The characteristics and evolution of accommodation zone in Xihu Sag, East China Sea Shelf Basin

2020 ◽  
Author(s):  
Bin Xu ◽  
Zhiping Wu ◽  
Yanjun Cheng ◽  
Yining Dai
Keyword(s):  
Tectonic Evolution ◽  
Early Stage ◽  
Western Slope ◽  
Accommodation Zone ◽  
Activation Rate ◽  
East China Sea Shelf ◽  
Spatial Differences ◽  
Formation And Evolution ◽  
The Difference ◽  
Activation Rates

<p>Accommodation zone is an important deformation structure in sedimentary basin, which is significant to understanding the basin structure. The formation and evolution of the Xihu Sag is controlled by the NNE-striking faults, whereas the NNE-striking deformation is offset by the NW-striking accommodation zone. However, the structure and evolution of the accommodation zone are poorly known. Based on the dips and activation rates of related NNE-striking faults on two sides of the NW-striking accommodation zone, 8 styles of NW-striking accommodation zones are divided in this sag, including the synthetic approaching style, synthetic broken line style, synthetic overlapping style, reverse approaching style, reverse broken line style, composite approaching style, composite broken line style, composite overlapping style. The relative accommodation ratio of the accommodation zone can be reflected by the difference-value of the faults activation rate of the NNE-striking faults. The results show that: (1) the most of the NW-striking accommodation zones formed at Early Cretaceous with low relative accommodation ratio, and reached its peak at Eocene, and disappeared at Late Oligocene. (2) The temporal and spatial differences of the NW-striking accommodation zones are very common in the Xihu Sag. Spatially, the accommodation zones are mainly developed in the western slope of Xihu Sag, and rarely developed in the middle and eastern of the Xihu Sag. Temporally, the accommodation zones developed in the northern area of the western slope of the Xihu Sag during the early stage, whereas, these zones migrated to the southern area of the western slope of the Xihu Sag during the late stage. This study on the tectonic evolution of the accommodation zone provides significant support to the study on the tectonic evolution of the Xihu sag.</p>

scholarly journals Differences in physical symptoms between those with and without kidney disease: a comparative study across disease stages in a UK population

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Thomas J. Wilkinson ◽  
Daniel G. D. Nixon ◽  
Jared Palmer ◽  
Courtney J. Lightfoot ◽  
Alice C. Smith
Keyword(s):  
Kidney Disease ◽  
Early Stage ◽  
Symptom Burden ◽  
Final Analysis ◽  
Physical Symptoms ◽  
Disease Trajectory ◽  
High Prevalence ◽  
Comparative Group ◽  
The Difference ◽  
Disease Stages

Abstract Background Those living with kidney disease (KD) report extensive symptom burden. However, research into how symptoms change across stages is limited. The aims of this study were to 1) describe symptom burden across disease trajectory, and 2) to explore whether symptom burden is unique to KD when compared to a non-KD population. Methods Participants aged > 18 years with a known diagnosis of KD (including haemodialysis (HD) and peritoneal dialysis (PD)) and with a kidney transplant) completed the Leicester Kidney Symptom Questionnaire (KSQ). A non-KD group was recruited as a comparative group. Multinominal logistic regression modelling was used to test the difference in likelihood of those with KD reporting each symptom. Results In total, 2279 participants were included in the final analysis (age 56.0 (17.8) years, 48% male). The main findings can be summarised as: 1) the number of symptoms increases as KD severity progresses; 2) those with early stage KD have a comparable number of symptoms to those without KD; 3) apart from those receiving PD, the most frequently reported symptom across every other group, including the non-KD group, was ‘feeling tired’; and 4) being female independently increased the likelihood of reporting more symptoms. Conclusions Our findings have important implications for patients with KD. We have shown that high symptom burden is prevalent across the spectrum of disease, and present novel data on symptoms experienced in those without KD. Symptoms requiring the most immediate attention given their high prevalence may include pain and fatigue. Trial registration The study was registered prospectively as ISRCTN11596292.

scholarly journals P300 and Decision Making under Risk and Ambiguity

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Lei Wang ◽  
Jiehui Zheng ◽  
Shenwei Huang ◽  
Haoye Sun
Keyword(s):  
Decision Making ◽  
Early Stage ◽  
Event Related Potentials ◽  
Underlying Mechanism ◽  
P300 Amplitude ◽  
Early Assessment ◽  
Decision Making Under Risk ◽  
Related Potentials ◽  
The Difference ◽  
Ambiguous Condition

Our study aims to contrast the neural temporal features of early stage of decision making in the context of risk and ambiguity. In monetary gambles under ambiguous or risky conditions, 12 participants were asked to make a decision to bet or not, with the event-related potentials (ERPs) recorded meantime. The proportion of choosing to bet in ambiguous condition was significantly lower than that in risky condition. An ERP component identified as P300 was found. The P300 amplitude elicited in risky condition was significantly larger than that in ambiguous condition. The lower bet rate in ambiguous condition and the smaller P300 amplitude elicited by ambiguous stimuli revealed that people showed much more aversion in the ambiguous condition than in the risky condition. The ERP results may suggest that decision making under ambiguity occupies higher working memory and recalls more past experience while decision making under risk mainly mobilizes attentional resources to calculate current information. These findings extended the current understanding of underlying mechanism for early assessment stage of decision making and explored the difference between the decision making under risk and ambiguity.

scholarly journals Different Tectonic Evolution of Fast Cooling Ophiolite Mantles Recorded by Olivine-Spinel Geothermometry: Case Studies from Iballe (Albania) and Nea Roda (Greece)

Minerals ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 64
Author(s):  
Micol Bussolesi ◽  
Giovanni Grieco ◽  
Alessandro Cavallo ◽  
Federica Zaccarini
Keyword(s):  
Tectonic Evolution ◽  
Early Stage ◽  
Mineral Chemistry ◽  
Northern Greece ◽  
Present Contribution ◽  
Cooling Rates ◽  
History Of ◽  
Ferrian Chromite ◽  
Fast Cooling ◽  
Subduction Setting

Mg-Fe2+ diffusion patterns in olivine and chromite are useful tools for the study of the thermal history of ultramafic massifs. In the present contribution, we applied the exponential modeling of diffusion patterns to geothermometry and geospeedometry of chromitite ores from two different ophiolite contexts. The Iballe ophiolite (Northern Albania) hosts several chromitite pods within dunites. Primary and re-equilibrated Mg#, estimated by using an exponential function, provided re-equilibration and primary temperatures ranging between 677 and 996 °C for chromitites and between 527 and 806 °C for dunites. Cooling rates for chromitites are higher than for dunites, suggesting a different genesis for the two lithologies, confirmed also by spinel mineral chemistry. Chromitites with MORB affinity formed in a SSZ setting at a proto-forearc early stage, explaining the higher cooling rates, while dunites, with boninitic affinity, were formed deeper in the mantle in a more mature subduction setting. At the Nea Roda ophiolite (Northern Greece) olivine in chromitites do not show Mg-Fe variations, and transformation into ferrian chromite produced “fake” diffusion patterns within chromite. The absence of diffusion patterns and the low estimated temperatures (550–656 °C) suggest that Nea Roda chromitites were completely re-equilibrated during an amphibolite-facies metamorphic event that obliterated all primary features.

scholarly journals Serum CYR61 As A Potential Biomarker for The Diagnosis of Esophagogastric Junction Tumor

2021 ◽  
Author(s):  
Ling-Yu Chu ◽  
Jian-Yuan Zhou ◽  
Yi-Xuan Zhao ◽  
Yan-Ting Ou ◽  
Tian Yang ◽  
...  
Keyword(s):  
Early Stage ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Operating Characteristics ◽  
Tumor Patients ◽  
Chi Square ◽  
Potential Biomarker ◽  
The Difference ◽  
Normal Controls

Background：Esophagogastric junction tumor (EGJ) is a rare but fatal disease with a rapid rising incidence worldwide in the late 20 years, and it lacks a convenient and safe method for diagnosis. This study aimed to evaluate the potential of serum CYR61 as a biomarker for the diagnosis of EGJ tumor. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to estimate CYR61 levels in sera of 152 EGJ tumor patients and 137 normal controls. Receiver operating characteristics (ROC) was carried out to evaluate the diagnostic accuracy. The Mann–Whitney’s U test was used to compare the difference of serum levels of CYR61 between groups. And chi-square tests were employed to estimate the correlation of the positive rate of serum CYR61 between/among subgroups. Results: Serum CYR61 levels were statistically lower in EGJ tumor and early-stage EGJ tumor patients than those in normal controls (P<0.0001). The sensitivity, specificity, and the area under the curve (AUC) of this biomarker in EGJ tumor were 88.2%, 43.8% and 0.691, respectively, and those for early stage of EGJ tumor were 80.0%, 66.4% and 0.722, respectively. Analyses showed that there was no correlation between the clinical data and the levels of CYR61 (P>0.05). Conclusion: This study showed that CYR61 might be a potential biomarker to assist the diagnosis of EGJ tumor.

scholarly journals Improvement in geriatric trauma outcomes in an evolving trauma system

2019 ◽  
Vol 4 (1) ◽  
pp. e000282 ◽  
Author(s):  
Amund Hovengen Ringen ◽  
Iver Anders Gaski ◽  
Hege Rustad ◽  
Nils Oddvar Skaga ◽  
Christine Gaarder ◽  
...  
Keyword(s):  
Trauma System ◽  
Trauma Team ◽  
The Elderly ◽  
Geriatric Trauma ◽  
Trauma Patients ◽  
Age Group ◽  
Trauma Team Activation ◽  
Activation Rate ◽  
Time Periods ◽  
Activation Rates

BackgroundThe elderly trauma patient has increased mortality compared with younger patients. During the last 15 years, initial treatment of severely injured patients at Oslo University Hospital Ulleval (OUHU) has changed resulting in overall improved outcomes. Whether this holds true for the elderly trauma population needs exploration and was the aim of the present study.MethodsWe performed a retrospective study of 2628 trauma patients 61 years or older admitted to OUHU during the 12-year period, 2002–2013. The population was stratified based on age (61–70 years, 71–80 years, 81 years and older) and divided into time periods: 2002–2009 (P1) and 2010–2013 (P2). Multiple logistic regression models were constructed to identify clinically relevant core variables correlated with mortality and trauma team activation rate.ResultsCrude mortality decreased from 19% in P1 to 13% in P2 (p<0.01) with an OR of 0.77 (95 %CI 0.65 to 0.91) when admitted in P2. Trauma team activation rates increased from 53% in P1 to 72% in P2 (p<0.01) with an OR of 2.16 (95% CI 1.93 to 2.41) for being met by a trauma team in P2. Mortality increased from 10% in the age group 61–70 years to 26% in the group above 80 years. Trauma team activation rates decreased from 71% in the age group 61–70 years to 50% in the age group older than 80 years. Median ISS were 17 in all three age groups and in both time periods.DiscussionDevelopment of a multidisciplinary dedicated trauma service is associated with increased trauma team activation rate as well as survival in geriatric trauma patients. As expected, mortality increased with age, although inversely related to the likelihood of being met by a trauma team. Trauma team activation should be considered for all trauma patients older than 70 years.Level of evidenceLevel IV.

scholarly journals Fluorescence-Labeled Amyloid Beta Monomer: A Molecular Dynamical Study

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3524
Author(s):  
János Gera ◽  
Gábor Paragi
Keyword(s):  
Single Molecule ◽  
Early Stage ◽  
Conformational Space ◽  
Dynamic Simulations ◽  
Dynamical Study ◽  
Fluorescence Dye ◽  
Aβ Aggregation ◽  
The Difference ◽  
Open Question ◽  
The Impact

The aggregation process of the Amyloidβ (Aβ) peptide is one of the central questions in Alzheimers’s research. Fluorescence-labeled single-molecule detection is a novel technique concerning the early stage investigation of Aβ aggregation, where the labeling dyes are covalently bound to the Aβ monomer. As the influence of the dye on the conformational space of the Aβ monomer can be significant, its effect on the seeding process is an open question. The applied fluorescent molecule continuously switches between an active (ON) and an inactive (OFF) state, where the latter supports an extra rotational restriction at many commercially available dyes. However, only a few theoretical studies simulated the Aβ monomer in the presence of a dye and none of them considered the difference between the ON and the OFF states. Therefore, we examined the impact of a selected fluorescence dye (Alexa 568) on the conformational space of the monomeric Aβ(1–42) peptide in its ON and OFF state by replica exchange molecular dynamic simulations. Investigations on secondary structure elements as well as dye-peptide contact analysis for the monomers are presented. Experimental and theoretical NMR shifts were contrasted to qualify the calculation protocol and theoretical values of the labeled and the non-labeled peptide were also compared. We found that the first five residues have higher helical propensity in the presence of the dye, and electrostatic properties could strongly affect the connection between the dye and the peptide parts.

scholarly journals Requirements for Electric Machine Design based on Operating Points from Real Driving Data in Cities

2019 ◽  
Vol 10 (4) ◽  
pp. 60
Author(s):  
Svenja Kalt ◽  
Lucas Brenner ◽  
Markus Lienkamp
Keyword(s):  
Time Pressure ◽  
Early Stage ◽  
Driving Cycle ◽  
Driving Cycles ◽  
New Concepts ◽  
The Difference ◽  
Electric Machine Design ◽  
The Impact ◽  
Operating Points

Increasing environmental awareness leads to the necessity for more efficient powertrains in the future. However, the development of new vehicle concepts generates a trend towards ever shorter development cycles. Therefore, new concepts must be tested and validated at an early stage in order to meet the increasing time pressure. This requires the determination of real driving data in fleet tests in order to generate realistic driving cycles, which correspond as closely as possible to the actual driving behavior of the applications use case. Within the scope of this paper, real driving data are analyzed and used to create a representative driving cycle. The resulting driving cycle based on real driving characteristics is then used to investigate the impact of application-based design for powertrains on the design of electric machines, by illustrating the difference between synthetic operating points and real driving data.

scholarly journals Dynamic Analysis and Security Characteristics of Carrier-Based Aircraft Arresting in Yaw Condition

2020 ◽  
Vol 10 (4) ◽  
pp. 1253
Author(s):  
Yiming Peng ◽  
Pengpeng Xie ◽  
Xiaohui Wei ◽  
Hong Nie
Keyword(s):  
Negative Impact ◽  
Early Stage ◽  
Dynamic Properties ◽  
Wave Model ◽  
The United States ◽  
Us Military ◽  
Load Fluctuation ◽  
Kink Wave ◽  
The Difference ◽  
Yaw Angle

In order to research the safety characteristics of carrier-based aircraft in yaw arrest, a complete dynamic model of the arresting system of a certain type of aircraft was developed to understand more about its dynamic properties. Based on the discrete kink-wave model, a simulation of centering arrest was conducted. The simulation results were compared with experimental data from the United States (US) military standards, demonstrating that the basic changing laws are almost the same. On the basis of centering arrest, a simulation of yaw arrest was carried out. The results show that in yaw state, the difference in the lengths of the arresting cables on either side of the hook is smaller in the early stage after the hook hangs on the rope, which leads to little influence on load fluctuation produced by the kink-wave. With the increase in arresting distance, the difference in the lengths of the arresting cables on either side becomes larger, resulting in a situation in which the cable tension on the departure side will gradually become greater than that on the opposite side. In this situation, yaw landing has a negative impact on the characteristics of arresting safety, and the excessive yaw angle causes the aircraft to rush out of the safe landing area.

scholarly journals Determination of surface-induced platelet activation by applying time-dependency dissipation factor versus frequency using quartz crystal microbalance with dissipation

2011 ◽  
Vol 8 (60) ◽  
pp. 988-997 ◽  
Author(s):  
Julien Fatisson ◽  
Sania Mansouri ◽  
Daniel Yacoub ◽  
Yahye Merhi ◽  
Maryam Tabrizian
Keyword(s):  
Platelet Activation ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Dissipation Factor ◽  
Surface Hydrophobicity ◽  
Activation Rate ◽  
Immunofluorescence Labelling ◽  
Activation Rates

Platelet adhesion and activation rates are frequently used to assess the thrombogenicity of biomaterials, which is a crucial step for the development of blood-contacting devices. Until now, electron and confocal microscopes have been used to investigate platelet activation but they failed to characterize this activation quantitatively and in real time. In order to overcome these limitations, quartz crystal microbalance with dissipation (QCM-D) was employed and an explicit time scale introduced in the dissipation versus frequency plots ( Df–t ) provided us with quantitative data at different stages of platelet activation. The QCM-D chips were coated with thrombogenic and non-thrombogenic model proteins to develop the methodology, further extended to investigate polymer thrombogenicity. Electron microscopy and immunofluorescence labelling were used to validate the QCM-D data and confirmed the relevance of Df–t plots to discriminate the activation rate among protein-modified surfaces. The responses showed the predominant role of surface hydrophobicity and roughness towards platelet activation and thereby towards polymer thrombogenicity. Modelling experimental data obtained with QCM-D with a Matlab code allowed us to define the rate at which mass change occurs ( A / B ), to obtain an A / B value for each polymer and correlate this value with polymer thrombogenicity.

The influence of temperature on the tension developed in an isometric twitch

1951 ◽  
Vol 138 (892) ◽  
pp. 349-354 ◽  
Keyword(s):  
Early Stage ◽  
Muscular Contraction ◽  
Effect Of Temperature ◽  
Maximum Tension ◽  
Velocity Of Shortening ◽  
Influence Of Temperature On ◽  
Higher Temperature ◽  
The Difference ◽  
Isometric Twitch ◽  
The One

In muscular contraction the development of tension requires that the contractile component should shorten and stretch the series elastic component. In an isometric twitch the maximum tension is reached as a balance between two opposing processes, internal shortening on the one hand and decay of the active state (relaxation) on the other. The fact that the maximum tension in a twitch is considerably less than in a tetanus has been attributed to oncoming relaxation allowing insufficient time for internal shortening to be completed. The maximum tension in a twitch is considerably reduced by a rise of temperature, while that in a tetanus is somewhat increased. This would require that the temperature coefficient of the velocity of shortening should be substantially less than that of the decay of activity. Evidence for this exists. On this view the effect of a quick stretch, applied during the early stage of a twitch, in increasing the tension ratio, stretch/isometric, should be much greater at a higher temperature. This expectation is confirmed on frogs’ muscles over the range 0 to 20°C. The effect of temperature, therefore, on the size of a twitch can be attributed to the difference between the temperature coefficients of velocity of shortening and rate of relaxation.

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