scholarly journals Developmental prospectives of new generation super absorbent wound dressing materials from sulfated polysaccharide of marine red algae

2021 ◽  
Vol 23 (09) ◽  
pp. 400-408
Author(s):  
Amruth P ◽  
◽  
Amruth P ◽  
Rosemol Jacob M ◽  
Suseela Mathew ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Wound Care ◽  
Healing Process ◽  
Cost Effective ◽  
Sulfated Polysaccharide ◽  
Wound Dressings ◽  
New Generation ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound healing remains as a dynamic process and the type of dressing material significantly affects the efficacy of healing. The identification of ideal dressings to use for a particular wound type is an important requisite facilitating the entire process of healing. Chronic, high exudate wounds are dynamic in presentation and remain as a major health care burden. Researchers have sort to design and optimize biodegradable wound dressings that focuses to optimize moisture retentiveness, as superior character in the healing process. In addition, dressings have been designed to visualize the wound bed by improving the optical property, target and kill infection-causing bacteria, with the incorporation of antimicrobial agents, nanomaterials and numerous other measures. For the practitioners, choosing the optimal dressing decreases time to healing, provides cost-effective care and improves patient quality of life. The current mini review highlights the ideal characters of wound dressing materials and presents insights on the superior characters of carrageenan bio composites for prospective advancements in research in the area of wound care and management.

scholarly journals Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

2021 ◽  
Vol 11 (4) ◽  
pp. 1713
Author(s):  
Ilenia De Luca ◽  
Parisa Pedram ◽  
Arash Moeini ◽  
Pierfrancesco Cerruti ◽  
Gianfranco Peluso ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Oils ◽  
Wound Dressing ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Efficient Treatment ◽  
Anti Inflammatory ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.

scholarly journals Recent Updates on Biopolymers based Wound Dressings

2021 ◽  
Vol 33 (7) ◽  
pp. 1457-1470
Author(s):  
Sonia Arora ◽  
Manju Nagpal ◽  
Malkiet Kaur
Keyword(s):  
Extracellular Matrix ◽  
Wound Dressing ◽  
Low Cost ◽  
Healing Process ◽  
Synthetic Polymer ◽  
Wound Dressings ◽  
Naturally Occurring ◽  
Current Review ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound dressing is designed to support the wound bed and protect it from the factors that may delay or impede its healing such as contamination and moisture thereby facilitating and accelerate the healing process. The material used to prepare wound dressing include natural and synthetic polymer as their combination in the form of film and sponges that may be extensively used in wound dressing material. Naturally occurring polymers having many importance because of high biocompatibility and environmentally finding properties. Polysaccharides are naturally occurring polymers that have been extensively used as wound dressing materials. Homopolysaccharide are a class of polysaccharides consists of only one type of monosaccharide. Naturally occurring polymers are used for wound dressing properties because of their extracellular matrix as good acceptance by biological system. Polysaccharide is type of naturally occurring polymers that offer the advantage of good hemocompatibility and low cost in comparison with other biopolymers. The current review intends to overview the studies in which wound dressings from naturally-occurring polymers including chitosan, silk fibroin, sodium alginate and hyaluronic acid were considered.

scholarly journals Co-electrospun nanofibrous mats loaded with bitter gourd (Momordica charantia) extract as the wound dressing materials: in vitro and in vivo study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mohammad Saeid Salami ◽  
Gholamreza Bahrami ◽  
Elham Arkan ◽  
Zhila Izadi ◽  
Shahram Miraghaee ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Biological Activities ◽  
Healing Process ◽  
Momordica Charantia ◽  
Wound Dressings ◽  
Vapor Permeability ◽  
Dressing Materials ◽  
Wound Dressing Materials

Abstract Background Interactive dressings are innovatively designed to interact with the wound surface and alter the wound environment to promote wound healing. In the current study, we integrated the physicochemical properties of Poly (caprolactone)/ Poly (vinyl alcohol)/Collagen (PCL/PVA/Col) nanofibers with the biological activities of Momordica charantia pulp extract to develop an efficient wound dressing. The electrospinning method was applied to fabricate the nanofibers, and the prepared wound dressings were thoroughly characterized. Results SEM imaging showed that the nanofibers were uniform, straight, without any beds with a diameter in the range of 260 to 480 nm. Increasing the concentration of the extract increased the diameter of the nanofibers and also the wettability characteristics while reduced the ultimate tensile strength from 4.37 ± 0.90 MPa for PCL/PVA/Col to 1.62 ± 0.50 MPa for PCL/PVA/Col/Ex 10% (p < 0.05). The in vivo studies showed that the application of the wound dressings significantly enhanced the healing process and the highest wound closure, 94.01 ± 8.12%, was obtained by PCL/PVA/Col/Ex 10% nanofibers (p < 0.05). Conclusion The incorporation of the extract had no significant effects on nanofibers’ porosity, water vapor permeability, and swelling characteristics. The in vitro evaluations showed that the fabricated nanofibers were hemocompatible, cytocompatible, and prevent bacterial penetration through the dressing. These findings implied that the PCL/PVA/Col/Ex nanofibers can be applied as the wound dressing materials.

scholarly journals Marine Algae Polysaccharides as Basis for Wound Dressings, Drug Delivery, and Tissue Engineering: A Review

2020 ◽  
Vol 8 (7) ◽  
pp. 481 ◽  
Author(s):  
Tatyana A. Kuznetsova ◽  
Boris G. Andryukov ◽  
Natalia N. Besednova ◽  
Tatyana S. Zaporozhets ◽  
Andrey V. Kalinin
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Wound Dressing ◽  
Biological Properties ◽  
Wound Dressings ◽  
Tissue Engineering Scaffolds ◽  
Treatment Of Wounds ◽  
New Generation ◽  
Dressing Materials

The present review considers the physicochemical and biological properties of polysaccharides (PS) from brown, red, and green algae (alginates, fucoidans, carrageenans, and ulvans) used in the latest technologies of regenerative medicine (tissue engineering, modulation of the drug delivery system, and the design of wound dressing materials). Information on various types of modern biodegradable and biocompatible PS-based wound dressings (membranes, foams, hydrogels, nanofibers, and sponges) is provided; the results of experimental and clinical trials of some dressing materials in the treatment of wounds of various origins are analyzed. Special attention is paid to the ability of PS to form hydrogels, as hydrogel dressings meet the basic requirements set out for a perfect wound dressing. The current trends in the development of new-generation PS-based materials for designing drug delivery systems and various tissue-engineering scaffolds, which makes it possible to create human-specific tissues and develop target-oriented and personalized regenerative medicine products, are also discussed.

scholarly journals Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing

2021 ◽  
Vol 19 ◽  
pp. 228080002110549
Author(s):  
Michael Rodrigues ◽  
Thilagavati Govindharajan
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Care ◽  
Cost Effective ◽  
Wound Dressings ◽  
Wound Management ◽  
Histopathological Analysis ◽  
Diabetic Wound ◽  
Functional Material ◽  
Diabetic Wound Healing

A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dressing is comparable to the established wound dressings like Carboxymethyl cellulose alginate dressings and autolytic enzyme based hydrogel. It is found to be superior to Polyhexamethylene biguanide dressing used as reference controls in this study. The reason for good wound healing performance of the dressing can be attributed to a combined property of effective exudates management and broad spectrum antimicrobial effect. The concept of functional hydro cellular material has shown good results due to the excellent balance of exudates pickup and drying it out. This ensures moist wound healing conditions on the wound. Because of its porous nature it allows good air flow and gaseous exchange in the structure. The cationic sites created on the surface of the dressing ensure a good antimicrobial action on the exudates in the dressing. It reduces the infection load on the wound. The nonleaching property of the dressing also helps in preventing the generation of more resistant and mutant strains of the microbes. The developed dressing can be used as a relatively durable long lasting dressing for wound management in diabetic wounds. The need of repetitive wound dressing changes can be brought down with this concept of dressing. It is not only cost effective in terms of its material cost but also is a cost effective solution when entire wound management cost is considered. Such novel wound dressing material can change the quality of life of diabetic wound patients especially in developing world, where access to functional advanced wound care dressings is limited.

scholarly journals Intelligent wound dressing for diagnostic & therapeutic applications - critical to wound infection

2020 ◽  
Vol 2 (7A) ◽  
Author(s):  
Zahid Mahmood ◽  
Anne-Marie Salisbury ◽  
Rui Chen ◽  
Stephen Rimmer ◽  
Steven Percival
Keyword(s):  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Detection System ◽  
Healing Process ◽  
Wound Dressings ◽  
Core Material ◽  
Wound Healing Process ◽  
Polymer Complex ◽  
Triggered Release ◽  
Antibiofilm Agents

A medical device comprising of biomaterials responsive to biochemical stimuli: channel for indicating the infective states of wounds and ensuring delivery of smart antimicrobial and antibiofilm agents to promote tissue regeneration and healing. The importance of providing diagnostic wound dressings that can inform healthcare professionals on the state of infection within wounds but also provide some of the treatment required in response to at risk or infected wounds is of key interest. The aim is to investigate an innovative proof of concept diagnostic and detection system, an intelligent hydrogel wound dressing that responds to specific biochemical stimuli in wounds (MMPs and pH) enabling the selective and triggered release of antibiofilm and antimicrobial agents (‘Detect and Treat’)to the trauma site. The dressing is made of a sterile alginate core material covered in a biocompatible dry or hydrated peptide-polymer-complex film and may include a fluorescent dye which upon release during the wound healing process indicates when a change in dressing is necessary. Efficacy studies of the hydrogel dressing were performed within a drip-flow bioreactor in which regression of Pseudomonas aeruginosa biofilm was observed. A 5-log reduction in biofilm was observed in comparison to an untreated control biofilm. The hydrogel dressing indicated a clear response when in contact with biofilms produced only by pathogenic strains of bacteria when analysed. This further confirmed the adequate release and function of the antimicrobial and antibiofilm agents within the peptide-polymer-complex formulation of the hydrogel wound dressing.

Effect of the Nano-SiO2 Particles in Gelatin and Chitosan Based Wound Dressing Materials on the Antimicrobial Effects

2014 ◽  
Vol 1002 ◽  
pp. 105-110
Author(s):  
Li Bo Wang ◽  
Xiao Yang Liu ◽  
Jun Wei ◽  
Hong Jiang
Keyword(s):  
Water Vapor ◽  
Water Uptake ◽  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Binding Capacity ◽  
Antimicrobial Effect ◽  
Barrier Property ◽  
Uptake Ratio ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound dressing materials were obtained from gelatin, chitosan and nanoSiO2particles as filler. The barrier property to water vapor, water uptake ratio and antimicrobial properties of the wound dressing materials were investigated. The addition of the nanoSiO2particles endowed the materials good water uptake ratio and the barrier property to water vapor, whereas the antimicrobial agents improve the barrier property producing more hydrogen bonds. Moreover, the networks of the wound dressing materials with nanoSiO2particles displayed excellent compound binding capacity could reduce the permeation of water and increase the antimicrobial effect of the materials. The antimicrobial agents endowed the wound dressing materials with antimicrobial effect.

Cytotoxicity Testing of Wound-Dressing Materials

2001 ◽  
Vol 29 (3) ◽  
pp. 269-275 ◽  
Author(s):  
Herman Sahlin ◽  
Håkan Nygren
Keyword(s):  
Nadph Oxidase ◽  
Respiratory Burst ◽  
Oxidase Activity ◽  
Cell Walls ◽  
Wound Dressing ◽  
Wound Dressings ◽  
Nadph Oxidase Activity ◽  
Kinase C ◽  
Dressing Materials ◽  
Wound Dressing Materials

A method was developed for testing the cytotoxicity of various bandage-like wound dressings and gel wound dressings. In this method, the ability of human polymor-phonuclear neutrophils (PMNs) to initiate a respiratory burst after exposure to the various wound dressings is used as a marker of cytotoxicity. Luminol-amplified chemiluminescence stimulated with opsonised zymosan or phorbol 12-myristate 13-acetate (PMA) is used to measure the degree of activation of the respiratory burst, i.e. the NADPH oxidase activity, after exposure to wound dressings. Opsonised zymosan (material from yeast cell walls) is a phagocytic stimulus that activates the NADPH oxidase by binding to Fc-receptors and complement receptors, and functions as an artificial bacterium, whereas PMA activates the NADPH oxidase by direct activation of protein kinase C. NADPH oxidase activity was inhibited by several wound dressings. The down-regulation of the respiratory burst is detrimental to the bactericial effect of PMNs, and can be used as a marker for the cytotoxicity of wound-dressing materials.

A clinically effective primary wound dressing that supports self-care for chronic and acute wounds

2019 ◽  
Vol 24 (Sup6) ◽  
pp. S30-S37 ◽  
Author(s):  
Stuart Elliott
Keyword(s):  
Wound Dressing ◽  
Wound Care ◽  
Self Care ◽  
Cost Effective ◽  
Healing Time ◽  
Wound Dressings ◽  
Effective Care ◽  
Nurse Time ◽  
Effective Product

Wound care forms a large component of the ever-increasing workload of district and community nurses. The need for a cost-effective product that can be used on a variety of wounds and that meets multiple requirements (e.g. protease modulation, anti-microbial, peri-wound skin protection, maceration control and barrier function) is well recognised. The plethora of wound dressings available today all fulfil some, although not all, of these requirements. Choosing the correct dressing decreases healing time, provides cost-effective care and improves patient quality of life. This article looks at the important properties of wound care products, investigates the need to release nurse time and describes how patients with wounds can engage in effective self-care, with a focus on 1 Primary Wound Dressing® (1PWD), a cost effective, easy-to-use product that has already demonstrated clinical efficacy. Case studies showing the successful use of 1PWD are also presented to highlight the clinical application of this novel product.

scholarly journals Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

2019 ◽  
Vol 20 (23) ◽  
pp. 5889 ◽  
Author(s):  
Matica ◽  
Aachmann ◽  
Tøndervik ◽  
Sletta ◽  
Ostafe
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Healing Process ◽  
Antimicrobial Properties ◽  
Starting Material ◽  
Wound Dressings ◽  
Current Status ◽  
Natural Polymers ◽  
Promising Source

Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. Finally, the applications of chitosan as a wound-dressing material are discussed along with the current status of chitosan-based wound dressings existing on the market.

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