scholarly journals Role of Serotonin Hormone at Development of Diabetes Mellitus Type 2 disease

2021 ◽  
Vol 23 (10) ◽  
pp. 327-331
Author(s):  
Dr.Mustafa Saleam Khalaf ◽  
◽  
Ali Hussein Mohammed Ali Al-Tameemi ◽  
Bahaa Burhanuldeen Kargule ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Concentration Level ◽  
Well Being ◽  
Control Group ◽  
Common Disease ◽  
Serotonin Concentration ◽  
Dm Type 2 ◽  
Serum Serotonin

Subject :Diabetes Mellitus (DM) type 2 is most common disease characterized by elevation of serum glucose level due to impair insulin production or impair cell response to insulin .Serotonin is hormonal neurotransmitter commonly found in brain cell but it also present in beta cells of pancreas . It is key hormone that stabilizes mood, feelings of well-being, and happiness . Objective of the Study: Role of serotonin in development of DM type 2 disease . Materials and Methods: This study was done on 30 patients with un-control DM type2 patients and 30 control DM type 2 patients , the all subjects age within this study were more than 50 years of both genders .After obtained serum , immediately used quantity method for measured level of serum serotonin concentration . Results: This study shows reduce of serum serotonin concentration level in un-control DM type 2 group compare with control group . Conclusion: This study confirms that decreased serum serotonin concentration level can act as support development of DM type 2 disease .

scholarly journals Effect of Stress Hormone on Development of Diabetes Mellitus Type 2 Disease

2021 ◽  
Vol 23 (08) ◽  
pp. 738-742
Author(s):  
Dr . Dina Ayed Mohammed ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Concentration Level ◽  
Serum Cortisol ◽  
Serum Glucose ◽  
Cortisol Concentration ◽  
Common Disease ◽  
Stress Hormone ◽  
Dm Type 2 ◽  
Serum Cortisol Concentration

Subject :Diabetes Mellitus (DM) is most common disease characterized by elevation of serum glucose level due to impair insulin production called type 1 DM or impair cell response to insulin called type 2 DM .Cortisol is the steroid hormone that secretion by adrenal gland and it’s consider as stress hormone , act many important role in humane body such as regulation of immune system and metabolic process . Objective of the Study: Role of cortisol in development of DM type 2 disease. Materials and Methods: This study was done on 30 patients with un-control DM type2 patients and 30 control DM type 2 patients , the all subjects age within this study were more than 50 years of both genders .After obtained serum , immediately used quantity method for measured level of serum cortisol concentration . Results: This study shows elevation of serum cortisol concentration level in uncontrol DM type 2 group compare with control DM type 2 group. Conclusion: This study confirms that serum cortisol concentration level can act as support DM type 2 disease .

ABOUT THE ROLE OF THE PODOCIN PROTEIN IN DYSFUNCTION OF KIDNEYS IN PATIENTS WITH DIABETES MELLITUS TYPE 2

2018 ◽  
Vol 22 (5) ◽  
pp. 31-38
Author(s):  
V. M. Ibragimov ◽  
A. M. Aliskandiev ◽  
I. V. Sarvilina
Keyword(s):  
Diabetes Mellitus ◽  
Functional Activity ◽  
Diabetes Mellitus Type 2 ◽  
Control Group ◽  
Mean Values ◽  
Ckd Stage ◽  
Patients With Diabetes ◽  
Dm Type 2

THE AIM: to investigate the role of the podocin in the progression of renal dysfunction in diabetic nephropathy (DN) in patients with diabetes mellitus (DM) type 2.PATIENTS AND METHODS.The study was open, controlled with parallel design in patients with DM type 2 and with CKD 1-3a. The  duration was 4 years. Standard methods for the assessing of  hormonal and metabolic profile of the blood and functional activity of kidneys were performed in patients groups and control group. The  primary endpoint is the dynamics of podocinuria in patients on the basis of the ELISA.RESULTS:The study included 119 patients (61 men and 58 women) with Diabetes mellitus type 2. Diabetic nephropathy. CKD 1-3a.  Patients were divided into 3 groups: group 1 – 37 patients with CKD  Stage 1; group 2 – 47 patients with CKD Stage 2; group 3 – 35  patients with CKD Stage 3a. Control group – persons without DM  and kidney injury (n=30). The participation of podocin in renal  functional activity regulation (dynamics of mean values and  correlations with albumin excretion rate and GFR) and hormonal and  metabolic interactions (dynamics of mean values of fasting glycemia, OGTT, Hb1Ac, C-peptide, creatinine, potassium, total cholesterol,  LDL-C, atherogenic index and their correlations with podocinuria) was shown in patients with DM type 2 and DN.CONCLUSION: podocinuria interrelations with the indices of kidneys functional activity, hormonal and metabolic profile of the blood helps  to detail the molecular mechanism of development of ND in type 2  diabetes. Podocin is promising biomarker of CKD 1-2 stages with type 2 DM.

scholarly journals The Role of Soluble L-Selectin with Polymorphism in Iraqi Arabs Patients with Diabetes Mellitus Type 2

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Asmaa M. Salih Almohaidi ◽  
Kebaa Ahmed Saeed
Keyword(s):  
Diabetes Mellitus ◽  
Serum Level ◽  
Healthy Subjects ◽  
Diabetes Mellitus Type 2 ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group

Diabetes mellitus type 2 [DMT2] is a disturbance of metabolism and complex diseases influenced by environmental, genetic agents, and linked with inflammation, happens when the pancreas either does not use the insulin as it should or the body does not make enough insulin, lead to insulin resistance [IR] alongside with gradual loss of ß-cell secretory ability. The aim of this study was to investigate the role of soluble L-selectin (sL-selectin) in diabetes mellitus type 2 patients in Iraqi Arabs patient. Study includes seventy six Iraqi Arabs patients (male and female) having newly diagnosed type 2 diabetes mellitus (T2DM), with Fifty three Iraqi Arabs healthy subjects matched in age, sex and ethnic group. Patients and healthy subjects were genotyped, by PCR-RFLP analysis, and mesure serum level of L-selectin by enzyme-linked immunosorbent assay (sandwich ELISA) test include 65 patients and 23 controls. The statistical analysis of serum level of sL-selectin in study groups showed that the mean of sL-selectin level high significantly increased in patients group (10.708±1.1007) compared to control group (7.055±0.767) respectively. Thus, our results suggest soluble L-selectin play a role in the development of DMT2 in Iraqi Arabs patients. Present results showed that genotype PS associated with increase the susceptibility of DMT2.

scholarly journals NEW PREDICTIVE FACTORS OF DIABETIC MACULOPATHY DEVELOPMENT IN DIABETES MELLITUS TYPE 2

2018 ◽  
Vol 14 (3-4) ◽  
pp. 60-65
Author(s):  
Yu.O. Panchenko ◽  
S.Yu. Mogilevskyy ◽  
S.V. Ziablitsev ◽  
O.P. Chernobrivtsev
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Logistic Regression ◽  
Prognostic Value ◽  
Control Group ◽  
Blood Levels ◽  
Diabetic Maculopathy ◽  
Factor Α

Relevance. In diabetes mellitus (DM), a cascade of pathological reactions unfolds in the vascular endothelium with the formation of endothelial dysfunction (EDF). Its main factors are endothelium hormone – endothelin-1 (ET1), nitric oxide (NO), endothelial NO-synthase (eNOS), and also tumor necrosis factor-α (TNFα). But the unexplored question remains whether EDFs can be used as prognostic markers for the development of diabetic maculopathy. Objective: to find out the prognostic value of EDF factors in the development of diabetic maculopathy (DM) in type 2 diabetes. Material and methods. This study included 152 patients (304 eyes) with type 2 diabetes, which were divided into groups according to the degree of diabetic retinopathy (DR): 1st – initial non-proliferative DR, 2nd – moderate or severe non-proliferative DR and 3rd – proliferative DR. DM was determined by the presence of specific diabetic retinal changes in the macular area according to the International Clinical Gravity Scale of the American Academy of Ophthalmology (2002). The control group consisted of 95 people. The content of ET1, eNOS and TNFα was determined by ELISA; the content of the final NO metabolites (NOx) was determined spectrophotometrically. Statistical data processing was performed using Statistica 10 (StatSoft, Inc., USA). Results. With the progression of DR, there was an increase in the frequency and severity level of DM (p=2.0e-06), which was accompanied by an increase in the blood levels ET1 (3.7-4.7 times), NOx (1.4-1.5  times) and TNFα (4.2-6.5 times), with a progressive decrease in the level of eNOS (P<0.01). Multifactorial logistic regression analysis (GLZ package; StatSoft, Inc., USA) showed that pathogenetic factors for the DM development were multiple increase in blood levels of ET1 and TNFα, which was confirmed by building a logistic regression model with satisfactory results of adequacy (p=0.039). Conclusions. This study confirmed the significant role of EDF in type 2 diabetes and proved the prognostic value of ET1 and TNFα blood levels for the development of DM.

scholarly journals THE ROLE OF BETA-BLOCKERS IN VETIANGINAL THERAPY IN THE CORRECTION OF VIOLATIONS OF THE AMINO ACID SPECTRUM IN PATIENTS WITH UNSTABLE ANGINA WITH CONCOMITANT DIABETES MELLITUS

2021 ◽  
Vol 77 (3) ◽  
pp. 24-30
Author(s):  
Tetiana Bohdan ◽  
Viktor Lizogub ◽  
Viktoriia Sobol ◽  
Viktor Bohdan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Plasma ◽  
Beta Blockers ◽  
Control Group ◽  
Isoleucine Leucine ◽  
Compensatory Response ◽  
Group I ◽  
Group Ii ◽  
Dm Type 2

The purpose of the study: to study the effect of bisoprolol and nebivolol on the spectrum of essential blood plasma AK in patients with concomitant diabetes mellitus (DM) type 2 in order to optimize drug treatment of this pathology in the future.Material and methods. The study involved 70 patients with NA with concomitant DM type 2, which was divided into two groups: group I (37 patients) as part of basic antianginal therapy received bisoprolol, group II (33 patients) received nebivolol. The control group (CG) consisted of 18 healthy individuals. All patients were tested for irreplaceable blood plasma AA by ion exchange liquid chromatography on an automatic analyzer AK T-339 produced by «Microtechna» (Czech Republic, Prague) at the Institute of Biochemistry named after OV Palladin NAMS of Ukraine. The following essential AAs were identified: arginine, valine, histidine, isoleucine, leucine, lysine, methionine, threonine, phenylalanine. Examination of patients was performed at the beginning of treatment and after 20 days. Results. It was determined that in patients with NA with concomitant DM type 2 under the influence of antianginal therapy in both groups significantly decreased the total amount of irreplaceable AA compared with control group, indicating an increase in intracellular metabolism as a compensatory response in coronary circulation. It should be noted that in patients of group II, in contrast to patients of group I, under the influence of treatment the level of histidine remained normal. The level of threonine significantly decreased compared to CG and the rate of patients in group I, the level of valine significantly increased compared to pre-treatment, the level of isoleucine significantly decreased compared with CG and with the rate of patients of group I. Importantly, ammonia levels returned to normal under the influence of basic therapy, which included nebivolol.Conclusion. The dynamics of changes in the levels of individual irreplaceable AA blood plasma, due to the mechanisms of their metabolic transformations in patients with NA with concomitant DM type 2 indicates greater effectiveness of nebivolol and the feasibility of its prescription іn complex of a basic antianginal therapy.

scholarly journals Impact of the level of metabolic control on the non-surgical periodontal therapy outcomes in diabetes mellitus type 2 patients: Clinical effects

2013 ◽  
Vol 141 (11-12) ◽  
pp. 738-743 ◽  
Author(s):  
Jelena Mirnic ◽  
Milanko Djuric ◽  
Tanja Predin ◽  
Ivana Gusic ◽  
Djordje Petrovic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Control ◽  
Chronic Periodontitis ◽  
Diabetes Mellitus Type 2 ◽  
Treatment Success ◽  
Periodontal Therapy ◽  
Control Group ◽  
Clinical Effects ◽  
Dm Type 2

Introduction. Diabetes mellitus as a complex metabolic disease influences functioning of numerous organs. Chronic periodontitis is one of frequent diabetic complications. Objective. The aim of this study was to compare the clinical effects of non?surgical periodontal therapy between diabetes mellitus type 2 patients (DM type 2) and non?diabetic individuals (control group). Methods. Our study included 41 DM type 2 subjects and 21 non?diabetic individuals, all of them with chronic periodontitis. The diabetic group was divided into two subgroups based on the level of glycosylated hemoglobin (HbA1c) as follows: D1 - 18 subjects with good metabolic control (HbA1c<7%), and D2 - 23 subjects with poor metabolic (HbA1c?7%). State of oral hygiene and periodontal clinical parameters of subjects, such as: plaque index (PI), gingival index (GI), papilla bleeding index (PBI), probing pocket depth (PPD) and clinical attachment level (CAL), were evaluated at the baseline and 3 months after scaling and root?planning. Results. ANOVA test showed that there was no statistically significant difference of treatment success between studied groups in relation to GI (p=0.52), PBI (p=0.36) and CAL (p=0.11). Reduction of PI and PPD in the control group (?PI=0.84; ?PPD=0.35 mm) was significantly higher (p<0.05) than the reduction of PI and PPD in patients with the diabetes (group D1 ?PI=0.60, ?PPD=0.11 mm; group D2 ?PI=0.53, ?PPD=0.11 mm). Conclusion. Although there were differences in treatment success between DM subjects and non?diabetic individuals, they were not significant for the most measured parameters. The results of this study did not absolutely support the assumption that the level of glycemic control significantly affected the periodontal therapy outcome in diabetics.

scholarly journals Spiritual Emotional Freedom Technique against Anxiety and Psychological Well-being of Type 2 DM Patients during the COVID-19 Pandemic

2021 ◽  
Vol 9 (G) ◽  
pp. 260-265
Author(s):  
Ratna Yunita Sari ◽  
Abdul Muhith ◽  
Riska Rohmawati ◽  
Umdatus Soleha ◽  
Imamatul Faizah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Intervention Group ◽  
Well Being ◽  
T Test ◽  
Control Group ◽  
Psychological Well Being ◽  
Type 2 Dm ◽  
The Mean

BACKGROUND: The COVID-19 pandemic makes patients with type 2 diabetes mellitus experience an increase in anxiety, considering that diabetes mellitus is one of the dangerous comorbidities for people infected with the COVID-19 virus so that it affects their psychological well-being. Low psychological well-being will have an impact on decreasing self-care, thereby increasing the occurrence of complications. AIM: The purpose of this study was to analyze the effect of the spiritual emotional freedom technique (SEFT) on anxiety and the psychological well-being of patients with type 2 DM during the COVID-19 pandemic. METHODS: The research design employed is a quasi-experimental research with the untreated control group design with dependent pre-test and post-test samples. The sampling technique used is probability sampling which is a random sampling to meet the inclusion and exclusion criteria with a total sample of 110 respondents with the distribution of the intervention group consisting of 55 respondents and the control group consisting of 55 respondents. The instrument used to measure the level of anxiety is the Hamilton Rating Scale for Anxiety and psychological well-being of Ryff’s psychological well-being. The statistical tests used are Paired Sample t-Test and Independent t-test with significant p < 0.05. RESULTS: The results showed that the mean level of anxiety in the intervention group before the implementation of the intervention was 21.89 (moderate), while after the intervention was 10.98 (mild) and the psychological well-being before the intervention was 147.49 (low), while after the intervention was 170.91 (moderate). Furthermore, in the case of the control group, the mean level of anxiety before the intervention was 19.16 and after the intervention was 19.11 and psychological well-being before the intervention was 146.67 while after the intervention was 146.45. Furthermore, the data analysis obtained that the SEFT affected the level of anxiety and psychological well-being of patients with type 2 diabetes during the COVID-19 pandemic with p = 0.00. CONCLUSION: The SEFT that is routinely implemented can reduce the level of anxiety so that it can improve the psychological well-being of patients with type 2 DM during the COVID-19 pandemic.

scholarly journals Dominant Factor of Diabetic Neuropathy on Diabetes Mellitus Type 2 Patients

2018 ◽  
Vol 6 (1) ◽  
pp. 60
Author(s):  
Arini Rahmawati ◽  
Arief Hargono
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Diabetes Type 2 ◽  
Dominant Factor ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
Dm Type 2

Background: The prevalence of diabetes mellitus (DM) type 2 increased in 2013 by 2.10% from the previous years. It has been reported that the patients of diabetes type 2 patients in RSUD Dr. M. Soewandhi as a public hospital in Surabaya increased in 2014-2016.  Purpose: This study aimed to analyze the dominant factor of diabetic neuropathy in patients with DM type 2. Methods: The study design was case control by taking sample through systematic random sampling. There were 36 respondents contributed in this study as case group and 36 respondents as control group. The independent variables in this study were family history, regulated treatment, diet, physical activity, duration of DM type 2, and hypertension history. Meanwhile, the dependent variable was the diabetic neuropathy of DM type 2 patients. Data were analyzed through a chi square test in order to analyze the relation between variables and logistic regression for dominant variables. Results: Diabetic neuropathy was determined by the regulated treatment (p = 0.02 OR = 5,50), diet (p = 0,04; OR = 4,80), physical activity (p = 0,04; OR = 3,57), and hypertension history (p = 0.03; OR = 3.14). The most dominant factor was regulated treatment (p = 0,01; OR = 13,24). Conclusion: The determinant factors of diabetic neuropathy were regulated treatment, diet, physical activity, and hypertension history, while the most dominant factor was regulated treatment. 

scholarly journals Роль инсулинорезистентности, адипокинового, липидного, провоспалительного статусов в оценке риска развития сахарного диабета через год от начала инфаркта миокарда с подъемом сегмента st

2019 ◽  
pp. 6-12
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Roc Curve ◽  
Prognostic Value ◽  
Adiponectin Concentration ◽  
St Elevation ◽  
One Year ◽  
Dm Type 2

The role of biomarkers of insulin resistance, adipokine, lipid and proinflammatory statuses in the development of new cases of diabetes mellitus (DM) type 2 one year after the start of myocardial infarction with ST elevation (MIwST) has been determined. The study included 136 men with MIwST at the age of 58 (53; 70) years. A year after the onset of myocardial infarction, diabetes debuted in 20 (14,7 %) patients. It has been established that the HOMA-IR index ≥2,77 possesses the greatest prognostic value in relation to the development of diabetes a year after IM on the 12th day of IM; 95 (0,92; 0,99), the sensitivity of the predictive value of the indicator – 95,0, specificity – 47,4. Also, an increase in the risk of diabetes is determined with an increase in the serum on the 12th day of IM levels of biomarkers such as: insulin ≥12,7 μIUml, the area under the ROC curve is 0,95 (0,91; 0,98), sensitivity – 95,0, specificity – 73,3; leptin ≥5,77 ng/ml, the area under the ROC curve is 0,76 (0,65; 0,87), sensitivity is 90,0, specificity is 45,7; interleukin-6 (IL-6) ≥5,7 pg/ml, the area under the ROC-curve – 0,73 (0,61; 0,86), sensitivity – 95,0, specificity – 28,4; free fatty acids (FFA) ≥0,61 mmol/l, the area under the ROC curve is 0,70 (0.56;0,84), sensitivity is 65,0, specificity is 44,0. With an increase in adiponectin concentration ≥8,2 µg / ml on the 12th day of IM, the likelihood of developing diabetes after a year from the onset of IM is reduced by 28,0 %, the area under the ROC curve is 0,74 (0,64; 0,85), sensitivity – 82,8, specificity – 35,0. When forming groups of patients with MIwST with a high risk of developing type 2 diabetes, the HOMA-IR index, insulin, leptin, IL-6, FFA, adiponectin levels determined on the 12th day of IM in serum should be taken into account.

ROLE OF HS-CRP AND IRISIN IN OBESITY AND TYPE II DIABETES MELLITUS

2021 ◽  
pp. 46-47
Author(s):  
Pankaj Kambale ◽  
Sandip Lambe ◽  
Kanchan Lambe
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Control Group ◽  
Case Group ◽  
Type Ii ◽  
Hs Crp

Background: Overweight and type of II diabetes is emerging as important disease and the prevalence of these diseases is also increasing signicantly. Studies had proposed that irisin is having a role to play in pathophysiology of obesity and other metabolic diseases. The patients who are having type 2 diabetes are found to have higher irisin levels. The study on the association of irisin and hs-CRP with obesity and type 2 diabetes is increasing. Aim: The aim of the present study is to identify the role of irisin and HS-CRP in obesity and type II diabetes mellitus. Material and Methods: This was a community based cross-sectional study which is conducted on the medical OPD visitors of a tertiary care centre. For conducting this study 50 participants ageing between 10-50 years were selected and both male and female participants were included in this research study. In this study 25 patients belong to the case group and 25 patients were of the control group. Results: In the present study the mean of the HS-CRP was found to be 1.45±0.56 for case group and for the control group it was found to be 0.83±0.49. In the present study the mean irisin value for the case group was found to be 8.27±3.21 and for the control group it was found to be 7.47±2.54. Conclusion: In the current study it was found that the hs-CRP and the irisin level of the patients with type 2 diabetes and obesity are higher as compared with the normal individuals. It can be said that both the hs-CRP and the irisin level are positively associated with the obesity and type II diabetes mellitus.

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