scholarly journals In vivo activity of Phaseolus vulgaris as an anti-hypercholesterolemic

2021 ◽  
pp. 184-188
Author(s):  
Keni Idacahyati ◽  
Yedy Purwandi Sukmawan ◽  
Nopi Yanti ◽  
Winda Trisna Wulandari ◽  
Firman Gustaman ◽  
...  
Keyword(s):  
Phaseolus Vulgaris ◽  
Ethyl Acetate ◽  
Total Cholesterol ◽  
Ethyl Acetate Extract ◽  
Ethanol Extract ◽  
Blood Cholesterol ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Levels

Introduction: Hyperlipidemia occurs due to increased levels of lipids and cholesterol in the blood. Phytosterols, such as stigmasterol in Phaseolus vulgaris, can reduce blood cholesterol levels. Objectives: The purpose of this study was to determine the activity of P. vulgaris in hypercholesterolemic rats. Methods: Nine groups underwent the anti-hypercholesterolemia test: control group, negative group, positive group, 150 mg/kg body weight (bw) and 300 mg/kg bw n-hexane extract groups, 150 mg/kg bw and 300 mg/kg bw ethyl acetate extract groups, and 150 mg/kg bw and 300 mg/kg bw ethanol extract groups. Results: All groups, except the control group, were given a high cholesterol diet to induce hypercholesterolemia (until the total cholesterol levels were higher than 200 mg/dL), followed by testing for ten days. The results showed that the 300 mg/kg bw ethyl acetate extract group had the best activity in reducing total cholesterol.

scholarly journals Potensi Ekstrak Etanol Kulit Jeruk Lemon (Citrus limon L.) Sebagai Obat Alternatif Hiperkolesterolemia Pada Tikus Wistar Hiperglikemik

2019 ◽  
Vol 6 (2) ◽  
pp. 81
Author(s):  
Deni Tri Hartanto ◽  
Ellen Lydia Kurniasari ◽  
Ribka Artha Maria ◽  
Puspa Sari Dewi ◽  
Vina Septiani
Keyword(s):  
Total Cholesterol ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Blood Cholesterol ◽  
Control Group ◽  
Citrus Limon ◽  
Lemon Peel ◽  
Cholesterol Levels ◽  
Protection Method ◽  
Alternative Drug

<p align="center"><strong>Abstrak</strong></p><p align="center"><strong> </strong></p><p>Jeruk lemon (<em>Citrus limon </em>L) secara empiris telah digunakan masyarakat untuk menurunkan berat badan.  Selain itu perasan jeruk lemon pun dipercaya mampu menurunkan kadar kolesterol darah. Penelitian ini bertujuan untuk menentukan potensi ekstrak etanol kulit jeruk lemon sebagai obat alternatif hiperkolesterolemia pada tikus <em>wistar</em> hiperglikemia dengan menggunakan metode proteksi. Proses ekstraksi kulit buah jeruk lemon dilakukan dengan metode maserasi.  Semua tikus diberi sediaan uji sesuai dengan kelompoknya (kontrol, ekstrak etanol jeruk lemon, pembanding simvastatin) bersamaan dengan intervensi fruktosa 60% yang dicampur dalam makanannya selama 6 minggu. Pemeriksaan kadar kolesterol total dilakukan setiap minggu. Hasil pengujian menunjukkan bahwa ekstrak etanol kulit buah lemon mampu menghambat peningkatan kadar kolesterol total tikus <em>wistar </em>hiperglikemia.  Ekstrak etanol kulit buah lemon dosis 70 mg/kg bb menunjukkan hasil terbaik yang berbeda bermakna dibanding kelompok kontrol (p&lt;0,05) pada penelitian ini. Dengan demikian, ekstrak etanol kulit jeruk lemon berpotensi untuk digunakan sebagai obat alternatif hiperkolesterolemia.</p><p> </p><p><strong>Kata Kunci :</strong> Hiperkolesterolemia, Lemon, Fruktosa 60%</p><p> </p><p align="center"><strong><em>Potency of lemon peel ethanolic extract (Citrus limon L.) as alternative drug for hypercholesterolemia in hyperglycemic wistar rat</em></strong></p><p><em> </em></p><p align="center"><strong><em>Abstract </em></strong></p><p align="center"><strong><em> </em></strong></p><p><em>Lemon (Citrus limon L) empirically has been used by the community to lose weight. Besides lemon juice is also believed to be able to reduce blood cholesterol levels. This study aims to determine the potential of ethanol extract of lemon peel as an alternative medicine for hypercholesterolemia in hyperglycemic wistar rats using the protection method. The process of extracting lemon peel is done by maceration method. All rats were given a test preparation according to their group (control, lemon ethanol extract, compared to simvastatin) together with intervention of fructose 60% mixed in the food for 6 weeks. Examination of total cholesterol levels is carried out every week. The test results showed that the ethanol extract of lemon peel was able to inhibit the increase of total cholesterol levels in hyperglycemic wistar rats. The ethanol extract of lemon peel doses of 70 mg / kg bw showed the best results which were significantly different than the control group (p &lt;0.05) in this study. Thus, the ethanol extract of lemon peel has the potential to be used as an alternative drug for hypercholesterolemia.</em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em> : Hypercholesterolemia, Lemon, Fructose 60 % </em></p>

scholarly journals The effect of ethanol extract from Portulaca oleracea on inhibiting total cholesterol on animal subjects

2021 ◽  
pp. 22-26
Author(s):  
Afifah Bambang Sutjiatmo ◽  
Fahmy Ahsanul Haq ◽  
Sulaeman Al Jati ◽  
Suci Nar Vikasari
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Ethanol Extract ◽  
Portulaca Oleracea ◽  
Control Group ◽  
High Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Test Parameters ◽  
Effect Test

Introduction: Hypercholesterolemia occurs when cholesterol levels in the blood increases. Traditionally, krokot (purslane, portulaca oleracea) is used to treat cardiovascular disease. Aim: This research evaluated the effect of purslane extract to inhibit increasing of cholesterol levels. Methods: The ethanol extract dosage of purslane was 27.5, 55, and 110 mg/kg body weight (bw) and simvastatin 1.8 mg/kg bw were used as comparisons. The anti-hyper cholesterol effect test was done by feeding a high cholesterol diet and drinks containing 0.01% propylthiouracil. The test parameters were body weight and total cholesterol levels on days 0, 7, 14, and 21. Results: The results showed that the extract was able to prevent the increase in body weight compared to the control group (p<0.05) and that it could inhibit the increase of total cholesterol levels at day 14 and 21 compared to control group (p<0.05) and equivalent to simvastatin (p>0.05).

scholarly journals PEMBERIAN EKSTRAK ETANOL BUAH BUNCIS (Phaseolus vulgaris L.) UNTUK MENURUNKAN KOLESTEROL TOTAL, Low Density Lipoprotein (LDL) DAN MENINGKATKAN High Density Lipoprotein (HDL) PADA TIKUS WISTAR DIET TINGGI LEMAK

Jurnal Kimia ◽  
2016 ◽  
Author(s):  
Sri Wahjuni ◽  
Ni Luh Rustini ◽  
Putu Yuliantari
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Density Lipoprotein ◽  
Ethanol Extract ◽  
Hdl Cholesterol ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels

Excessive fat consumption can increase blood cholesterol level. Phytosterol composition in the plant can decrease blood cholesterol level. One of the plants that contain phytosterol is beans. This study was to prove the effect of antihypercholesterol the ethanol extract of the beans (Phaseolus vulgaris L.) with variety of doses of 50 mg/Kg BW; 100 mg/Kg BW and 150 mg/Kg BW in male Wistar rats with high fat level condition. Subjects of this study were 24 Wistar rats divided into 6 groups randomly with posttest control group study design. First group as negative control, second group as positive control, and the third (high cholesterol diet and ethanol extract in dose of 50 mg/kg,bw), fourth ( high cholesterol diet and ethanol extractin dose of 100 mg/kg,bw), fifth ( high cholesterol diet and ethanol extract in dose of 150 mg/kg,bw),  sixth (high cholesterol diet and simvastatin drug). The data was analyzed with ANOVA Tukey test. The result of this study shows total cholesterol levels decrease 23,88%; 30,14%; 35,82%. Cholesterol LDL levels decrease 38,09%; 52,38%; 61,35%. Cholesterol HDL levels increase 21,86%; 56,56%; 63,84%. Dose variant on this study giving the best result to decrease total cholesterol levels and LDL was 150 mg/Kg BW. Furthermore, 100 mg/Kg BW dose gave the best result to increase HDL cholesterol level. Based on the results it can be suggested that beans ethanol extract is able to decrease total cholesterol level, LDL and increase HDL cholesterol levels.  

scholarly journals HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT

2017 ◽  
Vol 9 (3) ◽  
pp. 170 ◽  
Author(s):  
E. Sovia ◽  
W. Ratwita ◽  
D. Wijayanti ◽  
D. R. Novianty
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ethanol Extract ◽  
Normal Group ◽  
Islet Of Langerhans ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Annona Muricata ◽  
Cholesterol Levels

Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of Annona muricata L. leaf. At the end of the study, blood glucose and total cholesterol levels in all AMLEE treated group were decreased significantly (p<0.05). Final blood glucose level in the groups that given AMLEE 50 mg/kg body weight (86.7±14.6 mg/dl) was almost the same with that of the normal group (91.25±28.38 mg/dl). The result of the histopathological examination is not showed an improvement of the islet of Langerhans in AMLEE treated groups.Conclusion: In conclusion, the ethanol extract of Annona muricata L. leaf have hypoglycemic and hypolipidemic effects. However, there was no improvement in the islet of Langerhans damage.

scholarly journals Antimalarial Activity of Ethyl Acetate Extract and Fraction of Bidens pilosa against Plasmodium berghei (ANKA)

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Noumedem Anangmo Christelle Nadia ◽  
Yamssi Cédric ◽  
Simeni Njonnou Sylvain Raoul ◽  
Ngongang Ouankou Christian ◽  
Mounvera Abdel Azizi ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Crude Extract ◽  
Plasmodium Berghei ◽  
Ethyl Acetate Extract ◽  
Antimalarial Activity ◽  
Hematological Parameters ◽  
Control Group ◽  
Bidens Pilosa

Background. Malaria is one of the most critical diseases causing about 219 million cases worldwide in developing countries. The spread and development of resistance against chemical antimalarial drugs is one of the major problems associated with malaria control. The present study was to investigate the antimalarial efficacy of ethyl acetate extract and one fraction of Bidens pilosa in vivo in order to support the usage of this plant by traditional healers to treat malaria. Methods. The extracts were prepared by maceration of B. pilosa leaf powder in ethyl acetate. The liquid filtrate of the extract and the best in vitro antiplasmodial fraction using HPLC were concentrated and evaporated using a rotavapor under vacuum to dryness. The antimalarial activity of B. pilosa plant products were evaluated in vivo against Plasmodium berghei infected mice according to the Peter and Rane test. The antimalarial efficacy of the a selected crude extract (ethyl acetate extract) was evaluated at 125, 250, and 500 mg/kg, while a selected fraction from ethyl acetate extract (fraction 12) was evaluated at 62.5 and 125 mg/kg. Blood from experimental animals was collected to assess hematological parameters. Results. The crude extract of ethyl acetate and fraction 12 demonstrated 100% in vivo parasite suppressive activity at doses of 500 mg/kg and 125 mg/kg, respectively, for the crude extract and fraction 12. The mice treated with 250 and 500 mg/kg had their parasitemia (intraerythrocytic phase of P. Berghei) drop considerably, disappearing by the 8th day in mice receiving 500 mg/kg. The ethyl acetate extract of B. pilosa, fraction 12 showed an even higher antiplasmodial activity. By the 5th day of the experiment, the treatment led to a modification of hematological parameters in mice. The chloroquine (5 mg/kg), fraction 12 (125 mg/kg), and the crude extract (500 mg/kg) groups all survived the 30 days of the experiment, while the negative control group registered 100% of the deaths. Conclusion. This study scientifically supports the use of Bidens pilosa leaves in the traditional treatment of malaria. However, the mode of action and in vivo toxicity of the plant still need to be assessed.

ANTI-HYPERCHOLESTEROLEMIA ACTIVITY OF ETHANOL EXTRACT Peperomia pellucida

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
Chasanah Mazroatul
Keyword(s):  
Total Cholesterol ◽  
Ethanol Extract ◽  
Positive Control ◽  
Diet Group ◽  
In Vivo Studies ◽  
Control Group ◽  
Antioxidant Compounds ◽  
Control Group Design ◽  
White Rats

<p>Hypercholesterolemia is a major cause of cardiovascular disease such as coronary heart disease. Betel water (Peperomia pellucida) is a type of plants that have antioxidant compounds that could delay, retard and prevent the oxidation of lipids, both enzymatic and non-enzymatic. This study aimed to determine the effect of ethanol extract Peperomia pellucida against total cholesterol, HDL, LDL, and triglycerides in the serum of white rats (Wistar) were given a diet aterogenetik, so it can be used as prevention of atherosclerosis. The active compounds contained in the water after screnning betel phytochemicals includes flavonoids, tannins, alkaloids, steroids and quinones. In vivo studies conducted by true experimental method with pre and post test with control group design. Rats were divided into 3 groups: group A positive control is given aterogenetik diet, group B and C were given diet Peperomia Pellucida aterogenetik and extract orally at a dose of 150 mg/kg and 300 mg/kg. Diet aterogenetik given as much as 20 grams per day for 14 days. Data obtained include total cholesterol, HDL, LDL, and triglycerides were analyzed by statistical methods Paired T Test oneway ANOVA (P &lt; 0,05). The study of total cholesterol, HDL, LDL and triglycerides showed ethanol extract of Peperomia pellucida at a dose of 300 mg/kg body weight can lower total cholesterol and LDL significantly, but there was no significant decline in triglycerides and can increase HDL levels.</p>

scholarly journals ANTI-HYPERCHOLESTEROLEMIA ACTIVITY OF ETHANOL EXTRACT Peperomia pellucid

2016 ◽  
Vol 12 (1) ◽  
pp. 88 ◽  
Author(s):  
Chasanah Mazroatul ◽  
Glar Donia Deni ◽  
Nur Ahmad Habibi ◽  
Gita Febri Saputri
Keyword(s):  
Total Cholesterol ◽  
Ethanol Extract ◽  
Positive Control ◽  
Diet Group ◽  
In Vivo Studies ◽  
Control Group ◽  
Antioxidant Compounds ◽  
Control Group Design ◽  
White Rats

Hypercholesterolemia is a major cause of cardiovascular disease such as coronary heart disease. Betel water (Peperomia pellucida) is a type of plants that have antioxidant compounds that could delay, retard and prevent the oxidation of lipids, both enzymatic and non-enzymatic. This study aimed to determine the effect of ethanol extract Peperomia pellucida against total cholesterol, HDL, LDL, and triglycerides in the serum of white rats (Wistar) were given a diet aterogenetik, so it can be used as prevention of atherosclerosis. The active compounds contained in the water after screnning betel phytochemicals includes flavonoids, tannins, alkaloids, steroids and quinones. In vivo studies conducted by true experimental method with pre and post test with control group design. Rats were divided into 3 groups: group A positive control is given aterogenetik diet, group B and C were given diet Peperomia Pellucida aterogenetik and extract orally at a dose of 150 mg/kg and 300 mg/kg. Diet aterogenetik given as much as 20 grams per day for 14 days. Data obtained include total cholesterol, HDL, LDL, and triglycerides were analyzed by statistical methods Paired T Test oneway ANOVA (P &lt; 0.05). The study of total cholesterol, HDL, LDL and triglycerides showed ethanol extract of Peperomia pellucida at a dose of 300 mg/kg body weight can lower total cholesterol and LDL significantly, but there was no significant decline in triglycerides and can increase HDL levels.

scholarly journals UJI EFEK EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava L) TERHADAP KADAR KOLESTEROL TOTAL TIKUS WISTAR (Rattus norvegicus)

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Irianto Girik Allo ◽  
Pemsi Mona Wowor ◽  
Henoch Awaloei
Keyword(s):  
Total Cholesterol ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Psidium Guajava ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Cholesterol Levels ◽  
Guava Leaves ◽  
Guava Leaf

Abstract: This research aims to determine the effect of ethanol extract of guava leaves on levels of total cholesterol of rat that is induced propylthiouracil. This was an experimental research. The sample used was 15 rats were divided into 5 groups (1 group is consist of 3 rats), namely: 1) positive control, 2) extract dose of 200 mg/kgBB, 3) extract dose of 400 mg/kgBB, 4) extract dose of 800 mg/kgBB and 5) negative control. Group 1 to 4 are given propylthiouracil given for 14 days, then given treatment appropiate with the group. The result show that: 1) the average of total cholesterol levels increased after administration propylthiouracil from 156.34 mg/dL to 247.84 mg/dL, 2) at a dose of 200 mg/kgBB, 400 mg/kgBB and 800 mg/kgBB showed a decline in total cholesterol levels by 32.73%, 58.73% and 47.26%, 3) the positive control decreased total cholesterol levels by 39.46% and 4) total cholesterol levels on negative is unstable (there are up and some are down). The result of this research concluse that: guava leaf extract at dose of 200 mg/kgBB, 400 mg/kgBB and 800 mg kgBB have an effect in lowering total cholesterol of rat had been induced prophylthiouracil. Keywords: guava leaves, total cholesterol.     Abstrak: Penelitian ini bertujuan untuk mengetahui efek dari ekstrak etanol daun jambu biji terhadap kadar kolesterol total tikus wistar yang diinduksi propiltiourasil. Penelitian ini merupakan penelitian eksperimental. Sampel yang digunakan berjumlah 15 tikus wistar yang dibagi menjadi 5 kelompok (1 kelompok terdiri dari 3 tikus wistar), yaitu: 1) kontrol positif, 2) ekstrak dosis 200 mg/kgBB, 3) ekstrak dosis 400 mg/kgBB, 4) ekstrak dosis 800 mg/kgBB dan 5) kontrol negatif. Kelompok 1 sampai 4 diberikan propiltiourasil selama 14 hari, kemudian diberikan perlakuan sesuai kelompoknya. Hasil penelitian yang diperoleh: 1) rata-rata kadar kolesterol total meningkat setelah pemberian propiltiourasil yaitu dari 156,34 mg/dL menjadi 247,84 mg/dL, 2) pada dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB menunjukkan terjadi penurunan kadar kolesterol total sebesar 32,73%, 58,73% dan 47,26%, 3) pada kontrol positif terjadi penurunan kadar kolesterol total sebesar 39,46% dan 4) kadar kolesterol total pada kelompok negatif tidak stabil (ada yang naik dan ada yang turun). Hasil penelitian ini menyimpulkan bahwa ekstrak daun jambu biji pada dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB mempunyai efek dalam menurunkan kadar kolesterol total tikus wistar yang telah diinduksi propiltiourasil. Kata kunci: daun jambu biji, kadar kolesterol total.

scholarly journals ANTIHYPERLIPIDEMIC EFFECT OF THE ETHANOL EXTRACT FRACTION FROM MULBERRY (MORUS AUSTRALIS POIR.) LEAVES ON RATS INDUCED HIGH FAT-DIET (HFD) AND PROPYLTHIOURACIL (PTU)

2021 ◽  
pp. 157-161
Author(s):  
PRISKA ERNESTINA TENDA ◽  
ELEONORA MARYETA TOYO ◽  
ARBA PRAMUNDITA RAMADANI
Keyword(s):  
Ethyl Acetate ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Cholesterol Oxidase ◽  
Ethyl Acetate Fraction ◽  
Control Group ◽  
High Cholesterol Diet ◽  
High Fat ◽  
Control Group Design ◽  
Mulberry Leaf

Objectives: To evaluate the effect of extract and its fraction (n-hexane, ethyl acetate, and water) of the mulberry leaf (Morus australis Poir.) in reducing triglyceride and total cholesterol levels on HFD and PTU induced rats. Methods: In this study, mulberry leaves were collected from East Nusa Tenggara-Indonesia, extracted using maceration method, and fractionated with various solvents. The thin layer chromatography with silica gel 60 F254 was utilized to identify the active compound on both extract and fraction. Furthermore, using a quasi-experimental with control group design, this study employed 40 healthy male Wistar rats and divided into 8 groups, namely: normal and negative control, positive controls (simvastatin and gemfibrozil), ethanolic extract, and fractions (n-hexane, ethyl acetate, and water). All groups were fed with a high cholesterol diet and 0.01% PTU, except for the normal group. During the study, the blood was drawn at day 0, 28, 35, and 42. The triglyceride level was observed using Glycerophosphate-Oxidase Phenol Aminoantipyrine (GPO-PAP) method, while the total cholesterol was measured by Cholesterol Oxidase Phenol Aminoantipyrine (CHOD-PAP). Results: On the 42nd day, ethyl fraction of mulberry leaf (Morus australis Poir.) showed the most significant result of reducing the level of triglyceride and total cholesterol compared to the high-fat diet and PTU induced rat on day 0: triglyceride of 104.89±2.70 mg/dl vs 64.76±1.97 mg/dl and total cholesterol of 96.70±2.45 vs 88.02±1.38 mg/dl. Ethyl acetate fraction was similar to simvastatin in lowering the level of total cholesterol. TLC identification also showed that mulberry leaf contains flavonoids and polyphenols that act as anti-hyperlipidemic. Conclusion: Ethyl acetate fraction of mulberry leaf (Morus australis Poir.) showed best activity on lowering both triglyceride and total cholesterol.

scholarly journals In Vivo Antiplasmodial Activity of Entandrophragma cylindricum (Sprague) Sprague Ethyl Acetate Extract in Plasmodium berghei-Infected Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Noumedem Anangmo Christelle Nadia ◽  
Yamssi Cédric ◽  
Ngongang Ouankou Christian ◽  
Simeni Njonnou Sylvain Raoul ◽  
Yondo Jeanette ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Plasmodium Species ◽  
Negative Control Group ◽  
Stem Bark ◽  
Negative Control ◽  
Antiplasmodial Activity ◽  
Control Group

Background. One of the most dangerous Plasmodium species is Plasmodium falciparum. Hence, it causes a higher rate of mortality. The resistance of Plasmodium falciparum to the ACT (Artemisinin-based Combination Therapies) has led to the search for new antimalarial drugs. The purpose of this research was to assess the in vivo antiplasmodial activity of Entandrophragma cylindricum ethyl acetate extract to provide a scientific basis for the use of this medicinal plant to treat malaria. Methods. Entandrophragma cylindricum stem bark powder was macerated in ethyl acetate to obtain the extract. The extract liquid filtrate was concentrated, evaporated and dry using a Rotavapor. The Peter and Rane test were used for the suppressive and curative antiplasmodial activities at different doses (125, 250 and 500 mg/kg). A positive and negative control groups were administered chloroquine (5 mg/kg) and 10% hypromelose, respectively. To assess the parasitemia of the mice a thin blood smear was made. Results. The ethyl acetate extract completely (100%) inhibited the development of P. berghei in the suppressive test at the dose of 500 mg/kg while that of the curative test was inhibited at 95%. The extract-treated group (500 mg/kg) and (Chloroquine (5 mg/kg) group all survived. The negative control group recorded a 100% mortality rate. Conclusion. The present study provides scientific confirmation on the use of E. cylindricum stem bark as an antiplasmodial remedy. However, the identification of the mode of action and the purification of the active compounds are necessary for further studies.

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