scholarly journals Contact eczema induced by hybrid manicure. The role of acrylates as a causative factor

2021 ◽  
Author(s):  
Sandra Opalińska ◽  
Małgorzata Opalińska ◽  
Lidia Rudnicka ◽  
Joanna Czuwara
Keyword(s):  
Causative Factor ◽  
Contact Eczema

scholarly journals A Dual Role of Heme Oxygenase-1 in Cancer Cells

2018 ◽  
Vol 20 (1) ◽  
pp. 39 ◽  
Author(s):  
Shih-Kai Chiang ◽  
Shuen-Ei Chen ◽  
Ling-Chu Chang
Keyword(s):  
Cell Death ◽  
Heme Oxygenase ◽  
Cancer Progression ◽  
Critical Role ◽  
Causative Factor ◽  
Protective Role ◽  
Dark Side ◽  
Heme Oxygenase 1 ◽  
Cellular Iron

Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions. HO-1 is commonly regarded as a survival molecule, exerting an important role in cancer progression and its inhibition is considered beneficial in a number of cancers. However, increasing studies have shown a dark side of HO-1, in which HO-1 acts as a critical mediator in ferroptosis induction and plays a causative factor for the progression of several diseases. Ferroptosis is a newly identified iron- and lipid peroxidation-dependent cell death. The critical role of HO-1 in heme metabolism makes it an important candidate to mediate protective or detrimental effects via ferroptosis induction. This review summarizes the current understanding on the regulatory mechanisms of HO-1 in ferroptosis. The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator. Despite the dark side that is related to cell death, there is a prospective application of HO-1 to mediate ferroptosis for cancer therapy as a chemotherapeutic strategy against tumors.

scholarly journals PDGFBB promotes proliferation and migration via regulating miR-1181/STAT3 axis in human pulmonary arterial smooth muscle cells

2018 ◽  
Vol 315 (6) ◽  
pp. L965-L976 ◽  
Author(s):  
Zhengjiang Qian ◽  
Yanjiao Li ◽  
Haiyang Yang ◽  
Jidong Chen ◽  
Xiang Li ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Causative Factor ◽  
Loss Of Function ◽  
Migration Flow ◽  
Pulmonary Arterial ◽  
And Migration ◽  
Proliferation And Migration

Platelet-derived growth factor (PDGF) can induce hyperproliferation of pulmonary artery smooth muscle cells (PASMCs), which is a key causative factor to the occurrence and progression of pulmonary arterial hypertension (PAH). We previously identified that miR-1181 is significantly downregulated by PDGFBB in human PASMCs. In this work, we further explore the function of miR-1181 and underlying regulatory mechanisms in PDGF-induced PASMCs. First, the expression pattern of miR-1181 was characterized under PDGFBB treatment, and PDGF receptor/PKCβ signaling was found to repress miR-1181 expression. Then, gain- and loss-of-function experiments were respectively conducted and revealed the prominent role of miR-1181 in inhibiting PASMC proliferation and migration. Flow cytometry analysis suggested that miR-1181 regulated the PASMC proliferation through influencing the cell cycle transition from G0/G1 to S phase. Moreover, we exhibited that miR-1181 targeting STAT3 formed a regulatory axis to modulate PASMC proliferation. Finally, serum miR-1181 expression was also observed to be reduced in adult and newborn patients with PAH. Overall, this study provides novel findings that the miR-1181/STAT3 axis mediated PDGFBB-induced dysfunction in human PASMCs, implying a potential use of miR-1181 as a therapeutic and diagnostic candidate for the vascular remodeling diseases.

scholarly journals Role of Samyoga Viruddha Ahara in Kustha Vyadhi - An Observational Study

2020 ◽  
Vol 5 (04) ◽  
pp. 86-91
Author(s):  
Raosaheb A. Deshmukh
Keyword(s):  
Observational Study ◽  
Decisive Role ◽  
Causative Factor ◽  
Human Beings ◽  
Diseased State

Food plays a decisive role in development, sustain, reproduction and termination of life. Through centuries, Food has been recognized as an important factor for human beings, in health and diseased state. Viruddha Ahara is one potent causative factor for several diseases. Consumption of Viruddha Ahara gives rise to various disturbances of mild to violent nature and disease of acute to chronic nature including the eight Maharogas, genetic disturbances and even sometimes causes death of the person. To conduct on observational study to access the role of Samyoga Viruddha Ahara is one of the Nidana for manifestation of Kustha Vyadhi. In the present observational study were selected of total 50 patients was conducted at O.P.D, Patients were screened on the basis of specially prepared questionnaires format. On Observational study majority of patients i.e. 82% of patients were consumed Samyoga Viruddha Ahara majority of patients i.e. 58% were consuming Viruddha Ahara (Samyogaja Viruddha Ahara), 26% were doing Malamutra Vega Dharana, 16% were doing Vyayama after Bhojana and 36% patients were doing Diwaswapna.

scholarly journals OVERVIEW ON ASSOCIATION OF DIFFERENT TYPES OF LEUKEMIAS WITH RADIATION EXPOSURE

2015 ◽  
Vol 37 (2) ◽  
pp. 89-93 ◽  
Author(s):  
D F Gluzman ◽  
L M Sklyarenko ◽  
M Zavelevich ◽  
S V Koval ◽  
T Ivanivskaya ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Hematological Malignancies ◽  
Causative Factor ◽  
World Health ◽  
Lymphoid Tissues ◽  
Different Types ◽  
Large Populations ◽  
Precise Diagnosis ◽  
Health Organization

Exposure to ionizing radiation is associated with increasing risk of various types of hematological malignancies. The results of major studies on association of leukemias and radiation exposure of large populations in Japan and in Ukraine are analyzed. The patterns of different types of leukemia in 295 Chernobyl clean-up workers diagnosed according to the criteria of up-to-date World Health Organization classification within 10–25 years following Chernobyl catastrophe are summarized. In fact, a broad spectrum of radiation-related hematological malignancies has been revealed both in Life Span Study in Japan and in study of Chernobyl clean-up workers in Ukraine. The importance of the precise diagnosis of tumors of hematopoietic and lymphoid tissues according to up-to-date classifications for elucidating the role of radiation as a causative factor of leukemias is emphasized. Such studies are of high importance since according to the recent findings, radiation-associated excess risks of several types of leukemias seem to persist throughout the follow-up period up to 55 years after the radiation exposure.

scholarly journals Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues

2001 ◽  
Vol 281 (2) ◽  
pp. E217-E223 ◽  
Author(s):  
Elizabeth Stephens ◽  
Patti J. Thureen ◽  
Marc L. Goalstone ◽  
Marianne S. Anderson ◽  
J. Wayne Leitner ◽  
...  
Keyword(s):  
Growth Factors ◽  
Molecular Mechanisms ◽  
Fetal Liver ◽  
White Blood Cells ◽  
Causative Factor ◽  
Ras Proteins ◽  
Direct Infusion ◽  
Fetal Tissues ◽  
P21 Ras

Even though the role of fetal hyperinsulinemia in the pathogenesis of fetal macrosomia in patients with overt diabetes and gestational diabetes mellitus seems plausible, the molecular mechanisms of action of hyperinsulinemia remain largely enigmatic. Recent indications that hyperinsulinemia “primes” various tissues to the mitogenic influence of growth factors by increasing the pool of prenylated Ras proteins prompted us to investigate the effect of fetal hyperinsulinemia on the activitiy of farnesyltransferase (FTase) and the amounts of farnesylated p21 Ras in fetal tissues in the ovine experimental model. Induction of fetal hyperinsulinemia by direct infusion of insulin into the fetus and by either fetal or maternal infusions of glucose resulted in significant increases in the activity of FTase and the amounts of farnesylated p21 Ras in fetal liver, skeletal muscle, fat, and white blood cells. An additional infusion of somatostatin into hyperglycemic fetuses blocked fetal hyperinsulinemia and completely prevented these increases, specifying insulin as the causative factor. We conclude that the ability of fetal hyperinsulinemia to increase the size of the pool of farnesylated p21 Ras may prime fetal tissues to the action of other growth factors and thereby constitute one mechanism by which fetal hyperinsulinemia could induce macrosomia in diabetic pregnancies.

Nutritional Contributions to the CNS Pathophysiology of HIV-1 Infection and Implications for Treatment

CNS Spectrums ◽  
2000 ◽  
Vol 5 (4) ◽  
pp. 61-72 ◽  
Author(s):  
Teri T. Baldewicz ◽  
Pim Brouwers ◽  
Karl Goodkin ◽  
Adarsh M. Kumar ◽  
Mahendra Kumar
Keyword(s):  
Disease Progression ◽  
Causative Factor ◽  
Nutritional Deficiencies ◽  
Micronutrient Deficiencies ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Nutritional Deficits ◽  
Hiv 1

AbstractNutritional deficiencies are commonplace in patients with human immunodeficiency virus type 1 (HIV-1) infection, and recent research has indicated that nutritional factors may play an important role in the pathogenesis of HIV-1 disease. Although nutritional deficiencies are unlikely to be the primary causative factor in disease progression, they may contribute to cognitive dysfunction, neurologic abnormalities, mood disturbance, and immune dysregulation associated with HIV-1 infection. Furthermore, deficiencies of specific micronutrients have been associated with increased risk of HIV-1–associated mortality. This article will briefly summarize the role of macronutrient deficiency, the interactions of specific micronutrient deficiencies with neuropsychiatrie functioning, and the role of these factors in HIV-1 disease progression. Since recent research has shown that normalization of many nutritional deficits and supplementation beyond normal levels are associated with improvements in neuropsychiatrie functioning, potential treatment implications will also be discussed.

scholarly journals Postnatal Role of the Cytoskeleton in Adult Epileptogenesis

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Cezar Gavrilovici ◽  
Yulan Jiang ◽  
Ivana Kiroski ◽  
G Campbell Teskey ◽  
Jong M Rho ◽  
...  
Keyword(s):  
Animal Models ◽  
Neuronal Activity ◽  
Causative Factor ◽  
Cytoskeletal Proteins ◽  
Human Studies ◽  
Pathogenic Mechanism ◽  
Neuronal Connectivity ◽  
Cytoskeletal Disruption

Abstract Mutations in cytoskeletal proteins can cause early infantile and childhood epilepsies by misplacing newly born neurons and altering neuronal connectivity. In the adult epileptic brain, cytoskeletal disruption is often viewed as being secondary to aberrant neuronal activity and/or death, and hence simply represents an epiphenomenon. Here, we review the emerging evidence collected in animal models and human studies implicating the cytoskeleton as a potential causative factor in adult epileptogenesis. Based on the emerging evidence, we propose that cytoskeletal disruption may be an important pathogenic mechanism in the mature epileptic brain.

scholarly journals Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism

2005 ◽  
Vol 152 (3) ◽  
pp. 419-425 ◽  
Author(s):  
Alberto Ferlin ◽  
Andrea Garolla ◽  
Andrea Bettella ◽  
Lucia Bartoloni ◽  
Cinzia Vinanzi ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Causative Factor ◽  
Androgen Receptor Gene ◽  
Cag Repeats ◽  
Exon 1 ◽  
History Of ◽  
Receptor Gene Polymorphisms ◽  
Congenital Birth Defect

Objective: Cryptorchidism is the most common congenital birth defect in male children, and accumulating evidence suggests that genetic abnormalities may be associated with it. The androgen receptor has two polymorphic sites in exon 1, with different numbers of CAG and GGC repeats, resulting in variable lengths of polyglutamine and polyglycine stretches. Longer CAG repeats result in a reduced androgen receptor transcriptional activity, but the role of the GGC triplets is less clear. In this study we analysed CAG and GGC repeat lengths in men with a history of cryptorchidism, associated or not with impairment of sperm production, in comparison with normal fertile subjects. Methods: We analysed CAG and GGC repeat lengths in a group of 105 ex-cryptorchid men in comparison with 115 fertile non-cryptorchid men. Results: No difference was found between patients and controls in the mean and median values, and in distribution of CAG and GGC, when considered separately. However, the analysis of the joint distribution of CAG and GGC showed that some combinations are significantly more frequent in men with bilateral cryptorchidism (who frequently presented severe testiculopathies), in a manner similar to that found in idiopathic infertile subjects. Conclusions: Although further studies are needed to elucidate the possible role of specific CAG/GGC combinations as a causative factor, these data suggest a possible association between androgen receptor gene polymorphisms and cryptorchidism.

Viscoelastic Properties of the L3-L4 Myofascial Tissue in Ankylosing Spondylitis Patients

2018 ◽  
Author(s):  
Allison White ◽  
Hannah Abbott ◽  
Alfonse Masi ◽  
Kalyani Nair
Keyword(s):  
Ankylosing Spondylitis ◽  
Viscoelastic Properties ◽  
Causative Factor ◽  
Low Back ◽  
Muscle Properties ◽  
Linear Elastic ◽  
Lower Lumbar ◽  
Resting Muscle ◽  
Passive Muscle

Ankylosing spondylitis (AS) is a degenerative rheumatological disorder that mainly affects the spine. It has been reported that different degrees of human resting myofascial tone (HRMT) would affect spinal stability and may predispose to the respective curvature deformities of adolescent idiopathic scoliosis (AIS) and the enthesopathy of ankylosing spondylitis (AS). Although osteoligamentous impacts are prominently recognized in many chronic spine and low back conditions, no research has been performed on the possible role of passive axial (spinal) myofascial tone as a causative factor. In this particular study, the passive muscle properties of the lower lumbar regions of 24 healthy adults and 24 adult AS subjects were examined. Our recent publications examined the linear elastic properties among normal and AS subjects. In this study, those analyses are expanded to include detailed analysis and correlations of the linear elastic property of stiffness to two viscoelastic properties: stress relaxation time (SRT) and creep. Analyzed data supports the hypothesis that resting muscle properties of the lower lumbar muscles hold significance in differentiation of human back health between healthy and diseased subjects, but more testing should be performed to support this study’s results.

The Role of Correction of Anemia in Patients With Congestive Heart Failure Associated with Chronic Kidney Failure

2008 ◽  
Vol 21 (6) ◽  
pp. 420-423
Author(s):  
Donald S. Silverberg ◽  
Dov Wexler ◽  
Adrian Iaina ◽  
Doron Schwartz
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Chronic Kidney Failure ◽  
Causative Factor ◽  
Hospitalization Rate ◽  
Clinical Indicators ◽  
Important Relationship ◽  
Iv Iron ◽  
Positive Effect

Patients with congestive heart failure (CHF) who are also anemic have more severe CHF and a higher mortality, morbidity, and hospitalization rate than those who are not anemic. However, it is not known if the anemia is actually contributing to the CHF or if it is merely comorbidity (ie a marker of increased inflammation or chronic kidney disease [CKD]). The only way to demonstrate that anemia is a causative factor is to correct it, independent of other CHF factors. In this paper we review the results of the published papers about correction of anemia in patients with CHF. Taken in sum, these reports show a quite consistent positive effect of erythropoietic stimulating agents (ESAs) along with oral or intravenous (IV) iron or even of IV alone on clinical indicators and clinical outcomes of patients with CHF. More work is needed to clarify the important relationship between anemia, CHF, and CKD.

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