Overview of Results of Donor TTI (Transfusion Transmitted Infection) Screening in the Blood Transfusion Unit (UTD) PMI of North Aceh Regency in 2017-2018

Background. Blood transfusion is an important part of modern health services. When used properly, transfusion can save patient's life and improve health. Blood transfusion has risk of transmitted infectious diseases through blood transfusion (TTI) especially HIV / AIDS, Hepatitis C, Hepatitis B, and Syphilis, and Malaria, Dengue Fever (DHF) can only be done in endemic areas, as well as other transfusions which can be life threatening. Method. This was descriptive study with cross sectional approach and sampling techniques using secondary data with total population method. From the sample of 23,875 samples (12,305 (2017) and 11,573 (2018)), it was seen which results of TTI reactive from donor data to be included in finding research objects. Results. In 2017 HbSAg reactive TTI parameters 1.7%, Anti HCV 0.5%, HIV Ag / Ab 0.7%, and Treponema 4% and TTI reactive results in donors in 2018 HbSAg parameters 1.3%, Anti HCV 0.3%, HIV Ag / Ab 0.25% and Treponema 2.2%. Comparison of donor TTI screening results in Blood Center of North Aceh-Indonesia in the period 2017-2018 changes in the ratio of TTI reactive numbers in the HbSAg parameter of 0.4%, Anti HCV 0.2%, HIV Ag / Ab 0.45% and Treponema 1.8% in period 2018. Conclusion: Although the reactive rate in 2017 is relatively high, in 2018 the reactive TTI level shows a decline. This condition can be caused by two factors. ; (1) Implementation of donor selection was good with good data collection and documentation system. (2) The inspection method carried out affects the results of the existing inspection.

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Tubo-Ovarian Abscess: in Dr. Zainoel Abidin Banda Aceh Hospital: a Case Report

Journal Of The Indonesian Medical Association ◽

10.47830/jinma-vol.70.6-2020-264 ◽

2020 ◽

Vol 70 (6) ◽

pp. 128-131

Author(s):

Mohd Andalas ◽

Munawar ◽

Yusra ◽

Maqbul

Keyword(s):

Blood Transfusion ◽

Total Population ◽

Secondary Data ◽

Documentation System ◽

Cross Sectional ◽

Inspection Method ◽

Two Factors ◽

System 2 ◽

Ovarian Abscess ◽

Improve Health

Background: Blood transfusion is an important part of modern health services. When used properly, transfusion can save patient’s life and improve health. Blood transfusion has risk of transmitted infectious diseases through blood transfusion (TTI) especially HIV / AIDS, Hepatitis C, Hepatitis B, and Syphilis, and Malaria, Dengue Fever (DHF) can only be done in endemic areas, as well as other transfusions which can be life threatening.Method: This was descriptive study with cross sectional approach and sampling techniques using secondary data with total population method. From the sample of 23,875 samples (12,305 (2017) and 11,573 (2018)), it was seen which results of TTI reactive from donor data to be included in finding research objects. Results: In 2017 HbSAg reactive TTI parameters 1.7%, Anti HCV 0.5%, HIV Ag / Ab 0.7%, and Treponema 4% and TTI reactive results in donors in 2018 HbSAg parameters 1.3%, Anti HCV 0.3%, HIV Ag / Ab 0.25% and Treponema 2.2%. Comparison of donor TTI screening results in Blood Center of North Aceh-Indonesia in the period 2017-2018 changes in the ratio of TTI reactive numbers in the HbSAg parameter of 0.4%, Anti HCV 0.2%, HIV Ag / Ab 0.45% and Treponema 1.8% in period 2018.Conclusion: Although the reactive rate in 2017 is relatively high, in 2018 the reactive TTI level shows a decline. This condition can be caused by two factors. ; (1) Implementation of donor selection was good with good data collection and documentation system. (2) The inspection method carried out affects the results of the existing inspection.

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Asymptomatic Plasmodium Parasites among Adults in Eastern Uganda: A Case of Donor Blood Screening at Mbale Regional Blood Bank

Journal of Tropical Medicine ◽

10.1155/2018/6359079 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Simon Peter Inyimai ◽

Mosses Ocan ◽

Benjamin Wabwire ◽

Peter Olupot-Olupot

Keyword(s):

Blood Transfusion ◽

Adult Population ◽

Sampling Technique ◽

Plasmodium Malariae ◽

Blood Bank ◽

Donor Blood ◽

Transmitted Infection ◽

Cross Sectional ◽

Blood Transfusion Service ◽

Eastern Uganda

Background. There is a paucity of data on asymptomatic carriage of Plasmodium parasite among adult population in Eastern Uganda, an area of perennial high transmission of malaria. In this study, we estimated the prevalence of Plasmodium parasites in donor blood units at Mbale Regional Blood Bank (Mbale RBB), a satellite centre of the Uganda Blood Transfusion Service (UBTS). Method. This was a cross-sectional descriptive study in which 380 screened donor blood units were examined for the presence of Plasmodium parasites. A systematic random sampling technique using the interval of 7 was used in selecting the screened blood units for testing. Two experienced malaria slide microscopists (MC1 and MC2) independently examined each thick and thin blood slide under high power magnification of X400 and then X1000 as stated on the study standard operation procedure (SOP). Each slide was examined for 100 oil immersion fields before the examiner declared them negative for Plasmodium parasites. The results by each microscopist’s examination were tallied separately, and finally, the two tallies were compared. The third independent microscopist (MC3) was blinded to the results from MC1 and MC2, but whose role was to perform quality control on the slides randomly sampled and read 38 (10%) of all the slides and was available to examine any slides with inconsistent findings by MC1 or MC2. Results. All the microscopists were unanimous in all the slide readings. Five of the thick smears (1.3%) confirmed the presence of Plasmodium parasites among donor blood units. Of these, 4/5 were from male donors. Plasmodium falciparum was identified in 4 positive samples, while Plasmodium malariae was identified in one of the donor units. Conclusion. The 1.3% prevalence of Plasmodium malaria parasites in screened donor blood units represents risk of malaria blood transfusion transmitted infection and a pool of community transmittable malaria infections, respectively.

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Splenectomy and its relation to non-transfusion-transmitted infection in thalassemic patients

Paediatrica Indonesiana ◽

10.14238/pi46.3.2006.134-8 ◽

2016 ◽

Vol 46 (3) ◽

pp. 134

Author(s):

Mururul Aisyi ◽

Alan Roland Tumbelaka ◽

Bulan Ginting Munthe ◽

Bambang Madiyono

Keyword(s):

Risk Factors ◽

Common Cold ◽

Severe Infection ◽

Cross Sectional Study ◽

Control Group ◽

Transmitted Infection ◽

Cross Sectional ◽

Transfusion Transmitted Infection ◽

Common Group ◽

Level Of Significance

Background Splenectomy has been associated with an increasedsusceptibility to infection. Overwhelming postspelenectomy infec-tion (OPSI) can lead to high mortality. Decreased IgM and tuftsinconcentration on splenectomized patients seems to play a role ininfection’s susceptibility. Many studies have been performed todetermine the risk factors of infection in thalassemic patients.Objective To find out morbidity patterns and risk factors for pre-dicting the likelihood of infection in splenectomized thalassemicpatients.Methods A retrospective cross sectional study was conducted onconfirmed thalassemic children who came to Department of ChildHealth, Cipto Mangunkusumo Hospital within the period of 1973-2003. Splenectomized patients were categorized as cases groupand non-splenectomized patients as control group. Risk factors fordevelopment of common cold and diarrhea were analyzed usingchi-square test with level of significance <0.05.Results A total of 300 thalassemic patients, 100 of them were sple-nectomized, were enrolled in this study. The 15-year-age group orabove is the most common group underwent splenectomy (35%).Common cold is the most common mild infection in both splenec-tomized group (75%) and non-splenectomized (71%). A significantassociation was found between the risk of infection and splenec-tomy in thalassemic patients (OR=3.8;CI=2.2;6.62; P=0.000). As-sociation between time after splenectomy and frequency of com-mon cold in thalassemia was significant (OR=2.85;CI=1.16;7.14;P=0.011). Severe infection and acute diarrhea were considerednot significantly different between the two groups.Conclusion Splenectomy in thalassemia can increase the sus-ceptibility of non-transfusion-transmitted mild infection. Furtherstudy is needed to elaborate this finding

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Risk of Hepatitis B and Hepatitis C Among Whole Blood Transfused Chronic Hemodialysed Chronic Kidney Disease (CKD) Patients

Bangladesh Journal of Medicine ◽

10.3329/bjmed.v30i2.41534 ◽

2019 ◽

Vol 30 (2) ◽

pp. 78-82

Author(s):

Md Abdul Quader ◽

Khan Anisul Islam ◽

Tashmim Farhana Dipta ◽

Md Ashadul Islam

Keyword(s):

Hepatitis C ◽

Blood Transfusion ◽

Hepatitis B ◽

Hemodialysis Patients ◽

Maintenance Hemodialysis ◽

Control Group ◽

Transmitted Infection ◽

Transfusion Transmitted Infection ◽

Healthy Donors ◽

Significant Difference

Background: Patients with chronic renal failure on maintenance hemodialysis (MHD) have high risks of viral infections and the prevalence of transfusion transmissible viral infection is common among them. The aim of our study was to detect hepatitis B and hepatitis C virus in hemodialysis patients and healthy donors and to explore if there was a relationship between duration of hemodialysis and hepatitis B and hepatitis C in our patients. Methodology: A cross sectional study was conducted in a private hemodialysis clinic in Dhaka city with end stage renal disease on maintenance hemodialysis and an age matched healthy donors as comparable group from July 2015 to June 2016. Serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), HBsAg and anti HCV were determined along with duration and units of blood transfusion needed by them. Results: Our study showed the mean age of 126 MHD patients were 42.2±11.7 years along with 132 healthy donors as control group had mean age 39.2±9.7 years. Among the hemodialysis patients 34 (26.98%) showed transfusion transmitted infection positivity and in control group 11 (8.33%) showed transfusion transmitted infection positivity with the difference between two study group showed statistical significance (p<o.oo1). History of blood transfusion showed the significant predictor of occurrence of TTV infection in hemodialysis patients (p<0.01). Duration of hemodialysis and seropositivity of TTI was not significant (p>0.05). The number of units of blood transfusion and the TTI positivity also showed no significant difference (p>0.05) with HBsAg (17.46%) and anti HCV (9.52%). Conclusions: The prevalence of TTI in hemodialysis patients is significantly higher than that in healthy individuals. So, the regular screening of HBV and HCV among patients and healthy donors are strictly provided to monitor the communicable disease. Bangladesh J Medicine July 2019; 30(2) : 78-82

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Analysis of the profile of blood donors in a blood bank of a private medical college of Kolkata

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20174271 ◽

2017 ◽

Vol 4 (10) ◽

pp. 3899 ◽

Cited By ~ 2

Author(s):

Debdutta Haldar ◽

Kunal Kanti Majumdar ◽

Shilpa Karir ◽

Arun Kumar Chakraborty ◽

Ankita Dey ◽

...

Keyword(s):

Blood Group ◽

Blood Donors ◽

Cross Sectional Study ◽

Blood Bank ◽

The Body ◽

Transmitted Infection ◽

Cross Sectional ◽

Male Predominance ◽

Medical College ◽

Transfusion Transmitted Infection

Background: Blood is the only oxygen transporter in the body and is crucial in saving lives. Research has failed to find a true substitute for blood and blood components and depends on human donors. There are several infectious and non-infectious risks associated with transfusion. An unsafe transfusion is very costly from both human and economic points of view. In that perspective the present study is aimed to assess the profile of blood donors. The objectives of the study were to assess the profile of blood donors as per records of Blood Bank of a private medical college of Kolkata and to find out the prevalence and trends of transfusion transmitted infections among those donors.Methods: A record based cross sectional study was conducted for the period May 2013 to April 2016 at Blood Bank of a private medical college and information regarding 5383 blood donor’s profile were collected and analysed. Results: The total donors were found to be 5383 out of which (87.72%) were voluntary donors and (12.28%) replacement donors. The donors had a male predominance (79.84%). The most available blood group was B+ (49.42%) and the least available blood group was A- (0.38%). The commonest transfusion transmitted infection was Hepatitis B (1.11%) followed by Hepatitis C (0.28%) and HIV (0.21%). The transfusion transmitted infections (TTI) shows a decreasing trend over the 3 years. Conclusions: The voluntary donors have increased over the 3 years but there is always a male predominance. The pattern of TTIs in the blood bank depicts the national trend too.

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Epidemiology of Transfusion Transmitted Infection among Patients with β-Thalassaemia Major in Pakistan

Journal of Blood Transfusion ◽

10.1155/2016/8135649 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 16

Author(s):

Rizwan Ahmed Kiani ◽

Muhammad Anwar ◽

Usman Waheed ◽

Muhammad Javaid Asad ◽

Saleem Abbasi ◽

...

Keyword(s):

Cross Sectional Study ◽

Thalassaemia Major ◽

Sectional Study ◽

Transmitted Infection ◽

Cross Sectional ◽

Transfusion Transmitted Infection ◽

Blood Banks ◽

The World ◽

Chemiluminescent Immunoassay ◽

Medical University

Introduction. Transfusion Transmitted Infections (TTIs) continue to be a major risk in transfusions in many parts of the world. The transfusion-dependent β-thalassaemia patients are particularly at risk of acquiring TTIs. The current study was undertaken to estimate the prevalence of TTIs in transfusion-dependent β-thalassaemia patients. Material and Methods. A cross-sectional study of 1253 multitransfused thalassaemia major patients was conducted in five different centres of Islamabad, Rawalpindi, and Karachi. The study subjects were screened for HIV, HCV, and HBV. The screening was performed at two centres: Department of Pathology, Shaheed Zulfiqar Ali Bhutto (SZAB) Medical University, and Blood Transfusion Services, Jinnah Postgraduate Medical Centre, from July to December 2015. The confirmatory screening was performed by Chemiluminescent Immunoassay (CLIA). Results. Out of the 1253 multiple transfused patients, 317 (25.3%) were infected with TTIs. HCV was positive in 273 cases (21.7%), HBV in 38 cases (3.0%), and HIV in 6 cases (0.5%). Conclusion. HCV was the leading TTI in multitransfused thalassaemia major patients in the study. Presence of HIV in thalassaemia patients is a recent disturbing development in Pakistan. Improved regulation of blood banks including use of internationally or nationally evaluated kits will bring down the incidence of TTIs in transfusion-dependent β-thalassaemia patients. More stringent behavioral and serological pretransfusion screening of blood for TTIs must be implemented in blood banks.

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Transfusion Transmitted Infection: Viral and Exotic Diseases

Anaesthesia and Intensive Care ◽

10.1177/0310057x9302100109 ◽

1993 ◽

Vol 21 (1) ◽

pp. 24-30 ◽

Cited By ~ 23

Author(s):

B. R. Wylie

Keyword(s):

Human Immunodeficiency Virus ◽

Lyme Disease ◽

Blood Transfusion ◽

Blood Components ◽

Hepatitis Viruses ◽

Transmitted Infection ◽

Transfusion Transmitted Infection ◽

Immunodeficiency Virus ◽

Blood Banks ◽

Screening Procedures

Viral and other exotic diseases may be transmitted by blood transfusion. These infections include human immunodeficiency virus (HIV), hepatitis viruses (A, B, C, D and E), syphilis, malaria, retrovirus HTLV-1, and cytomegalovirus. Other more exotic diseases which may be transmitted by transfusion of blood or blood components include Chagas’ disease (Trypanosomiasis cruzi), Lyme disease (Borrelia burgdorferi), and Jakob-Creutzfeldt disease. Screening procedures currently used in Australian blood banks minimise transfusion-transmitted infection. The risk of acquiring any infection in this manner may be less than 0.1%.

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Impact of COVID-19 pandemic on rare diseases- A case study on thalassaemia patients in Bangladesh

10.1101/2021.03.29.21254589 ◽

2021 ◽

Author(s):

Mohammad Sorowar Hossain ◽

Farhana Runa ◽

Abdullah Al Mosabbir

Keyword(s):

Blood Transfusion ◽

Healthcare Access ◽

Healthcare Services ◽

Median Number ◽

Cross Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Life Threatening ◽

The Impact

Objectives Thalassaemia is a life-threatening rare disease, which requires regular blood transfusion and medical care. The information on how thalassaemia patients are affected during the unprecedented COVID-19 crisis is scarce. This study aimed to assess the impact of the COVID-19 pandemic on the blood transfusion and healthcare access of thalassaemia patients at the community level in Bangladesh. Methods A cross-sectional study was conducted among thalassaemia patients registered in a community-based thalassaemia registry in Jamapur, Bangladesh. Results As compared to pre-COVID-19 time, the number of blood transfusions among patients under the thalassaemia registry was significantly reduced during COVID-19 pandemic (190 units versus 81 units). In addition, the median number of red cell transfusions per patient was dropped significantly from 4 units to one unit. Over 80% of patient had no access to healthcare services at all during the early phase of the pandemic. Conclusion Emergency response with appropriate mitigative measures must be a priority for addressing an acute shortage of blood supply in situations like COVID-19 pandemic.

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