Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1240
Author(s):  
Bjorn Criel ◽  
Steff Taelman ◽  
Wim Van Criekinge ◽  
Michiel Stock ◽  
Yves Briers

Phage lytic proteins are a clinically advanced class of novel enzyme-based antibiotics, so-called enzybiotics. A growing community of researchers develops phage lytic proteins with the perspective of their use as enzybiotics. A successful translation of enzybiotics to the market requires well-considered selections of phage lytic proteins in early research stages. Here, we introduce PhaLP, a database of phage lytic proteins, which serves as an open portal to facilitate the development of phage lytic proteins. PhaLP is a comprehensive, easily accessible and automatically updated database (currently 16,095 entries). Capitalizing on the rich content of PhaLP, we have mapped the high diversity of natural phage lytic proteins and conducted analyses at three levels to gain insight in their host-specific evolution. First, we provide an overview of the modular diversity. Secondly, datamining and interpretable machine learning approaches were adopted to reveal host-specific design rules for domain architectures in endolysins. Lastly, the evolution of phage lytic proteins on the protein sequence level was explored, revealing host-specific clusters. In sum, PhaLP can act as a starting point for the broad community of enzybiotic researchers, while the steadily improving evolutionary insights will serve as a natural inspiration for protein engineers.


2012 ◽  
Vol 23 (5) ◽  
pp. 844-852 ◽  
Author(s):  
H. Jafarpour ◽  
B. Hore ◽  
S. Mehrotra ◽  
N. Venkatasubramanian
Keyword(s):  

BMJ Open ◽  
2015 ◽  
Vol 5 (8) ◽  
pp. e008160 ◽  
Author(s):  
J MacRae ◽  
B Darlow ◽  
L McBain ◽  
O Jones ◽  
M Stubbe ◽  
...  
Keyword(s):  
Big Data ◽  
The Rich ◽  

2020 ◽  
Vol 44 (3) ◽  
pp. 45-52
Author(s):  
K. Buzaubakova ◽  

The article highlights the content of pedagogical technology for preparing lectures in higher pedagogical institutions and the stages of lectures. The new content determined the purpose, structure, didactic functions, and types of lectures. There are revealed the features of a consultation lecture, an introductory, informational, visual, especially confused, problematic lecture, as well as a system of basic pedagogical requirements for a problem lecture. In addition, the article specifies the pedagogical requirements for organizing a modern lecture in higher pedagogical institutions: the relevance of the topic; science; conceptual idea; the existence of worldview and methodological foundations; compliance of the topic and content of lectures with the curriculum and curriculum; formulation of the problem; integrity and consistency; clarity; rich content; reliability; connection with life; practical significance; visibility; intersubject communication; performance activity; creativity, etc.


Author(s):  
Nourah F. Bin Hathlian ◽  
Alaaeldin M. Hafez

The need for designing Arabic text mining systems for the use on social media posts is increasingly becoming a significant and attractive research area. It serves and enhances the knowledge needed in various domains. The main focus of this paper is to propose a novel framework combining sentiment analysis with subjective analysis on Arabic social media posts to determine whether people are interested or not interested in a defined subject. For those purposes, text classification methods—including preprocessing and machine learning mechanisms—are applied. Essentially, the performance of the framework is tested using Twitter as a data source, where possible volunteers on a certain subject are identified based on their posted tweets along with their subject-related information. Twitter is considered because of its popularity and its rich content from online microblogging services. The results obtained are very promising with an accuracy of 89%, thereby encouraging further research.


2016 ◽  
Vol 5 (1) ◽  
pp. 44
Author(s):  
Ümmet Erkan

<p align="center"><strong>Some Polemics and Discussions which were Subjected In Turk Yurdu Magazine Between 1911-1918</strong><strong> </strong></p><p><strong>Abstract</strong></p><p>Started to press in 1911, The Turk Yurdu Magazine which is the longest press in Turkish Nationalism, leaded by the Turks in Russia whose aims were the Turkish Nation’s going up in all areas. This article examines some polemics, letters and replies for these letters took place in the issues between the years 1911/1918. In this polemics, the topics of what should be understood from the simplification of Turkish and its boundaries, the lack of idealism in education, education with Turkish language, the damages of minority schools on the social life of Ottoman people, the success of the programs of Tanzimat, the effects of national ID on religious ID and the like were discussed. These polemics which the authors of Turk Yurdu and the other intellectuals who took place in the discussion from different newspapers and magazines got a very rich content. This article focuses on the topics which the debates revolves around and and the intellectual discussions about them. </p><p align="center"><strong><br /></strong></p><p align="center"><strong>1911-1918 Yılları Arasında Türk Yurdu Dergisine Konu Olan</strong></p><p align="center"><strong>Bazı Tartışma ve Polemikler </strong></p><p><strong>Öz</strong></p><p>Türk Yurdu Dergisi 1911 yılında yayın hayatına başlamış, Türk milliyetçiliinin en uzun soluklu yayın organıdır. Rusya Türklerinin öncülük ettiği dergide Türklüğün her alanda yükselmesi amaçlanmıştır. Bu makalede Türk Yurdu dergisinin 1911-1918 yılları arasındaki sayılarından yola çıkılarak dergideki bazı kalem tartışmaları, mektuplar ve onlara verilen cevaplar incelenecektir. Bu kalem tartışmalarında Türkçenin sadeleştirilmesinden ne anlaşılması gerektiği ve sınırları, eğitimde ideal eksikliği, eğitim dilinin Türkçe olması ve azınlık okullarının Osmanlı sosyal bünyesine verdiği zararlar, Tanzimatçı reform programının başarılı olup olmadığı ve nedenleri, milli kimliğin dini aidiyete zarar verip vermeyeceği konuları ele alınacaktır. Türk Yurdu dergisi yazarları ile dönemin diğer önemli entelektüellerinin çeşitli gazete ve dergilerde dâhil olduğu bu kalem tartışmaları zengin bir muhteva kazanmıştır. Bu tartışmalar dönemin entelektüel fikir hareketleri ve siyasi akımlar hakkında önemli bilgiler içermektedir. Bu araştırma, yapılan tartışma ve polemiklerin hangi konular etrafında yoğunlaştığını ve Türk Yurdu dergisinin bu tartışma ve polemiklerde ne tür bir yöntem izlediğini ortaya koymaktadır. </p>


2021 ◽  
pp. 35-48
Author(s):  
Julia Zamjatina ◽  
Alexey Kashin ◽  
Olesja Kondrat’eva ◽  
Il’shat Muhametshin

The article presents the concept of reconstruction of the Fertiki unit of the biogeoecological station of the Udmurt State University (hereinafter – the Fertiki campus), formed in the process of joint work of geographers and designers. The presence of a field campus is a necessary condition for the professional skills and abilities formation of students in a number of training areas in a classical university. However, the requirements for the campuses internal space formation are changing. If one and a half to two decades ago it was enough to have a minimally equipped site on the territory that meets the basic needs in terms of the field practices and scientific research content, now the need to expand the functionality and types of activities is becoming more and more obvious. At the same time, it is proposed to put natural, cultural and historical features of the area within which the campus is located as the basis for modern design solutions. In conditions of limited funding and a general unstable financial situation, there is a need for more efficient use of the property complex of the university, including field campuses. They should not only satisfy the needs of conducting educational practices and scientific research, but become complex out-of-town (field) divisions of universities aimed at various types of activities. The proposed concept provides the reconstruction of the biogeoecological station in the direction of forming a focus point of natural and cultural landscapes of a vast territory. On the one hand, the campus must organically fit into the surrounding space, and on the other hand, it must reflect its main natural, cultural and historical features in order to get rich content. Only complexity and polyfunctionality can be stimuli and conditions for its development.


Author(s):  
Charles E. Beck ◽  
Gary R. Schornack

A new world of distance education demands new thinking. Key components to completing the distance educational system requires that institutions determine how the process is designed, delivered, integrated, and supported. Unfortunately, educational administrators tend to view distance education merely as a process of taking existing readings, exercises, handouts, and posting them to the Web. While this approach may seem cost effective, such an approach is not educationally effective. Although the meaningful transition to e-education has just begun, determining measures of effectiveness and efficiency requires innovations in social and political thought beyond the advances in technology. The educational process requires feedback from the professor, from the student, and from the wider community, especially businesses who hire the graduates. As e-learning and higher education reach new heights, they are changing the functions of the university. E-learning changes all the ground rules, including time, distance, and pedagogy. We now have new ways to reach and interact with students, present rich content in courses, and deliver the technologies of the smart classroom to students, wherever they are in the world.


Author(s):  
David R. Dannenberg

While the educational use of Second Life by the academic community is well established, the number of corporate training and development programs utilizing Second Life has yet to be fully determined. However, while the corporate training use of Second Life may not be as prolific as the academic use, it is occurring. To support this argument the author combines the use of ethnographic evaluation with a review of the existing literature surrounding the corporate use of Second Life. Presented within are what the author found to be the main advantages and hesitations that surround the corporate use of Second Life. The affordances of Second Life, the communication channels, the immersive self-directed building opportunities, and rich, content driven environments, are a unique mix that makes Second Life an ideal medium for developing corporate learning programs.


Author(s):  
Robert S. Stephenson

The rise of the Internet has started a knowledge revolution whose extent can only be guessed at. The last revolution of this magnitude, brought on by the printing press, led to the proliferation of books and the rise of the modern university system. If universities are to survive the latest knowledge revolution, they must adapt with unaccustomed speed and learn how to use the Internet for more effective teaching. Most universities adopt a limited approach to building on-line courses. However, many studies have found that merely transplanting materials to the Web does not significantly improve learning (Russell, 1999). In fact, handouts, slides, and viewgraphs that have been “repurposed” for the Web are sometimes derisively referred to as “shovelware” (Fraser, 1999). So while moving existing materials to the Web may increase their accessibility, it will not necessarily improve their effectiveness. The Internet’s real value as a medium and teaching platform is that it makes possible rich, interactive content such as simulations, animations, and 3-D models. These learning objects, or rich content, can significantly enhance learning, especially in the sciences, and can be just as useful inside the classroom as outside. The difficulty is how to create this enhanced content, since the task demands a broad range of technical skills and enormous effort. Besides faculty domain experts and experienced teachers, rich content development typically requires illustrators, Web designers, programmers, instructional designers, testers, and Webmasters. The only way faculty and institutions can meet this challenge is to embrace collaboration more broadly and seriously than they have in the past. One approach is the multi-institutional consortium. Another solution is a collaboration of faculty to build rich content in their discipline. This chapter chronicles an example of the latter sort: a bottom-up, cross-institutional project. For such a grass roots collaboration to succeed, it must recruit many faculty pioneering the use of the Internet in their teaching, as well as artists and technical professionals. It must offer collaborators an incentive to participate, and it must attract not only volunteers, but also institutional and agency funding as well. Finally, as a pioneering project, it must create standards and develop paradigms as it goes. This case study describes a work-in-progress to solve these issues.


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