scholarly journals FREQUENCY AND ASSOCIATIONS OF MARCUS GUNN PHENOMENON IN CONGENITAL PTOSIS

2021 ◽  
Vol 71 (3) ◽  
pp. 783-86
Author(s):  
Maqsood Ahmad ◽  
Hafiza Sadia Imtiaz ◽  
Usama Iqbal ◽  
Muhammad Sharjeel ◽  
Syed Imad Zahir ◽  
...  
Keyword(s):  
Family History ◽  
Observational Study ◽  
Study Design ◽  
Refractive Error ◽  
Positive Family History ◽  
Common Type ◽  
Cross Sectional ◽  
Congenital Ptosis ◽  
Anisometropic Amblyopia ◽  
Department Of Ophthalmology

Objective: To determine the frequency and various associations of Marcus Gunn Phenomenon in patients of congenital ptosis. Study Design: Cross-sectional observational study. Place and Duration of Study: Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, from Jun to Sep 2020. Methodology: A total of 100 patients with congenital ptosis were included. Patients with any cause of secondary or acquired ptosis were excluded. Congenital ptosis was classified as simple and complex. Assessment for ptosis severity, presence of jaw winking ptosis, jaw winking severity, refractive error, amblyopia, strabismus, systemic association and family history for congenital ptosis was performed. Results: Simple congenital ptosis was the most common type overall (84%). A total of 60% patients were males and 40% were females. More than 90% of the patients had severe ptosis. Ninety eight percent cases had onset since birth. No patient had systemic association or positive family history. Nine percent frequency of Marcus Gunn Phenomenon was noted with congenital ptosis. All the patients with Marcus Gunn Phenomenon had unilateral presentation. Left eye was affected predominantly (88.89%). A total of 22.22% of the patients with Marcus Gunn Phenomenon had anisometropic amblyopia. No other ocular or systemic association of Marcus Gunn Phenomenon was observed. Conclusion: Simple congenital ptosis is the most common type of congenital ptosis. The authors report 9% frequency of Marcus Gunn Phenomenon with congenital ptosis and left side effected predominantly. Anisometropic amblyopia was the major ocular association of Marcus Gunn Phenomenon observed.

scholarly journals A cross-sectional analysis of refractive error prevalence and associated factors among elementary school children in Hawassa, Ethiopia

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199889
Author(s):  
Kindie Desta Alem ◽  
Elias Abera Gebru
Keyword(s):  
Elementary School ◽  
Family History ◽  
School Children ◽  
Refractive Error ◽  
Grade Level ◽  
Elementary School Children ◽  
Associated Factors ◽  
Positive Family History ◽  
School Type ◽  
Cross Sectional

Objective This study assessed the prevalence of refractive error (RE) and its associated factors among elementary school children in Hawassa, Ethiopia. Methods In this school-based cross-sectional study, a random selection technique with proportional allocation was used to ensure a representative sample of students. Survey questionnaires were used to collect sociodemographic, environmental, and family history data. Clinical examinations were performed to assess RE and ocular health. Associations between dependent and independent variables were computed using adjusted odds ratios (AORs) and 95% confidence intervals (CIs). Results Overall, 529 children participated in this study, with a response rate of 95.5% (529/554). Most participants were aged ≥12 years (337 [63.7%]), in grade levels 5 to 8 (307 [58%]), and attended public schools (366 [69.2%]). RE prevalence was 12.9% (95% CI: 10.0–16.1). Higher grade level (AOR=3.18, 95% CI: 1.68–5.97), positive family history of RE (AOR=3.69, 95% CI: 1.57–8.67), lack of paternal formal education (AOR=3.25, 95% CI: 1.20–8.77), and public school attendance (AOR=3.33, 95% CI: 1.52–7.27) were factors significantly associated with RE. Conclusions RE prevalence among elementary school children in Hawassa was higher than in previous reports. Grade level, family history, paternal education level, and school type significantly influenced RE status.

scholarly journals Prevalence of Refractive Errors among Medical Students and Identification of Associated Factors

2021 ◽  
Vol 2 (4) ◽  
pp. 5
Author(s):  
Saadia Maqbool ◽  
Abdul Rehman Rizwan ◽  
Iram Manzoor ◽  
Ali Qais ◽  
Aleena Furqan ◽  
...  
Keyword(s):  
Medical Students ◽  
Family History ◽  
Refractive Error ◽  
Family Income ◽  
Positive Family History ◽  
Sampling Technique ◽  
P Value ◽  
Refractive Errors ◽  
Cross Sectional ◽  
Mobile Use

Objective: To determine the prevalence of refractive errors among medical students and identify associatedfactors.Study Design: Analytical, cross-sectional study.Place and Duration of Study: The study was conducted in the Department of Community Medicine at AkhtarSaeed Medical and Dental College, Lahore from September 2020 to December 2020.Materials and Methods: The study included 300 medical students using convenience sampling technique. Aself- structured pre- tested questionnaire was used. All medical students including MBBS, BDS, Pharm –D andallied health sciences were included in the study. Those students who did not give consent were excluded fromthe study. Data analysis was done with SPSS version 23. Chi square test of significance was applied to findassociation between the variables and p-value < 0.05 was considered statistically significant.Results: Refractive error was observed in 203 students (67.7%). The commonest refractive error was myopia(37%) followed by hypermetropia (23.7%) and astigmatism (7%). The prevalence of refractive errors wassignificantly associated with positive family history (p value=<.001), family income per month (p value=0.01)and mobile use per day (p value=0.001). Higher percentage of refractive error (70.6%) was reported byparticipants who were comfortable with light in which they study (p value=0.03).Conclusion: The prevalence of refractive error was 67.7% among medical students, and myopia was the mostprevalent refractive error. Refractive errors were significantly associated with positive family history, familyincome and mobile use per day.

scholarly journals Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Uzair Abbas ◽  
Bushra Imdad ◽  
Sikander Adil Mughal ◽  
Israr Ahmed Baloch ◽  
Afshan Mehboob Khan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Micro Rna ◽  
Cross Sectional ◽  
Family History Of Diabetes ◽  
History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

What is known about Prostate Cancer? Response from Men Aged 50 Years and Above in Lindi Municipal, Tanzania

2020 ◽  
Vol 31 (2) ◽  
pp. 33-44
Author(s):  
Simon Francis ◽  
Obadia V. Nyongole
Keyword(s):  
Prostate Cancer ◽  
Family History ◽  
Positive Family History ◽  
Negative Attitude ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Adult Men ◽  
History Of ◽  
One Year ◽  
High Level

Background: The incidence of prostate cancer in Tanzania is among the highest recorded in Africa. Prostate cancer is also the most common cancer among men aged 50 years and above in Tanzania. Our study aimed to determine the awareness, knowledge, and attitudes among adult men with age 50 years and above regarding prostate cancer.Methods: This was a cross-sectional study that included 250 adult men aged 50 years and above in Lindi municipal being purposively selected and we interviewed them by using a structured questionnaire. A stratified random sampling method was used for obtaining our participants. All men who had stayed for not less than one year in Lindi and willing to participate were enrolled in the study. These men were selected at households without screening whether or not they had taken prostate screening test or had been diagnosed with prostate cancer Quantitative data were cleaned and analyzed with SPSS version 20.Results: Majority, 216(86.7%) of our study participants were aged 50–69 years and most of them, 142(56.8%) had primary education with 93.2% of them being married. Among the study subjects 7.2% had positive family history of cancer and 195(78%) were aware of prostate cancer with source of information being mass media (62.6%). Majority of them, 63.2%, did not know the risk age group. Few, 20.8% of our participants had good knowledge while majority, 95.2% had negative attitude toward prostate cancer. We found a statistically significant association between level of education, family history and level of knowledge regarding prostate cancer with p < 0.005.Conclusion: This study revealed high level of awareness, but poor knowledge regarding prostate cancer and negative attitude toward prostate cancer among men with age ≥50 years in Lindi municipal Tanzania. Key words: Awareness, knowledge, attitude, prostate cancer.

Adolescent-Onset Hidradenitis Suppurativa: Prevalence, Risk Factors and Disease Features

Dermatology ◽  
2018 ◽  
Vol 235 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Alejandro Molina-Leyva ◽  
Carlos Cuenca-Barrales
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Hidradenitis Suppurativa ◽  
Disease Duration ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Female Sex ◽  
Potential Risk Factors ◽  
Sex Positive

Background/Aims: Hidradenitis suppurativa (HS) is a chronic inflammatory and destructive skin disorder. Early diagnosis and treatment are critical to stop its progression. Data concerning adolescent-onset HS are scarce. The aims of this study are to describe the prevalence of adolescent-onset HS and to explore potential risk factors and the disease features of these patients. Patients and Methods: A cross-sectional study including 134 patients was performed. Results: Adolescent-onset HS occurred in 51.5% (69/134) of patients. Adolescent-onset HS was associated with female sex, positive family history, presence of pilonidal sinus, acne conglobata, longer disease duration and a worse perception of disease severity. Conclusion: Adolescent-onset HS might be more frequent than previously reported. Female sex, positive family history and the presence of elements of the follicular occlusion tetrad identify individuals with a higher risk of early onset. These patients experience a longer disease duration and perceive their disease as severer.

scholarly journals Clinical and Demographic Profiles of Patients Diagnosed as Cough Variant Asthma attended at Tertiary Referral Hospital

2017 ◽  
Vol 2 (1) ◽  
pp. 30-33
Author(s):  
SK Shahinur Hossain ◽  
Md Safiul Islam ◽  
Md Mustafizur Rahman ◽  
Shubhashish Dey ◽  
Khurshid Mahmud
Keyword(s):  
Family History ◽  
Positive Family History ◽  
Challenge Test ◽  
Young Male ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
Cough Variant Asthma ◽  
Demographic Profiles ◽  
History Of ◽  
Study Population

Background: Cough variant asthma is presented with different clinical and demographic characteristics.Objectives: The purpose of the present study was to see the clinico-demographic profiles of cough variant asthma patients.Methodology: This descriptive type of cross-sectional study was carried out in theDepartment of Respiratory Medicine at National Institute of Diseases of the Chest and Hospital (NIDCH), Dhaka, Bangladesh from September 2014 to August 2015 for a period of one year. Patients presented with cough variant asthma attending in NIDCH were selected as study population. Methacholine challenge test was performed to diagnosis of Cough Variant Asthma. Result: A total number of 50 patients were recruited for this study. The mean age±SD was found 19.1±7.6 years. Male was predominant than female with a ratio of 1.4.:1. Among the study population positive family history of asthma was found in 39.0% cases and associated allergic rhinitis was reported in 58.0% cases. Eczema was associated with 16.0% patients;however, only 4% patients had associate conjunctivitis. Conclusion: In conclusion young male is more commonly affected by cough variant asthma of which majority have family history of asthma. Journal of National Institute of Neurosciences Bangladesh, 2016;2(1):30-33

scholarly journals Sociodemographic and Clinical Variables of Depression among Patients with Epilepsy in a Neuropsychiatric Hospital in Nigeria

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Nasir Olamide Madandola ◽  
Shehu Sale ◽  
Adebayo Sunday Adebisi ◽  
Ayodele Obembe ◽  
Auwal S. Salihu ◽  
...  
Keyword(s):  
Family History ◽  
Depressive Disorder ◽  
General Health Questionnaire ◽  
Positive Family History ◽  
Composite International Diagnostic Interview ◽  
Minority Ethnic Group ◽  
Cross Sectional ◽  
History Of ◽  
Patients With Epilepsy ◽  
Minority Ethnic

Background. Depression is a major contributor to the global burden of disease. Its occurrence in patients living with epilepsy is not just common but also a serious comorbidity. Patients tend to suffer if the depressive disorder is undetected and thus untreated. The aim of this study is to estimate the prevalence of depressive disorder in patients with epilepsy. Also, the sociodemographic and clinical factors that are associated with the development of depression in people living with epilepsy were examined. Materials and Method. This was a descriptive cross-sectional study of participants living with epilepsy and receiving care at the Federal Neuropsychiatric Hospital, Sokoto, Nigeria. Participants were recruited consecutively as they come for follow-up care. A sociodemographic/clinical questionnaire and General Health Questionnaire version 28 (GHQ-28) were first administered to participants followed by the Composite International Diagnostic Interview (CIDI). The descriptive statistics were generated and analyzed. Logistic regression was also done to determine the predictors of depression in the study participants. All test of probability was set at p<0.05. Results. A total of 400 participants with epilepsy were examined with GHQ-28 and CIDI. Out of the GHQ-28 examined individuals, 71 people (17.8%) met criteria for caseness while 35 participants (8.8%) were depressed when assessed with CIDI. The predictors of depressive illness in participants living with epilepsy were GHQ caseness (p≤0.001), minority ethnic group (p=0.006), and a positive family history of mental illness (p=0.021). Conclusion. Depression is common in people with epilepsy. Physicians should actively assess individuals with epilepsy for symptoms of depression. Special attention should be paid to patients with a family history of epilepsy and those from minority ethnic groups.

scholarly journals The Early Prelinguistic Skills in Iranian Infants and Toddlers

2021 ◽  
Vol 19 (4) ◽  
pp. 441-454
Author(s):  
Narges Bayat ◽  
◽  
Atieh Ashtari ◽  
Mohsen Vahedi ◽  
◽  
...  
Keyword(s):  
Family History ◽  
Speech Therapy ◽  
Positive Family History ◽  
Age Groups ◽  
Language Disorders ◽  
Cross Sectional ◽  
History Of ◽  
The Impact ◽  
Children's Development ◽  
Children’S Development

Objectives: The prelinguistic skills which pave the way for language development have always been an area of research in the Speech Therapy field. Although studying these skills is important, there is a study gap among Persian children. Therefore, this study explored prelinguistic skills among a sample of Persian-speaking children aged 6 to 24 months and made a comparison between different age groups. We also studied the effects of gender and family history of speech-language disorders on children’s prelinguistic abilities. Methods: In the present study, 277 mothers of Iranian Persian-speaking children aged 6 to 24 months were asked to fill a research-made checklist that evaluated the prelinguistic skills of their children. This study was cross-sectional and was conducted in Tehran City, Iran, in 2021. Children’s abilities in different age groups were compared using the analysis of variance (ANOVA), Scheffe test, the Kruskal-Wallis test, and the post-hoc test. The differences between the total scores of the two genders were also determined using the Mann-Whitney U test. Results: Comparing the prelinguistic skills in different age groups indicated a statistically significant increase in the scores as children grow up. Children with a positive family history of speech-language disorders scored lower on the checklist than the others (91.03±17.37). Furthermore, there were statistically significant differences between the two genders in developing gesture, vocalization, first words, social interaction, imitation, and play; girls had higher scores. Conclusion: Based on the studies conducted in different countries, prelinguistic skills develop as children grow up; these skills facilitate language acquisition and other social skills. The present study also demonstrated the development of these skills alongside children’s development. This similarity between Persian-speaking children and other children from different cultures and languages, as well as better performance in children with a negative family history of speech-language impairments, confirm the role of genetic factors in children’s development. Moreover, the differences in the development of some prelinguistic skills between girls and boys reveal the impact of various factors, such as social factors, on prelinguistic skills development.

scholarly journals Prevalence, Types and Risk Factors of Congenital Anomalies (A Hospital Based Study)

2020 ◽  
Author(s):  
Amira M. Shalaby ◽  
Amira F. EL-Gazzar
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Congenital Anomalies ◽  
Urban Areas ◽  
Positive Family History ◽  
Consanguineous Marriage ◽  
Cross Sectional ◽  
Children's Hospital ◽  
Significant Difference ◽  
Children’S Hospital

Abstract Background: Congenital anomalies (CA) are common causes of infant’s and childhood deaths and disability. Objectives: The aim of the study is to determine the prevalence, describe the types and risk factors of congenital anomalies among newborns admitted to Neonatal Intensive Care Unit (NICU) of a Children's Hospital. Study design: It is a prospective observational study(analytic cross sectional study) was performed and screening of the newborn admitted at NICU of a Children's Hospital during the period of 6 months from 1 to 12-2017 to the end of 5-2018. The sample was 346 newborns, 173 cases and 173 control. We collected data using a record checklist and an interviewing questionnaire.Results: There were a significant difference between cases and control concerning gestational age (P=0.001), single or multiple babies (P=0.002), residence (P=0.001), consanguineous marriage (P=0.01) and family history of unfavorable outcome (P=0.001). We also found that the most common type of congenital anomalies was gastrointestinal anomalies 63 cases (36.4%) with tracheoesophageal fistula 17 cases (27%) being the most common GIT anomalies. Then the musculoskeletal anomalies being the second common anomalies 14.5% with diaphragmatic hernia 10 cases being the most common in musculoskeletal anomalies followed by other anomalies (22 multiple +1Conjoined Twins 23 cases (13.3%) followed by circulatory anomalies 22 cases (12.7%), followed by CNS anomalies 18 cases (10%). Conclusion: The prevalence of congenital anomalies was 22.97%. The most common anomalies were gastrointestinal anomalies (GIT), musculoskeletal anomalies, multiple anomalies and circulatory system anomalies. The risk factors were consanguineous marriage, positive family history, urban areas, full-term and singleton pregnancies.

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