Neurofibromatosis in Pregnancy

Author(s):  
HK Premi ◽  
Sonika Dahiya ◽  
Shobha Mukherjee

ABSTRACT Neurofibromatosis (NF) is one of the most frequent genetic diseases in humans. It is less common to find pregnancy in NF patients. It may not reflect the real situation as most current information on pregnancy and NF is derived from case reports. In the past 15 years only two series of pregnant NF patients were reported in English language literature. Neurofibromatosis is a genetic disorder which increases the risk of obstetric complications as well as aggravation of maternal disease. However, here is a case of NF in which transmission to baby has also occurred, which is very rare. How to cite this article Dahiya S, Mukherjee S, Premi HK. Neurofibromatosis in Pregnancy. Int J Adv Integ Med Sci 2016; 1(2):91-92.

1997 ◽  
Vol 5 (2) ◽  
pp. 118-122
Author(s):  
Hubert YM Chao ◽  
Ralph T Manktelow

Pectoralis major rupture is uncommon. Injury usually occurs from sporting activities. The incidence and management of pectoralis major rupture is not well known, despite 74 case reports in the English language literature over the past 34 years. Two cases of chronic pectoralis ruptures and their successful surgical management are described. A review of the literature shows that most injuries occur at the humeral insertion, and most are complete ruptures. Distinguishing between complete and partial ruptures is important. Complete ruptures are best treated surgically in the acute situation. When chronic complete ruptures present, surgical repair yields fair to good results. Acute partial ruptures can be effectively managed conservatively or with surgery. Chronic partial ruptures can be managed surgically with good results, following unsatisfactory conservative management in the acute situation.


1995 ◽  
Vol 3 (6) ◽  
pp. 248-251 ◽  
Author(s):  
Gary M. Joffe

Background: Hepatitis C virus (HCV) is now recognized as the cause of 90% of non-A, non-B (NANB) hepatitis. This virus is responsible for a large percentage of chronic persistent and chronic active hepatitis in the United States. Parenteral and sexual transmission are well described, so a significant population of pregnant patients is at risk. Vertical transmission of the virus to the fetus is dependent upon the level of maternal viremia.Case: The cases described in the following report demonstrate that fulminant disease may present in pregnancy. They also demonstrate the cofactors promoting the severity of illness, methods of diagnosis, potential treatment, and outcome of the infection.Conclusion: HCV may be encountered in pregnancy. Although most acute-phase illness will be self limiting, some patients will manifest liver failure during gestation. Because vertical transmission to the fetus is possible, the pediatrician should be informed of the maternal disease. Chronic hepatitis is almost the rule rather than the exception, so patients require close postpartum follow-up. Interferon, which may alter the course of the chronic disease, has been used on rare occasions in pregnancy.


1998 ◽  
Vol 7 (1) ◽  
pp. 73-76 ◽  
Author(s):  
LJ Miller ◽  
R Wiles-Pfeifler

OBJECTIVE: To report a case in which propofol was used successfully in an intubated patient on a prolonged basis and to review the literature that discusses long-term infusions (> 7 days) of propofol. METHODS: Information was retrieved from a MEDLINE search of the English-language literature. Reports of clinical trials and case reports that compared the safety and efficacy of long-term propofol and midazolam were included in this review. Information about the study design and the efficacy and adverse effects of the drugs was collected, and the data were synthesized. RESULTS: Clinical reports indicate that a long-term infusion of propofol is comparable in safety and efficacy to a long-term infusion of midazolam. The distinct adverse-effect profile of long-term use of propofol, including hypertriglyceridemia, was evaluated and reported as significant. CONCLUSION: The limited data available suggest that long-term infusion of propofol is a practical alternative to use of standard agents for sedation of intubated patients. Adverse effects such as cardiovascular depression, respiratory depression, and hypertriglyceridemia may limit the routine use of propofol.


1993 ◽  
Vol 27 (2) ◽  
pp. 167-170 ◽  
Author(s):  
Karen A. Pallone ◽  
Morton P. Goldman ◽  
Matthew A. Fuller

Objective To describe a case of isoniazid-associated psychosis and review the incidence of this adverse effect. Data Sources Information about the patient was obtained from the medical chart. A MEDLINE search of the English-language literature published from 1950 to 1992 was conducted and Index Medicus was manually searched for current information. Study Selection All case reports describing isoniazid-associated psychosis were reviewed. Data Extraction Studies were evaluated for the use of isoniazid, symptoms of psychosis, onset of symptoms, and dosage of isoniazid. Data Synthesis The case report is compared with others reported in the literature. The incidence of isoniazid-associated psychosis is rare. Conclusions The mechanism of isoniazid-associated psychosis is uncertain. It appears that isoniazid was associated with the psychosis evident in our patient and in the cases reviewed.


Neurosurgery ◽  
2003 ◽  
Vol 52 (6) ◽  
pp. 1436-1442 ◽  
Author(s):  
Jay S. Loeffler ◽  
Andrzej Niemierko ◽  
Paul H. Chapman

Abstract OBJECTIVE Radiosurgery-associated second tumors have been reported in four isolated patients during the past 2 years. In our own experience, we are aware of two additional patients. The purpose of this report is to call attention to this potentially emerging problem. METHODS A review of the English-language literature concerning patients with radiosurgery-associated second tumors was performed. In addition, we report on two patients in our own practice who were treated in the past year. RESULTS Four patients were found in the literature, and two additional patients were seen by the authors. Malignant tumors occurred as early as 6 years after radiosurgery. The pathological findings in three of these four malignant tumors were glioblastoma multiforme. Benign tumors developed between 16 and 19 years later. Tumors developed both within the full-dose prescription volume and in the lower-dose periphery. Of interest, three of the six patients experienced complications of the radiosurgery treatment before developing second tumors. CONCLUSION Although patients will increasingly be reported with second tumors after radiosurgery in the future, the overall incidence seems quite low and should not alter current radiosurgical practice. However, continual surveillance of treated patients should be considered.


2021 ◽  
Vol 10 (19) ◽  
pp. 4377
Author(s):  
Michał Hutny ◽  
Jagoda Hofman ◽  
Aleksandra Klimkowicz-Mrowiec ◽  
Agnieszka Gorzkowska

Levodopa remains the primary drug for controlling motor symptoms in Parkinson’s disease through the whole course, but over time, complications develop in the form of dyskinesias, which gradually become more frequent and severe. These abnormal, involuntary, hyperkinetic movements are mainly characteristic of the ON phase and are triggered by excess exogenous levodopa. They may also occur during the OFF phase, or in both phases. Over the past 10 years, the issue of levodopa-induced dyskinesia has been the subject of research into both the substrate of this pathology and potential remedial strategies. The purpose of the present study was to review the results of recent research on the background and treatment of dyskinesia. To this end, databases were reviewed using a search strategy that included both relevant keywords related to the topic and appropriate filters to limit results to English language literature published since 2010. Based on the selected papers, the current state of knowledge on the morphological, functional, genetic and clinical features of levodopa-induced dyskinesia, as well as pharmacological, genetic treatment and other therapies such as deep brain stimulation, are described.


2019 ◽  
Author(s):  
Daniel Schulz ◽  
Štěpán Bahník

The data required to study stereotypes held in the past are often not available. Using Google Books Ngram corpus, we explored the depiction of male and female characters in the twentieth-century English-language fiction. By analyzing adjective-noun bigrams, we examined adjectives used in association with “man”, “woman”, “boy”, and “girl”. Men were described in more positive terms than women. Girls were depicted in more positive terms than boys at the beginning of the twentieth century, but the tendency reversed in the middle of the century. Boys were described in more masculine terms than girls; however, men were described in similarly masculine adjectives as women. Despite limitations of interpretability of the results, the study presents a possible approach of exploring past stereotypes.


2002 ◽  
Vol 49 (2) ◽  
pp. 9-12
Author(s):  
D. Ignjatovic ◽  
R. Bergamaschi

An outsider to the Held of surgery would probably take it for granted that surgeons have a highly developed rationale for choosing a laparoscopic approach to Crohns disease. After all, an increasing number of surgeons are performing laparoscopic surgery for Crohn's disease as witnessed by several articles published in the 1990s (Table)1-19. In fact this is not quite true. Most papers are case reports or series without controls, capable only of suggesting feasibility. Furthermore, comparison studies often feature selection flaws, and therefore beg the question of whether laparoscopic surgery should or not be considered as standard care. An attempt is made herein to give readers a concise insight of the evidence available in the English language literature. It does not pretend to offer a comprehensive review of the topic rather, it highlights some relevant issues, and then outlines what role, if any, laparoscopic surgery should play in Crohn's disease. There are at least 6 categories for discussion.


2016 ◽  
Vol 60 (1) ◽  
pp. 71-94 ◽  
Author(s):  
TOM SMITH

ABSTRACTIn this article, I consider Polynesian genealogies, which took the form of epic poems composed and recited by specialist genealogists, and were handed down orally through generations of Polynesians. Some were written down in the nineteenth century, reaching an English-speaking audience through a number of works largely neglected by historians. In recent years, some anthropologists have downplayed the possibility of learning anything significant about Polynesian thought through English-language sources, but I show that there is still fresh historical insight to be gained in demonstrating how genealogies came to interact with the traditions of outsiders in the nineteenth century. While not seeking to make any absolute claims about genealogy itself, I analyse a wide body of English-language literature, relating chiefly to Hawai‘i, and see emerging from it suggestions of a dynamic Polynesian oral tradition responsive to political, social, and religious upheaval. Tellingly, Protestant missionaries arriving in the islands set their own view of history against this supposedly irrelevant tradition, and in doing so disagreed with late nineteenth-century European and American colonists and scholars who sought to emphasize the historical significance of genealogy. Thus, Western ideas about history found themselves confounded and fragmented by Polynesian traditions.


2000 ◽  
Vol 23 (6) ◽  
pp. 371-374 ◽  
Author(s):  
A. Wichert ◽  
P. Lukasewitz ◽  
M. Häuser ◽  
J. Bittersohl ◽  
H. Lennartz

We report a 47-year-old male patient with fulminant ornithosis who developed severe respiratory failure leading to acute respiratory distress syndrome (ARDS) complicated by gastrointestinal, neurological and renal symptoms. ARDS was successfully treated by extracorporeal lung assist. As leukocytosis is typically absent in ornithosis, C-reactive protein, interleukin 6 and procalcitonin were used as infection parameters in order to monitor clinical development. The English-language literature on severe cases of ornithosis requiring respiratory support over the past 30 years is reviewed.


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