scholarly journals Combined effect of Levothyroxine, Antihyperlipidemic and oral hypoglycemic agents on lipid profile and cognition level in hypothyroidism patients

2021 ◽  
Vol 23 (11) ◽  
pp. 20-29
Author(s):  
S. Anandkumar ◽  
◽  
P. Shanmugapandiyan ◽  
Keyword(s):  
Combination Therapy ◽  
Lipid Profile ◽  
Cognitive Skills ◽  
Density Lipoprotein ◽  
Hypoglycemic Agents ◽  
Control Group ◽  
Thyroid Disorder ◽  
Oral Hypoglycemic Agents ◽  
Group 3 ◽  
Group 1

Aim: To evaluate the effect of combination therapy on lipid profile and cognition level in hypothyroidism patients. Methods: A prospective observational study was conducted in a private hospital at Tiruchengode. Patients who were under the management of thyroid disorder and hyperlipidemia more than 10 years was screened and selected for the study. There were 155 patients were included in the study and the patients who were on Levothyroxine 50mcg as control (Group 1), Group 2 Patients prescribed with levothyroxine 50mcg and Atorvastatin 20mg were checked with lipid profile parameter like Total cholesterol (TC), Triglycerides (TG), High density Lipoprotein (HDL-C), Low density Lipoprotein (LDL-C) and compared with control group values. Group 3 patients prescribed with levothyroxine 50mcg and Atorvastatin 20mg, Glimepride 2mg, Metformin 500mg were checked with lipid profile, compared with control group. The patients were interviewed using a Mini mental state examination questionnaire and their cognitive skills were assessed and compared with control group. Independent samples T test was used to compare the complication of the management. Conclusion: Hyperlipidemia management with levothyroxine 50mcg and Atorvastatin 20mg, Glimepride 2mg, Metformin 500mg (Group 3) has an association on the managing lipid profile efficiently than the control (Group 1) Significant (p<0.01). Cognition impairment was high in the combination therapy. (p <0.01)

scholarly journals Arterial hypertension in combination with atrial fibrillation and extracardiac diseases

2018 ◽  
Vol 99 (6) ◽  
pp. 894-899 ◽  
Author(s):  
L D Khidirova ◽  
D A Yakhontov ◽  
S A Zenin
Keyword(s):  
Atrial Fibrillation ◽  
Arterial Hypertension ◽  
Comparison Group ◽  
Density Lipoprotein ◽  
Control Group ◽  
Galectin 3 ◽  
Group 3 ◽  
The Difference ◽  
Group 5 ◽  
Group 1

Aim. To evaluate the character of the course and to determine the features of biochemical manifestations in patients with atrial fibrillation and arterial hypertension combined with extracardiac diseases. Methods. To study the features of the course of persisting form of atrial fibrillation (AF) in patients with arterial hypertension (AH) stage 3 combined with extracardiac diseases. 374 patients aged 45 to 65 years were examined. Among them chronic obstructive pulmonary disease (COPD; n = 37), diffuse toxic goiter (DTG; n = 33), hypothyroidism (HT; n = 69), diabetes mellitus (DM; n = 49) and abdominal obesity (AO; n = 64) of mild and moderate degree were detected. 5 groups were formed: group 1 - AH + AF + COPD, group 2 - AH + AF + HT, group 3 - AH + AF + DTG, group 4 - AH + AF + DM, group 5 - AH + AF + AO. The control group included 56 patients with AH and AF without concomitant diseases, and the comparison group included 36 patients with AF without AH and 30 patients with AH without AF. The study evaluated clinical, anthropometric and laboratory parameters, the results of instrumental diagnostic investigation. The level of galectin-3 was determined in the serum by ELISA. The concentration of brain natriuretic peptide (NT-proBNP) was measured with a panel “NT-proBNP - ELISA - Best”. Multiple comparisons of the groups were performed with Kruskal - Wallis test. To compare binary and categorical parameters, exact two-tail Fisher’s test was used. Optimal multivariate regression models were developed directly and reversely. Verification of statistical hypotheses was carried out with critical value of significance p = 0.05 i.e. the difference was considered statistically significant if p < 0.05. All statistical calculations were performed with the use of R-Studio soft. Results. When assessing the lipid profile in the studied groups, significant differences were detected for HDL (high density lipoprotein) the values of which were the highest in the control group; TC (total cholesterol) was significantly lower in group 1 and 2; LDL (low density lipoprotein) and TG (triglycerides) - in group 3. The level of uric acid in the serum in all clinical groups was higher compared to those of the control group but significance was reached only in group 3. The concentration of K+ in the blood was significantly higher in all groups compared to the control group. The study of NT-proBNP and galectin-3 as markers reflecting the processes of remodeling and myocardial fibrosis in patients with atrial fibrillation combined with arterial hypertension, demonstrated that the average level of NT-proBNP in all groups was higher than in the control group but the difference was significant only in group 5. The level of galectin-3 in the serum of patients with arterial hypertension and atrial fibrillation combined with comorbid extracardiac pathology was significantly higher in the groups compared to the control group (except for group 3 where the number of patients was the lowest) and significantly lower in the comparison group of patients with atrial fibrillation without arterial hypertension. Conclusion. The course of arterial hypertension and atrial fibrillation with concomitant extracardiac diseases is characterized by the changes of biochemistry, which manifest as the changes of lipid profile, electrolyte content and factors inducing fibrosis. The obtained data confirm the possible role of galectin-3 as a biological marker of fibrosis and myocardial remodeling in patients with AF and AH and comorbid extracardiac pathology.

Pattern of dyslipidemia among patients with subclinical hypothyroidism and its relation with thyroid stimulating hormone

2021 ◽  
Vol 11 (3) ◽  
pp. 172-178
Author(s):  
Nazma Akter ◽  
Tangera Akter
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
Thyroid Stimulating Hormone ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Thyroid Disorder ◽  
Serum Tsh ◽  
Stimulating Hormone

Background: The relationship between subclinical hypothyroidism (SCH) and dyslipidemia is still debatable about whether SCH is constantly associated with lipid disorder. The aim of this study was to assess the lipid abnormalities in patients with SCH and to evaluate the relation between thyroid stimulating hormone (TSH) and lipid profile. Methods: This cross-sectional observational study was conducted in outpatient department (OPD) of the Hormone and Diabetes Clinic at MARKS Medical College & Hospital in Dhaka, Bangladesh from May 2018 to October 2019. A total of 308 subjects (age 30 - 60 years) were included in this study using covenience sampling. Among them, 156 were diagnosed case of SCH, while 152 were euthyroid healthy individuals in control group (matched for age, gender and weight). Laboratory test included serum TSH and free thyroxine (FT4) and fasting lipid profile. Data were analyzed using SPSS version 18 statistical software. Results: In this study, dyslipidemia was more prevalent in patients with SCH compared to control group [p<0.001]. SCH group showed altered lipid profile i.e. significantly higher serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglycerides (TGs) and lower high density lipoprotein cholesterol (HDL-C) when compared with the euthyroid subjects [p < 0.05 for each]. Pearson’s correlation coefficient for the relationships between serum TSH and lipid level showed that TSH levels were positively correlated with TC, LDL-C, TG and negatively correlated with HDL-C in patients with SCH [p < 0.05 for each]. Conclusions: Dyslipidemia is a common feature in SCH compared to euthyroid controls. The study showed that TSH level was positively correlated with TC, LDL-C, TG and negatively correlated with HDL-C. SCH should be a matter for further investigation because dyslipidemia is associated with this thyroid disorder. BIRDEM Med J 2021; 11(3): 172-178

scholarly journals Effects of Methanolic Root Extract of Holarrhena floribunda on the Lipid Profile and Sex Hormones in Wistar Rats

2019 ◽  
pp. 1-7
Author(s):  
Dennis, Amaechi ◽  
E. O. Udosen ◽  
V. S. Ekam ◽  
I. P. Ekpe
Keyword(s):  
Lipid Profile ◽  
Sex Hormones ◽  
Wistar Rats ◽  
Test Group ◽  
Control Group ◽  
Root Extract ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim: This study aims to determine the effects of methanolic root extract of Holarrehna floribunda on the level of some serum sex hormones, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, estradiol, progesterone and lipid profile in Wistar rats.   Materials and Methods: Twenty- four male and female Wistar rats (150-250 g body weight) were randomly assigned into 4 groups of 6 rats each. Group 1 (control male) took normal rat chow and drinking water. Group 2 (control female) took normal rat chow and drinking water, Group 3(Male test group), was administered with 200 mg/kg of Holarrehna floribunda extract, Group 4(Female test group), was administered with 200 mg/kg of Holarrehna floribunda. The feeding regimens lasted for 5weeks. Results: The values for the lipid profile shows CHOL in Group 1 and Group 3 were 4.02±0.41 mmol/l  and 5.75±0.09 mmol/l, Group 2 and Group 4 were 3.87±0.22 mmol/l  and 5.80±0.10 mmol/l  respectively, TRIG  for Group 1 and Group 3 were 1.30±0.05 mmol/l  and 2.11±0.15 mmol/l  for Groups 2 and 4 were 1.15±0.03 mmol/l  and (2.10±0.12 mmol/l,HDL-C for Groups 1 and 3 were 30.01±0.82 mg/dL  and 39.88± 1.24mg/dL,for Groups 2 and 4 were 29.98± 0.77 mg/dL  and 38.20± 1.83 mg/dL, LDL-C for Groups 1 and 3 were 2.26±0.37 mmol/L  and 4.17±0.35 mmol/L respectively, for Groups 2 and 4 were 3.27±0.47 mmol/L  and 4.06±0.21 mmol/L  respectively, shows significant increase(p<0.05) in HDL-C (mg/dL) in Groups 1,2,3 and 4.The values obtained showed significant increase (p<0.05) in HDL-C (mg/dL) in Groups 1,2,3and 4The serum concentrations of FSH, Estradiol, LH and progesterone in the control Group 2 were 0.38 ±0.07mIU/mL, 7.83±0.35 mIU/mL, 15.50±0.15 Pg/mL and 0.86±0.03 ng/mL respectively, and in test Group 4 were 0.77±0.04mIU/mL, 8.75±0.17 mIU/mL, 21.09±0.79 Pg/Ml 0.33±0.05 ng/mL. Follicle stimulating hormone levels was significantly higher (p<0.05) in test group compared with control. While in Group 1 and 3, the serum concentrations of FSH, LH, and testosterone in control Group 1 were (0.51 ±0.06) mIU/mL, (16.44±0.31) mIU/mL and (8.41±0.50) ng/mL respectively and in test Group 3 were 0.88±0.06 mIU/mL19.88±1.46mIU/mL and10.68±0.64 ng/mL, respectively. Conclusion: The extract improves the level of sex hormones in both the male and female rats.  which could enhance reproductive functions in normal rats and those with loss of reproductive function.

scholarly journals Effects of Feeding Periods of High Cholesterol and Saturated Fat Diet on Blood Biochemistry and Hydroxyproline Fractions in Rabbits

2008 ◽  
Vol 2 ◽  
pp. BBI.S445 ◽  
Author(s):  
Mohamed A.K. Abdelhalim ◽  
N.J. Siiddiqi ◽  
A.S. Alhomida ◽  
Mohammed S. Al-Ayed
Keyword(s):  
White Male ◽  
Saturated Fat ◽  
Density Lipoprotein ◽  
Total Serum ◽  
Control Group ◽  
High Cholesterol ◽  
Group 3 ◽  
Significant Change ◽  
Group 2 ◽  
Group 1

Hypercholesterolemia and hypertriglyceridemia are considered as important risk factors during the atherosclerotic process. The aim of the present investigation was to study the total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), high density lipoprotein (HDL), triglyceride (TG), platelet levels and hydroxyproline fractions during the pathogenesis of atherosclerosis. For this purpose, twenty five 12-weeks, New Zealand white male rabbits, were purchased, individually caged, and divided into either control group or cholesterol-fed group. The control group (n = 10) was fed 100 g/day of normal diet, ORC-4 (Oriental Yeast Co. Ltd., Tokyo, Japan) for a period of 15 weeks. The cholesterol-fed group (n = 15) was fed a high cholesterol and saturated fat diet of ORC-4 containing 1% cholesterol plus 1% olive oil (100 g/day) for periods of 5 (group 1), 10 (group 2) and 15 (group 3) weeks. Blood sample from each animal was taken at the end of the experimental period for the biochemical analysis. The results of the present study showed that TC, LDLC, TG, HDLC and platelets were significantly (P < 0.01) increased in cholesterol-fed rabbits as compared with control rabbits. The serum hydroxyproline (Hyp) in rabbits belonging to group 1 showed no significant alteration when compared to control group. Group 2 rabbits showed a significant increase of 103% (P < 0.01) and 100% (P < 0.001) in free and protein—bound hydroxyproline fractions respectively when compared to control rabbits. However, there was no significant change in peptide—bound and total serum hydroxyproline levels as compared to the control group (P > 0.05). There was no significant (P > 0.05) decrease of free serum hydroxyproline in group 3 rabbits when compared to control rabbits. On the other hand, group 3 rabbits showed a significant increase in peptide-bound and protein- bound Hyp by 517% (P < 0.05) and 100% (P < 0.01) respectively when compared to control rabbits. However, total serum Hyp in group 3 rabbits showed no significant (P > 0.05) change when compared to control rabbits. These results suggest that feeding rabbits high cholesterol and saturated fat diet for feeding periods of 5, 10 and 15 weeks induced significant change in TC, LDLC, HDL, TG, platelet levels and various Hyp fractions in serum without any significant change in the total Hyp content.

scholarly journals Effects of splenic allograft in lipid profile of non-splenectomized rats: the immune and metabolic role of the "double spleen"

2014 ◽  
Vol 41 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Thiago Barbosa Gonçalves ◽  
Vitor Nagai Yamaki ◽  
Daniel Haber Feijó ◽  
Luis Eduardo Almeida de Souza ◽  
Edvaldo Silveira ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Splenic Tissue ◽  
Control Group ◽  
Group 4 ◽  
Metabolic Role ◽  
Male Wistar Rats ◽  
Group 3 ◽  
Group 1

OBJECTIVE: To elucidate the role of the spleen and splenic allograft in lipid control and evaluate its effect on the lipid profile of rats.METHOD: 32 male Wistar rats were randomly assigned into four groups: control group (1), total splenectomy group (2), splenectomy and implantation of allograft group (3) and double spleen group (4). Each group was subdivided into two subgroups: A and B, based on the death of the animals after 30 or 120 days of monitoring. The procedures in groups 2, 3 and 4 were made simultaneously, and splenectomized animals, groups 2 and 3 were donors, respectively, for the animals of groups 3 and 4. In group 4 the spleen was preserved and the animals received implants from the spleens of rats from group 3. The regeneration of splenic tissue was evaluated by macroscopic and microscopic analyzes of the grafts and own spleens, as well as with measurements of VLDL, HDL, LDL, total cholesterol and triglycerides.RESULTS: after 120 days, Group 4 showed levels of total cholesterol and LDL lower than the other groups. Group 1 had higher levels of lipids.CONCLUSION: The technique of double spleen was effective in the control of lipid metabolism, corroborating the function of the spleen as a reserve of lipids.

scholarly journals THE EFFECT OF NUTRITION EDUCATION AND GYMNASTICS CREATIONS OF SASAK (Rudat dance) AGAINST WEIGHT CHANGE, BMI, AND LIPID PROFILE TO OVERWEIGHT STUDENTS AT NUTRITION DEPARTMENT OF POLITEKNIK KESEHATAN MATARAM

2018 ◽  
Vol 12 (2) ◽  
pp. 124
Author(s):  
Retno Wahyuningsih ◽  
Ni Putu Anita Candri ◽  
Siti Noor Aulya Faridha
Keyword(s):  
Lipid Profile ◽  
Nutrition Education ◽  
Weight Change ◽  
High Energy ◽  
Lifestyle Changes ◽  
Blood Cholesterol ◽  
Control Group ◽  
Group 3 ◽  
Keywords Education ◽  
Group 1

Abstract: The lifestyle changes in some societies today lead to a modern lifestyle, including dietary changes that change to the selection of foods with high energy and fat. Excessive energy consumption becomes the cause of obesity. Obesity, in addition becomes a health problem, also a problem for one's appearance. Obesity is associated with lipid profile. Obesity interventions can be done by setting the diet through nutrition education and exercise in the form of gymnastics creations dance exercises. Objective study was to know the effect of nutrition education (REST diet) and gymnastics creations (Rudat dance) against weight change, BMI, and lipid profile to overweight students at Nutrition Department of Politeknik Kesehatan Mataram. Research Method was Quasi experiment, randomized pre-post control group to 33 students, age 18-22 years. The data were analyzed by Univariat for the distribution of research variables and Bivariate test with different test of Paired t-test. There was significant weight loss in group 1 (χ ± SD: 0.35 kg ± 0.43, p: 0.030), and group 3 (1.72 ± 1.78, p: 0.014). While on IMT decrease in. group 1 (0.15 kg/m2 ± 0.19, p: 0.033), and group 3 (0.68 ± 0.63, p: 0.008). As for the lipid profile, there was no decrease in blood cholesterol levels, and there was a decrease in triglycerides in group 3 (24.4 ± 28.59, p: 0.024). Keywords: Education REST Diet, Creative Gymnastics, Weight, BMI, Lipid Profile, Excess Weight.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

The Effects of the "XGTQ" Medicine in Treating Cirrhosis in Wistar Rats

2020 ◽  
Vol 06 ◽  
Author(s):  
Ngan Nguyen Hoang ◽  
Thang Duong Minh ◽  
Tuan Anh Hoang ◽  
Son Le Ngoc Bich ◽  
Duong Nguyen Huu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reference Group ◽  
Control Group ◽  
Plain Water ◽  
Group 4 ◽  
White Rats ◽  
Collagen Accumulation ◽  
Activity Of Enzymes ◽  
Group 3 ◽  
Group 1

Objectives: Evaluate the effects of "XGTQ" in the treatment of cirrhosis induced by Carbon tetrachloride (CCL4) in combination with alcohol and high-fat diet on Wistar rats. Materials and methods: Cirrhosis on white rats was induced by subcutaneously injecting CC14 at an initial dose of 5,0ml/kg, followed by 1,2ml/kg once a week in 10 weeks. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered every day with plain water and 1 day with water mixed with 30% ethanol. The rats were randomly divided into 5 groups and given distilled water (group 1 and 2 or control group), silymarin (group 3 or reference group) or the "XGTQ" drug extract (group 4, 5) for 4 weeks. Collected blood for biochemical test and liver were dissected to evaluate weight, morphology and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation. Results: In cirrhotic wistar rats, "XGTQ" drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability of reducing the activity of enzymes AST, ALT in the blood (p<0.01), increasing plasma albumin and decreasing prothrobin time (p<.05); improving physical condition, macroscopic and microscopic images of H&E-stained liver; decreasing the concentration of hydroxyproline in the liver and reducing the level of cirrhosis on the masson-stained templates. The effects of "XGTQ" increased with the dose, and was equivalent to silymarin at the dose of 70 mg/kg/24h. Conclusion: The extract of "XGTQ" drug is effective in treating cirrhosis in Wistar rats.

scholarly journals Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177® (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3534
Author(s):  
Joseph Aliaga ◽  
Aldo Bonaventura ◽  
Eleonora Mezzaroma ◽  
Yogesh Dhakal ◽  
Adolfo Gabriele Mauro ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Diastolic Function ◽  
Nlrp3 Inflammasome ◽  
Ischemic Cardiomyopathy ◽  
Left Ventricular ◽  
Control Group ◽  
Contractile Reserve ◽  
Standard Diet ◽  
Group 3 ◽  
Group 1

Interleukin-1β (IL-1β), a product of the NLRP3 inflammasome, modulates cardiac contractility and diastolic function. We proposed that OLT1177® (dapansutrile), a novel NLRP3 inhibitor, could preserve contractile reserve and diastolic function after myocardial infarction (MI). We used an experimental murine model of severe ischemic cardiomyopathy through the ligation of the left coronary artery without reperfusion, and after 7 days randomly assigned mice showing large anterior MI (>4 akinetic segments), increased left ventricular (LV) dimensions ([LVEDD] > 4.4 mm), and reduced function (LV ejection fraction <40%) to a diet that was enriched with OLT1177® admixed with the chow in the diet at 3.75 g/kg (Group 1 [n = 10]) or 7.5 g/kg (Group 2 [n = 9]), or a standard diet as the no-treatment control group (Group 3 [n = 10]) for 9 weeks. We measured the cardiac function and contractile reserve with an isoproterenol challenge, and the diastolic function with cardiac catheterization at 10 weeks following the MI surgery. When compared with the control (Group 3), the mice treated with OLT1177 (Group 1 and 2) showed significantly greater preservation of their contractile reserve (the percent increase in the left ventricular ejection fraction [LVEF] after the isoproterenol challenge was +33 ± 11% and +40 ± 6% vs. +9 ± 7% in the standard diet; p < 0.05 and p < 0.005 for Group 1 and 2, respectively) and of diastolic function measured as the lower left ventricular end-diastolic pressure (3.2 ± 0.5 mmHg or 4.5 ± 0.5 mmHg vs. 10.0 ± 1.6 mmHg; p < 0.005 and p < 0.009 respectively). No differences were noted between the resting LVEF of the MI groups. These effects were independent of the effects on the ventricular remodeling after MI. NLRP3 inflammasome inhibition with OLT1177® can preserve β-adrenergic responsiveness and prevent left ventricular diastolic dysfunction in a large non-reperfused anterior MI mouse model. OLT1177® could therefore be used to prevent the development of heart failure in patients with ischemic cardiomyopathy.

scholarly journals Effect of Whole Quail (Coturnix japonica) Egg Consumption on some Reproductive Parameters and Lipid Profile of Male Albino Rat (Rattus norvegicus)

2017 ◽  
Vol 9 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Chidozie N. OKOYE ◽  
Samuel O. EKERE ◽  
Onyinyechukwu A. AGINA ◽  
Ikechukwu J. UDEANI ◽  
Chukwunonso K. EZEASOR
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Epididymal Sperm ◽  
Treatment Groups ◽  
Egg Consumption ◽  
Group A ◽  
The Mean

The present study evaluated the effect of whole egg consumption on the liver, testes, cauda epididymal sperm reserve and lipid profile of male rats. These evaluations were carried out on adult twenty (20) male albino rats, which were randomly selected into four groups of 5 rats each, designated groups A, B, C and D. Group A was the control group and received only equivalent volume of distilled water, while groups B, C and D received 0.25mg/kg, 0.5mg/kg; and 1.0mg/kg body weight of the quail egg respectively. Standard procedures were carried out in the tissue processing, cauda epididymal sperm reserve and in lipid profile determinations. On days 35 and 49, the mean serum total cholesterol value of group D was significantly lower than that of the control group. On day 35, the mean serum low density lipoprotein and high density lipoprotein (LDL and HDL cholesterol) values of all the treatment groups were significantly lower and higher than that of the control group, respectively. However, on days 49 and 63, the mean serum very low density lipoprotein (VLDL cholesterol) and triglyceride values of all the treatment groups were significantly higher than that of the control group. A significant increase in cadual epididymal sperm count (CESR) was recorded on day 63 at the mid and high doses. No obvious pathological lesions were observed in the histomorphology of the testes and liver when compared to the control. Therefore, whole quail egg consumption caused an increase in serum triglyceride and very low density lipoprotein concentration, and also improved fertility. In other words, prolonged consumption of quail egg should be done with caution as it may predispose one to cardiovascular disease.

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