the apnoea-hypopnoea index (ρ = 0.40) and oxygen desaturation index (ρ = 0.43, all p < 0.05). However, there was no relationship between the AIP and markers of sleep quality such as total sleep time, sleep period time, sleep efficiency, arousal index or percentage of REM sleep (all p > 0.05). AIP was not a better predictor for self-reported cardiovascular disease or diabetes than HDL-C. Conclusions: AIP is elevated in OSA and is related to disease severity. However, it does not seem to have an additional clinical value compared to HDL-C.

scholarly journals Atherogenic index of plasma and 10-year risk of cardiovascular disease in adult Africans living with HIV infection: A cross-sectional study from Yaoundé, Cameroon

2017 ◽  
Vol 6 ◽  
pp. 204800401774047
Author(s):  
Steve Raoul Noumegni ◽  
Jobert Richie Nansseu ◽  
Jean Joel Bigna ◽  
Vicky Jocelyne Ama Moor ◽  
Felix Kembe Assah ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Hiv Infection ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Sectional Study ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Living With Hiv

scholarly journals Lipid Profile, Atherogenic Index of Plasma, and Anthropometric Measurements Among Osteoporotic Postmenopausal Sudanese Women: Possible Risk for Cardiovascular Disease

2021 ◽  
Author(s):  
Abdelgadir Elmugadam ◽  
Ghada A. Elfadil ◽  
Abdelrahman Ismail Hamad ◽  
Mawahib Aledrissy ◽  
Hisham N. Altayb ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Postmenopausal Women ◽  
Density Lipoprotein ◽  
Anthropometric Measurements ◽  
Atherogenic Index ◽  
Cvd Risk ◽  
Atherogenic Index Of Plasma ◽  
Blood Samples ◽  
T Score

Abstract Background: Osteoporosis and menopausal women’s health had paucity data from Africa, especially Sub-Saharan countries. The current study aimed to assess the relationship between lipid profile, atherogenic Index of Plasma (AIP), anthropometric measurements, and the risk of cardiovascular disease (CVD) among osteoporotic Sudanese postmenopausal women.Methods: An epidemiological, cross-sectional comparative, community-based study was conducted. Postmenopausal women (n = 300), aged 47- 90 years, with an average one year postmenopause, were recruited from various centers in Khartoum State. Dual-energy X-ray absorptiometry (DEXA) was used to assess bone density. DEXA scan was interpreted in terms of T-score as per World Health Organization guidelines. Weight, height, and waist circumference were measured twice following standard protocols. In addition, fasting blood samples (5ml) were collected for the determination of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). AIP was calculated as an indicator for CVD risk. Blood samples were assayed on the Roche/Hitachi Cobas c311 system (Roche Diagnostics GmbH, Germany). Statistical analysis was carried out using SPSS version 26. Results: The mean age of the postmenopausal women was 61.7±10.3 years, with 80 women having normal T-score and an equal number of osteoporotic and osteopenic (n = 110 each). Most women (59%) aged 47-64 years. The prevalence of osteoporosis was 36.7%. Many postmenopausal women with normal BMD suffered from general (68%) and central obesity (94%) compared with their counterparts. Hypercholesterolemia, hypertriglyceridemia, high LDL-C, hypo-HDL-C were identified among 26.4%, 31%, 16.3%, and 32.7% osteoporotic women respectively. Osteoporotic postmenopausal (36.4%) women had medium to high risk of CVD according to their AIPs. There was a significantly inverse correlation between age and HDL-C (r= -0.205; p=0.032) whereas positive association between AIP and TC (r=0.230; p=0.016), among osteoporotic women. Osteoporotic (52%) and osteopenic (42%) women had ≥2 CVD risk factors. Multiple Linear regression analysis showed T-score value decreased significantly with age and AIP and increased with BMI. Conclusion: Osteoporosis is prevalent among Sudanese postmenopausal women who are at increased risk for CVD. Necessary steps are needed for public education and wider dissemination of information about osteoporosis, CVD and their prevention.

scholarly journals Atherogenic Index of Plasma in Postmenopausal Women

2018 ◽  
Vol 16 (2) ◽  
pp. 175-177
Author(s):  
Gita Khakurel ◽  
Rajat Kayastha ◽  
Sanat Chalise ◽  
Prabin K Karki
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Postmenopausal Women ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Premenopausal Women ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma

Background: Hyperlipidemia is one of the important risk factor for development of cardiovascular disease in post menopausal women.Our study compared the serum lipid profile and atherogenic index of plasma between premenopausal and post menopausal women.Methods: This was a cross sectional study conducted in Kathmandu Medical College. A total number of 194 women in the age group 30 to 60 years were studied. They include 108 postmenopausal women and 86 premenopausal controls. Total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglycerides were determined. Results: The mean value of total cholesterol, low-density lipoprotein cholesterol and triglyceride were significantly increased in postmenopausal women when compared to premenopausal women. There was increase in high-density lipoprotein cholesterol in postmenopausal women but the difference was not significant. The atherogenic index of plasma was increased in postmenopausal women (0.22 ± 0.25 mmol/l). This shows that postmenopausal women in our setting are at medium risk of developing cardiovascular disease. Atherogenic index of plasma was positively and significantly correlated with age (r= 0.29, p<0.05), body mass index (r=0.24, p<0.05), systolic blood pressure (r=0.20, p<0.05) and diastolic blood pressure (r=0.45, p<0.05).Conclusions: Postmenopausal women were at greater risk for developing cardiovascular disease when compared to premenopausal women due to increase in atherogenic lipid profile. There was a significant correlation of atherogenic index of plasma with age, body mass index, systolic blood pressure and diastolic blood pressure.Keywords: Keywords: Atherogenic index of plasma; lipid profile; menopause.

scholarly journals CORRELATION OF ATHEROGENIC INDEX OF PLASMA WITH STENOSIS LEVEL OF CORONARY ARTERY IN ACUTE CORONARY SYNDROME

2019 ◽  
Vol 25 (1) ◽  
pp. 53
Author(s):  
Ilhamifithri Ilhamifithri ◽  
Rismawati Yaswir ◽  
Eugeny Alia ◽  
Efrida Efrida
Keyword(s):  
Cardiovascular Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Spearman Correlation ◽  
Atherogenic Index Of Plasma ◽  
Coronary Syndrome ◽  
The Mean ◽  
Moderate Positive Correlation

Atherogenic dyslipidemia is the main risk factor of Acute Coronary Syndrome (ACS), caused atherosclerosis plaque and stenosis of artery coronary. Lipid profile ratio used as a marker of cardiovascular disease severity. Atherogenic Index of Plasma (AIP) calculated as logarithm triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) is a reflection of plasma atherogenicity degree and indicator of small dense low-density lipoprotein (LDL). Small dense LDL is the best predictor for cardiovascular disease, but expensive and difficult to examined. The aim of this study to determine the correlation of AIP with stenosis level of the coronary artery in ACS.  This research was an analytical study with cross-sectional design in 24 ACS patients meet the inclusion and exclusion criteria and conduct blood tests at the Central Laboratory Installation of Dr. M. Djamil Hospital Padang in January 2017- September 2017. Triglycerides and HDL-C performed by an enzymatic colorimetric method and stenosis level determined by coronary angiography. Spearman correlation was used to analyze correlation of atherogenic plasma index with stenosis level of the coronary artery, significant if p<0.05.  The subjects of this study were 20 males (83.3%) and 4 females (16.6%) with mean age 57.6(7.9) years. The mean level of HDL cholesterol and triglycerides in ACS were 34.8 (8.7) mg/dL and 155.8 (51.8)  mg/dL. The mean level of  AIP in ACS was 0.28 (0.18). Median of stenosis level of coronary artery was 80% with range 50% - 95%. Spearman correlation test showed a moderate positive correlation between AIP with stenosis level of the coronary artery in ACS (r= 0.426 ; p<0.05).  There is a moderate positive correlation between AIP with stenosis level of the coronary artery in ACS.

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