scholarly journals CLINICAL ASSESSMENT OF THE ROLE OF KANSA HARITAKI AND VIRECHANA IN THE MANAGEMENT OF AMAVATA

2020 ◽  
Vol p4 (06) ◽  
pp. 2474-2479
Author(s):  
Rita Singh ◽  
M. S. Baghel ◽  
Anurag Singh Rajput
Keyword(s):  
Signs And Symptoms ◽  
Medical Advice ◽  
Stool Examination ◽  
Acid Urine ◽  
Pathological Conditions ◽  
American Rheumatism Association ◽  
Common Drug ◽  
Trial Drug ◽  
Rule Out

Amavata is a clinical condition described in Ayurveda that closely resembles with the clinical features of Rheumatoid Arthritis. A Clinical Study was conducted at IPGT and RA, Jamnagar in Kaya Chikitsa de-partment to evaluate the efficacy of Virechan Karma with Eranda Taila and Trivrita Kwatha in patients suffering from Amavata and compared with the trial drug Kansa Haritaki described in Charak Samhita. Efficacy of both of these was compared with the known common drug Trayodashanga Guggulu. In this study, 38 patients of Amavata were registered, of which 29 patients completed the course of the treatment and 9 patients discontinued before completion of course against medical advice. The disease was diag-nosed on the basis of signs and symptoms as described in Ayurvedic and Modern text, aided by American Rheumatism Association Criteria (1988). RA factor test was done in all the patients. The Routine Blood examination (CBC, ESR) with Serum Uric acid, Urine and Stool examination was done to rule out other pathological conditions.

Role of B-type natriuretic peptide (BNP) in heart failure

2017 ◽  
Vol 16 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Md. Helal Uddin ◽  
Tasnuva Rashid ◽  
Salim Mahmud Chowdhury
Keyword(s):  
Heart Failure ◽  
Natriuretic Peptide ◽  
Signs And Symptoms ◽  
Urgent Care ◽  
Extensive Literature ◽  
Diagnostic Pathways ◽  
Worse Prognosis ◽  
Rule Out

Abstract Introduction: Early clinical diagnosis of heart failure (HF) is challenging because the signs and symptoms are neither sensitive nor specific for diagnosis. B-type natriuretic peptide (BNP), a cardiac neurohormone is a useful biomarker for patients with HF. Objectives: The purpose of this review is to evaluate the role of BNP in HF as a diagnostic, prognostic, and therapeutic marker in both outpatient care and urgent care settings. Methodology: An extensive literature review was conducted for this study. Findings: Determination of BNP is particularly useful as a rule-out test for suspected cases of HF in patients with dyspnoea. HF is very unlikely in patients with levels of BNP <100 pg/mL whereas BNP levels >400 pg/mL strongly support the diagnosis of HF. Elevated level of BNP indicates a worse prognosis in patients with HF. Conclusion: Although, it is recommended in the diagnostic pathways of guidelines for HF, it is not well established to recommend measurement of BNP to titrate HF medications because of lack of enough evidence. It requires further in-depth research.

Dietary Carotenoids in Managing Metabolic Syndrome and Role of PPARs in the Process

2020 ◽  
Vol 16 (6) ◽  
pp. 846-853
Author(s):  
Raghunandan Purohith ◽  
Nagendra P.M. Nagalingaswamy ◽  
Nanjunda S. Shivananju
Keyword(s):  
Metabolic Syndrome ◽  
Dietary Intervention ◽  
Bioactive Constituents ◽  
Dietary Antioxidants ◽  
Predisposing Factor ◽  
Beneficial Effects ◽  
Pathological Conditions ◽  
Established Relationship ◽  
Comprehensive Study

Metabolic syndrome is a collective term that denotes disorder in metabolism, symptoms of which include hyperglycemia, hyperlipidemia, hypertension, and endothelial dysfunction. Diet is a major predisposing factor in the development of metabolic syndrome, and dietary intervention is necessary for both prevention and management. The bioactive constituents of food play a key role in this process. Micronutrients such as vitamins, carotenoids, amino acids, flavonoids, minerals, and aromatic pigment molecules found in fruits, vegetables, spices, and condiments are known to have beneficial effects in preventing and managing metabolic syndrome. There exists a well-established relationship between oxidative stress and major pathological conditions such as inflammation, metabolic syndrome, and cancer. Consequently, dietary antioxidants are implicated in the remediation of these complications. The mechanism of action and targets of dietary antioxidants as well as their effects on related pathways are being extensively studied and elucidated in recent times. This review attempts a comprehensive study of the role of dietary carotenoids in alleviating metabolic syndromewith an emphasis on molecular mechanism-in the light of recent advances.

The Role of Androgen Under Normal and Pathological Conditions in Sebaceous Glands: The Possibility of Target Therapy

2016 ◽  
Vol 9 (4) ◽  
pp. 311-319 ◽  
Author(s):  
Abdullah Azmahani ◽  
Yasuhiro Nakamura ◽  
Keely M. McNamara ◽  
Hironobu Sasano
Keyword(s):  
Target Therapy ◽  
Sebaceous Glands ◽  
Pathological Conditions

Therapeutic efficacy of Kantakari Ghrita in Tamaka Shwasa

2018 ◽  
Vol 3 (01) ◽  
Author(s):  
Dhanesh Kannan ◽  
Ravindra Angadi ◽  
Krishnendu O. Nambiar
Keyword(s):  
Marked Improvement ◽  
Signs And Symptoms ◽  
Unique Property ◽  
Test Design ◽  
Once Daily ◽  
Respiratory Condition ◽  
Post Test ◽  
Clinical Practise ◽  
Single Blind

Background: Ghrta Kalpana has a major role in clinical practise, because of its unique property of Samskarasya Anuvartanam. Tamaka Shwasa a Pranavaha Srothovikara, may be correlated to Bronchial Asthma, where in remissions and exacerbations are the typical features. The management of this acute respiratory condition is the long quest in the medical fraternity of all types. Hence, the present study was aimed to evaluate the role of Shamana therapy in the form of Kantakari Ghrta3 in Tamaka Shwasa patients. Objectives: To evaluate the effect of Kantakari Ghrta in Tamaka Shwasa. Methods: A total number of 30 patients were administered with 24 mgs of ‘Kantakari Ghrta’ once daily in the morning on empty stomach with Ushna Jala as Anupana. It was a single blind study with pre and post-test design. The effect was assessed by standard scoring assessment criteria followed by statistical analyses. Results: There was marked improvement in signs and symptoms and all were statistically significant. .

scholarly journals From Exosome Glycobiology to Exosome Glycotechnology, the Role of Natural Occurring Polysaccharides

2021 ◽  
Vol 2 (2) ◽  
pp. 311-338
Author(s):  
Giulia Della Rosa ◽  
Clarissa Ruggeri ◽  
Alessandra Aloisi
Keyword(s):  
State Of The Art ◽  
Cell Communication ◽  
Pathological Conditions ◽  
New Findings ◽  
Cell Type Specific ◽  
New Perspective ◽  
And Function ◽  
And Personalized Medicine ◽  
Innate Ability

Exosomes (EXOs) are nano-sized informative shuttles acting as endogenous mediators of cell-to-cell communication. Their innate ability to target specific cells and deliver functional cargo is recently claimed as a promising theranostic strategy. The glycan profile, actively involved in the EXO biogenesis, release, sorting and function, is highly cell type-specific and frequently altered in pathological conditions. Therefore, the modulation of EXO glyco-composition has recently been considered an attractive tool in the design of novel therapeutics. In addition to the available approaches involving conventional glyco-engineering, soft technology is becoming more and more attractive for better exploiting EXO glycan tasks and optimizing EXO delivery platforms. This review, first, explores the main functions of EXO glycans and associates the potential implications of the reported new findings across the nanomedicine applications. The state-of-the-art of the last decade concerning the role of natural polysaccharides—as targeting molecules and in 3D soft structure manufacture matrices—is then analysed and highlighted, as an advancing EXO biofunction toolkit. The promising results, integrating the biopolymers area to the EXO-based bio-nanofabrication and bio-nanotechnology field, lay the foundation for further investigation and offer a new perspective in drug delivery and personalized medicine progress.

scholarly journals Effects of Rifaximin on Luminal and Wall-Adhered Gut Commensal Microbiota in Mice

2021 ◽  
Vol 22 (2) ◽  
pp. 500
Author(s):  
Marina Ferrer ◽  
Mònica Aguilera ◽  
Vicente Martinez
Keyword(s):  
Fluorescent In Situ Hybridization ◽  
Fragment Length Polymorphism ◽  
Functional Gastrointestinal Disorders ◽  
Antibacterial Properties ◽  
Broad Spectrum Antibiotic ◽  
Commensal Microbiota ◽  
Bacterial Biodiversity ◽  
Rule Out

Rifaximin is a broad-spectrum antibiotic that ameliorates symptomatology in inflammatory/functional gastrointestinal disorders. We assessed changes in gut commensal microbiota (GCM) and Toll-like receptors (TLRs) associated to rifaximin treatment in mice. Adult C57BL/6NCrl mice were treated (7/14 days) with rifaximin (50/150 mg/mouse/day, PO). Luminal and wall-adhered ceco-colonic GCM were characterized by fluorescent in situ hybridization (FISH) and microbial profiles determined by terminal restriction fragment length polymorphism (T-RFLP). Colonic expression of TLR2/3/4/5/7 and immune-related markers was assessed (RT-qPCR). Regardless the period of treatment or the dose, rifaximin did not alter total bacterial counts or bacterial biodiversity. Only a modest increase in Bacteroides spp. (150 mg/1-week treatment) was detected. In control conditions, only Clostridium spp. and Bifidobacterium spp. were found attached to the colonic epithelium. Rifaximin showed a tendency to favour their adherence after a 1-week, but not 2-week, treatment period. Minor up-regulation in TLRs expression was observed. Only the 50 mg dose for 1-week led to a significant increase (by 3-fold) in TLR-4 expression. No changes in the expression of immune-related markers were observed. Rifaximin, although its antibacterial properties, induces minor changes in luminal and wall-adhered GCM in healthy mice. Moreover, no modulation of TLRs or local immune systems was observed. These findings, in normal conditions, do not rule out a modulatory role of rifaximin in inflammatory and or dysbiotic states of the gut.

scholarly journals Nutritional Optic Neuropathies: State of the Art and Emerging Evidences

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2653
Author(s):  
Matilde Roda ◽  
Natalie di Geronimo ◽  
Marco Pellegrini ◽  
Costantino Schiavi
Keyword(s):  
Bariatric Surgery ◽  
Optic Neuropathy ◽  
Multidisciplinary Approach ◽  
State Of The Art ◽  
Signs And Symptoms ◽  
Therapeutic Strategies ◽  
Scientific Interest ◽  
Optic Nerve Atrophy ◽  
Prompt Diagnosis

Nutritional optic neuropathy is a cause of bilateral, symmetrical, and progressive visual impairment with loss of central visual acuity and contrast sensitivity, dyschromatopsia, and a central or centrocecal scotoma. The clinical features are not pathognomonic, since hereditary and toxic forms share similar signs and symptoms. It is becoming increasingly common due to the widespread of bariatric surgery and strict vegetarian or vegan diets, so even the scientific interest has recently increased. In particular, recent studies have focused on possible pathogenetic mechanisms, and on novel diagnostic and therapeutic strategies in order to prevent the onset, make a prompt diagnosis and an accurate nutritional supplementation, and to avoid irreversible optic nerve atrophy. Nowadays, there is clear evidence of the role of cobalamin, folic acid, thiamine, and copper, whereas further studies are needed to define the role of niacin, riboflavin, and pyridoxine. This review aims to summarize the etiology, diagnosis, and treatment of nutritional optic neuropathy, and it is addressed not only to ophthalmologists, but to all physicians who could come in contact with a patient with a possible nutritional optic neuropathy, being a fundamental multidisciplinary approach.

scholarly journals The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury

2007 ◽  
Vol 7 ◽  
pp. 56-74 ◽  
Author(s):  
Antonietta Rossi ◽  
Carlo Pergola ◽  
Salvatore Cuzzocrea ◽  
Lidia Sautebin
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Biological Activities ◽  
Ischemia Reperfusion ◽  
Targeted Disruption ◽  
Pathological Conditions ◽  
Metabolic Products ◽  
Important Regulator ◽  
Multicellular Organisms

The leukotrienes (LTs) are metabolic products of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. The biological activities of LTs suggest that they are mediators of acute inflammatory and immediate hypersensitivity responses. In particular, the 5-LO activation has been proposed to be an important regulator for pathogenesis in multicellular organisms. The role of LTs in tissue damage, associated with septic and nonseptic shock and ischemia-reperfusion, has been extensively studied by the use of 5-LO inhibitors, receptor antagonists, and mice with a targeted disruption of the 5-LO gene (5-LOKO). In particular, several data indicate that LTs regulate neutrophil trafficking in damaged tissue in shock and ischemia-reperfusion, mainly through the modulation of adhesion molecule expression. This concept may provide new insights into the interpretation of the protective effect of 5-LO inhibition, which may be useful in the therapy of pathological conditions associated with septic and nonseptic shock and ischemia-reperfusion injury.

Role of the defective signal transduction in the impaired endothelium-dependent relaxations under pathological conditions

1994 ◽  
Vol 1 ◽  
pp. 20
Author(s):  
H. Shimokawa ◽  
R. Nakaike ◽  
A. Ito
Keyword(s):  
Signal Transduction ◽  
Pathological Conditions
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