scholarly journals Niosomes As an Ideal Drug Delivery System

2021 ◽  
Vol 3 (3) ◽  
pp. 1-9
Author(s):  
Vikram B Madane ◽  
◽  
Nagesh H Aloorkar ◽  
Vinod J Mokale ◽  
◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Evaluation Studies ◽  
Receptor Site ◽  
Cost Effective ◽  
Active Pharmaceutical Ingredient ◽  
Systemic Circulation ◽  
Future Perspective ◽  
Final Conclusion

Niosomes are a non-ionic spherical surfactant that is biodegradable, non-toxic, more durable, and cost effective as compare to liposomes. Through niosomes delivery of both hydrophilic and liophilic drug can be achieve very constructively. To achieve targeted drug delivery, drug binds to receptor site and then we can get the therapeutic action without attaching to other sites to prevent the undesirable or side effect of active pharmaceutical ingredient to the systemic circulation, hence niosomes is a very novel drug delivery system by which we can achieve very safe drug delivery at the site of action needed with high efficacy. In this review paper we try to compile all the information related with niosomes like introduction, structure, composition advantages, types, disadvantage, preparation methods, factor affecting, evaluation studies, applications of niosomes, difference between liposomes and niosomes, current available marketed formulation and patents, final conclusion and at last future perspective of niosomes.

scholarly journals Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 619
Author(s):  
Krisztián Pamlényi ◽  
Katalin Kristó ◽  
Orsolya Jójárt-Laczkovich ◽  
Géza Regdon
Keyword(s):  
Drug Delivery ◽  
Tensile Strength ◽  
Sodium Alginate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymer Films ◽  
Hydroxypropyl Methylcellulose ◽  
Chemical Properties ◽  
Active Pharmaceutical Ingredient ◽  
Swallowing Problems

Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, and polymer films, are among these possible products. Oral mucoadhesive systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused on formulating buccal mucoadhesive polymer films and investigating the physical and physical–chemical properties of films. Sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) were used as film-forming agents, glycerol (GLY) was added as a plasticizer, and cetirizine dihydrochloride (CTZ) was used as an active pharmaceutical ingredient (API). The polymer films were prepared at room temperature with the solvent casting method by mixed two-level and three-level factorial designs. The thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, and Raman spectra, as well as the dissolution of the prepared films, were investigated. The investigations showed that GLY can reduce the mucoadhesivity of films, and CTZ can increase the tensile strength of films. The distribution of CTZ proved to be homogeneous in the films. The API could dissolve completely from all the films. We can conclude that polymer films with 1% and 3% GLY concentrations are appropriate to be formulated for application on the buccal mucosa as a drug delivery system.

scholarly journals Development and evaluation of buccal patches of theophylline

2021 ◽  
Vol 16 (3) ◽  
pp. 235-240
Author(s):  
Kapil Kumar ◽  
Gurleen Kaur ◽  
Seema ◽  
Deepak Teotia ◽  
Ikram
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Buccal Mucosa ◽  
Systemic Circulation ◽  
Pharmacological Response ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

Buccal patches are the types of formulations in which the drug is administered through buccal mucosa. these patches are or placed in between the gums and the for the pharmacological response. The main advantage of these patches is there is no first pass metabolism takes place and easily absorb in systemic circulation through themucosa .the main objective of this drug delivery system is to elevate or increase the bioavailability of the drug. the review informs about the steps involve in the preparation of buccal patch and to promote the awareness towards this type of drug delivery system. This article intends to analyze the overall profile of Buccal Patches and scope of future advances.

TOPICAL DELIVERY OF DRUGS USING ETHOSOMES: A REVIEW

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (08) ◽  
pp. 7-20
Author(s):  
V Sankar ◽  
V. Wilson ◽  
K. Siram ◽  
A. Karuppaiah ◽  
S Hariharan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Skin Permeation ◽  
Protective Layer ◽  
Systemic Circulation ◽  
Healing Time ◽  
Androgenic Alopecia ◽  
Recurrent Herpes

The skin is the largest organ of the human body that restricts the movement of drug to the systemic circulation. Topical drug delivery system is a system where the drug reaches the systemic circulation through the protective layer i.e. skin. The main disadvantage of this route is the low diffusion rate of the drugs which is across the stratum corneum layer of the skin. To overcome this problem to a certain extent, ethosomal delivery for drugs and herbal compounds has been recently introduced. Literature studies indicate that ethosomal formulation of acyclovir shows high therapeutic efficiency with shorter healing time in the treatment of recurrent herpes labialis than conventional Zovirax. Also, the ethosomes of minoxidil enhanced the skin permeation of minoxidil in vitro in comparison to its ethanolic or phospholipid ethanolic micellar solution or hydroethanolic solution. T he advantages of this system include increased drug permeation, increased drug entrapment and improved drug delivery. Ethosomal drug delivery system opens up doors for the development of new and novel therapies for treating male pattern baldness, as it is an easier way to prepare, in addition to its safety and efficacy. In this review article, we have focused on methods of preparation of ethosomes, characterization techniques, applications, details about the various research trials for the management of androgenic alopecia and various ethosomal products in market.

scholarly journals Frog nest foam as a drug delivery system

2021 ◽  
Author(s):  
Sarah Brozio ◽  
Erin M O Shaughnessy ◽  
Stuart Woods ◽  
Ivan Hall-Barrientos ◽  
Patrica E Martin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Active Pharmaceutical Ingredient ◽  
Natural World ◽  
Ex Situ ◽  
Foaming Properties ◽  
Amphibian Skin ◽  
Tropical Environments ◽  
Therapeutic Molecules

Foams have frequently been used as systems for the delivery of cosmetic and therapeutic molecules; however, there is high variability in the foamability and long-term stability of synthetic foams. The development of pharmaceutical foams that exhibit desirable foaming properties, delivering appropriate amounts of the active pharmaceutical ingredient (API) and that have excellent biocompatibility is of great interest. The production of stable foams is rare in the natural world; however, certain species of frogs have adopted foam production as a means of providing a protective environment for their eggs and larvae from a predators and parasites, to prevent desiccation, to control gaseous exchange, temperature extremes, and to reduce UV damage. These foams show great stability (up to 10 days in tropical environments) and are highly biocompatible due to the sensitive nature of amphibian skin. This work demonstrates for the first time, that nests of the Tungara frog (Engystomops pustulosus) is stable ex situ with useful physiochemical and biocompatible properties and is capable of encapsulating a range of compounds, including antibiotics. These protein foam mixtures may find utility as a topical drug delivery system (DDS).

scholarly journals Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

2020 ◽  
Vol 13 (4) ◽  
pp. 246-254 ◽  
Author(s):  
Zufika Qamar ◽  
Farheen Fatima Qizilbash ◽  
Mohammad Kashif Iqubal ◽  
Asgar Ali ◽  
Jasjeet Kaur Narang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Residence Time ◽  
Delivery System ◽  
Future Perspective ◽  
Nanostructured Lipid Carrier ◽  
Solid Lipid Nanoparticle ◽  
Routes Of Administration ◽  
The Past ◽  
Recent Developments

The structure of the eye is very complex in nature which makes it a challenging task for pharmaceutical researchers to deliver the drug at the desired sites via different routes of administration. The development of the nano-based system helped in delivering the drug in the desired concentration. Improvement in penetration property, bioavailability, and residence time has all been achieved by encapsulating drugs into liposomes, dendrimers, solid lipid nanoparticle, nanostructured lipid carrier, nanoemulsion, and nanosuspension. This review puts emphasis on the need for nanomedicine for ocular drug delivery and recent developments in the field of nanomedicine along with recent patents published in the past few years.

Microsponges as Innovative Drug Delivery Systems

2012 ◽  
Vol 5 (1) ◽  
pp. 1597-1606
Author(s):  
Dipit Jagannath Ingale ◽  
N H Aloorkar ◽  
A S KulkarnI ◽  
R.A. Patil Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Circulation ◽  
Release Mechanism ◽  
Transdermal Drug Delivery System ◽  
Innovative Drug ◽  
Pharmaceutical Ingredients ◽  
Improved Stability ◽  
Highly Porous

Transdermal drug delivery system (TDDS) is not practicable for delivery of materials whose final target is skin itself. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is a challenging area of research. Microsponges are highly porous micro-sized particles with a unique ability for entrapping active pharmaceutical ingredients. To control the delivery rate of active agents to a predetermined site in human body has been one of the biggest challenges faced by scientists. Microsponges are safe biologically and offer unique advantage of programmable release. This technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance and enhanced formulation flexibility. This technology is being used for topical formulations and also for oral administration. The present review describes microsponge technology including its preparation, characterization, programmable parameters and release mechanism of microsponge drug delivery system.

scholarly journals Intra Nasal In situ Gelling System of Lamotrigine Using Ion Activated Mucoadhesive Polymer

2017 ◽  
Vol 11 (1) ◽  
pp. 222-244 ◽  
Author(s):  
Asha Paul ◽  
K.M .Fathima ◽  
Sreeja C. Nair
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Evaluation Studies ◽  
Nasal Administration ◽  
Permeation Studies ◽  
Novel Drug Delivery System ◽  
Histopathological Studies ◽  
Novel Drug

Background:A novel drug delivery system for treating acute epileptic condition.Objective:To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loadedinsitugel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment.Methods:Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum.Results:All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between 5.8 ±.001 to 6.8 ±.005 indicating that no mucosal irritation is expected as pH was in acceptable range.Invitrodrug release from the mucoadhesiveinsitugel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% for optimized G5 formulation within 20min.Exvivopermeation studies of optimized formulation G5 and control formulation was estimated.Exvivopermeation studies of G5insituformulation done for a period of 12 h resulted in slow, sustained release and greater permeability significance(P <0.05) through nasal mucosa when compared to control. Histopathological studies showed that G5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45 days in refrigerated condition (4±2ºC).Conclusion:The intranasalinsitugelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which could enhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug for treating acute epileptic conditions.

scholarly journals Revolutionary Approach towards Transdermal Drug Delivery: Ethosomal Gels

2021 ◽  
pp. 35-43
Author(s):  
Ezekiel O. Kehinde ◽  
Shah Akrutiben ◽  
Janki Patel
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Circulation ◽  
The Body ◽  
Topical Drug Delivery ◽  
Biological Barrier ◽  
Advantages And Disadvantages ◽  
Non Invasive

The human body is up of the skin which is the largest organ in the body and hence acts as a biological barrier that obstructs drug movement across the stratum corneum into the systemic circulation. The topical drug delivery system serves as a delivery system in which drugs are delivered for systemic circulation through the skin. Low diffusion rate across the stratum corneum is the main disadvantage of this system and for this limitation to be overcome, an Ethosomal formulation can be formulated which acts as a delivery system for the drug to be delivered across the biological barrier of the skin into the body. In ethosomal gel formulation, The prepared Ethosome is converted into a gel that can be applied to the skin what makes ethosomal gel formulation unique which enables drugs to reach the deep skin layers and/or the systemic circulation and enhance the delivery of active agents. In addition to this, it is also a malleable vesicular delivery carrier, soft and non-invasive. There is also a higher influx of drugs transdermally into the skin as ethosomal gel formulation allows drug to penetrate deep into the skin and enters systemic circulation. There is the development of new and novel therapies for the treatment of disease through the ethosomal drug delivery system as it is safe and effective and also easy to prepare. Topics ranging from preparation of ethosomes, Ethosomal gel, advantages and disadvantages, and characterization techniques are focused on in this review article.

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