scholarly journals The effect of ethanol extract from Portulaca oleracea on inhibiting total cholesterol on animal subjects

2021 ◽  
pp. 22-26
Author(s):  
Afifah Bambang Sutjiatmo ◽  
Fahmy Ahsanul Haq ◽  
Sulaeman Al Jati ◽  
Suci Nar Vikasari
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Ethanol Extract ◽  
Portulaca Oleracea ◽  
Control Group ◽  
High Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Test Parameters ◽  
Effect Test

Introduction: Hypercholesterolemia occurs when cholesterol levels in the blood increases. Traditionally, krokot (purslane, portulaca oleracea) is used to treat cardiovascular disease. Aim: This research evaluated the effect of purslane extract to inhibit increasing of cholesterol levels. Methods: The ethanol extract dosage of purslane was 27.5, 55, and 110 mg/kg body weight (bw) and simvastatin 1.8 mg/kg bw were used as comparisons. The anti-hyper cholesterol effect test was done by feeding a high cholesterol diet and drinks containing 0.01% propylthiouracil. The test parameters were body weight and total cholesterol levels on days 0, 7, 14, and 21. Results: The results showed that the extract was able to prevent the increase in body weight compared to the control group (p<0.05) and that it could inhibit the increase of total cholesterol levels at day 14 and 21 compared to control group (p<0.05) and equivalent to simvastatin (p>0.05).

scholarly journals HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT

2017 ◽  
Vol 9 (3) ◽  
pp. 170 ◽  
Author(s):  
E. Sovia ◽  
W. Ratwita ◽  
D. Wijayanti ◽  
D. R. Novianty
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ethanol Extract ◽  
Normal Group ◽  
Islet Of Langerhans ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Annona Muricata ◽  
Cholesterol Levels

Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of Annona muricata L. leaf. At the end of the study, blood glucose and total cholesterol levels in all AMLEE treated group were decreased significantly (p<0.05). Final blood glucose level in the groups that given AMLEE 50 mg/kg body weight (86.7±14.6 mg/dl) was almost the same with that of the normal group (91.25±28.38 mg/dl). The result of the histopathological examination is not showed an improvement of the islet of Langerhans in AMLEE treated groups.Conclusion: In conclusion, the ethanol extract of Annona muricata L. leaf have hypoglycemic and hypolipidemic effects. However, there was no improvement in the islet of Langerhans damage.

scholarly journals Effect of garlic (Allium sativum) extract on reduction of total cholesterol and HDL cholesterol ratio in hypercholesterolemic rats

2008 ◽  
Vol 6 (2) ◽  
pp. 45-51
Author(s):  
MARIA PRISKILA ◽  
DIAN ARININGRUM ◽  
ENDANG LISTYANINGSIH SUPARYANTI
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Hdl Cholesterol ◽  
Garlic Extract ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Ratio ◽  
Group I

Priskila M, Ariningrum D, Suparyanti ES. 2008. Effect of garlic (Allium sativum Linn.) extract on reduction of total cholesterol and HDL cholesterol ratio in hypercholesterolemic rats (Rattus norvegicus). Biofarmasi 6: 45-51. Garlic has been widely recognized as herbal medicine for prevention and treatment of cardiovascular disease, atherosclerosis, and hyperlipidemia. The main bioactive compound, allicin, can influence cholesterol metabolism, reduce total cholesterol and increase HDL cholesterol. The purpose of this research was to find out the effect of garlic extract on the reduction of total cholesterol and HDL cholesterol ratio in hypercholesterolemic rats. This research was an experimental research with pre and post-test control group design. The research used male Wistar rats (Rattus norvegicus) with ±3 mounts old and ±200 grams of body weight. The rats were divided into two groups, group I and II; each group consisted of 15 rats. Before the treatment, all rats were induced by a high-cholesterol diet for two weeks, to get a hypercholesterolemic condition. Group I, as a control group, were induced by a high-cholesterol diet, while group II, treatment group, were also induced by a high-cholesterol diet orally by 0.432 grams garlic extract /200 grams body weight/day. The treatment occurred for 25 days. The data were taken before the treatment and after the last treatment, by taking the blood from orbital sine of rats which been fasted for 12 hours, and the level of serum cholesterol total and the level of serum HDL cholesterol were checked from both groups, then the results were analyzed with t-test. Based on the results, it could be concluded that the oral induction of 0.432 grams garlic extract /200 grams body weight/day for 25 days on rats, could not reduce total cholesterol, therefore the serum total cholesterol and HDL cholesterol ratio was not significant (p>0.05). Meanwhile, the decrease of total cholesterol in treatment group and the decrease of HDL cholesterol in both groups were significant (p<0.05).

scholarly journals In vivo activity of Phaseolus vulgaris as an anti-hypercholesterolemic

2021 ◽  
pp. 184-188
Author(s):  
Keni Idacahyati ◽  
Yedy Purwandi Sukmawan ◽  
Nopi Yanti ◽  
Winda Trisna Wulandari ◽  
Firman Gustaman ◽  
...  
Keyword(s):  
Phaseolus Vulgaris ◽  
Ethyl Acetate ◽  
Total Cholesterol ◽  
Ethyl Acetate Extract ◽  
Ethanol Extract ◽  
Blood Cholesterol ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Levels

Introduction: Hyperlipidemia occurs due to increased levels of lipids and cholesterol in the blood. Phytosterols, such as stigmasterol in Phaseolus vulgaris, can reduce blood cholesterol levels. Objectives: The purpose of this study was to determine the activity of P. vulgaris in hypercholesterolemic rats. Methods: Nine groups underwent the anti-hypercholesterolemia test: control group, negative group, positive group, 150 mg/kg body weight (bw) and 300 mg/kg bw n-hexane extract groups, 150 mg/kg bw and 300 mg/kg bw ethyl acetate extract groups, and 150 mg/kg bw and 300 mg/kg bw ethanol extract groups. Results: All groups, except the control group, were given a high cholesterol diet to induce hypercholesterolemia (until the total cholesterol levels were higher than 200 mg/dL), followed by testing for ten days. The results showed that the 300 mg/kg bw ethyl acetate extract group had the best activity in reducing total cholesterol.

scholarly journals PEMBERIAN EKSTRAK ETANOL BUAH BUNCIS (Phaseolus vulgaris L.) UNTUK MENURUNKAN KOLESTEROL TOTAL, Low Density Lipoprotein (LDL) DAN MENINGKATKAN High Density Lipoprotein (HDL) PADA TIKUS WISTAR DIET TINGGI LEMAK

Jurnal Kimia ◽  
2016 ◽  
Author(s):  
Sri Wahjuni ◽  
Ni Luh Rustini ◽  
Putu Yuliantari
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Density Lipoprotein ◽  
Ethanol Extract ◽  
Hdl Cholesterol ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels

Excessive fat consumption can increase blood cholesterol level. Phytosterol composition in the plant can decrease blood cholesterol level. One of the plants that contain phytosterol is beans. This study was to prove the effect of antihypercholesterol the ethanol extract of the beans (Phaseolus vulgaris L.) with variety of doses of 50 mg/Kg BW; 100 mg/Kg BW and 150 mg/Kg BW in male Wistar rats with high fat level condition. Subjects of this study were 24 Wistar rats divided into 6 groups randomly with posttest control group study design. First group as negative control, second group as positive control, and the third (high cholesterol diet and ethanol extract in dose of 50 mg/kg,bw), fourth ( high cholesterol diet and ethanol extractin dose of 100 mg/kg,bw), fifth ( high cholesterol diet and ethanol extract in dose of 150 mg/kg,bw),  sixth (high cholesterol diet and simvastatin drug). The data was analyzed with ANOVA Tukey test. The result of this study shows total cholesterol levels decrease 23,88%; 30,14%; 35,82%. Cholesterol LDL levels decrease 38,09%; 52,38%; 61,35%. Cholesterol HDL levels increase 21,86%; 56,56%; 63,84%. Dose variant on this study giving the best result to decrease total cholesterol levels and LDL was 150 mg/Kg BW. Furthermore, 100 mg/Kg BW dose gave the best result to increase HDL cholesterol level. Based on the results it can be suggested that beans ethanol extract is able to decrease total cholesterol level, LDL and increase HDL cholesterol levels.  

scholarly journals Effect of green tea on obesity and serum lipid profiles in both normo- and hyper-cholesterolemic rabbits

2019 ◽  
Vol 10 (2) ◽  
pp. 1035-1041
Author(s):  
Dlawer Abdulhammed Ahmad AL-Jaff
Keyword(s):  
Body Weight ◽  
Green Tea ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
The Body ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Group I

Obesity has been linked with several comorbidities like cardiovascular disorders, diabetes, and hypertension. Weight reduction is directly associated with the consumption of green tea. So, with this premise of background, we evaluated the potential of green tea consumption on obesity and serum lipid profiles in both normo- and hyper-cholesterol emic rabbits. Sixty New Zealand white rabbits (age: 6-8 months; weight 1.5-2 kg) were used for this experiment. Rabbits were randomized and equally divided into three different groups. Group I (control group) received 10 ml/kg of distilled water twice daily, Group II received high cholesterol diet twice daily, and Group III received high cholesterol diet along with green tea solution 10 ml/kg, twice daily for 90 days. Weight measurements and serum analysis were conducted on Day 0 and day 90. For the obtained data, SPSS analysis was performed (SPSS 21). A significant increment of body weight was observed in control (1.97 ± 0.12 vs 2.87 ± 0.21, p<0.0001) and high cholesterol groups (1.91 ± 0.23 vs 3.13 ± 0.31, p<0.0001) at Day 90 when compared with Day 0. Though the results were not significant, there was a reduction in the body weight in the green tea group (2.20 ± 1.47 vs 1.72 ± 0.22) at Day 90 when compared with Day 0. Consumption of green tea for 90 days resulted in weight loss and inhibition of the increase in the levels of TC, LDL, and VLDL. So, green tea can act as a natural food supplement for the management of obesity and dyslipidemia.

scholarly journals POTENTIAL EFFECT OF MACRO ALGA Caulerpa sp. AND Gracilaria sp. EXTRACT LOWERING MALONDIALDEHYDE LEVEL OF WISTAR RATS FED HIGH CHOLESTEROL DIET

2017 ◽  
Vol 5 (1) ◽  
pp. 71
Author(s):  
Ketut Srie Marhaeni Julyasih ◽  
I Gede Putu Wirawan
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Design Research ◽  
Wistar Rat ◽  
Negative Control ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Standard Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

Seaweed has potential nutrient content such as carotenoids, vitamins, fatty acids, carbohydrates, minerals, and other essential substances. Carotenoids have important biological functions as an antioxidant, and immunostimulatory which can prevent the disease, anti-inflammatory, anti-stress, anti-aging, and protect the skin from the harmful effects of ultraviolet radiation. Seaweed generally consumed as a vegetable by people in Bali, known as the local name Bulung Boni (Caulerpa spp.) and Bulung Sangu (Gracilaria spp.).. So far there has been no report or results of research on the effects of extract ethanol of Bulung Boni (Caulerpa sp.) and Bulung Sangu (Gracilaria sp.) as an antioxidant that can prevent lipid peroxidation which can be seen in decreased level of MDA in liver tissue or blood plasma. Therefore it is necessary to determine of plasmaMDA level of Wistar rat after fed high cholesterol diet treated with extract ethanol of Caulerpa sp. and Gracillaria sp. This experimental study used completely randomized design. Research using total of 24 Wistar rats divided into six sample groups of equal size, all fed with a diet high in cholesterol especially in negative control. The study consisted of negative control group (standard diet), positive control group (high cholesterol diet), high-cholesterol diet with Caulerpa sp. extract dose of 20 mg and 60 mg/100 g, high cholesterol diet with Gracilaria sp. extract dose of 20 mg and 60 mg/100 g body weight rat per day.The study resulted that rats fed high cholesterol diet with treated extract ethanol Caulerpa sp. and Gracilaria sp. with a dose of 20 mg and 60 mg per 100 g body weight rat / day had plasma MDA level significantly lower (p <0.05) compared with rats fed high cholesterol diet without treated with extract of Caulerpa sp. and Gracilaria sp.

scholarly journals UJI EFEK EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava L) TERHADAP KADAR KOLESTEROL TOTAL TIKUS WISTAR (Rattus norvegicus)

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Irianto Girik Allo ◽  
Pemsi Mona Wowor ◽  
Henoch Awaloei
Keyword(s):  
Total Cholesterol ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Psidium Guajava ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Cholesterol Levels ◽  
Guava Leaves ◽  
Guava Leaf

Abstract: This research aims to determine the effect of ethanol extract of guava leaves on levels of total cholesterol of rat that is induced propylthiouracil. This was an experimental research. The sample used was 15 rats were divided into 5 groups (1 group is consist of 3 rats), namely: 1) positive control, 2) extract dose of 200 mg/kgBB, 3) extract dose of 400 mg/kgBB, 4) extract dose of 800 mg/kgBB and 5) negative control. Group 1 to 4 are given propylthiouracil given for 14 days, then given treatment appropiate with the group. The result show that: 1) the average of total cholesterol levels increased after administration propylthiouracil from 156.34 mg/dL to 247.84 mg/dL, 2) at a dose of 200 mg/kgBB, 400 mg/kgBB and 800 mg/kgBB showed a decline in total cholesterol levels by 32.73%, 58.73% and 47.26%, 3) the positive control decreased total cholesterol levels by 39.46% and 4) total cholesterol levels on negative is unstable (there are up and some are down). The result of this research concluse that: guava leaf extract at dose of 200 mg/kgBB, 400 mg/kgBB and 800 mg kgBB have an effect in lowering total cholesterol of rat had been induced prophylthiouracil. Keywords: guava leaves, total cholesterol.     Abstrak: Penelitian ini bertujuan untuk mengetahui efek dari ekstrak etanol daun jambu biji terhadap kadar kolesterol total tikus wistar yang diinduksi propiltiourasil. Penelitian ini merupakan penelitian eksperimental. Sampel yang digunakan berjumlah 15 tikus wistar yang dibagi menjadi 5 kelompok (1 kelompok terdiri dari 3 tikus wistar), yaitu: 1) kontrol positif, 2) ekstrak dosis 200 mg/kgBB, 3) ekstrak dosis 400 mg/kgBB, 4) ekstrak dosis 800 mg/kgBB dan 5) kontrol negatif. Kelompok 1 sampai 4 diberikan propiltiourasil selama 14 hari, kemudian diberikan perlakuan sesuai kelompoknya. Hasil penelitian yang diperoleh: 1) rata-rata kadar kolesterol total meningkat setelah pemberian propiltiourasil yaitu dari 156,34 mg/dL menjadi 247,84 mg/dL, 2) pada dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB menunjukkan terjadi penurunan kadar kolesterol total sebesar 32,73%, 58,73% dan 47,26%, 3) pada kontrol positif terjadi penurunan kadar kolesterol total sebesar 39,46% dan 4) kadar kolesterol total pada kelompok negatif tidak stabil (ada yang naik dan ada yang turun). Hasil penelitian ini menyimpulkan bahwa ekstrak daun jambu biji pada dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB mempunyai efek dalam menurunkan kadar kolesterol total tikus wistar yang telah diinduksi propiltiourasil. Kata kunci: daun jambu biji, kadar kolesterol total.

scholarly journals Potensi Ekstrak Etanol Kulit Jeruk Lemon (Citrus limon L.) Sebagai Obat Alternatif Hiperkolesterolemia Pada Tikus Wistar Hiperglikemik

2019 ◽  
Vol 6 (2) ◽  
pp. 81
Author(s):  
Deni Tri Hartanto ◽  
Ellen Lydia Kurniasari ◽  
Ribka Artha Maria ◽  
Puspa Sari Dewi ◽  
Vina Septiani
Keyword(s):  
Total Cholesterol ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Blood Cholesterol ◽  
Control Group ◽  
Citrus Limon ◽  
Lemon Peel ◽  
Cholesterol Levels ◽  
Protection Method ◽  
Alternative Drug

<p align="center"><strong>Abstrak</strong></p><p align="center"><strong> </strong></p><p>Jeruk lemon (<em>Citrus limon </em>L) secara empiris telah digunakan masyarakat untuk menurunkan berat badan.  Selain itu perasan jeruk lemon pun dipercaya mampu menurunkan kadar kolesterol darah. Penelitian ini bertujuan untuk menentukan potensi ekstrak etanol kulit jeruk lemon sebagai obat alternatif hiperkolesterolemia pada tikus <em>wistar</em> hiperglikemia dengan menggunakan metode proteksi. Proses ekstraksi kulit buah jeruk lemon dilakukan dengan metode maserasi.  Semua tikus diberi sediaan uji sesuai dengan kelompoknya (kontrol, ekstrak etanol jeruk lemon, pembanding simvastatin) bersamaan dengan intervensi fruktosa 60% yang dicampur dalam makanannya selama 6 minggu. Pemeriksaan kadar kolesterol total dilakukan setiap minggu. Hasil pengujian menunjukkan bahwa ekstrak etanol kulit buah lemon mampu menghambat peningkatan kadar kolesterol total tikus <em>wistar </em>hiperglikemia.  Ekstrak etanol kulit buah lemon dosis 70 mg/kg bb menunjukkan hasil terbaik yang berbeda bermakna dibanding kelompok kontrol (p&lt;0,05) pada penelitian ini. Dengan demikian, ekstrak etanol kulit jeruk lemon berpotensi untuk digunakan sebagai obat alternatif hiperkolesterolemia.</p><p> </p><p><strong>Kata Kunci :</strong> Hiperkolesterolemia, Lemon, Fruktosa 60%</p><p> </p><p align="center"><strong><em>Potency of lemon peel ethanolic extract (Citrus limon L.) as alternative drug for hypercholesterolemia in hyperglycemic wistar rat</em></strong></p><p><em> </em></p><p align="center"><strong><em>Abstract </em></strong></p><p align="center"><strong><em> </em></strong></p><p><em>Lemon (Citrus limon L) empirically has been used by the community to lose weight. Besides lemon juice is also believed to be able to reduce blood cholesterol levels. This study aims to determine the potential of ethanol extract of lemon peel as an alternative medicine for hypercholesterolemia in hyperglycemic wistar rats using the protection method. The process of extracting lemon peel is done by maceration method. All rats were given a test preparation according to their group (control, lemon ethanol extract, compared to simvastatin) together with intervention of fructose 60% mixed in the food for 6 weeks. Examination of total cholesterol levels is carried out every week. The test results showed that the ethanol extract of lemon peel was able to inhibit the increase of total cholesterol levels in hyperglycemic wistar rats. The ethanol extract of lemon peel doses of 70 mg / kg bw showed the best results which were significantly different than the control group (p &lt;0.05) in this study. Thus, the ethanol extract of lemon peel has the potential to be used as an alternative drug for hypercholesterolemia.</em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em> : Hypercholesterolemia, Lemon, Fructose 60 % </em></p>

scholarly journals Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets

2021 ◽  
Vol 13 (4) ◽  
pp. 396-402
Author(s):  
I Gede Widhiantara ◽  
Anak Agung Ayu Putri Permatasari ◽  
I Wayan Rosiana ◽  
Putu Angga Wiradana ◽  
Luh Putu Widiastini ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Luteinizing Hormone ◽  
Total Cholesterol ◽  
Reproductive Function ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Male Reproductive Function ◽  
Antioxidant Effects

BACKGROUND: The discovery of herbal ingredients for antihypercholesterolemic and to improve male reproductive function is very necessary due to high-cholesterol diet factors. Blumea balsamifera leaf extract (BBLE) is known to be able to increase the number and diameter of Leydig cells in rats given high-fat feed. This study was to conducted to determine the levels of total cholesterol, body weight, plasma malondialdehyde (MDA), Superoxide Dismutase (SOD), Luteinizing Hormone (LH) in high-cholesterol-fed male rats provided with BBLE.METHODS: This research utilized a randomized post-test only control group. Ethanol was used to extract the BBLE, which was then evaporated. For 21 days, 16 Wistar rats were given a high-cholesterol diet. To determine the effect of BBLE on the high-cholesterol diet, the samples were divided into two groups (control and BBLE group) on day 22. The treatments lasted 30 days. SOD, plasma MDA, LH, and total cholesterol were measured.RESULTS: The results showed that the SOD and LH parameters were significantly higher in the treatment of BBLE compared to the control group (p<0.05). The parameters of total cholesterol levels, bodyweight, and MDA of rats given BBLE were significantly lower than those of the control group (p<0.05).CONCLUSION: Our findings highlight that BBLE has antihypercholesterolemic and antioxidant effects. The BBLE also has potential to be used as a therapy to maintain male reproductive function because it has a positive effect on the hypothalamic-pituitary axis through increasing LH secretion.KEYWORDS: Malondialdehyde, Superoxide dismutase, Luteinizing hormone, Blumea balsamifera extract, High-cholesterol diet

scholarly journals Anti-hypercholesterolemic effect of Zingiber montanum extract

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1798
Author(s):  
Swandari Paramita ◽  
Meiliati Aminyoto ◽  
Sjarif Ismail ◽  
Enos Tangke Arung
Keyword(s):  
Total Cholesterol ◽  
High Fat Diet ◽  
Diet Group ◽  
High Density Lipoproteins ◽  
Control Group ◽  
High Cholesterol ◽  
High Fat ◽  
Cholesterol Levels ◽  
White Rats ◽  
Diet Control

Background: Hypercholesterolemia, high cholesterol levels in the blood, can contribute to many forms of disease, most notably cardiovascular disease. Anti-hypercholesterolemic agents generally used for those conditions have several side effects for patients. Zingiber montanum, known locally as “bangle”, belongs to the family Zingiberaceae and is a potential plants for alternative anti-hypercholesterolemic agents. This plant, from East Kalimantan, is used in traditional medicine for health problems caused by high cholesterol levels. The aim of this research was to find alternatives to anti-hypercholesterolemic agents, especially from natural sources. Methods: This study was an experimental study using 30 Wistar male white rats. Subjects were randomly divided into 6 groups (n=5): (1) normal control group; (2) high fat diet control group; (3) high fat diet with simvastatin; (4-6) high fat diet with Zingiber montanum extracts 100, 200, and 400 mg/kg. After 4 weeks of treatment, blood was collected from all groups, and plasma concentrations of triglycerides, total cholesterol, high density lipoproteins (HDL), and low density lipoproteins (LDL) were measured. Results: The results showed significant differences in total cholesterol (p=0.000), LDL (p=0.000) and triglycerides (p=0.001) in the high-fat diet group with Z. montanum extract, as compared to the high-fat diet control. Meanwhile, there were no significant differences in HDL levels (p=0.830) between the high-fat diet group and other groups. The results also showed significant differences in total cholesterol and LDLs for rats treated with Z. montanum extract, 100 mg/kg (p=0.000), 200 mg/kg (p=0.000), and 400 mg/kg (p=0.000) compared to the high-fat diet group. The result of Z. montanum 400 mg/kg also showed a significant reduction, not only for total cholesterol and LDLs, but also for triglycerides (p=0.030). Conclusion: It could be concluded that Z. montanum extracts have the potency to be further developed as a new natural source of the anti-hypercholesterolemic agents.

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