MATERNAL C-REACTIVE PROTEIN IN PREGNANCY AND ITS RELATION WITH EARLY  ONSET NEONATAL SEPSIS

Objective:To determine association of early-onset neonatal sepsis (EONS) in newborns of serum C-reactive protein positive mothers. Study Design: Cross sectional study Place and duration of study: Department of Pediatrics, Combined Military Hospital Quetta, Pakistan from September 2016 to March 2018. Material and Methods: 105 neonates (both gender) of all mothers who were C - reactive protein positive were enrolled in this study using inclusion and exclusion criteria.Neonatal sepsis was diagnosed by clinical examination, which was carried out by senior pediatrician, blood complete picture and c reactive protein. Neonates were treated as per departmental protocol. Stratification was done in regard to gestational age, birth weight and age of neonates in hours. Post stratification chi square test was applied and p-value less than 0.05 was considered significant. Results:Out of total 105 patients, 46 (44%) were male and 59 (56%)were female neonates. Amongst the babies of 105 CRP positive mothers, 79 babies were having signs and symptoms of neonatal sepsis and 26 babies were having no signs and symptoms of neonatal sepsis with statistically significant relation between maternal CRP and neonatal sepsis of p value <0.05. Conclusion:Increased maternal CRP level is associated with increased risk of neonatal sepsis. Maternal CRP may be used as a good screening tool for early detection of neonatal sepsis.

Download Full-text

CORRELATION BETWEEN SERUM C-REACTIVE PROTEIN LEVEL WITH SEVERITY OF THE DISEASE IN COVID-19 PATIENTS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i11.2302 ◽

2021 ◽

Vol 5 (11) ◽

Author(s):

Sangeeta Gahlot ◽

Surendra Yadav ◽

Makkhan Lal Saini

Keyword(s):

Severe Disease ◽

Serum Levels ◽

Cross Sectional Study ◽

P Value ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Group I ◽

Moderate Disease ◽

Severity Of The Disease

Background: To find the levels of serum CRP in confirmed Covid-19 patients and to compare their levels in patients with mild to moderate disease and patients with severe disease who required ICU care for management. Methods: A Cross sectional study was carried out on 100 confirmed cases of Covid-19, in whom Serum levels of Random sugar (RBS), Creatinine, Urea, C- reactive protein (CRP) were measured. Results: The levels of serum Urea, Creatinine were significantly increased in group II when compared to group 1, and the levels of CRP were significantly increased with p value <0.0001 in group IIwhen compared to group I. Conclusion: Findings of our study suggest that determination of biochemical parameters like CRP at the time of hospitalization helps in predicting the severity of disease and need for ICU for better treatment management and prevention of adverse outcome. Keywords: Severe acute respiratory syndrome, Covid-19, C- reactive protein, Intensive care unit.

Download Full-text

Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study

Jornal de Pediatria ◽

10.1016/j.jped.2021.01.004 ◽

2021 ◽

Author(s):

Angie M.S. Tosson ◽

Dina Koptan ◽

Rabab Abdel Aal ◽

Marwa Abd Elhady

Keyword(s):

Neonatal Sepsis ◽

Late Onset ◽

Cross Sectional Study ◽

Sectional Study ◽

Single Center ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein

Download Full-text

SMOKELESS TOBACCO;

The Professional Medical Journal ◽

10.29309/tpmj/2017.24.09.881 ◽

2017 ◽

Vol 24 (09) ◽

pp. 1310-1315

Author(s):

Imran Ali Shaikh ◽

Naila Masood ◽

Fouzia Aijaz Sheikh ◽

Talha Shaikh

Keyword(s):

Vitamin B12 ◽

Serum Ferritin ◽

Smokeless Tobacco ◽

Negative Impact ◽

Cross Sectional Study ◽

P Value ◽

Betel Nut ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein

Objectives: To know the serum ferritin and vitamin B12 levels in relation to Creactive protein in individuals using smokeless tobacco in Hyderabad, sindh, Pakistan. StudyDesign: Cross sectional study. Place of Study: Private clinics of consultants of Hyderabad,Sindh, Pakistan. Duration of Study: January 2016 to February 2017. Methodology: Onehundred eighty three individuals were selected from different clinics of physicians, dentalsurgeons of sadder Hyderabad sindh Pakistan by judgmental sampling. Patients were youngsubjects, mean age was 21.4±7.4 years, mean BMI was 22.1±3.8 and mean duration ofchewing tobacco was 2±1.5 years. All types and forms of gutaka, manpuri and flavored betelnut were included like bombart, zafri and panparag. The dose was 30-100grams once or twotimes. SPSS 16 was used as statical software and Chai square test was used to calculatep value. P value was taken <0.05 statically significant. Results: Frequency of use of gutkawas 32%, Betel nut 38% and 29% had habit of chewing manpuri. Serum ferritin was low andc reactive protein was high, p value was <0.05 in gutaka and manpuri users. Vitamin B12was reduced significantly in gutaka user p value was <0.05. In betel nut chewers significantfinding was only high C reactive protein, p value <0.04. Conclusion: Smokeless tobacco hassignificant negative impact on serum ferritin and vitamin B12 levels. These chewing agents alsoincreased inflammatory markers like c reactive protein.

Download Full-text

Evaluation of Procalcitonin, C-Reactive Protein, and Interleukin-6 as Early Markers for Diagnosis of Neonatal Sepsis

International Journal of Microbiology ◽

10.1155/2020/8889086 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Emad A. Morad ◽

Rehab A. Rabie ◽

Mohamed A. Almalky ◽

Manar G. Gebriel

Keyword(s):

16S Rdna ◽

Interleukin 6 ◽

Neonatal Sepsis ◽

Neonatal Intensive Care ◽

Cross Sectional Study ◽

Sepsis Group ◽

C Reactive Protein ◽

University Hospitals ◽

Cross Sectional ◽

Reactive Protein

Background. Neonatal sepsis diagnosis is a challenge because of its nonspecific presentation together with low sensitivity of the time-consuming bacterial cultures. So, many sepsis markers, like C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6), are emerging to improve its diagnosis. Aim. This study was done to investigate the role of CRP, PCT, and IL-6 in promoting the early diagnosis of neonatal sepsis in an attempt to decrease morbidity and mortality. Methods. This cross-sectional study was conducted on 50 neonates suspected with sepsis enrolled from the neonatal intensive care unit (NICU) of Zagazig University Hospitals, Egypt. Blood cultures for these neonates were done before starting antibiotics. Also, bacterial DNA was revealed from the blood by broad-range 16S rDNA polymerase chain reaction (PCR). Measurements of CRP using the immunoturbidimetry method, PCT using fluorescence immunoassay quantitative method, and IL-6 using commercially available ELISA kit were done to all enrolled neonates. Results. Forty-one neonates with proved sepsis were found to be positive in blood culture and/or PCR for bacterial 16S rDNA. The most common isolated organisms were Klebsiella (61.3%), followed by E. coli (9.7%) and CONS (9.7%). We detected much significant higher levels of PCT, CRP, and IL-6 in the proved sepsis group than the suspected neonatal sepsis cases (p≤0.001, 0.001, and 0.004, respectively). Serum PCT levels showed the highest sensitivity, specificity, PPV, NPV, and accuracy of 97.6%, 89%, 97%, 88.9%, and 96% than other studied sepsis markers. Conclusion. PCT has satisfactory characteristics as a good marker than IL-6 and CRP for the diagnosis of neonatal sepsis.

Download Full-text

NEONATAL SEPSIS;

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.04.3362 ◽

2019 ◽

Vol 26 (04) ◽

Author(s):

Mohammad Irshad ◽

Mohsin Hayat ◽

Hina Parvez ◽

Ihsan Ullah ◽

Zia ur Rehman

Keyword(s):

Neonatal Sepsis ◽

Gold Standard ◽

Antibiotic Use ◽

Cross Sectional Study ◽

Blood Cultures ◽

C Reactive Protein ◽

Cross Sectional ◽

Predictive Values ◽

Female Ratio ◽

Reactive Protein

Objectives: To determine the diagnostic accuracy of C-reactive protein in the diagnosis of neonatal sepsis keeping blood cultures as gold standard. Study Design: Descriptive cross-sectional study. Setting: Pediatric Unit of Lady Reading Hospital Peshawar Pakistan. Duration: Six months from 09-06-2012 to 08-12-2012. Methodology: Total of 196 patients meeting the required inclusion criteria with clinical suspicion of sepsis. Those neonates were subjected to investigations. C.R.P. was tested using the Quantitative method according to the instructions provided with the kit. By keeping blood culture as gold standard, patients with both positive and negative cultures were taken and the results compared to the results of C.R.P. in these subjects being positive or negative. Results: Among the 196, majority of the neonates included were less than a week old having a mean age of 4.5 days. There were 57 (29%) females and 139 (71%) males, with male to female ratio of 2.4:1. Blood cultures were positive in 85 (43%) and negative in 111 (57%) cases, while C.R.P. was positive in 95 (48%) and negative in 101 (52%) cases. Sensitivity, specificity, and positive and predictive values of C-reactive protein were calculated using formulas, and they turned out to be 77.6%, 73.8%, 69.4%, and 81.2% respectively with accuracy being 0.41%. Conclusion: An accurate and timely diagnosis of early onset neonatal sepsis remains challenging to the clinician as well as laboratory. Physicians can prevent unnecessary antibiotic use by performing the qualitative estimation CRP as a single, rapid and inexpensive test with a negative predictive value of 81.2%.

Download Full-text

Diagnostic role of interleukin-6 and quantitative C-reactive protein in suspected early onset neonatal sepsis

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2020.8.1.0369 ◽

2020 ◽

Vol 8 (1) ◽

pp. 263-270

Author(s):

Priti Chowdhary ◽

Ritesh Ranjan ◽

Anita Pandey

Keyword(s):

Blood Culture ◽

Interleukin 6 ◽

Neonatal Sepsis ◽

Early Onset ◽

Signs And Symptoms ◽

Care Hospital ◽

Age Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Early Onset Sepsis

Introduction: Neonatal sepsis is a major cause of morbidity and mortality most remarkable in the third world nations. Early diagnosis and subsequent therapy for the infected infants may play a vital role in lowering such mortality and morbidity rates. Aim: To study the clinical profile of neonatal sepsis in a tertiary care hospital and to correlate the findings with quantitative C-reactive protein (CRP) and Interleukin-6 (IL-6). Settings and Design: A total of 296 neonates admitted in neonatal intensive care unit (NICU) with clinical signs and symptoms suggestive of sepsis were studied. Based on their age the study population was divided into early onset sepsis (EOS): age group less 72 hours and late onset sepsis (LOS): age group more than 72 hours. Also healthy neonates who had no signs and symptoms of sepsis were taken as control for the study. Material and Methods: Blood culture was carried out using BacT/ Alert-3D automated system. Quantitative CRP by nephelometry and IL-6 by ELISA was done in all culture positive cases and controls. Correlation of detection of cases of sepsis by quantitative CRP and IL-6 with blood culture was carried out. Statistical analysis: Statistical parameters such as sensitivity, specificity, predictive values, accuracy and significance levels were calculated Results: In EOS the sensitivity and negative predictive value (NPV) of IL-6 was 62.32% and 33.33% respectively as compared to sensitivity of 27.5% and NPV of 26.47% of CRP. Conclusions: IL-6 is a good marker for early onset sepsis than CRP detecting a greater number of sepsis cases.

Download Full-text

C-reactive protein as the marker of COVID-19 severity at Sanjiwani general hospital, Gianyar, Bali in 2020

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20210864 ◽

2021 ◽

Vol 9 (3) ◽

pp. 676

Author(s):

I. Gusti Ayu Putu Putri Ulandari ◽

Putu Dyah Widyaningsih

Keyword(s):

General Hospital ◽

Secondary Data ◽

Cross Sectional Study ◽

Study Data ◽

P Value ◽

C Reactive Protein ◽

Cross Sectional ◽

Severity Level ◽

Reactive Protein ◽

The Mean

Background: Coronavirus disease-2019 (COVID-19) is a novel coronavirus type infection disease that was first reported at Wuhan city, Hubei province, China in December 2019. Cases of COVID-19 in Indonesia were increasing, reaching up to 287,008 confirmed cases on 30th September 2020. Sanjiwani general hospital Gianyar, Bali, one of the COVID-19 referral hospital at Gianyar, Bali, has treated as many as 149 confirmed COVID-19 cases from August to October 2020. The most significant laboratory parameter associated with COVID-19 severity was C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR).Methods: This study is a descriptive cross-sectional study. Data were gathered through secondary data from the medical records using the total sampling method. Descriptive analyses were performed to describe the samples characteristics and to calculate the mean CRP level. Meanwhile, the chi-square test was done to investigate the association between CRP level and the severity level of COVID-19. The result is considered statistically significant if the p value is <0.05Results: Most of the samples are >60 years old (24.4%), female (56.6%), and have diabetes mellitus as their comorbid (46,7%). The mean CRP level is 8.9 mg/L. CRP level >8.9 mg/l significantly affects COVID-19 patients’ severity with the p value of 0.000 (p<0.005). The higher the initial CRP level of COVID-19 patients, the higher the severity level will be.Conclusions: There is an association between the increased CRP level at the beginning of hospital admission and the severity of COVID-19 patients.

Download Full-text