scholarly journals An Experimental Study to Evaluate the Anti-Diarrheal Activity of Bhuvaneshwara Rasa in Wistar Albino Rats

2021 ◽  
pp. 27-35
Author(s):  
Simi Jose ◽  
Chaitra L.V
Keyword(s):  
Experimental Study ◽  
Castor Oil ◽  
Raw Materials ◽  
Life Time ◽  
Drug Group ◽  
Albino Rats ◽  
Test Drug ◽  
Wistar Albino Rats ◽  
Important Disease

Atisara (Diarrhea) is most commonly encountered disease of the present era, due to unhealthy and irregular habits. Atisara (Diarrhea) finds a place as important disease in individual’s life as everyone suffers from it at least once in life time. Bhuvaneshwara rasa is a unique herbo-mineral formulation explained in Bhaishajya ratnavali indicated for all kinds of diarrhea cases. Bhuvaneshwara rasa is a potent formulation having Saindhava, Triphala, Yamani, Bilva peshika and Gruhadhooma. Materials and methods: Raw materials were screened and collected and the formulation selected for the present study Bhuvaneshwara rasa was prepared accordingly. Anti-diarrheal activity of Bhuvaneshwara rasa was evaluated experimentally in albino rats. Experimental study was conducted in 3 groups of animals for anti-diarrheal study each. Anti-diarrheal study was done by castor oil induced diarrhoea and castor oil induced enter-pooling method. Bhuvaneshwara rasa (test drug) and Loperamide are effective in controlling diarrheal episodes. Bhuvaneshwara rasa has shown significant Anti-diarrheal activity in both Castor oil -induced diarrhea and castor oil induced enteropooling, test drug effective than control. Result: Bhuvaneshwara rasa was prepared according to SOP. Test drug group have shown effect experimentally. Conclusion: Bhuvaneshwara rasa is a good anti-diarrheal drug. It can be administered in all types of Atisara.

scholarly journals AN EXPERIMENTAL EVALUATION OF RASA PANCHAKA (ATTRIBUTES) OF FOLK MEDICINAL PLANT Andrographis Macrobotrys Nees

2020 ◽  
Vol 8 (8) ◽  
pp. 4116-4124
Author(s):  
Ranjitha S ◽  
Chandrakanth Bhat ◽  
Sudhakar Bhat ◽  
Reju krishnan
Keyword(s):  
Experimental Study ◽  
Medicinal Plants ◽  
Direct Perception ◽  
Albino Rats ◽  
Test Drug ◽  
Endothermic Reaction ◽  
Liver Disorders ◽  
Whole Plant ◽  
Animal Experimental Study ◽  
Wistar Albino Rats

Background and Objective: Folk medicinal plants are densely found in India which needs to be thorough-ly studied and documented. Andrographis Macrobotrys (Nees) is an erect, stout herb of Acanthaceae fami-ly is used in the treatment of snake bite, diarrhea, muscle pain, fever, jaundice, liver disorders and skin dis-ease by the tribes of Kerala. According to the principles of Ayurveda, basis for use of drug is by analysing its Rasapanchaka (attributes) namely rasa (taste), guna (qualities), vipaka (taste after digestion), virya (po-tency), and prabhava (special action). Hence assessment of Rasapanchaka is necessary for thorough knowledge of the drug. Aim of the present study is to evaluate the Rasa, Guna, Virya, Vipaka and prabha-va of Andrographis Macrobotrys Nees. Methods: Rasa of whole plant was assessed by direct perception by administering test drug to 25 volun-teers. Virya was assessed by exothermic and endothermic reaction of the drug with water in different con-centrations. Vipaka, guna and prabhava were determined through animal experimental study by adminis-tering drug to 12 Wistar Albino rats. Result and Conclusion: The assessment of study on rasapanchaka reveals that test drug possess Tiktha (bitter) rasa, Kashaya (astringent) anurasa, laghu (light), ruksha (dry), ushna (hot) guna, katu (pungent) vipaka, sheetha (cold) virya, pachana (digestive), lekhana (scraping) karma (action).

scholarly journals Histopathologcal Effects of Methotrexate on Rat Kidney –An Experimental Study on Wistar Albino Rats.

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Kamaldeep Singh Balowria ◽  
◽  
Masooma Syed ◽  
Sheikh Tousia ◽  
Nafis Ahmad Faruqi ◽  
...  
Keyword(s):  
Experimental Study ◽  
Rat Kidney ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Screening of anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats

2020 ◽  
Vol 9 (12) ◽  
pp. 1803
Author(s):  
Biacin Babu ◽  
Madhavrao Chavan
Keyword(s):  
Albino Rats ◽  
High Dose ◽  
Anticonvulsant Effect ◽  
Low Doses ◽  
Test Drug ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Wistar Albino Rats

Background: Epilepsy is one of the major central nervous system disorders. The parent study aimed to screen the anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats.Methods: This study was done in Wistar albino rats. A total of 30 rats were divided into 6 groups each of six rats. group-I (0.9% normal saline), group-II diphenylhydantoin (10 mg/kg/BW/ip), group-III carvedilol (1mg/kg/BW/PO), group-IV carvedilol (2 mg/kg/BW/PO) and group-V carvedilol (4 mg/kg/BW/PO). All the groups were administered drugs and subjected to electric shock. Scores of seizures and percentage of protection were recorded to compare between the groups. One was ANOVA (post hoc) followed by Dunnet t test applied to find the statistically significant between the groups.Results: Group-I showed significant difference compared to other groups. Group-II showed significant difference with group-III and IV not with V. High dose of test drug and standard drug showed similar results in percentage of seizures prevention. Control and low doses of test drugs showed significant difference compared to standard and high dose of test drug in seizures prevention.Conclusions: High of carvedilol showed significant seizures prevention compared to low doses and control group.

scholarly journals Antidiarrhoeal Studies of Methanol Leaf Extract of Cassia sieberiana Dc in Wistar Albino Rats

2021 ◽  
pp. 43-49
Author(s):  
Jude Nwaogu ◽  
Ibrahim Babangida Abubakar ◽  
Esther Omolade Olaosebikan
Keyword(s):  
Activated Charcoal ◽  
Castor Oil ◽  
Cardiac Glycosides ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Gastrointestinal Transit ◽  
Albino Rats ◽  
Phytochemical Screening ◽  
Standard Methods ◽  
Wistar Albino Rats

Aim: This study was aimed at evaluating the antidiarrhoeal effect methanol leaf extract of Cassia sieberiana. Methodology: The leaf extract of Cassia sieberiana was obtained by extraction using methanol and subjected to phytochemical screening using standard methods. The anti-diarrhoeal effect of methanol leaf extract of Cassia sieberiana DC was investigated in Wistar Albino rats. Results: The result of phytochemical screening revealed the presence of saponins, tannins, phenols, terpenoids, cardiac glycosides, steroids, flavonoids and anthraquinoes. The methanol extract significantly (P<.05) reduced the number of unformed faeces in castor oil induced diarrhoea in the rats. It also significantly (P<.05) reduced the gastrointestinal transit of activated charcoal as well as enteropooling in the rats used for the experiment was significantly reduced (P<.05) in the groups treated with 500 mg/kg and 750 mg/kg. Conclusion: Based on the findings of this research, the methanol leaf extract of Cassia sieberiana possess anti-diarrheal activity and therefore validates its use in traditional medicine for the treatment of diarrhoea.

Impact of sperm retrieival on testis and epididymis: an experimental study using Wistar albino rats

2013 ◽  
Vol 59 (5) ◽  
pp. 261-269 ◽  
Author(s):  
Elumalai Prithiviraj ◽  
Sekar Suresh ◽  
Monica Manivannan ◽  
Seppan Prakash
Keyword(s):  
Experimental Study ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals ASSESSMENT OF PERIODIC DISSIMILARITY OF PHYTOCHEMICAL AND ANTIDIARRHEAL ACTIVITY OF ETHANOLIC EXTRACT OF PSIDIUM GUAJAVA LINN (MYRTACEAE) LEAVES USING WISTAR ALBINO RATS

2018 ◽  
Vol 11 (1) ◽  
pp. 431
Author(s):  
Uttam Borah ◽  
Biswajit Dash ◽  
Jashabir Chakraborty
Keyword(s):  
Castor Oil ◽  
Ethanolic Extract ◽  
Psidium Guajava ◽  
Negative Control ◽  
Albino Rats ◽  
Biosynthesis Pathway ◽  
Phytochemical Variation ◽  
Antidiarrheal Activity ◽  
Wistar Albino Rats ◽  
Different Doses

  Objective: The current investigation was achieved to treasure out the modification of antidiarrheal activity of ethanoic leaves extract of Psidium guajava Linn. with respect to change of season, namely, autumn and spring.Methods: The castor oil induced diarrhea method is employed for assessment of periodic dissimilarity of antidiarrheal activity of ethanolic extract of P. guajava Linn. (Myrtaceae) leaves. Phytochemical variation is resolute as per typical procedure using various reagents.Results: Phytochemical scrutiny discloses that small fluctuation of phytoconstituent content was observed. The extract was initially assayed for its possessions in castor oil-induced diarrhea at different doses (200, 400, and 600 mg/kg, p.o.). There was statistically noteworthy lessening (p<0.05) in the number of wet feces by 78.33% during spring season and 78.26% during autumn season at 600 mg/kg body weight, and when compared to negative control rats, which might be due to change in climate or due to alteration in plant biosynthesis pathway in different season.Conclusion: The outcomes deliver the suggestion for variation in phytochemical contents as well as amendment in antidiarrheal activity of ethanoic extract of P. guajava leaves during autumn and spring.

The effects of tamoxifen on radiation-induced pulmonary fibrosis in Wistar albino rats: Results of an experimental study

The Breast ◽  
2006 ◽  
Vol 15 (3) ◽  
pp. 455-459 ◽  
Author(s):  
Nuran Senel Bese ◽  
Cenk Umay ◽  
Sukru Yildirim ◽  
Sennur Ilvan ◽  
Ahmet Dirican ◽  
...  
Keyword(s):  
Experimental Study ◽  
Pulmonary Fibrosis ◽  
Albino Rats ◽  
Radiation Induced ◽  
Wistar Albino Rats
Sign in / Sign up

Export Citation Format

Share Document