scholarly journals Clean Blood: Transfusion Transmitted Infection days are not over

2021 ◽  
Author(s):  
Mahwish Majid Bhatti ◽  
Ayesha Junaid ◽  
Fouzia Sadiq
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Safety Issue ◽  
Tertiary Care ◽  
Age Groups ◽  
Care Hospital ◽  
Transmitted Infection ◽  
Blood Transfusion Center ◽  
Group B ◽  
Age Range

Objective: Blood transfusion saves millions of lives but there is always a potential risk of transmission of blood borne infections from the donor to the recipient if the blood is not thoroughly screened. A high seroprevalence of transfusion transmitted infections (TTI) in donated blood remains the blood safety issue in Pakistan. This study was aimed to determine the frequency of TTIs (Human Immunodeficiency virus (HIV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV), syphilis and malaria) among blood donors. Methods: Data records of all registered blood donors (n=120,968) during 2008-2019, at blood transfusion center in the tertiary care hospital were assessed. Frequency of the seropositive donors for HIV, HCV, HBV, syphilis and malaria was analyzed. Results: Donors were predominately males (99%) with age groups ranging from 25-65 years. HCV, syphilis and malaria positive cases were mostly in the age range of 26-35 years. Most of the donors (81.1%) were residents of Islamabad. The most prevalent infection among the screened blood donors was HCV (1.52% with 95% CI 0.423-0.661) followed by syphilis (0.85% with 95% CI1.149-1.432). HCV and syphilis were most frequently observed in blood group B positive patients while HIV was common in O positive patients. The frequency of co-infection of syphilis with HCV and HIV was 0.02% and 0.01% respectively. Conclusion: Among males, the most prevalent TTI infection was HCV followed by HIV; the latter is on the rise. However, HCV and syphilis are the most frequent co-infections. So, TTIs days are not over.

Increasing Seroprevalence of Hepatitis C Virus among Blood Donors - A 3 Year Study in North India

2021 ◽  
Vol 8 (07) ◽  
pp. 379-383
Author(s):  
Jagjeewan Ram ◽  
Namrata Nigam ◽  
Aparna Singh ◽  
Lubna Khan
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Transfusion ◽  
Blood Donors ◽  
Tertiary Care ◽  
North India ◽  
Enzyme Linked Immunosorbent Assay ◽  
Care Hospital ◽  
Hepatitis C Infection ◽  
Case Volume

BACKGROUND The primary aspect of blood transfusion lies in the availability of blood and blood components which are tested and reported negative for transfusion transmitted infections (TTI’s). The increased seroprevalence of TTI’s indicate their prevalence in general public. The study was conducted to analyse the increasing seroprevalence of hepatitis C virus (HCV) over a period of 3 years. The objectives of the study determine the seroprevalence of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) among the voluntary blood donors at a tertiary care hospital & associated blood bank. METHODS This cross-sectional study was done at the Department of Transfusion Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, over a period of 3 years from July 2017 to June 2020. The samples collected were screened by enzyme-linked immunosorbent assay (ELISA) tests. RESULTS A total of 69561 blood units were collected during this 3-year study from July 2017 to June 2020. Of all the blood bags screened, the highest prevalence was seen for HBV followed by HCV and HIV. 949 (1.4 %) were reactive for HBV, 75 (0.1 %) were reactive for HIV and 332 (0.5 %) were reactive for HCV. The results show a remarkable increase in the seropositivity for hepatitis C infection. CONCLUSIONS The seroprevalence of HCV has seen an increase in case load over the years as compared to HBV and HIV. This increase in case volume is indicative of impending liver diseases progressing to chronic stage over the years. Thus, it is imperative to create awareness in the general population to help reduce the risk factors responsible for HCV infection. KEYWORDS Blood Transfusion, Voluntary Donors, HCV, HBV, HIV, Seroprevalence, Transfusion Transmitted Infections (TTI’s)

scholarly journals A study to evaluate the demographic profile of voluntary and replacement blood donors at tertiary care hospital in Mumbai, India: a 5-year retrospective comparative analysis

2021 ◽  
Vol 9 (3) ◽  
pp. 866
Author(s):  
Khaneta Parveen ◽  
Abdul F. Khan ◽  
Abdul S. Khan
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Care Hospital ◽  
Demographic Profile ◽  
Medical College ◽  
Donor Type ◽  
Males And Females ◽  
And Gender

Background: Blood donor base is the foundation of any blood transfusion system. Donor screening plays an important role in ensuring the safety of the blood supply.1 This study was undertaken with the aim to screen the blood donor’s demographic profile as male, female voluntary and replacement blood donors and to estimate seroprevalence of HIV, HBV, HCV and VDRL transmissible by blood transfusion in voluntary and replacement male and female blood donors during the last 5 year period.Methods: The present study was conducted over a period of 5 years (2001-2005) and involved 1,53,020 blood donors including both (voluntary, replacement males and females) who were thoroughly screened and selected for blood donation in blood bank at Departments of Pathology, Seth GS Medical College and KEM hospital, Mumbai. We determine among blood donors by their donor type (voluntary and replacement type) and gender wise.Results: The total number of blood donors in five years period was 1,53,020 (100%). Maximum number of voluntary  blood donors 1,00,316 (65.55%), followed by replacement blood donors 52,704 (34.33%).The overwhelming majority of donors in entire 5 years period was of male, comprising 1,36,195 (89.0%), while the female donors comprised of 16825 (10.99%).Conclusions: The maximum number of donors are voluntary males (55.69%) followed by replacement males (33.30%). Our results indicate that the number of female blood donors were less in comparison to male blood donors, so proper health education is required for female blood donors.

scholarly journals Donor Hemovigilance Programme in managing Blood Transfusion Needs: Complications of Whole Blood Donation

2013 ◽  
Vol 3 (6) ◽  
pp. 459-463 ◽  
Author(s):  
S Mangwana
Keyword(s):  
Blood Transfusion ◽  
Adverse Effects ◽  
Adverse Events ◽  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Care Hospital ◽  
Blood Donations ◽  
Vasovagal Reactions

Background: Hemovigilance like quality systems and audits have become an integral part of Blood Transfusion Services in the developed countries and has contributed greatly to its development. Hemovigilance begins with donors and must enable the collection of information on reactions occurring during the donation of blood, selections of donors and to prevent such incidents. The aim of study was to help identify the trends of adverse events , occurring in blood donors at a tertiary-care hospital, to recommend best practices to improve donor care and safety Materials and Methods: This record-based study was conducted on all adverse events related to allogenic whole blood donations performed over 24 months. All whole blood donations were analyzed. All adverse events occurring during or at the end of the donation were noted using a standardized format and analyzed determining significance at p<0.05. Results: Overall rate was 0.3% with vasovagal reactions constituting 82%, and 18% mild syncopal reactions (p<0.001). Immediate vasovagal reaction with injury was very rare (0.007%). Vasovagal reactions showed a significant association with young age, female gender, first time donation status. Mean age of persons recording adverse effects was 30.23 ± 7.49 years as compared to those without adverse effects, 31.14 ± 8.56 years. Conclusion: Donor safety is an essential perquisite to increase voluntary blood donation. AE analysis helps in identifying the blood donors at risk of AE, applying appropriate motivational strategies, predonation counseling, care during and after donation, developing guidelines and hemovigilance programme in countries with limited resources. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8993   Journal of Pathology of Nepal (2013) Vol. 3, 459-463

scholarly journals A comparative single dose study of oral acetaminophen 650 mg to its standard 500 mg dose in adult pyrexia patients in a tertiary care hospital

2020 ◽  
Vol 9 (3) ◽  
pp. 388
Author(s):  
Pradeepkumar B. T. ◽  
Jayanthi C. R. ◽  
Raveendra K. R. ◽  
Ramya Y. S.
Keyword(s):  
Adverse Effects ◽  
Tertiary Care ◽  
Age Groups ◽  
General Medicine ◽  
Low Grade ◽  
Care Hospital ◽  
Single Dose Study ◽  
Hospitalised Patients ◽  
Group A ◽  
Group B

Background: Acetaminophen commonly called as paracetamol is the most used ‘over-the-counter’ analgesic for headache, musculoskeletal pain, dysmenorrhoea etc. It is the best drug to be used as antipyretic for fever due to any cause and safest to be prescribed in all age groups. Antipyretic dose of acetaminophen is 325 to 650 mg; 3 to 4 times a day and is available in the strength of 650 mg and 500 mg tablets. This study was conducted to analyse the antipyretic efficacy and safety profile of two different doses of acetaminophen in patients with low grade fever.Methods: 300 hospitalised patients aged more than 18 years, in department of General Medicine, having low grade fever (38º to 39º C) were randomly allocated into two groups of 150 each, group A received 500 mg and group B received 650 mg of single oral dose of acetaminophen tablets. Oral temperature was measured before dosing, 30 minutes after dosing, one hour, two hourlies thereafter for 6 hours after the dose. Safety was assessed by monitoring for adverse effects during the study and 24 hours after administration of the assigned drug.Results: There was a statistically significant decrease in temperature in group B patients from baseline 39.06±0.87º C to 37.02±0.89º C at the end of 6th hour as compared with 39.18±0.80º C to 38.03±0.77º C in Group A patients (p=0.031).Conclusions: Our study concluded that acetaminophen in a dose of 650 mg is highly efficacious antipyretic drug compared to acetaminophen 500 mg with no adverse effects.

scholarly journals Analysis of Blood Donor Deferral in a Tertiary Care Hospital

2020 ◽  
Vol 10 (2) ◽  
pp. 373-376
Author(s):  
Farida Parvin ◽  
Daanish Arefin Biswas ◽  
Bepasha Naznin ◽  
Tamanna Afroz ◽  
Mohammad Ali ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Blood Donor ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Medical Officer ◽  
Uncontrolled Hypertension ◽  
Care Hospital ◽  
Safe Blood ◽  
Donor Deferral

Introduction: Selection of proper donor according to stringent selection criteria is the prerequisite for safe blood transfusion practice. It is widely known that a large number of blood donors are deferred for different reasons. Objective: The aim of present study is to evaluate the incidence and different reasons of blood donor deferral in atertiary care hospital. Methodology: This retrospective cross-sectional study was carried out in Transfusion Medicine and Clinical Haematology Department of BIRDEM General Hospital, Dhaka, during the period from July 2016 to June 2017.The blood donor of either sex attending the mentioned department were selected purposively and categorized into four groups according to their age for this study. Donors were selected and deferred by medical officer according to national guideline. Deferred blood donors were recorded in register book and were analyzed retrospectively. Results: In current study, 1152 blood donor (8.8%) were deferred attending for allogeneic blood donation during the study period. Out of 13082 registered blood donor 11961were male (91.43%) and 1121 were female (8.57%) and deferral rate was 2.37 times more in female. Majority of the deferred donors (55.38%) were under the age of 40 where 26.82% were in between 40-49 years and 17.8% were in the range of 50 years and above. Age range of highest deferred donors (32.20%) was between 30-39 years. The number of temporary and permanent deferral were 836 (72.57 %) and 316 (27.43%) respectively. Anaemia (33.01%), underweight (21.53%) and hypotension (17.34%) were the most common reason of temporary deferral. Chronic uncontrolled hypertension (42.4%), donors with medication (16.77%) and asthma (15.18%) was the most common cause of permanent deferral. Conclusion: The deferral rate was low and most of the deferred donors were young adult. Temporary deferred donors were higher than permanent deferred donors. The most common reasons for temporary deferral were anemia, underweight and hypotension. Permanent deferral causes were chronic uncontrolled hypertension, donors on medication for various reason and asthma. Donors should be informed with a clear message on their deferral status. It is important to determine the rate and causes of donor deferral for the safety of blood transfusion and to guide the recruitment efforts for safe blood transfusion and to avoid the permanent loss of blood donors. Northern International Medical College Journal Vol.10 (2) Jan 2019: 373-376

scholarly journals Seroprevalence and trends of transfusion transmitted infections in blood donors of rural tertiary care hospital blood bank: a 3 year retrospective study in Chamba (HP)

2018 ◽  
Vol 5 (6) ◽  
pp. 2453
Author(s):  
Ishan Arora ◽  
Shairoly Singh ◽  
Shireen Singh
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Blood Bank ◽  
Care Hospital ◽  
Total Blood ◽  
Medical College ◽  
Disease Pattern ◽  
Donor Population

Background: Timely transfusion of blood saves millions of lives, but unsafe transfusion practices puts millions of people at risk of transfusion transmissible infections (TTIs). Blood transfusion carries the risk of transfusion-transmissible infections including human immunodeficiency virus (HIVI&II), hepatitis B virus (HBV), hepatitis C virus (HCV), malaria and syphilis. With every unit of blood there are 1% chances of transfusion associated diseases.Methods: This study was conducted over a period of 3 years (1stJanuary 2015-31st December 2017) at hospital blood bank of Pt. Jawaharlal Nehru Government Medical College, Chamba (H.P). The study was conducted on both voluntary and replacement blood donors who came to our blood bank and voluntary blood donation camps in and around Chamba. Statistical analysis used. Collected data was analyzed using appropriate statistical softwares such as EPI-INFO and MS-Excel.Results: In our study, we observed a total of 2616 donors over a period of 3 years. In the present study, 847 (32.37%) were voluntary donors and 1769 (67.62%) were replacement donors. Out of 2616 blood samples, 8 were HBsAg positive, 1 HCV positive.Conclusions: Our study shows that the number of blood donors is increasing every year. In our study, the seroprevalence of HBsAg was 0.3% and Hep C was 0.03% in total blood donors. The knowledge of current infectious disease pattern and trends in donor population can help in planning of future blood transfusion related health challenges. 

scholarly journals Frequency of Transfusion Transmitted Infection Among Blood Donors at Specialized Tertiary Care Hospital in Bangladesh

2015 ◽  
Vol 1 (1) ◽  
pp. 12-14
Author(s):  
Ferdous Ara ◽  
Zubaida Nasreen ◽  
Md Aminul Islam ◽  
Md Abdullah Yusuf ◽  
Mohammad Syaeed Hassan ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Venereal Disease ◽  
Tertiary Care ◽  
Malarial Parasite ◽  
Care Hospital ◽  
Transmitted Infection ◽  
Major Health Problem ◽  
The Status

Background: Blood transfusion is associated with a number of complications. Transfusion transmitted infections (TTI) are one of the major health problem in Bangladesh.Objective: The objective of the present study was to assess the status of transfusion transmitted infections among the apparently healthy donors.Methods: This study we carried out among 585 blood donors in the transfusion medicine department from April 2013 to March 2014 at National Institute of Neurosciences (NINS) and Hospital in Dhaka, Bangladesh. All the samples were screened for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2, venereal disease research laboratory test (VDRL) and malaria to see the prevalence of TTI.Results: Prevalence of hepatitis B virus (HBV), HCV, and syphilis were 1.20, 0.68 and 0.34% respectively. No blood donor tested showed positivity for malarial parasite and HIV.Conclusion: Mandatory screening of donated blood and use of sensitive screening test should be done to reduce TTI in Bangladesh.J. Natl Inst. Neurosci Bangladesh 2015;1(1):12-14

scholarly journals Frequency and distribution of ABO and rhesus (D) blood groups in district Chamba, Himachal Pradesh: a study from rural tertiary care hospital

2018 ◽  
Vol 5 (2) ◽  
pp. 689 ◽  
Author(s):  
Shairoly Singh ◽  
Ishan Arora
Keyword(s):  
Blood Transfusion ◽  
Blood Group ◽  
Human Blood ◽  
Tertiary Care ◽  
Blood Groups ◽  
Blood Group System ◽  
Care Hospital ◽  
Blood Transfusion Service ◽  
The Status ◽  
Group B

Background: In 1901, ABO blood group was the first human blood group system to be discovered by Karl Landsteiner. After that Rh blood grouping was discovered by Landsteiner and Weiner 1941. Since then for blood transfusion purposes, these two systems have proved to be the most important systems. Agglutinins are the antibodies against red blood cell antigens and based on presence of these antigens and agglutinins human blood is divided into four major blood groups A, B, AB and O. Methods: A retrospective study was conducted in the Department of Blood Bank of our college. A total of 600 fit donors were selected in the time period of seven months from 1st March 2017 to 30th September, 2017. The blood samples were obtained by standard procedures of venepuncture. Results: From our study, it is observed that blood group B is commonest with 229 donors (38.16%), followed by A with 173 donors (28.82%), O blood group with 131donors (21.82%) and blood group AB contributes minimum of study subjects, 71 donors (11.82%). Rh+ve donors were 93.83% whereas Rh-ve donors were 6.17% according to our study. Conclusions: The present study is useful in providing information on the status of ABO and Rh-D blood group distribution of Chamba and knowledge of it will help in effective management of regional blood transfusion service of the area. 

SEROPREVALENCE OF HIV AND HBsAg AMONGST BLOOD DONORS IN A TERTIARY CARE HOSPITAL, CHHATTISGARH.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Anusha P ◽  
Bankar Nandkishor J ◽  
Karan Jain ◽  
Ramdas Brahmane ◽  
Dhrubha Hari Chandi
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Laboratory Diagnosis ◽  
Blood Bank ◽  
Care Hospital ◽  
Medical College ◽  
The World ◽  
First Time

INTRODUCTION: India being the second highly populated nation in the world. HIV/AIDS has acquired pandemic proportion in the world. Estimate by WHO for current infection rate in Asia. India has the third largest HIV epidemic in the world. HIV prevalence in the age group 15-49 yrs was an estimate of 0.2%. India has been classified as an intermediate in the Hepatitis B Virus (HBV) endemic (HBsAg carriage 2-7%) zone with the second largest global pool of chronic HBV infections. Safety assessment of the blood supply, the quality of screening measures and the risk of transfusion transmitted infectious diseases (TTIs) in any country can be estimated by scrutinizing the files of blood donors. After the introduction of the blood banks and improved storage facilities, it became more extensively used. Blood is one of the major sources of TTIs like hepatitis B, hepatitis C, HIV, syphilis, and many other blood borne diseases. Disclosure of these threats brought a dramatic change in attitude of physicians and patients about blood transfusion. The objective of this study is to determine the seroprevalence of transfusion transmitted infections amidst voluntary blood donors at a rural tertiary healthcare teaching hospital in Chhattisgarh. MATERIAL AND METHODS: This retrospective study was carried out in Chandulal Chandrakar Memorial Medical College, Kachandur, Durg. Blood donors were volunteers, or and commercial donors who donated the blood and paid by patients, their families, or friends to replace blood used or expected to be used for patients from the blood bank of the hospital. After proper donation of blood routine screening of blood was carried out according to standard protocol. Laboratory diagnosis of HIV 1 and HIV 2 was carried out by ELISA test. Hepatitis B surface antigen was screened by using ELISA. RESULTS: A total of 1915 consecutive blood donors’ sera were screened at Chandulal Chandrakar Memorial Medical College, blood bank during study period. Of these 1914 were male and 1 female. The mean age of patients was found to be 29.34 years with standard deviation (SD) of 11.65 Years. Among all blood donors in present study, 759(39.63%) were first time donors and 1156(60.37%) were repeated donors. 1 patient was HIV positive in first donation group while 3 (75%) were positive in repeat donation group. 7 (38.9%) were HBsAg positive in in first donation group while 11(61.1%) were positive in repeat donation group. Two patients in first donation group had dual infection of HIV and HBsAg. CONCLUSION: Seropositivity was high in repeated donors as compared to first time donors. The incidence of HIV is observed to be 0.2% and that of HBsAg is 0.94%. Strict selection of blood donors should be done to avoid transfusion-transmissible infections during the window period.

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