scholarly journals Epidemiological Profile of the Head- Neck Pathologies in a Peripheral Referral Institute

2019 ◽  
Vol 27 (2) ◽  
pp. 113-120
Author(s):  
Sabyasachi Ghosh ◽  
Tarak Nath Saha ◽  
Indranil Sen
Keyword(s):  
Head And Neck ◽  
Histopathological Examination ◽  
Neck Region ◽  
Head And Neck Cancers ◽  
Base Line ◽  
Age Group ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Epidemiological Profile ◽  
Head Neck

Introduction   Head and neck lesions encompass a multitude of disorders which can be broadly classified into two groups: Benign and Malignant. Overall 57.5% of global head and neck cancers comes from Asia itself and India alone constitutes 30% of it. Therefore, it is of prime essence that need based and coordinated research for understanding the threats to the nation from chronic diseases such as head and neck cancers and ways to defy such threats should gain the utmost importance. The present study attempts to present the epidemiological profile of the patients attending a peripheral referral institute of this state with head-neck pathologies and has undergone a histopathological examination of their lesions within a period of three years period (2016-18) based on the histopathological evidences. Materials and Methods The accumulated data regarding the aforesaid patients as per records of the histopathological reports available in the Department of Pathology was used as the primary material and the interrelation of different epidemiological parameters were studied using the statistical methods Results Six hundred and eighty seven cases from the head and neck region were analysed during this three-year period. Age range was from 3 years to 96 years with maximum cases in the age group of 20-29 years (16.1%). The Male: Female ratio in our study was 1.34:1 (Males 394, Females 293). In this study, 38.8% benign, 32.46% malignant, 25.32% inflammatory and 3.3% congenital cases were recorded. Maximum number of benign lesions was in the age group of 10-39 years. Malignancies were noted to be higher in ages 40 years and above. Squamous cell carcinoma was the most common malignancy observed. Conclusion  Specific data obtained like this from histopathological records is helpful in evaluating patterns of head and neck lesions and augment the base line data of institute and the region.

scholarly journals Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

2017 ◽  
Vol 5 (4) ◽  
pp. 1282 ◽  
Author(s):  
Mahima Sharma ◽  
Anuja Sharma ◽  
Shivani Gandhi ◽  
Arvind Khajuria ◽  
K. C. Goswami
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Base Line ◽  
Age Group ◽  
Female Ratio ◽  
Head And Neck Region ◽  
Specific Data ◽  
Graduate Department ◽  
Male Female Ratio ◽  
Age Range

Background: Head and neck lesions include a spectrum of pathological lesions ranging from simple benign to highly malignant entities. These lesions contribute significantly to morbidity and mortality of patients. The aim of this study was to determine the histological patterns of head and neck lesions, both non- neoplastic and neoplastic and to analyse the data in relation to age, gender, topography.Methods: A two year retrospective study was conducted in the Post Graduate Department of Pathology, ASCOMS and Hospital and histopathological data pertaining to all head and neck lesions was reviewed. Each case was analysed with respect to age, gender, site and histological type.Results: One hundred and forty-five cases from the head and neck region were analysed during this two-year period. Age range was from 3 months to 85 years with maximum cases in the age group of 21-50 years (51.03%). The Male: Female ratio was 1.37:1. In our study, 53.79% benign, 24.13% inflammatory and 22.06% malignant cases were recorded. Maximum number of benign lesions was in the age group of 21-50 years. Malignancies were noted to be higher in ages 51 years and above.  Squamous cell carcinoma was the most common malignancy observed.Conclusions: We conclude that site specific data like this is helpful in evaluating patterns of head and neck lesions and augment the base line data of institute and the region.

scholarly journals The role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region

2019 ◽  
Vol 10 (1) ◽  
pp. 48-53
Author(s):  
Mohammad Sowkat Hossain ◽  
S M Mahbubul Alam ◽  
Sk Md Jaynul Islam ◽  
Wasim Selimul Haque ◽  
Shamoli Yasmin
Keyword(s):  
Head And Neck ◽  
Soft Tissues ◽  
Histopathological Examination ◽  
Malignant Neoplasm ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Head And Neck Region

Background: Undifferentiated tumours in the head and neck region are not uncommon. They can arise from different sites like in mucosa as well as in salivary glands, soft tissues or lymph nodes. Histopathological examination plays a central role in the diagnosis but difficulties arise with some tumours which are poorlydifferentiated due to their high inter- and intra-observer variability. In those cases, immunohistochemistry has greatly assisted to diagnose the tumours that cannot be accurately identified using routine histopathological procedures. The correct histopathological diagnosis is essential especially in case of malignant tumourwhere subsequent specific therapy is required. The aim of this study was to determine the role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region. Methods: This cross-sectional study was conducted during July 2014 to June 2015. A total of 35 Bangladeshi patient’s specimens of head and neck swelling were collected from two renowned laboratories in Dhaka city.These cases were diagnosed as undifferentiated tumour in histopathological examination.Standard protocol was followed for immunohistochemistry.Then primary immunohistochemical panel which included the markers for Epithelial CK (AE1/AE3),mesenchymal marker (Vimentin) and lymphoid marker (LCA) were used.The cases which were not resolved by primary immunohistochemistry panel, the second panel was applied for further sub classification (Desmin, Chromogranin, CK20, CEA, CD20, CD30, HMB45, NSE). Based on interpretation of immunohistochemical findings final diagnoses were made.Data analysis was performed using the Statistical Package for the Social Sciences for Windows version 22.0 (SPSS, Chicago, Illinois, USA). Results: A total of 35 undifferentiated tumorsof head-neck region were studied.The mean age was 46.3±17.6 years and male to female ratio was 4.8:1. The majority 13 (37.1%) patient had cervical lymphadenopathy, 11 (31.4%) had neck mass and 4(11.4%) had in nasal/sinonasal mass.Regarding histopathologicalcell types, round cell was 21 (60.0%), spindle cell 6 (17.1%), pleomorphic cells 6(17.1%) and epithelioid cells 2(5.7%). In initial histopathological examination, majority 25(71.4%) were undifferentiated malignant neoplasm, 8(22.8%) were metastatic undifferentiated carcinoma, 1(2.9%) was pleomorphic sarcoma and the remaining 1(2.9%) had malignant adnexal tumour. By application of immunohistochemistry, most (33, 94.3%) of the cases were resolved and the two cases remained unresolved. Among the resolved cases majority (15, 45.5%) were lymphoma, 4(12.1%) were metastatic carcinoma, 3(9.1%) were Ewing’s sarcoma and malignant melanoma were found in 3(9.1%) cases. Conclusion: This study supports that the immunohistochemical technique has a fundamental role in the investigation of undifferentiated tumour origin, to determine the correct guidance for treatment and improving the prognosis for head and neck tumour patients. Birdem Med J 2020; 10(1): 48-53

Pattern of head and neck cancers in a Nigerian tertiary health center: A 10-year review

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e17054-e17054
Author(s):  
S. Alabi ◽  
G. Rahman ◽  
K. Badmos
Keyword(s):  
Head And Neck ◽  
Paranasal Sinuses ◽  
Sex Differentiation ◽  
Age Distribution ◽  
Neck Region ◽  
Head And Neck Cancers ◽  
Teaching Hospitals ◽  
Unknown Primary ◽  
Female Ratio ◽  
Histological Types

e17054 Background: Cancer is a rising health problem worldwide, Nigeria inclusive. A variety of different tumour types may arise at a host of sites within the head and neck region. This 10-year review is to assess the various sites of primary lesion, gender and age distribution and histopathological types, so as to update data with an earlier study done in our centre between 1997–2001. Methods: This 10 year review of patients with head and neck cancers was carried out at the University of Ilorin teaching, Ilorin, North central Nigeria between January 1997 and December 2006.The hospital is one of 2 teaching hospitals in the zone of 6 constituent states out of 36 states in Nigeria, with an average population of 5 to 6 million (2003 Nigerian census). Information extracted from the case notes of patients with histological results included: Age, sex, clinical features, site of tumour, and the histological types of tumour. The International classification of disease oncology (ICDO) ninth version was used to categorize the sites of the tumour. Results: A total of 138 cases of head and cancers were seen over the 10 year period with an average occurrence of 14 cases/year, male/ female ratio of 1.1 to 1.0, age range of 1.5 years to 85 years with a mean age of 45.23 years, the peak age incidence of fifth to sixth decades of life being 47.2%.The commonest histological type was carcinoma (78.3%), then lymphomas (12.3%), blastomas (5.1%), sarcomas (4.3%). The commonest site were the nose, paranasal sinuses and ears (23.9%), eye (15.2%), nasopharynx (13%), neck (13% -metastatic unknown primary 4.3%), thyroid (12.3%), larynx (10.2%), oral cavity and oropharynx (6.5%), salivary glands (3.6%), mandible (1.4%), and skin (0.74%). Conclusions: This result shows that head and neck cancers occur among Nigerians with no sex differentiation in their prime of life, the histological types are similar to the previous series, however the site seems to have changed with the nose and paranasal sinuses, eye, and nasopharynx being the commonest sites. The metastatic unknown primaries in the neck are much lower. The devastating effects on the individual, family and the community are enormous in a setting with late presentations at the hospital and a strong belief in traditional medicine. Emphasis on prevention of these cancers is stressed. No significant financial relationships to disclose.

PREVALENCE OF CARCINOMA GALLBLADDER IN PATIENTS OF CHOLELITHIASIS

2021 ◽  
pp. 1-3
Author(s):  
Mishra Braja Mohan ◽  
Mishra Sandeep ◽  
Bedbak Biswajeet
Keyword(s):  
Open Surgery ◽  
Histopathological Examination ◽  
Gall Stone ◽  
P Value ◽  
Age Group ◽  
Female Ratio ◽  
Carcinoma Gallbladder ◽  
Number Of Patients ◽  
Male Female Ratio ◽  
Surgery Department

Gall stone is the most common risk factor for carcinoma gall bladder. The aim of this study nds out the prevalence of malignancy in patients with Cholelithiasis. All the radiologically diagnosed cased of cholelithiasis underwent surgery were taken into consideration. All the cases of cholelithiasis operated of in General Surgery Department of VSSIMSAR, Burla were considered for study. The diagnosis conrmed by Ultrasonography /MRCP in Department of Radio diagnosis. Total numbers of patients operated are 347, out of which 279 undergone laparoscopic surgery, 58 cases undergone open surgery and 10 cases converted from laparoscopic to open surgery. Most number of patients belongs to age group 31-40, consisting of 32.85% of total number, followed by age group 41-50, and consisting of 25.07%. A female patient constitutes about 77.81 % of total number. Male: female ratio is 1: 3.5. The mean age of the patients of study group is 41 .71. Mean age of female patients is 41.09 and male is 43.88, p value 0.072 (no signicant deference between mean of female and male). The excised specimens sent for histopathological examination in Department of Pathology, VSSIMSAR, Burla. Out of 347 cases nine cases found to have carcinoma specically adenocarcinoma of gallbladder.

scholarly journals DIAGNOSTIC ACCURACY OF THE FNAC IN STUDY OF THE LESIONS IN THE ANTERIOR TRIANGLE OF NECK IN CORRELATION WITH HISTOPATHOLOGY.

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Ravi Shankar ◽  
Alok Kumar ◽  
Bejoy Chand Banerjee ◽  
Rajkumar Prasad
Keyword(s):  
Subcutaneous Tissue ◽  
Neck Region ◽  
Submandibular Salivary Gland ◽  
Age Group ◽  
Surgical Biopsy ◽  
Female Ratio ◽  
Neck Masses ◽  
Male Female Ratio ◽  
Malignant Lesions ◽  
Thyroid Lesions

Method: The study consists of 516 patients with palpable anterior triangle neck masses coming to the Department of Pathology. Result: Out of total 516 patients, 122 patients of thyroid lesions came for FNAC. Female were more affected than males with male: female ratio of 1:4.9. Most commonly affected age group was 16-30 years of age. Conclusion: Out of the 516 FNAC, maximum number were from lymph node consisting of 360 cases (69.86%), 122 cases (23.64%) were thyroid lesions, 34 cases (6.50%)  were miscellaneous lesions from the submandibular salivary gland, soft tissue and subcutaneous tissue of anterior triangle of neck region. FNAC is important diagnostic test for differentiating inflammatory from malignant lesions so that unnecessary surgical biopsy can be avoided and helps in proper management of the patients. Keywords: Diagnostic, FNAC, Lesions, Ant. Triangle & Histopathology.

Issues of geriatric otolaryngologic emergency have not been widely applied despite increase in geriatric population. (Preprint)

2019 ◽  
Author(s):  
Waheed Atilade Adegbiji ◽  
Shuaib Kayode Aremu ◽  
AbdulAkeem Adebayo Aluko
Keyword(s):  
Foreign Body ◽  
Head And Neck ◽  
Clinical Features ◽  
University Teaching ◽  
Age Group ◽  
Geriatric Population ◽  
Female Ratio ◽  
Common Diagnosis ◽  
Foreign Body Impaction ◽  
Nose And Throat

BACKGROUND Issues of geriatric otolaryngologic emergency have not been widely applied despite increase in geriatric population. OBJECTIVE This study aimed at determining prevalence, sociodemographic features, aetiology, clinical features, Complications and sources ofreferral of geriatric otorhinolaryngological, head and neck emergency in our center. METHODS This was a prospective hospital based study of geriatric otorhinolaryngology emergency in the Ear, Nose and Throat Department of Ekiti State University Teaching Hospital. The study was carried out between October 2016 and September 2018. Data were obtained by using pretested interviewers questionnaire.All data were collated and analyzed using SPSS version 18.0. The data were expressed by frequency table, percentage, bar charts and pie charts. RESULTS Geriatric otorhinolaryngology, head and neck emergency accounted for 5.3%. Major prevalence age group was 43.9% in the age group (60-64). There were 38.6% males with male to female ratio of 1:1.5. The main aetiology of geriatric otorhinolaryngology emergency was 29.5% trauma/road traffic accident/foreign body impaction and 25.8% tumour. Main anatomical distribution of geriatric otorhinolaryngology emergency were 38.6% throat diseases and 31.1% ear diseases. The most frequent clinical features were pain in 27.3%, hearing loss in 21.2%, tinnitus in 15.9%, bleeding in 14.4%, difficulty breathing in 12.9% and discharge in 11.4%. Common diagnosis in this study were 15.9% sinonasal tumour, 14.4% upper aerodigestive foreign body impaction, 10.6% earwax impaction and 19.8% otitis externa. Acute presentation (<13 weeks) occurred in 1 week in 74.2% and 2-13 weeks In 19.7%. Commonest time of presentation was daytime in 65.9%. Major sources of referral were 43.2% general practitioner and 31.1% casualty officers. Presentation of geriatric otorhinolaryngology emergency were mainly ear, nose and throat clinic in 59.8% with accident and emergency in 28.8%. Commonest associated comorbid illnesses among the geriatric patients were 18.2% hypertension, 14.4% arthritis and 9.8% diabetes mellitus. CONCLUSIONS Geriatric otorhinolaryngological emergency are common pathology with associated with comorbid illnesses. Detailed clinical assessment are mandatory for effective management outcome.

Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy

2021 ◽  
Vol 28 ◽  
Author(s):  
Ivana Ratkaj ◽  
Martina Mušković ◽  
Nela Malatesti
Keyword(s):  
Photodynamic Therapy ◽  
Head And Neck ◽  
Tumour Progression ◽  
Neck Region ◽  
Angiogenesis Inhibitors ◽  
Tumour Microenvironment ◽  
Head And Neck Cancers ◽  
Skin Cancers ◽  
Tumour Vasculature ◽  
Optimal Drug

Background: Photodynamic therapy (PDT), in comparison to other skin cancers, is still far less effective for melanoma, due to the strong absorbance and the role of melanin in cytoprotection. The tumour microenvironment (TME) has a significant role in tumour progression, and the hypoxic TME is one of the main reasons for melanoma progression to metastasis and its resistance to PDT. Hypoxia is also a feature of solid tumours in the head and neck region that indicates a negative prognosis. Objective: The aim of this study was to individuate and describe systematically the main strategiesthe main strategies systematically in targeting the TME, especially hypoxia, in PDT against melanoma and head and neck cancers (HNC), and assess the current success in their application. Methods: PubMed, was used for searching, in MEDLINE and other databases were used for searching, for the most recent publications on PDT against melanoma and HNC in combination with the TME targeting and hypoxia. Results: In PDT for melanoma and HNC, it is very important to control hypoxia levels, and, amongst the different approaches, oxygen self-supply systems are often applied. Vascular targeting is promising, but to improve it, optimal drug-light interval, and formulation to increase the accumulation of the photosensitiser in the tumour vasculature, have to be established. On the other side, the use of angiogenesis inhibitors, such as those interfering with VEGF signalling are somewhat less successful than expected and need to be further investigated. Conclusion: Combination The combination of PDT with immunotherapy by using multifunctional nanoparticles continues to develop and seems to be the most promising for achieving a complete and lasting antitumour effect.

scholarly journals Clinicopathological study of sinonasal masses

1970 ◽  
Vol 16 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Abu HenaMohammad Parvez Humayun ◽  
AHM Zahurul Huq ◽  
SM Tarequddin Ahmed ◽  
Md Shah Kamal ◽  
Kyaw Khin U ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Malignant Lesion ◽  
Malignant Tumour ◽  
Neck Surgery ◽  
Female Ratio ◽  
Medical College ◽  
Male To Female ◽  
Study Setting ◽  
Head Neck Surgery ◽  
Head Neck

Objective: To observe the incidence, clinical presentation and to perform comparative studyof different sinonasal masses. Study design: Prospective study. Setting: Department ofotolaryngology and Head-Neck Surgery & ENT OPD of Chittagong Medical College Hospital.Patients & methods: 50 patients are included in this study (39 male & 11 female) between theages of 3 years and 80 years who were treated between August 2006 to January 2007. Studybased on history, clinical, radiological, laboratory and histopathological examination. Results:Mean age for male was 35.12 years and for female was 22.63 years. Male to female ratio was3.5:1. Highest frequency was noted in second decade. Most of patient (78%) were from poorclass. Frequency of inflammatory nasal masses were more in second decade, benign tumourin fourth and fifth decade, malignant tumour in second decade (OAN & NHL) and fifth andsecond decades (others). Rhinosporidiosis were most frequent inflammatory nasal masses.Nasal obstruction was the commonest and orbitus symptoms were less frequent symptoms.But orbital symptoms were more prevalent in malignant lesion. Conclusion: sinonasal massesare found in all age group. Rhinosporidiosis are appearing to be the commonest nasal masses.The prevalence of nasal polyp is also high. Among the malignant sinonasal masses thepercentage of squamous cell carcinoma is high.DOI: 10.3329/bjo.v16i1.5776Bangladesh J Otorhinolaryngol 2010; 16(1): 15-22

scholarly journals An 8-year Pattern of Orofacial Sarcoma from the National Referral Hospital in United Republic of Tanzania

2016 ◽  
Vol 7 (4) ◽  
pp. 207-212 ◽  
Keyword(s):  
Head And Neck ◽  
Demographic Data ◽  
Neck Region ◽  
Referral Hospital ◽  
Histopathological Diagnosis ◽  
Primary Tumors ◽  
Female Ratio ◽  
United Republic ◽  
United Republic Of Tanzania ◽  
National Referral Hospital

ABSTRACT Aim: This study aimed at evaluating the pattern of head and neck sarcomas among patients treated at Muhimbili National Hospital, Tanzania. Background Sarcomas of the head and neck are very rare, representing only 1% of all primary tumors arising within the head and neck region and accounting for 4 to 10% of all sarcomas, with more than 50 distinct existing histologic subtypes. Materials and methods It was a retrospective study whereby histological results of the lesions arising from oral and maxillofacial region between 2008 and 2016 were analyzed. Patient's demographic data, histopathological diagnosis, and the type of sarcoma were recorded. The lesions were broadly grouped as soft and hard tissue sarcomas (HTSs). Data analysis was done using Statistical Package for the Social Sciences version 19 computer program. Results Sarcomas accounted for 7% of all lesions occurring in orofacial region. Male to female ratio was 1:1.4. The age ranged from 3 to 81 years, mean age being 33 ± 16 years. The most affected age groups were of 30 to 39 followed by 20 to 29 years. Approximately half of the patients were aged below 30 years and three quarters below 40 years. Kaposi's sarcoma (KS) and rhabdomyosarcoma were the most common soft tissue sarcoma (STS), while osteosarcoma and chondrosarcoma were the commonest HTS. Conclusion The analysis demonstrated that the head and neck sarcomas are a very rare group of neoplasm, with approximately 20 cases per year. The STSs are more common than the HTSs, while KS is the most common, followed by osteosarcoma and rhabdomyosarcoma. Generally, patients less than 40 years of age are the mostly affected, with a slightly higher female predominance. Clinical significance By contributing to the identification of the incidence of sarcomas at a tertiary hospital in Tanzania, this study promotes scientific understanding of pattern of occurrence and underscores the necessity of early detection of sarcomas, since the affected are young individuals. How to cite this article Moshy JR, Owibingire SS, Sohal KS. An 8-year Pattern of Orofacial Sarcoma from the National Referral Hospital in United Republic of Tanzania. Int J Head Neck Surg 2016;7(4):207-212.

scholarly journals A RETROGRADE STUDY OF MYIASIS IN A TERTIARY CARE CENTRE

2020 ◽  
pp. 3-5
Author(s):  
Ayesha Goel ◽  
Ritu Nigam
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Tertiary Care ◽  
Personal Hygiene ◽  
Intracranial Extension ◽  
Atrophic Rhinitis ◽  
Time Interval ◽  
Age Group ◽  
Predisposing Factor ◽  
Female Ratio

Myiasis in head and neck region is a rare occurrence and is usually found in tropical countries like India. Poor hygiene, unsanitary living conditions, mental retardation, neglected wounds, diabetes mellitus and old age along with a warm and humid climate lay down a conducive environment for the larva of dipterous fly to infest humans. Maggots due to their tissue destructive properties can affect many regions in otolaryngorhinology like nasal cavity, ears, oral cavity, tracheostomy site ostoma, PNS, the skin and ulcerative lesions of head and neck. The burden of the disease lies in the fact that the complications range from minor tissue destruction, perforation of either the tympanic membrane, palate or septum, vertigo, angioedema to severe neurological manifestations, intracranial extension or rarely even death. Objective: To assess the commonly affected age group and gender infested by myiasis, it’s seasonal trend, socioeconomic status of the affected patients and the relationship of myiasis infestation with various predisposing factors. Methodology: Retrograde study was conducted on 95 patients of department of otorhinolaryngology. The study was done from January 2015 to October 2018 by collecting data of 3 years 10 months time interval and results tabulated. Ethical clearance was sort and patients consent obtained. Result: The most commonly affected age group was found to be elderly, in the 7th decade of life (56.84%). Females were more commonly affected than males consisting of 55 out of 95 cases (57.89%), with a male female ratio of 1:1.4. Majority of cases presented in the months of October-January, with a peak in November (32/95). Nasal myiasis was found to be more common (69 cases) in comparison to aural and oral cavity myiasis. The most common predisposing factor was found to be Atrophic Rhinitis in 66.7% cases. Conclusion : With awareness and improved personal hygiene a devastating disease like myiasis is easily preventable and curable.

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