scholarly journals Involvement of Probiotics and Postbiotics in the Immune System Modulation

Biologics ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 89-110
Author(s):  
Neslihan Yeşilyurt ◽  
Birsen Yılmaz ◽  
Duygu Ağagündüz ◽  
Raffaele Capasso
Keyword(s):  
Immune System ◽  
Pharmaceutical Industry ◽  
Intestinal Microbiota ◽  
Health Benefits ◽  
The Body ◽  
Future Research ◽  
Immune Systems ◽  
Advantages And Disadvantages ◽  
Immune System Modulation ◽  
Molecular Patterns

Intestinal microbiota interacts with other systems, especially the immune system, which is responsible for protecting the body by recognizing “stranger” (pathogen associated molecular patterns-PAMPs) and “danger” (damage-associated molecular patterns-DAMPs) molecular motifs. In this manner, it plays an important role in the pathogenesis of various diseases and health. Despite the use of probiotics that modulate the intestinal microbiota in providing health benefits and in the treatment of diseases, there are some possible concerns about the possibility of developing adverse effects, especially in people with suppressed immune systems. Since probiotics provide health benefits with bioactive compounds, studies are carried out on the use of products containing non-living probiotic microorganisms (paraprobiotics) and/or their metabolites (postbiotics) instead of probiotic products. It is even reported that these microbial compounds have more immunomodulatory activities than living microorganisms via some possible mechanism and eliminates some disadvantages of probiotics. Considering the increasing use of functional foods in health and disease, further studies are needed with respect to the benefits and advantages of parabiotic and/or postbiotic use in the food and pharmaceutical industry as well as immune system modulation. Although probiotics have been extensive studied for a long time, it seems that postbiotics are promising tools for future research and applications according to the recent literature. This review aimed to evaluate the interaction of probiotics and postbiotics with the immune systems and also their advantages and disadvantages in the area of food-pharmaceutical industry and immune system modulation.

Developing an Algorithm for the Application of Bayesian Method to Software Using Artificial Immune Systems

2021 ◽  
Author(s):  
Shafagat Mahmudova
Keyword(s):  
Immune System ◽  
Artificial Immune System ◽  
Bayesian Method ◽  
Artificial Immune Systems ◽  
Artificial Immune ◽  
Computational System ◽  
Malicious Software ◽  
Immune Systems ◽  
Advantages And Disadvantages ◽  
Protection Systems

Abstract This study provides information on artificial immune systems. The artificial immune system is an adaptive computational system that uses models, principles, mechanisms and functions to describe and solve the problems in theoretical immunology. Its application in various fields of science is explored. The theory of natural immune systems and the key features and algorithms of artificial immune system are analyzed. The advantages and disadvantages of protection systems based on artificial immune systems are shown. The methods for malicious software detection are studied. Some works in the field of artificial immune systems are analyzed, and the problems to be solved are identified. A new algorithm is developed for the application of Bayesian method in software using artificial immune systems, and experiments are implemented. The results of the experiment are estimated to be good. The advantages and disadvantages of AIS were shown. To eliminate the disadvantages, perfect AISs should be developed to enable the software more efficient and effective.

scholarly journals Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions

Viruses ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 150
Author(s):  
Wan Rong Sia ◽  
Yichao Zheng ◽  
Fei Han ◽  
Shiwei Chen ◽  
Shaohua Ma ◽  
...  
Keyword(s):  
Immune System ◽  
Disease Transmission ◽  
Viral Infections ◽  
Current Knowledge ◽  
Future Research ◽  
Global Public Health ◽  
Immune Systems ◽  
Adaptive Immune ◽  
Adaptive Immune Cells ◽  
Innate Lymphocytes

Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although bats are natural carriers of multiple pathogenic viruses, they rarely display signs of disease. Recent insights suggest that bats have a more balanced host defense and tolerance system to viral infections that may be linked to the evolutionary adaptation to powered flight. Therefore, a deeper understanding of bat immune system may provide intervention strategies to prevent zoonotic disease transmission and to identify new therapeutic targets. Similar to other eutherian mammals, bats have both innate and adaptive immune systems that have evolved to detect and respond to invading pathogens. Bridging these two systems are innate lymphocytes, which are highly abundant within circulation and barrier tissues. These cells share the characteristics of both innate and adaptive immune cells and are poised to mount rapid effector responses. They are ideally suited as the first line of defense against early stages of viral infections. Here, we will focus on the current knowledge of innate lymphocytes in bats, their function, and their potential role in host–pathogen interactions. Moreover, given that studies into bat immune systems are often hindered by a lack of bat-specific research tools, we will discuss strategies that may aid future research in bat immunity, including the potential use of organoid models to delineate the interplay between innate lymphocytes, bat viruses, and host tolerance.

The Ouroboros of Inflammatory Signaling to the Brain for the Control of Neuroendocrine Function

2021 ◽  
Author(s):  
Georgia E. Hodes
Keyword(s):  
Nervous System ◽  
Immune System ◽  
Immune Regulation ◽  
The Body ◽  
Immune Disorders ◽  
Inflammatory Signaling ◽  
Late 20Th Century ◽  
Immune Systems ◽  
Neuroendocrine Function ◽  
The Brain

In the late 20th century, the discovery that the immune system and central nervous system were not autonomous revolutionized exploration of the mechanisms by which stress contributes to immune disorders and immune regulation contributes to mental illness. There is increasing evidence of stress as integrated across the brain and body. The immune system acts in concert with the peripheral nervous system to shape the brain’s perception of the environment. The brain in turn communicates with the endocrine and immune systems to guide their responses to that environment. Examining the groundwork of mechanisms governing communication between the body and brain will hopefully provide a better understanding of the ontogeny and symptomology of some mood disorders.

Roles of Secreted Phospholipases A2 in the Mammalian Immune System

2014 ◽  
Vol 21 (12) ◽  
pp. 1201-1208
Author(s):  
Igor Krizaj
Keyword(s):  
Immune System ◽  
Acute Inflammation ◽  
The Body ◽  
Innate Immune ◽  
Future Research ◽  
Biological Processes ◽  
Phospholipases A2 ◽  
Protective Reaction ◽  
Severe Pathology ◽  
Mammalian Immune System

Secreted phospholipase A2 (sPLA2) molecules constitute a family of proteins that are involved functionally in many biological processes. In particular, they participate in diverse pathophysiological settings as enzymes that release free fatty acids and lysophospholipids from phospholipids in biological membranes, or as ligands for various cellular receptors. In this review the confirmed or expected functions of sPLA2s in the mammalian immune system are surveyed. Some of the twelve mammalian sPLA2 molecules constitute part of the so-called innate immune system by virtue of their antibacterial, antiviral and antifungal activities. They are also involved in acute inflammation, a protective reaction of the body to infection or injury. The acute inflammation sometimes escapes regulation, becomes chronic and can evolve into a severe pathology. One or more types of sPLA2 are involved in asthma, rheumatoid arthritis, sepsis, atherosclerosis, myocardial infarction, Crohn’s disease, ulcerative colitis and cancer. sPLA2s are thus important therapeutic targets as well as biotherapeutic molecules. Improving the selectivity of inhibitors of sPLA2s to be able to target a particular sPLA2 could therefore be one of the most important tasks for future research.

Wearable sensing devices for upper limbs: A systematic review

2020 ◽  
Vol 235 (1) ◽  
pp. 117-130
Author(s):  
Mingjie Dong ◽  
Bin Fang ◽  
Jianfeng Li ◽  
Fuchun Sun ◽  
Huaping Liu
Keyword(s):  
Upper Limb ◽  
State Of The Art ◽  
Electronic Devices ◽  
The Body ◽  
Future Research ◽  
Upper Limbs ◽  
Advantages And Disadvantages ◽  
Wearable Sensing ◽  
Fast Development ◽  
Manufacturing Technologies

Wearable sensing devices, which are smart electronic devices that can be worn on the body as implants or accessories, have attracted much research interest in recent years. They are rapidly advancing in terms of technology, functionality, size, and real-time applications along with the fast development of manufacturing technologies and sensor technologies. By covering some of the most important technologies and algorithms of wearable devices, this paper is intended to provide an overview of upper-limb wearable device research and to explore future research trends. The review of the state-of-the-art of upper-limb wearable technologies involving wearable design, sensor technologies, wearable computing algorithms and wearable applications is presented along with a summary of their advantages and disadvantages. Toward the end of this paper, we highlight areas of future research potential. It is our goal that this review will guide future researchers to develop better wearable sensing devices for upper limbs.

scholarly journals Rosmarinic Acid–Human Pharmacokinetics and Health Benefits

Planta Medica ◽  
2020 ◽  
Author(s):  
Maja Hitl ◽  
Nebojša Kladar ◽  
Neda Gavarić ◽  
Biljana Božin
Keyword(s):  
Human Body ◽  
Rosmarinic Acid ◽  
Structural Changes ◽  
Wide Spectrum ◽  
Health Benefits ◽  
The Body ◽  
Herbal Remedies ◽  
Future Research ◽  
Human Pharmacokinetics ◽  
Positive Effects

AbstractRosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae) plant species. It is considered responsible for a wide spectrum of biological and pharmacological activities of plants containing this compound. The aim of the current review is to present the fate of rosmarinic acid inside the human body, explained through pharmacokinetic steps and to briefly present the health benefits of RA. Pharmacokinetics was at first studied in animal models, but several studies were conducted in humans as well. This compound can be applied topically, pulmonary, intranasally, and via intravenous infusion. However, peroral application is the main route of entry into the human body. Presumably, it is mainly metabolized by the gut microflora, providing simple, more easily absorbed phenolic units. Inside the body, the rosmarinic acid molecule undergoes structural changes, as well as conjugation reactions. Renal excretion represents the main path of elimination. Previously conducted studies reported no serious adverse effects of herbal remedies containing RA, as well as their positive effects on human health. In addition to in vitro studies, clinical investigations suggested its benefits in dermatological, allergic, and osteoarthritic disorders, as well as for improving cognitive performance and in metabolic syndrome treatment. Future studies should investigate the kinetics during long-term application in patients who would have potential benefits from RA usage. Pharmaceutical formulations designed to prevent the fast metabolism of RA and allow its penetration into other compartments of the human body are also interesting topics for future research.

scholarly journals Trade-Offs for Viruses in Overcoming Innate Immunities in Plants

2016 ◽  
Vol 29 (8) ◽  
pp. 595-598 ◽  
Author(s):  
Yuri Miyashita ◽  
Go Atsumi ◽  
Kenji S. Nakahara
Keyword(s):  
Immune System ◽  
Adaptive Evolution ◽  
Viral Protein ◽  
Viral Proteins ◽  
Host Immune System ◽  
Immune Receptor ◽  
Immune Systems ◽  
Trade Offs ◽  
Molecular Patterns ◽  
Increased Susceptibility

Plants recognize viral infection via an immune receptor, i.e., nucleotide-binding site (NB)-leucine-rich repeat (LRR) proteins. Another immune receptor, receptor-like kinase proteins, which share an LRR domain with NB-LRRs, perceive conserved molecules of pathogens called pathogen- or microbe-associated molecular patterns, but NB-LRRs generally perceive particular viral proteins. As viruses can evolve more rapidly than the host immune system, how do plant immune systems, which rely on the perception of proteins, remain effective? Viral adaptive evolution may be controlled by penalties that result from mutations in viral proteins that are perceived by NB-LRRs. Our recent studies in pea (Pisum sativum) suggest a penalty of increased susceptibility to another immune system. When a viral protein mutates to evade one immune system, the virus with the mutated protein becomes more susceptible to another. Such antagonistic pleiotropy of a viral protein by two independent plant immune systems may have precedents. Plants may rely on pairs of immune systems to constrain adaptive evolution by viruses and thereby maintain durable antiviral immunity.

scholarly journals Nanoparticle interaction with the immune system / Interakcije nanodelcev z imunskim sistemom

2015 ◽  
Vol 66 (2) ◽  
pp. 97-108 ◽  
Author(s):  
Veno Kononenko ◽  
Mojca Narat ◽  
Damjana Drobne
Keyword(s):  
Immune System ◽  
Chemical Properties ◽  
The Body ◽  
Future Research ◽  
Molecular Response ◽  
Nanoparticle Interactions ◽  
Biological Environment ◽  
Physical And Chemical

Abstract When nanoparticles enter the body, their interactions with cells are almost unavoidable. Unintended nanoparticle interaction with immune cells may elicit a molecular response that can have toxic effects and lead to greater susceptibility to infectious diseases, autoimmune disorders, and cancer development. As evidenced by several studies, nanoparticle interactions with biological systems can stimulate inflammatory or allergic reactions and activate the complement system. Nanoparticles can also stimulate immune response by acting as adjuvants or as haptens. Immunosuppressive effects have also been reported. This article gives a brief review of in vitro and in vivo research evidencing stimulatory or suppressive effects of nanoparticles on the immune system of mammals. In order to ensure safe use of nanosized particles, future research should focus on how their physical and chemical properties influence their behaviour in the biological environment, as they not only greatly affect nanoparticle-immune system interactions but can also interfere with experimental assays

scholarly journals The Role of Arginine in Disease Prevention, Gut Microbiota Modulation, Growth Performance and the Immune System of Broiler Chicken – A Review

2020 ◽  
Vol 20 (2) ◽  
pp. 325-341
Author(s):  
Harry A. Aguzey ◽  
Zhenhua Gao ◽  
Wu Haohao ◽  
Cheng Guilan ◽  
Wu Zhengmin ◽  
...  
Keyword(s):  
Immune System ◽  
Disease Prevention ◽  
Broiler Chickens ◽  
Broiler Chicken ◽  
Building Blocks ◽  
The Body ◽  
Necrotic Enteritis ◽  
Poultry Production ◽  
Growth Promoters ◽  
Immune System Modulation

AbstractThe effect of dietary arginine on disease prevention, immune system modulation, the gut micro-biota composition and growth of broiler chicken was reviewed. The main aim of poultry production is the maximization of profit at the least possible cost. This objective can mainly be achieved by ensuring that there is no interference in growth or disease outbreak and by feeding chicken with the best possible level of nutrients. With the ban on antibiotic growth promoters, attention is shifted towards other nutrition methods to prevent diseases and promote growth. More attention is therefore given to protein diets in animal nutrition due to their importance as essential part of active biological compounds in the body, assisting in the breakdown of body tissue and helping in the physiological processes of the animal. Arginine plays important function in serving as building blocks of proteins and polypeptides. It performs other roles during the regulation of important biochemical functions such as maintenance, growth, reproduction and immunity. Arginine cannot be synthesized by the body so it has to be supplemented in the diet. When arginine is supplemented above the recommended level, the gut mucosa is protected, immunosuppression is alleviated, diseases like necrotic enteritis, infectious bursal disease and coccidiosis in broiler chickens are prevented. There is an improvement in growth resulting from the increase in intestinal absorption, barrier function and microbiota composition.

Microbioma en los trastornos de la conducta alimentaria

2021 ◽  
Vol 22 (3) ◽  
Author(s):  
Norma Cipatli Ayuzo del Valle ◽  
◽  
Laura Leticia Zavala ◽  
Brenda Ayuzo ◽  
Victoria Villafuerte ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Immune System ◽  
Gastrointestinal Tract ◽  
Health Benefits ◽  
Vagal Nerve ◽  
Future Research ◽  
Umbrella Review ◽  
Psychiatric Illnesses ◽  
Microbiome Research

Introduction: eating disorders are serious illnesses with genetic and neurobiological bases where the main organs affected are the gastrointestinal tract and the neurologic system making important the role of the microbiome. Objectives: summarize the results of the latest microbiome research that could be future tools in the management of eating disorders. Materials and methods: umbrella review of pubmed publications in humans of the last 10 years regarding microbiome and eating disorders. Results: since the discovery of the microbiome and the function on the cerebral-intestinal axis, through pathways such as vagal nerve, neurotransmitters and immune system, related to symptoms presented on anorexic patients. Conclusions: psychobiotics, live organisms that when ingested in adequate amounts produce health benefits in patients suffering from psychiatric illnesses are the new topic of future research in eating disorders.

Sign in / Sign up

Export Citation Format

Share Document