Microbioma en los trastornos de la conducta alimentaria

2021 ◽  
Vol 22 (3) ◽  
Author(s):  
Norma Cipatli Ayuzo del Valle ◽  
◽  
Laura Leticia Zavala ◽  
Brenda Ayuzo ◽  
Victoria Villafuerte ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Immune System ◽  
Gastrointestinal Tract ◽  
Health Benefits ◽  
Vagal Nerve ◽  
Future Research ◽  
Umbrella Review ◽  
Psychiatric Illnesses ◽  
Microbiome Research

Introduction: eating disorders are serious illnesses with genetic and neurobiological bases where the main organs affected are the gastrointestinal tract and the neurologic system making important the role of the microbiome. Objectives: summarize the results of the latest microbiome research that could be future tools in the management of eating disorders. Materials and methods: umbrella review of pubmed publications in humans of the last 10 years regarding microbiome and eating disorders. Results: since the discovery of the microbiome and the function on the cerebral-intestinal axis, through pathways such as vagal nerve, neurotransmitters and immune system, related to symptoms presented on anorexic patients. Conclusions: psychobiotics, live organisms that when ingested in adequate amounts produce health benefits in patients suffering from psychiatric illnesses are the new topic of future research in eating disorders.

scholarly journals The Role of the Gut Microbiome, Immunity, and Neuroinflammation in the Pathophysiology of Eating Disorders

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 500
Author(s):  
Michael J. Butler ◽  
Alexis A. Perrini ◽  
Lisa A. Eckel
Keyword(s):  
Eating Disorders ◽  
Eating Disorder ◽  
Immune System ◽  
Binge Eating ◽  
Gut Microbiome ◽  
Diet Composition ◽  
Caloric Intake ◽  
Psychiatric Illnesses ◽  
Increased Risk

There is a growing recognition that both the gut microbiome and the immune system are involved in a number of psychiatric illnesses, including eating disorders. This should come as no surprise, given the important roles of diet composition, eating patterns, and daily caloric intake in modulating both biological systems. Here, we review the evidence that alterations in the gut microbiome and immune system may serve not only to maintain and exacerbate dysregulated eating behavior, characterized by caloric restriction in anorexia nervosa and binge eating in bulimia nervosa and binge eating disorder, but may also serve as biomarkers of increased risk for developing an eating disorder. We focus on studies examining gut dysbiosis, peripheral inflammation, and neuroinflammation in each of these eating disorders, and explore the available data from preclinical rodent models of anorexia and binge-like eating that may be useful in providing a better understanding of the biological mechanisms underlying eating disorders. Such knowledge is critical to developing novel, highly effective treatments for these often intractable and unremitting eating disorders.

scholarly journals Involvement of Probiotics and Postbiotics in the Immune System Modulation

Biologics ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 89-110
Author(s):  
Neslihan Yeşilyurt ◽  
Birsen Yılmaz ◽  
Duygu Ağagündüz ◽  
Raffaele Capasso
Keyword(s):  
Immune System ◽  
Pharmaceutical Industry ◽  
Intestinal Microbiota ◽  
Health Benefits ◽  
The Body ◽  
Future Research ◽  
Immune Systems ◽  
Advantages And Disadvantages ◽  
Immune System Modulation ◽  
Molecular Patterns

Intestinal microbiota interacts with other systems, especially the immune system, which is responsible for protecting the body by recognizing “stranger” (pathogen associated molecular patterns-PAMPs) and “danger” (damage-associated molecular patterns-DAMPs) molecular motifs. In this manner, it plays an important role in the pathogenesis of various diseases and health. Despite the use of probiotics that modulate the intestinal microbiota in providing health benefits and in the treatment of diseases, there are some possible concerns about the possibility of developing adverse effects, especially in people with suppressed immune systems. Since probiotics provide health benefits with bioactive compounds, studies are carried out on the use of products containing non-living probiotic microorganisms (paraprobiotics) and/or their metabolites (postbiotics) instead of probiotic products. It is even reported that these microbial compounds have more immunomodulatory activities than living microorganisms via some possible mechanism and eliminates some disadvantages of probiotics. Considering the increasing use of functional foods in health and disease, further studies are needed with respect to the benefits and advantages of parabiotic and/or postbiotic use in the food and pharmaceutical industry as well as immune system modulation. Although probiotics have been extensive studied for a long time, it seems that postbiotics are promising tools for future research and applications according to the recent literature. This review aimed to evaluate the interaction of probiotics and postbiotics with the immune systems and also their advantages and disadvantages in the area of food-pharmaceutical industry and immune system modulation.

scholarly journals Role of Immunity in Pathogenesis of Psychosis

2021 ◽  
Author(s):  
Wafa Abdelghaffar ◽  
Oussama Sidhom ◽  
Lilia Laadhar ◽  
Rym Rafrafi
Keyword(s):  
Mental Health ◽  
Immune System ◽  
Psychiatric Symptoms ◽  
Scientific Evidence ◽  
Health Conditions ◽  
Future Research ◽  
Antineuronal Antibodies ◽  
System Components ◽  
The Brain

The involvement of immunity in the pathogenesis of schizophrenia and related psychoses was suspected a century ago but was shadowed by the dopaminergic hypothesis after the discovery of antipsychotics. We currently know that this latter theory has many limits and cannot account for the wide variety of psychotic conditions. The immune-inflammatory theory is now one of the most promising axes of research in terms of pathogenesis of several mental health conditions. Immunity and inflammation play a role at least in a subgroup of patients with psychosis. The immune system is complex with a variety of components and mediators that can all have effects on the brain and thus mediate psychiatric symptoms. In this chapter we will explore the scientific evidence of the role of immune system in pathophysiology of psychosis. The sections of this chapter will discuss the role of innate system components (cytokines, microglia, inflammation.), the role of adaptive system (lymphocytes and antibodies) with a section focusing on auto-immunity and particularly antineuronal antibodies. Finally we will discuss how this research can impact patients management and elaborate recommendations for future research.

scholarly journals Gut Microbiome and Its Interaction with Immune System in Spondyloarthritis

2020 ◽  
Vol 8 (11) ◽  
pp. 1727
Author(s):  
Jacqueline So ◽  
Lai-Shan Tam
Keyword(s):  
Immune System ◽  
Gut Microbiome ◽  
Current Evidence ◽  
Future Research ◽  
Hla B27 ◽  
Human Immune System ◽  
Gut Inflammation ◽  
Germ Free ◽  
Gut Microorganisms

Emerging evidence suggests there is a gut-joint axis in spondyloarthritis (SpA). In a study, subclinical gut inflammation occurred in nearly 50% of SpA. Chronic gut inflammation also correlated with disease activity in SpA. Trillions of microorganisms reside in the human gut and interact with the human immune system. Dysbiosis affects gut immune homeostasis and triggers different autoimmune diseases including SpA. The absence of arthritis in HLA-B27 germ-free mice and the development of arthritis after the introduction of commensal bacteria to HLA-B27 germ-free mice proved to be the important role of gut bacteria in shaping SpA, other than the genetic factor. The recent advance in gene sequencing technology promotes the identification of microorganisms. In this review, we highlighted current evidence supporting the link between gut and axial SpA (axSpA). We also summarized available findings of gut microbiota and its interaction with the immune system in axSpA. Future research may explore the way to modulate gut microorganisms in axSpA and bring gut microbiome discoveries towards application.

scholarly journals The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids

2019 ◽  
Author(s):  
Sarah Jane Charles ◽  
Miguel Farias ◽  
R. I. M. Dunbar
Keyword(s):  
Mental Health ◽  
Immune System ◽  
Mental Health Disorders ◽  
Social Bonding ◽  
Endogenous Opioids ◽  
Future Research ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Health Disorders

The American National Institute for Mental Health (NIMH) has put out a set of research goals that include a long-term plan to identify more reliable endogenous explanations for a wide variety of mental health disorders (Insel, 2013). In response to this, we have identified a major symptom that underlies multiple mental health disorders – social bonding dysfunction. We suggest that endogenous opioid abnormalities can lead to altered social bonding, which is a symptom of various mental health disorders, including depression, schizophrenia and ASD. This article first outlines how endogenous opioids play a role in social bonding. Then we show their association with the body’s inflammation immune function, and review recent literature linking inflammation to mental health ‘immunophenotypes’. We finish by explaining how these immunophenotypes may be caused by alterations in the endogenous opioid system. This is the first overview of the role of inflammation across multiple disorders where we provide a biochemical explanation for why immunophenotypes might exist across diagnoses. We propose a novel mechanism of how the immune system may be causing ‘sickness-type’ behaviours (fatigue, appetite change, social withdrawal and inhibited motivation) in those who have these immunophenotypes. We hope that this novel aetiology can be used as a basis for future research in mental health.

scholarly journals The potential use of some spices as immunity booster

2021 ◽  
Vol 16 (1) ◽  
pp. 157-169
Author(s):  
Gamal AH Zaharan ◽  
Shams SR Omima ◽  
Hanan A. Hussien
Keyword(s):  
Immune System ◽  
Health Benefits ◽  
High Light ◽  
Bakery Products ◽  
Nutritional Values ◽  
Black Cumin ◽  
Potential Use

Spices are normally used for flavor to make food aromatic, hot, savory and sweet. Spices not only add aroma to the food but also give a lot of health benefits and nutritional values. Some of the spices used in Egypt are cinnamon, cumin, turmeric, black cumin etc. Many people do not know the importance of spices and its effect on the immune system. The main aim is to high light the role of commonly used spices on immunity. In this review we list some bakery products that use some spices and can be used to improve the immunity of humans.

Interpersonal Psychotherapy for the Treatment of Eating Disorders

2017 ◽  
Author(s):  
Natasha L. Burke ◽  
Anna Karam ◽  
Marian Tanofsky-Kraff ◽  
Denise E. Wilfley
Keyword(s):  
Eating Disorders ◽  
Behavioral Therapy ◽  
Clinical Care ◽  
Risk Groups ◽  
Interpersonal Psychotherapy ◽  
Future Research ◽  
Dissemination And Implementation ◽  
Research Directions ◽  
Future Research Directions

Interpersonal psychotherapy (IPT) is a focused, time-limited treatment that targets interpersonal problem(s) associated with the onset and/or maintenance of eating disorders. It is supported by substantial empirical evidence documenting the role of interpersonal factors in the onset and maintenance of eating disorders. Interpersonal psychotherapy is a viable alternative to cognitive-behavioral therapy for the treatment of bulimia nervosa and binge eating disorder. The effectiveness of IPT for the treatment of anorexia nervosa requires further investigation. The utility of IPT for the prevention of obesity is promising. Future research directions include enhancing the delivery of IPT for eating disorders, increasing the availability of IPT in routine clinical care settings through dissemination and implementation efforts, exploring IPT adolescent and parent-child adaptations in diverse and high-risk groups, and further exploring IPT for the prevention of eating and weight-related problems that may promote full-syndrome eating disorders or obesity.

scholarly journals Do Transgenerational Epigenetic Inheritance and Immune System Development Share Common Epigenetic Processes?

2021 ◽  
Vol 9 (2) ◽  
pp. 20
Author(s):  
Rwik Sen ◽  
Christopher Barnes
Keyword(s):  
Immune Response ◽  
Immune System ◽  
System Development ◽  
Epigenetic Inheritance ◽  
Epigenetic Modifications ◽  
Future Research ◽  
Transgenerational Epigenetic Inheritance ◽  
Immune System Development ◽  
And Function

Epigenetic modifications regulate gene expression for development, immune response, disease, and other processes. A major role of epigenetics is to control the dynamics of chromatin structure, i.e., the condensed packaging of DNA around histone proteins in eukaryotic nuclei. Key epigenetic factors include enzymes for histone modifications and DNA methylation, non-coding RNAs, and prions. Epigenetic modifications are heritable but during embryonic development, most parental epigenetic marks are erased and reset. Interestingly, some epigenetic modifications, that may be resulting from immune response to stimuli, can escape remodeling and transmit to subsequent generations who are not exposed to those stimuli. This phenomenon is called transgenerational epigenetic inheritance if the epigenetic phenotype persists beyond the third generation in female germlines and second generation in male germlines. Although its primary function is likely immune response for survival, its role in the development and functioning of the immune system is not extensively explored, despite studies reporting transgenerational inheritance of stress-induced epigenetic modifications resulting in immune disorders. Hence, this review draws from studies on transgenerational epigenetic inheritance, immune system development and function, high-throughput epigenetics tools to study those phenomena, and relevant clinical trials, to focus on their significance and deeper understanding for future research, therapeutic developments, and various applications.

scholarly journals Intestinal Permeability, Inflammation and the Role of Nutrients

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1185 ◽  
Author(s):  
Ricard Farré ◽  
Marcello Fiorani ◽  
Saeed Abdu Rahiman ◽  
Gianluca Matteoli
Keyword(s):  
Immune System ◽  
Gastrointestinal Tract ◽  
Intestinal Permeability ◽  
Barrier Function ◽  
Critical Role ◽  
Dietary Factors ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Dietary Nutrients

The interaction between host and external environment mainly occurs in the gastrointestinal tract, where the mucosal barrier has a critical role in many physiologic functions ranging from digestion, absorption, and metabolism. This barrier allows the passage and absorption of nutrients, but at the same time, it must regulate the contact between luminal antigens and the immune system, confining undesirable products to the lumen. Diet is an important regulator of the mucosal barrier, and the cross-talk among dietary factors, the immune system, and microbiota is crucial for the modulation of intestinal permeability and for the maintenance of gastrointestinal tract (GI) homeostasis. In the present review, we will discuss the role of a number of dietary nutrients that have been proposed as regulators of inflammation and epithelial barrier function. We will also consider the metabolic function of the microbiota, which is capable of elaborating the diverse nutrients and synthesizing products of great interest. Better knowledge of the influence of dietary nutrients on inflammation and barrier function can be important for the future development of new therapeutic approaches for patients with mucosal barrier dysfunction, a critical factor in the pathogenesis of many GI and non-GI diseases.

scholarly journals Reducing Disease Activity of Inflammatory Bowel Disease by Consumption of Plant-Based Foods and Nutrients

2021 ◽  
Vol 8 ◽  
Author(s):  
Christian S. Antoniussen ◽  
Henrik H. Rasmussen ◽  
Mette Holst ◽  
Charlotte Lauridsen
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Western Diet ◽  
Future Research ◽  
Anatomic Site ◽  
Inflammatory Bowel ◽  
Dietary Components

Inflammatory bowel disease is a chronic and recurring inflammatory condition of the gastrointestinal tract encompassing ulcerative colitis and Crohn's disease. Although the pathogenesis of inflammatory bowel disease remains to be fully elucidated, environmental factors such as diet are believed to play a pivotal role in the onset and management of inflammatory bowel disease. Diet is thought to play an essential role in intestinal inflammation due to its regulatory effects on the microbiota, gut immune system, and epithelial barrier function. Although the evidence remains insufficient to draw firm conclusions on the role of specific dietary components in gastrointestinal diseases, studies have suggested that a Western diet with high intakes of total fats, omega-6 fatty acids, and meat have been associated with intestinal inflammation and relapse of inflammatory bowel disease. In contrast to a Western diet, plant-based diets often result in a reduced intake of total fats and meats and an increased intake of plant fibers which may contribute to reduced intestinal inflammation. This review critically examines the influence of plant-based dietary components on the clinical disease course of inflammatory bowel disease. Furthermore, this review discusses the benefits and possible limitations of plant-derived dietary components in the treatment of inflammatory bowel disease while addressing the principal type of disease and the anatomic site of inflammation within the gastrointestinal tract. Finally, this review points out important directions for future research on the role of diet in inflammatory bowel disease. A better understanding of the role of diet and intestinal inflammation may pave the way for novel dietary interventions and specific foods- or food supplements, which can support the treatment of inflammatory bowel disease.

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